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| 1 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 6 |
| 2 | Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice显示文摘BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic retinopathy.AIM To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse model.METHODS The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield microscopy.RESULTS Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba mice.Furthermore, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced in Akimba mice when compared to DMSO treated mice. In addition, empagliflozin resulted in suppression of succinate levels in Akimba mice. The beneficial SCFA known as butyric acid was significantly increased in Akita mice after treatment with dapagliflozin when compared to vehicle treated mice. The norepinephrine content in the kidney was significantly reduced with both dapagliflozin and empagliflozin therapy in Akita mice and was significantly reduced in Akimba mice treated with empagliflozin.In non-diabetic C57 BL/6 J and Kimba mice, serum leptin levels were significantly reduced after dapagliflozin therapy.CONCLUSION The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1 D. Collectively, these improvements may represent an important mechanism underlying the potential benefits of SGLT2 inhibition in T1 D and its complications. | Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 3 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 2 |
| 4 | The United Kingdom public health re- sponse to an imported laboratory confirmed case of a no- vel coronavirus in September 2012显示文摘 | Pebody R G Chand M A Thomas H L Green H K Boddington N L Carvalho C Brown C S Anderson S R Rooney C Crawley-Boevey E Irwin D J Aarons E Tong C Newsholme W Price N Langrish C Tucker D Zhao H Phin N Crofts J Bermingham A Gil- gunn-Jones E Brown K E Evans B Catchpole M Watson J M | 2012 | Euro Surveill2012，17，20： | 1 |
| 5 | Uniform coverage of automotive surface patches显示文摘 | PRASAD N. A AARON G CONNER D. C CHOSET H ALFRED A.R | | 0，，11： | 1 |
| 6 | Improved methods for the ,cxtraction and analysis of isoflavones from soycontaining foods and nutritional suftplements by reversed-phase high-performance liquid chromatography and liquid chromatographymass spectrometry 显示文摘 | Aaron P G Mark W C | 2001 | Journal of Chromatography A2001，913，： | 1 |
| 7 | Evidence- based practice implementation: the impact of public versus private sector organization type on organizational support, provider atti- tudes, and adoption of evidence-based practice显示文摘 | Aarons G A Sommerfeld D H Walrath-Greene C M | 2009 | Implement Sci2009，，4： | 1 |
| 8 | Enduring effect of chronic corticosterone treatment on spatial learning,synaptic plasticity,and hippocampal neuropathology in young and mid-aged rats显示文摘 | SHARI R B AARON G H JEMMIFER C L | 1995 | J Neurosci1995，15，1： | 1 |
| 9 | Multiplexed toxin analysis using four colors of quantum dot fluororeagents 显示文摘 | Ellen R G Aaron R C George P A | 2004 | Anlytical Chemistry2004，76，： | 1 |
| 10 | Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-generated superoxide显示文摘 | Straub Adam C Clark Katherine A Ross Mark A Chandra Ashwin G Li Song Gao Xiang Pagano Patrick J Stolz Donna B Barchowsky Aaron | 2008 | Journal of Clinical Investigation2008，，12： | 1 |
| 11 | Potentiation of pa- clitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/ protein kinase B (Akt)-mediated signaling pathway 显示文摘 | Dao M N Aaron G C Rishindra R | 2004 | The Journal of Thoracic and Cardiovascular Surgery2004，，127： | 1 |
| 12 | Rituximab therapy for HIV-associated Castleman disease显示文摘 | Marcelin A G Aaron L Mateus C | 2003 | Blood2003，102，10： | 1 |
| 13 | Twin-screw extrusion pink salmon muscle and rice flour blends: effects of J Aquatic Food Product kneading elements 显示文摘 | Gour S C Binoy K G Aaron J O | 1998 | Technology1998，7，2： | 1 |
| 14 | Production of α-1,3-galactosyltransferase knockout Pigs by nuclear transfer cloning显示文摘 | Donna K S Kwang W P Hee T C Julia L G Gi S I Melissa S Aaron B August R Billy N D Clifton N M David B C Robert J H Randall S P | 2002 | Science2002，295，5557： | 1 |
| 15 | A comparison of strength and muscle mass increases during resistance training in young women 显示文摘 | PHILIP D C AARON W C DIGBY G S | 1998 | Eur J Appl Phys- iol1998，77，2： | 1 |
| 16 | Rituximab therapy for HIV-associated Castleman disease 显示文摘 | Marcelin A G Aaron L Mateus C | 2003 | Blood2003，102，8： | 1 |
| 17 | Assessment of Family Functioning in Caucasian and Hispanic Americans:Reliabili-ty,validity,and factor structure of the Family Assessment Device显示文摘 | Aarons G A Mcdonald E J Connelly C D | 2007 | Family Process2007，46，4： | 1 |
| 18 | Mammalian cell gene mutation assays working group report 显示文摘 | Aaron C S Bolcsfodi G Glatt H R | 1994 | Mutat Res1994，312，3： | 1 |
| 19 | Controlling the dimensions,reactivity and crystallinity of multiwalled carbon nanotubes using low ethanol concentrations显示文摘 | ANDRE B M JESSICA C D AARON M G | 2008 | Chem Phys Lett2008，453，13： | 1 |
| 20 | Hop is an unusual homeobox gene that modulates cardiac development显示文摘 | Fabian C Hyun K Aaron D G | 2002 | Cell2002，110，： | 1 |
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