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| 1 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 2 | 通过业余时间运动的中老年的运动心电图:100次运动试验足以确定一个无症状心肌缺血的心脏事件风险显示文摘运动心电图在预防运动员心脏事件方面的重要性一直存在争议。为了确定运动心电图中无症状心肌缺血(silent myocardial ischemia,SMI)的频率及运动心电图与冠状动脉造影评估结果和潜在可预防的心脏事件的关系。Hupin等纳入2011-2014年就诊于Saint-Etienne大学医院运动医学科年龄≥35岁的无症状业余运动员,进行前瞻性队列研究。 | 刘青 叶鹏 Hupin D Edouard P Oriol M Laukkanen J Abraham P Doutreleau S Guy JM CarréF Barthélémy JC Roche F Chatard JC | 2018 | 中华高血压杂志2018，26，4： | 6 |
| 3 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 4 | Efficacy and safety of liquid nitrogen cryotherapy for treatment of Barrett's esophagus显示文摘AIM To evaluate the efficacy and safety of liquid nitrogen cryotherapy as a primary or rescue treatment for BE,with and without dysplasia,or intramucosal adenocarcinoma (IMC).METHODS This was a retrospective,single-center study carried out in a tertiary care center including 45 patients with BE who was treatment-na?ve or who had persistent intestinal metaplasia(IM),dysplasia,or IMC despite prior therapy.Barrett's mucosa was resected via EMR when clinically appropriate,then patients underwent cryotherapy until eradication or until deemed to have failed treatment.Surveillance biopsies were taken at standard intervals.RESULTS From 2010 through 2014,33 patients were studied regarding the efficacy of cryotherapy.Overall,29 patients (88%) responded to cryotherapy,with 84% having complete regression of all dysplasia and cancer.Complete eradication of cancer and dysplasia was seen in 75% of subjects with IMC; the remaining two subjects did not respond to cryotherapy.Following cryotherapy,15 patients with high-grade dysplasia (HGD) had 30% complete regression,50% IM,and 7% low-grade dysplasia (LGD); one subject had persistent HGD.Complete eradication of dysplasia occurred in all 5 patients with LGD.In 5 patients with IM,complete regression occurred in 4,and IM persisted in one.In 136 cryotherapy sessions amongst 45 patients,adverse events included chest pain (1%),stricture (4%),and one gastrointestinal bleed in a patient on dual antiplatelet therapy who had previously undergone EMR.CONCLUSION Cryotherapy is an efficacious and safe treatment modality for Barrett's esophagus with and without dysplasia or intramucosal adenocarcinoma. | Kristen Suchniak-Mussari Charles E Dye Matthew T Moyer Abraham Mathew Thomas J McGarrity Eileen M Gagliardi Jennifer L Maranki John M Levenick | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 4 |
| 5 | Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered显示文摘AIM: To study the blood-brain barrier integrity in prehe-patic portal hypertensive rats induced by partial portal vein ligation, at 14 and 40 d after ligation when portal pressure is spontaneously normalized. METHODS: Adult male Wistar rats were divided into four groups: GroupⅠ: Sham14d, sham operated; GroupⅡ: PH14d, portal vein stenosis; (both groups were used 14 days after surgery); GroupⅢ: Sham40d, Sham operated and GroupⅣ: PH40d Portal vein stenosis (GroupsⅡandⅣused 40 d after surgery). Plasma ammonia, plasma and cerebrospinal fluid protein and liver enzymes concentrations were determined. Trypan and Evans blue dyes, systemically injected, were investigated in hippocampus to study blood-brain barrier integrity. Portal pressure was periodically recorded. RESULTS: Forty days after stricture, portal pressure was normalized, plasma ammonia was moderately high, and both dyes were absent in central nervous system parenchyma. All other parameters were reestablished. When portal pressure was normalized and ammonia level was lowered, but not normal, the altered integrity of blood-brain barrier becomes reestablished. CONCLUSION: The impairment of blood-brain barrier and subsequent normalization could be a mechanism involved in hepatic encephalopathy reversibility, Hemo-dynamic changes and ammonia could trigger blood-brain barrier alterations and its reestablishment. | Francisco Eizayaga Camila Scorticati Juan P Prestifilippo Salvador Romay Maria A Fernandez José L Castro Abraham Lemberg Juan C Perazzo | 2006 | World Journal of Gastroenterology2006，12，9： | 3 |
| 6 | Liver dysfunction and SARS-CoV-2 infection显示文摘Severe acute respiratory syndrome coronavirus 2 infection is the cause of coronavirus disease 2019(COVID-19),which predominantly affects the respiratory system;it also causes systemic and multi-organic disease.Liver damage is among the main extrapulmonary manifestations.COVID-19-associated liver injury is defined as any liver damage occurring during the disease course and treatment of COVID-19 in patients with or without pre-existing liver disease,and occurs in approximately one in five patients.Abnormal liver test results have been associated with a more severe course of COVID-19 and other complications,including death.Mechanisms linking COVID-19 to liver injury are diverse.Particular consideration should be made for patients with pre-existing liver disease,such as metabolic dysfunction-associated fatty liver disease,chronic liver disease due to viral or autoimmune disease,liver transplant carriers,or cirrhosis,given the risk for more severe outcomes.This manuscript summarizes the current lines of evidence on COVID-19-associated liver injury regarding pathophysiology,clinical significance,and management in both patients with or without preexisting liver disease,to facilitate clinicians’access to updated information and patient care.Finally,we mention the ideas and recommendations to be considered for future research. | Abraham Edgar Gracia-Ramos Joel Omar Jaquez-Quintana Raúl Contreras-Omaña Moises Auron | 2021 | World Journal of Gastroenterology2021，27，26： | 2 |
| 7 | Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Christopher J L Murray Theo Vos Rafael Lozano Mohsen Naghavi Abraham D Flaxman Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A | 2012 | The Lancet . 2012 (9859)2012，，9859： | 2 |
| 8 | 显示文摘 | Abrahams S C Redy J M Bernstein J L | 1966 | J Phys Chem Solids1966，27，： | 2 |
| 9 | Preparation of liposomes from stratum corneum lipids 显示文摘 | Wertz PW Abraham W Landmann L | 1986 | J Invest Dermatol1986，87，5： | 1 |
| 10 | market structure and the holdup problem: investment incentives and coordination f 7 显示文摘 | ABRAHAM W INNOVATION L | 2004 | International Journal of Industrial Organization2004，22，71： | 1 |
| 11 | Cytokine receptor signaling mechanisms显示文摘 | Karnitz L M Abraham R T | 1995 | Current Opinion in muology1995，，7： | 1 |
| 12 | Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation显示文摘 | ABRAHAM M R HENRIKSON C A TUNG L | 2005 | Circ Res2005，97，： | 1 |
| 13 | Effects of Cardiac Resynchronization on Disease Progression in Patients With Left Ventricular Systolic Dysfunction, an Indication for an Implantable Cardioverter-Defibrillator, and Mildly Symptomatic Chronic Heart Failure显示文摘 | William T. Abraham James B. Young Angel R. León Stuart Adler Alan J. Bank Shelley A. Hall Randy Lieberman L Bing Liem John B. O’Connell John S. Schroeder Kevin R. Wheelan | 2004 | Circulation2004，，18： | 1 |
| 14 | The relation of mark- ers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study显示文摘 | Barzilay JI Abraham L Heckbert SR | 2001 | Diabetes2001，50，6： | 1 |
| 15 | The relation of markers of inflammation to the development of glucose disorders in the elderly,the Cardiovascular Health Study显示文摘 | Arilay JI Abraham L Heckbert SR | 2001 | Diabetes2001，50，10： | 1 |
| 16 | Regulation of human heme oxygenase in endothelial cells by using sense and antisense retroviral constructs 显示文摘 | Quan S Yang L Abraham NG | 2001 | Proc Natl Acad Sci USA2001，98，12： | 1 |
| 17 | Randomized, double-masked,sham-controlled trial of ranibizumab for neovascular agerelatedmacular degeneration:PIER study year 2显示文摘 | Abraham P Yue H Wilson L | 2010 | Am J Ophthalmol2010，150，3： | 1 |
| 18 | Key features of successful BNR operation显示文摘 | Barnard J L Abraham K | | 0，，12： | 1 |
| 19 | Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity 显示文摘 | Hood C L Abraham J Boyington J C | 2010 | J Virol2010，84，6： | 1 |
| 20 | Mast eeU-orchestmted imrrmnity to pathogens 显示文摘 | Abraham S N St John A L | 2010 | Nat Rev Immunol2010，10，6： | 1 |
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