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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | YKL40 expression in CD14^+ liver cells in acute and chronic injury显示文摘AIM:To demonstrate that CD14 + cells are an important source of the growth factor YKL40 in acute and chronic liver damage.METHODS:Rats were inoculated with one dose of CCl4 to induce acute damage.Liver biopsies were obtained at 0,6,12,24,48 and 72 h.For chronic damage,CCl4 was administered three days per week for 6 or 8 wk.Tissue samples were collected,and cellular populations were isolated by liver digestion and purified by cell sorting.YKL40 mRNA and protein expression were evaluated by realtime polymerase chain reaction and western blot.RESULTS:Acute liver damage induced a rapid increase of YKL40 mRNA beginning at 12 h.Expression peaked at 24 h,with a 26fold increase over basal levels.By 72 h however,YKL40 expression levels had nearly returned to control levels.On the other hand,chronic damage induced a sustained increase in YKL40 expression,with 7and 9fold higher levels at 6 and 8 wk,respectively.The pattern of YKL40 expression in different subpopulations showed that CD14+cells,which include Kupffer cells,are a source of YKL40 after acute damage at 72 h[0.09 relative expression units(REU)]as well as after chronic injury at 6 wk(0.11 REU).Hepatocytes,in turn,accounted for 0.06 and 0.01 REU after 72 h(acute)or 6 wk(chronic),respectively.The rest of the CD14cells(including T lymphocytes,B lymphocytes,natural killer and natural killer T cells) yielded 0.07 and 0.15 REU at 72 h and 6 wk,respectively.YKL40 protein expression in liver was detected at 72 h as well as 6 and 8 wk,with the highest expression relative to controls(11fold;P≤0.05)seen at 6 wk.Macrophages were stimulated by lipopolysaccharide.We demonstrate that under these conditions,these cells showed maximum expression of YKL40 at 12 h,with P<0.05 compared with controls.CONCLUSION:Hepatic CD14 + cells are an YKL40 mRNA and protein source in acute and chronic liver injury,with expression patterns similar to growth factors implicated in inflammationfibrogenesis. | Oscar Pizano-Martínez Irinea Yaez-Sánchez Pilar Alatorre-Carranza Alejandra Miranda-Díaz Pablo C Ortiz-Lazareno Trinidad García-Iglesias Adrian Daneri-Navarro Mónica Vázquez-Del Mercado Mary Fafutis-Morris Vidal Delgado-Rizo | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 3 | Expression profiling identifies genes expressed early during lint fibre initiation in cotton显示文摘 | Wu Yingru Adriane C M Rosemary G W | 2006 | Plant and Cell Physiology2006，47，1： | 1 |
| 4 | Quantitation of Phytoest rogens in legumes by HPLC 显示文摘 | ADRIAN A F EAURIE J C CAMENCITA M | 1994 | J Agr Food Chem1994，42，： | 1 |
| 5 | HPLC analysis of grapevine phytoalexins coupling photodiode array detection and fluorometry显示文摘 | JEANDET P BREUIL A C ADRIAN M WESTON L A DEBORD S MEUNIER P MAUME G BESSIS R | 1997 | Analytical Chemistry1997，69，24： | 1 |
| 6 | 3D structure of Alzheimer's amyloid-β(1-42) fibrils显示文摘 | L(U)HRS T RITTER C ADRIAN M | 2005 | Proc Natl Acad Sci USA2005，102，17： | 1 |
| 7 | Anaerobic bioaansformation of explosives in aquifer slurries amended with ethanol and propylene glycol显示文摘 | ADRIAN N R ARNETT C M | 2007 | Chemosphere2007，66，10： | 1 |
| 8 | 查看详情显示文摘 | Andrei C M Adrian I O Mircea M | | 0，，03： | 1 |
| 9 | Physiological responses to temperature and irradiance in Spirogyra ( Zygnematales : Charophyceae) 显示文摘 | Graham J M Lembi C A Adrian H L | 1995 | J Phycol1995，31，： | 1 |
| 10 | Effects of epidermal growth factor on neonatal pancreatic growth in the guinea pig显示文摘 | HERRINGTON M K JOEKEL C S ADRIAN T E | 1998 | International journal of pancreatology:official journal of the International Association of Pancreatology1998，24，1： | 1 |
| 11 | Immunological events in regressing genital warts显示文摘 | Nicholas C Humphrey DL Adrian M | 1994 | Am J Clin Pathol1994，102，： | 1 |
| 12 | Risk factors of early-and late-onset ventilator-associated pneumonia and their influence onmortality in the ICU setting显示文摘 | Ryan M Adrian C Llorin | 2005 | Int J Antimicrob Agents2005，26，1： | 1 |
| 13 | Hepatitis C–related hepatocellular carcinoma in the United States: influence of ethnic status显示文摘 | Adrian M Di Bisceglie Andre C Lyra Myron Schwartz Rajender K Reddy Paul Martin Gregory Gores Anna S.F Lok Khozema B Hussain Robert Gish David H Van Thiel Zobair Younossi Myron Tong Tarek Hassanein Luis Balart Jacquelyn Fleckenstein Stephen Flamm Andres Bl | 2003 | The American Journal of Gastroenterology2003，，9： | 1 |
| 14 | Performance-based design in earthquake engineering:A multi-disciplinary review显示文摘 | Adrian M C Nelson T K L | 2001 | Engineering Structures2001，23，： | 1 |
| 15 | Cryo-electron microscopy of vitrified specimens显示文摘 | Dubochet J M Adrian J J Chang J C | 1988 | Q Rev Biophys1988，21，2： | 1 |
| 16 | 3D structure of Alzheimer' s amyloid-β (1-42) fibrils显示文摘 | Lüihrs T Ritter C Adrian M | 2005 | Proc Natl Acad Sci USA2005，102，17： | 1 |
| 17 | Solidphase extraction and gas chromatography with mass spectrometric determination of capsaicin and some of its analogues form chilipeppers (Capsicumspp)显示文摘 | PHILEMON M ADRIAN C PAUL S | 1999 | JAOAC Intemational1999，82，6： | 1 |
| 18 | 3D structure of Alzheimer's amyloid-L3(l-42) fibrils显示文摘 | LtihrsT Ritter C Adrian M | 2005 | Proc Natl Acad Sci USA2005，102，17： | 1 |
| 19 | Lakes as sentinels of climate change显示文摘 | ADRIAN R O'REILLY C M ZAGARESE H | 2009 | Limnology and Oceanography2009，54，6： | 1 |
| 20 | Lakes as sentinelsof climate change显示文摘 | Adrian R O’Reilly C M Zagarese H | 2009 | Limnology and Oceanography2009，54，62： | 1 |
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