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| 1 | Hepatitis B genotypes: Relation to clinical outcome in patients with chronic hepatitis B in Saudi Arabia显示文摘AIM: To identify the most common hepatitis B virus (HBV) genotype in Saudi Arabia, and correlate the prevailing genotypes with the clinical outcome of patients. METHODS: Patients were consecutively recruited from the hepatology clinics of two tertiary care referral cen- ters. Patients were categorized into 4 different groups: group 1, patients with hepatitis B and normal liver en- zymes; group 2, patients with hepatitis B and abnormal liver enzymes but without cirrhosis; group 3, patients with hepatitis B and liver cirrhosis; group 4, patients with hepatitis B and hepatocellular carcinoma. All patients had a positive hepatitis B surface antigen (HBsAg). Ge- notyping of HBV was performed by nested PCR-mediated amplification of the target sequence and hybridization with sequence-specific oligonucleotides. RESULTS: Seventy patients were enrolled in this study. They were predominantly male (72.9%) in their mid- forty’s (mean age 47 years). Forty-nine (70%) patients were hepatitis B envelope antigen (HBeAg) negative. The majority of patients (64%) acquired HBV through unknown risk factors. Hepatitis B genotyping revealed that 57 patients (81.4%) were genotype D, 1 patient (1.4%) had genotype A, 1 patient (1.4%) had geno- type C, and 4 patients (5.7%) had genotype E, while 7 patients (10%) had mixed genotype (4 patients ADG, 1 patient DE, 1 patient DF, and 1 patient ADFG). Based on univariate analysis of genotype D patients, significant predictors of advanced liver disease were age, gender, aspartate transaminase, alanine transaminase, albumin,bilirubin, and alkaline phosphatase (all P < 0.001). In multivariate analysis decreased hemoglobin (r = -0.05; 95% CI: -0.08 to -0.03; P = 0.001) and albumin levels (r = -0.004; 95% CI: -0.007 to -0.001; P = 0.002) were highly significant predictors of advanced liver disease. In patients with HBV genotype D, HBeAg negativity was found to increase across advancing stages of liver dis- ease (P = 0.024). CONCLUSION: This study highlights that the vast ma- jority of Saudi patients with chronic hepatitis B have genotype D. No correlation could be observed between the different genotypes and epidemiological or clinical factors. The relationship between genotype D and HBeAg status in terms of disease severity needs to be further elucidated in larger longitudinal studies. | Ayman A Abdo Badr M Al-Jarallah Faisal M Sanai Ahmad S Hersi Khalid Al-Swat Nahla A Azzam Manal Al-Dukhayil Amira Al-Maarik Faleh Z Al-Faleh | 2006 | World Journal of Gastroenterology2006，12，43： | 7 |
| 2 | Antioxidant Effect of Sepia Ink Extract on Extrahepatic Cholestasis Induced by Bile Duct Ligation in Rats显示文摘Objective The aim of our study was to assess the complications of hepatic fibrosis associated with bile duct ligation and the potential curative role of sepia ink extract in hepatic damage induced by bile duct ligation. Methods Rattus norvegicus rats were divided into 3 groups: Sham-operated group, model rats that underwent common bile duct ligation(BDL), and BDL rats treated orally with sepia ink extract(200 mg/kg body weight) for 7, 14, and 28 d after BDL. Results There was a significant reduction in hepatic enzymes, ALP, GGT, bilirubin levels, and oxidative stress in the BDL group after treatment with sepia ink extract. Collagen deposition reduced after sepia ink extract treatment as compared to BDL groups, suggesting that the liver was repaired. Histopathological examination of liver treated with sepia ink extract showed moderate degeneration in the hepatic architecture and mild degeneration in hepatocytes as compared to BDL groups. Conclusion Sepia ink extract provides a curative effect and an antioxidant capacity on BDL rats and could ameliorate the complications of liver cholestasis. | Hanan Saleh Amel M Soliman Ayman S Mohamed Mohamed-Assem S Marie | 2015 | Biomedical and Environmental Sciences2015，28，8： | 6 |
| 3 | Six Minute Walk Test to assess functional capacity in chronic liver disease patients显示文摘AIM: To examine the utility of Six Minute Walk Test (6MWT) in patients with chronic liver disease (CLD). METHODS: Two hundred and fifty subjects between the ages of 18 and 80 (mean 47) years performed 6MWT and the Six Minute Walk Distance (6MWD) was measured. RESULTS: The subjects were categorized into four groups. Group A (n = 45) healthy subjects (control); group B (n = 49) chronic hepatitis B patients; group C (n = 54) chronic hepatitis C patients; group D (n = 98) liver cirrhosis patients. The four groups differed in terms of 6MWDs (P < 0.001). The longest distance walked was 421 ± 47 m by group A, then group B (390 ± 53 m), group C (357 ± 72 m) and group D (306 ± 111 m). The 6MWD correlated with age (r = -0.482, P < 0.01), hemoglobin (r = +0.373, P < 0.001) and albumin (r = +0.311, P < 0.001) levels. The Child-Pugh classification was negatively correlated with the 6MWD in cirrhosis (group D) patients (r = -0.328, P < 0.01). At the end of a 12 mo follow-up period, 15 of the 98 cirrhosis patients had died from disease complications. The 6MWD for the surviving cirrhotic patients was longer than for non-survivors (317 ± 101 vs 245 ± 145 m, P = 0.021; 95% CI 11-132). The 6MWD was found to be an independent predictor of survival (P = 0.024). CONCLUSION: 6MWT is a useful tool for assessing physical function in CLD patients. We suggest that 6MWD may serve as a prognostic indicator in patients with liver cirrhosis. | Hatem F Alameri Faisal M Sanai Manal Al Dukhayil Nahla A Azzam Khalid A Al-Swat Ahmad S Hersi Ayman A Abdo | 2007 | World Journal of Gastroenterology2007，13，29： | 5 |
| 4 | Nonlinear transient analysis of reinforced concrete slabs subjected to blast loading and retrofitted with CFRP composites 显示文摘 | Khalid M Mosallam Ayman S Mosallam | 2001 | Composites Structure: Part B2001，32，3： | 1 |
| 5 | Nonlinear transient analysis of reinforced concrete slabs subjected to blast loading and retrofitted with CFRP composites显示文摘 | Khalid M Mosallam Ayman S Mosallam | 2001 | Composites Structure:Part B2001，32，62： | 1 |
| 6 | Cytochromec and dATP-mediated oligomerization of aPaf-1 is a prerequisite for procaspase-9 activation显示文摘 | Ayman S Srinivasa M S Samir A | 1999 | J Biol Chem1999，274，25： | 1 |
| 7 | The Effect of Adjusting pH on Stretchability and Meltability to White Brined Nabulsi Cheese显示文摘 | AYMAN S M JIHAD M Q | 2009 | American Journal of Applied Sciences2009，76，4： | 1 |
| 8 | Apoptosis in murine hepatoma hepa 1c1c7 wild-type, C12, and C4 cells mediated by bilirubin 显示文摘 | Seubert John M Darmon Alison J El Kadi Ayman O S | 2002 | Mol-Pharmacol (Molecular)2002，62，2： | 1 |
| 9 | Flow injection fluorimetric determination of chromium(VI)in electroplating baths by luminescence quenching of tris(2,2'-bipyridyl)ruthenium(11)显示文摘 | Saad S M Hassan Ayman A Abdel-Shafi Ayman H K Mohammed | 2005 | Talanta2005，67，4： | 1 |
| 10 | Nonlinear transient analysis of reinforced concrete slabs subjected to blast loading and retrofitted with CFRP composites 显示文摘 | Mosalam Khalid M Mosallam Ayman S | 2001 | Composites: Part B2001，32，8： | 1 |
| 11 | Strengthening of Two-Way Concrete Slabs with FRP Composite laminates 显示文摘 | Ayman S Mosallam Khalid M Mosallam | 2003 | Conetruction and Building Material2003，，17： | 1 |
| 12 | Nonlinear Transient Analysis of Reinforced Concrete Slabs Subjected to Blast Loading and Retrofitted with CFRP Composite 显示文摘 | Khalid M Mosalam Ayman S Mosallam | 2001 | Composites(Part B:Engineering)2001，32，： | 1 |
| 13 | Genome-wide association study of chronic hepatitis B virus infection reveals a novel candidate risk allele on 11q22.3显示文摘 | Ahmed Al-Qahtani Hanif G Khalak Fowzan S Alkuraya Waleed Al-hamoudy Khalid Alswat Mohammed A Al Balwi Ibrahim Al AbdulKareem Faisal M Sanai Ayman A Abdo | 2013 | Journal of Medical Genetics2013，，11： | 1 |
| 14 | Endomyocardial fibrosis in Egypt:anillustrated review显示文摘 | Rashwan MA Ayman M Ashour S | 1995 | Br Heart J1995，73，： | 1 |
| 15 | Spinal accessory neuropathy in patients with chronic neck pain显示文摘AIM: To assess the presence of spinal accessory neuropathy in patients with chronic neck pain.METHODS: Patients with pain either regional or focal in the neck or shoulders for at least 6 mo(chronic neck pain) were recruited randomly from the Rheumatology and Rehabilitation Outpatient Clinic at the Faculty of Medicine-Suez Canal University. Two groups were compared: 30 patients with chronic neck pain with mean age(36.97 ± 12.45 years) and 10 apparently healthy controls. Trapezius muscle examination including inspection and range of motion both active and passive was performed. A full clinical neurological examination was carried out to exclude peripheral neuropathy and motor neuron disease. According to the subject's type of work, cases were categorized into labor-intensive and non-labor intensive tasks. A nerve conduction study(NCS) was performed on spinal accessory nerves at both sides for all patients and controls. Parameters including latencies and amplitudes of compound motor action potential(CMAP) were compared with the chronicity of neck pain using the neck disability score. This cross sectional study was carried in the Rheumatology and Rehabilitation Department, at Suez Canal University Hospital, Ismailia, Egypt.RESULTS: Physical examination revealed that 80% of cases had spinal trapezius muscle spasm. Restricted neck motion was present in 16.6% of cases. No one suffered from muscle wasting or weakness. Pain was bilateral in 18 patients(60%), localized to the right side in six patients(20%) and localized to the left side in six patients(20%). The causes of neck pain in the patients studied were nonspecific, due to physical stresses, cervical spondylosis and mild cervical disc herniation. Mean disease duration in patients with labor-intensive tasks was(3.9 ± 2.1 years), which was longer than that in patients with non-labor intensive tasks(3.1 ± 1.9 years); however, this difference was statistically insignificant. Spinal accessory NCSs were performed while subjects were in sitting positions and relaxed with naturally suspended arms to minimize muscular movement. The results of electrophysiological studies revealed that mean right and left latencies of the spinal accessory nerve were 2.96 ± 0.69 ms, 2.98 ± 0.61 ms in the patient group and 2.44 ± 0.38 ms, 2.33 ± 0.36 ms in control group respectively. These differences were statistically significant with P = 0.028 and 0.006 respectively. Spinal accessory NCS showed normal CMAP amplitude in both patients and controls. Comparing the results of the neck disability index(NDI) to different characteristics in patients with chronic neck pain, showed that patients with labor-intensive work had a higher NDI score mean(34.7 ± 9.5) compared to those with non-labor-intensive work, with significant statistical difference(P = 0.011). In addition, mean NDI scores were higher in males, and patients aged over 40 years and this difference was statistically significant(P = 0.007 and P = 0.009 respectively). Correlation studies between right and left spinal accessory nerve latencies and disability percent calculated using the NDI revealed a positive correlation. Moreover, there was a positive correlation between age and disability percent.CONCLUSION: This study demonstrates electrophysiological evidence of demyelination in a significant proportion of patients with chronic cervical pain. | Mohamed A Hefny Mona S Ghaly Sahar M Greish Noha M Abogresha Ayman E Fahim | 2012 | World Journal of Rheumatology2012，2，2： | 1 |
| 16 | Improved flux pattern by third harmonic injection for multiphase induction machines using neural network 显示文摘 | AYMAN S KHALIK A GADOUE S M | 2011 | Alexandria Engineering Journal2011，50，2： | 1 |
| 17 | Decreased serum paraoxonase-1 activity during intestinal nematode (nippostrongylus brasiliensis) infection in rats显示文摘 | AYMAN S F KEIKO N NOBORU M | 2008 | Am J Trop Med Hyg2008，78，： | 1 |
| 18 | Y-type zeolite-encapsulated copper (II) salicylidene-p-aminobenzoic Schiff base complex:Synthesis,characterization and carbon monoxide adsorption显示文摘 | Tarek M S Ayman H A Zeinhom M | 2006 | Microporous and Mesoporous Materials2006，89，13： | 1 |
| 19 | Stress- strain model for concrete confined by FRP composites 显示文摘 | MARWAN N Y MARIA Q F AYMAN S M | 2007 | Composites Part B-Engineering2007，38，56： | 1 |
| 20 | Optimum flux distribution with harmonic injection for a multiphase induction machine using genetic algorithm显示文摘 | Ayman S A-K Shady M G Mahmoud I M | 2011 | IEEE Transactions on Energy Conversion2011，26，2： | 1 |
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