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| 1 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 2 | Querying XML streams显示文摘 | Vanja Marcus F Attila B | 2005 | The VLDB Journal2005，，14： | 1 |
| 3 | A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China显示文摘 | You-lin Qiao John W Sellors Paul S Eder Yan-ping Bao Jeanette M Lim Fang-hui Zhao Bernhard Weigl Wen-hua Zhang Roger B Peck Ling Li Feng Chen Qing-jing Pan Attila T Lorincz | 2008 | Lancet Oncology2008，，10： | 1 |
| 4 | Photocatalytic oxidation of oxalic acid enhanced by silver deposition on a TiO2 surface 显示文摘 | Erzsebet S B Hajnalka C and Attila H | 2003 | J Photochem Photobio A: Chemistry2003，154，23： | 1 |
| 5 | Viral load of human papillomavirus and risk of CIN3 or cervical cancer显示文摘 | Attila T Lorincz Philip E Castle Mark E Sherman David R Scott Andrew G Glass Sholom Wacholder Brenda B Rush Patti E Gravitt John E Schussler Mark Schiffman | 2002 | The Lancet . 2002 (9328)2002，，9328： | 1 |
| 6 | Expression pattern of clock under acute phase-delay of the light/dark cycle in the chicken pineal model显示文摘 | Siri K Gergely B Attila M | | 0，，01： | 1 |
| 7 | CONSTITUTIVELY PHOTOMORPHOGENIC1 is required for the UV-B response in Arabidopsis显示文摘 | Attila O Alexander B Zoltán M Agnieszka B Jean M Edward J O (E)va (A) Eberhard S Ferenc N Roman U | | 0，，08： | 1 |
| 8 | Comparison of early and lyear follow up results of conventional hemorrhoidectomy and hemorrhoid artery ligation: a randomized study 显示文摘 | Attila B Krisztina M Peter K | 2004 | Int J Col Dis2004，3，19： | 1 |
| 9 | Silicones on fibrous substrates: their mode of action显示文摘 | ATTILA B DIETER R ANDREAS M | 2001 | AATCC Review2001，1，1： | 1 |
| 10 | PhotocatalytiC Oxidation of Oxalic Acid Enhanced by Silver Deposition on a TiO2 Surface显示文摘 | Hajnalka C Attila H | 2003 | J Photochem Photohio A:Chem2003，154，23： | 1 |
| 11 | TRP channels in the skin显示文摘 | Balázs I Tóth Attila Oláh Attila Gábor Sz?ll?si Tamás Bíró | 2014 | Br J Pharmacol2014，，10： | 1 |
| 12 | spinal canal remodeling in burst fractures of the thoracolumbar spine:a computerized tomographic comparison between operative and nonoperafive treatment显示文摘 | Attila B Tepe S | 1996 | J Spinal Disord1996，9，： | 1 |
| 13 | Acoustic radiation force impulse quantitative elastography: a new noninvasive technique for the evaluation of parotid glands, a preliminary study in controls and in patients with irradiated nasopharyngeal carcinoma 显示文摘 | Iulia B Attila T S Ioana C Maria C Elisabeta C Grigore B Mindra B | 2015 | Medical Ultrasonography2015，17，3： | 1 |
| 14 | Comparison of early and 1-year follow-up results of conventional hemorrhoideetomy and hemorrhoid artery ligation: a randomized study显示文摘 | Attila B Krisztina M Peter K | 2004 | Int J Colorectal Dis2004，3，19： | 1 |
| 15 | Determination of ethyl carbarnate in palinka spirits by liquid chromatography-electrospray tandem mass spectrometry after derivatization显示文摘 | EDIT D ATTILA G EVA S B | 2010 | Food Research International2010，43，10： | 1 |
| 16 | Thoracic paravertebral blockade 显示文摘 | Attila B Szilard S Gabriella I | 2010 | Medical Ultrasonography2010，12，3： | 1 |
| 17 | Yttrium Normalisation: a New Tool for Detection of Chromium Contamination in Soil Samples显示文摘 | József Prokisch Béla Kovács Attila J. Palencsár Ildikó Szegvári Zoltán Gy?ri | 2000 | Environmental Geochemistry and Health2000，，4： | 1 |
| 18 | Effect of organized screening on cervical cancer incidence显示文摘 | Attila A Pukkala E sideman B | 1999 | Int J Cancer1999，83，： | 1 |
| 19 | Volatile Composition of Macedonian and Hungarian Wines Assessed by GC/MS显示文摘 | Violeta Ivanova Marina Stefova Borimir Vojnoski Traj?e Stafilov Ildiko Bíró Anita Bufa Attila Felinger Ferenc Kilár | 2013 | Food and Bioprocess Technology2013，，6： | 1 |
| 20 | Comparison of early and l-year follow-up results of conventional hemorrhoidectomy and hemorrhoid artery ligation:a randomized study显示文摘 | Attila B Krisztina M Peter K | 2004 | lnt J Colorectal Dis2004，3，19： | 1 |
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