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| 1 | Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases显示文摘Gangliocytic paraganglioma(GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindlelike/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy. Using Pub Med, EMBASE, EBSCOhost MEDLINE and CINAHL, and Google Scholar, we searched the literature for cases of GP with regional lymph node metastasis and evaluated the varying presentations, diagnostic workup, and disease management of identified cases. Thirty-one cases of GP with metastasis were compiled(30 with at least lymph node metastases and one with only distant metastasis to bone), with age at diagnosis ranging from 16 to 74 years. Ratio of males to females was 19:12. The most common presenting symptoms were abdominal pain(55%) and gastrointestinal bleeding or sequelae(42%). Twenty-five patients underwent pancreaticoduodenectomy. Five patients were treated with local resection alone. One patient died secondary to metastatic disease, and one died secondary to perioperative decompensation. The remainder did well, with no evidence of disease at follow-up from the most recent procedure(except two in which residual disease was deliberately left behind). Of the 26 cases with sufficient histological description, 16 described a primary tumor that infiltrated deep to the submucosa, and 3 described lymphovascular invasion. Of the specific immunohistochemistry staining patterns studied, synaptophysin(SYN) stained all epithelioid endocrine cells(18/18). Neuron specific enolase(NSE) and SYN stained most ganglion-like cells(7/8 and 13/18 respectively), and S-100 stained all spindle-like/sustentacular cells(21/21). Our literature review of published cases of GP with lymph node metastasis underscores the excellent prognosis of GP regardless of specific treatment modality. We question the necessity of aggressive surgical intervention in select patients, and argue that local resection of the mass and metastasis may be adequate. We also emphasize the importance of pre-surgical assessment with imaging studies, as well as post-surgical follow-up surveillance for disease recurrence. | Sahara J Cathcart Aaron R Sasson Jessica A Kozel Jennifer M Oliveto Quan P Ly | 2017 | World Journal of Clinical Cases2017，5，6： | 9 |
| 2 | Improved endpoint detector for isolated word recognition显示文摘 | Lori F Lamel Lawrence R Rabiner Aaron E Rosenberg | | 0，，04： | 1 |
| 3 | Evaluation of SiO2 and TiO2 coated BaFeO4 cathode ma- terials for zinc alkaline and lithium non-aqueous primary bat- teries显示文摘 | Kenneth A Walz Aaron Handrick Jeannine R Szczech | 2007 | J Power Sources2007，167，2： | 1 |
| 4 | The effect of chronic infection with Aspergillus fumigatus on lung {unction and hospitalization in patients with cystic fibrosis 显示文摘 | Amin R Dupuis A Aaron SD | 2010 | Chest2010，137，1： | 1 |
| 5 | The influences of attitudes, beliefs and label information on perceptions of reduced-fat spread 显示文摘 | Aaron J I Mela D J Evans R E | 1994 | Appetite1994，22，： | 1 |
| 6 | On the Growth Kineties of Grain Boundary Ferrite Allotriomorphs 显示文摘 | Atkinson C Aaron H B Kinsman K R | 1973 | Metall Trans1973，4，： | 1 |
| 7 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 8 | Effect of weight reduction on respiratory function and airway reactivity in obese women显示文摘 | Aaron SD Fergusson D Dent R | | 0，，： | 1 |
| 9 | Serum Uric Acid and Risk of Coronary Heart Disease显示文摘 | Joseph T Moriarity Aaron R Folsom Carlos Iribarren F.Javier Nieto Wayne D Rosamond | 2000 | Annals of Epidemiology2000，，3： | 1 |
| 10 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
| 11 | Contemporary diagnosis and management of preterm premature rupture of membranes显示文摘 | Aaron B Julian N Errol R | 2008 | Rev Obstet Gynecol2008，1，1： | 1 |
| 12 | Supracondylar fracture of the femur after total knee arthroplasty显示文摘 | Aaron RK Scott R | 1987 | Clin Orthop1987，，219： | 1 |
| 13 | Blood pressure, atherosclerosis, and albuminuria in 10 113 participants in the Atherosclerosis Risk In Communities study显示文摘 | Charles C Hsu Frederick L Brancati Brad C Astor Wen Hong Kao Michael W Steffes Aaron R Folsom Josef Coresh | 2009 | Journal of Hypertension2009，，2： | 1 |
| 14 | Application of two ant colony optimisation algorithms to water distribution system optimization显示文摘 | ANGUS R S | 2006 | Mathematical and Computer Modelling2006，44，5： | 1 |
| 15 | Race and sex specific associations of obesity measures with ischemic stroke incidence in the ARIC Study显示文摘 | Hiroshi Yatsuya Aaron R Folsom Kazumasa Yamagishi | 2010 | Stroke2010，41，3： | 1 |
| 16 | Structural and near-IR photophysical studies on ternary lanthanide complexes containing poly(pyrazolyl)borate and 1,3-diketonate ligands显示文摘 | DAVIES G M AARONS R J MOTSON G R | 2004 | Dalton Trans2004，8，： | 1 |
| 17 | BacterialheatshockproteinsenhanceclassⅡ MHCantigenprocessingandpresentationofchaperonedpeptidesto CD4+ T cells显示文摘 | Aaron A R T CanadayD H HardingC V | 2004 | JImmunol2004，173，： | 1 |
| 18 | The United Kingdom public health re- sponse to an imported laboratory confirmed case of a no- vel coronavirus in September 2012显示文摘 | Pebody R G Chand M A Thomas H L Green H K Boddington N L Carvalho C Brown C S Anderson S R Rooney C Crawley-Boevey E Irwin D J Aarons E Tong C Newsholme W Price N Langrish C Tucker D Zhao H Phin N Crofts J Bermingham A Gil- gunn-Jones E Brown K E Evans B Catchpole M Watson J M | 2012 | Euro Surveill2012，17，20： | 1 |
| 19 | Perfusion ab- normalities in subchondral bone associated with marrow edema, os- teoarthritis, and avascular necrosis 显示文摘 | AARON R K DYKE J P C1OMBOR D M | 2007 | Ann N Y Acad Sci2007，1117，： | 1 |
| 20 | Maze exploration and learning in C elegans显示文摘 | QIN Jianhua AARON R W | 2007 | Lab on a Chip2007，7，12： | 1 |
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