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| 1 | Improvement of visual acuity based on optical coherence tomography patterns following intravitreal bevacizumab treatment in patients with diabetic macular edema显示文摘AIM:To report the visual outcome based on various patterns of optical coherence tomography(OCT)morphology in diabetic macular edema(DME),following treatment with anti-VEGF intravitreal bevacizumab(IVB)injection.METHODS:Sixty-seven consecutive subjects with centre involving DME underwent intravitreal injection of bevacizumab(1.25 mg/0.05 mL)in this retrospective,comparative,non randomized study.The DME was classified into one of four categories:focal,diffuse,focal cystoid and neurosensory detachment based on OCT.Best corrected visual acuity(BCVA),macular appearance,and OCT findings were used to decide whether the subject should have a repeat injection of intravitreal bevacizumab.Outcome measures were a change in mean BCVA(Snellen converted to logMAR)and central macular thickness(CMT)in each group during the six month follow-up period.RESULTS:The mean BCVA improved to logMAR 0.23at final follow-up from a baseline of 0.32 logMAR(P=0.040)in the focal group,logMAR 0.80 at final follow-up from a baseline of 0.82 logMAR(P=0.838)in the diffuse group,worsened to logMAR 0.53 at final follow-up from a baseline of 0.43 logMAR(P=0.276)in the focal cystoid group,and improved to logMAR 0.79 at final follow-up from a baseline of 0.93 logMAR(P=0.490)in the neurosensory detachment group.The mean CMT before treatment were 298.8±25.03μm in the focal group,310.8±40.6μm in the diffuse group,397.15±31.05μm in the focalcystoid group and 401.03±75.1μm in the neurosensory detachment group.A mean of 2.05(range:1-5)injections in the focal group,1.32(range:1-2)in the diffuse group,2.6(range:1-6)in the focal cystoid group and 2.6(range:1-6)in the neurosensory detachment group were performed during the six month follow-up period.Following intravitreal bevacizumab treatment,vision improved,remained unchanged or worsened in 11,7 and2 subjects in focal group;11,9 and 8 in diffuse group;0,2 and 4 in focal cystoid group and 5,5 and 3 subjects respectively in neurosensory detachment group.CONCLUSION:OCT morpholgy patterns in DME may predict the effects of intravitreal bevacizumab treatment,and patients with focal DME are most likely to benefit from the improvent of visual acuity from this treatment. | Haider R.Cheema Ahmed Al Habash Essam Al-Askar | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 3 |
| 2 | Dynamics of organic carbon and nitrogen in deep soil profile and crop yields under long-term fertilization in wheat-maize cropping system显示文摘Soil organic carbon(SOC)and nitrogen(N)are two of the most important indicators for agricultural productivity.The primary objective of this study was to investigate the changes in SOC and N in the deep soil profile(up to 100 cm)and their relationships with crop productivity under the influence of long-term(since 1990)fertilization in the wheat-maize cropping system.Treatments included CK(control),NP(inorganic N and phosphorus(P)fertilizers),NPK(inorganic N,P and potassium fertilizers),NPKM(NPK plus manure),and M(manure).Crop yield and the properties of topsoil were measured yearly from 2001 to 2009.C and N contents were measured at five different depths in 2001 and 2009.The results showed that wheat and maize yields decreased between 2001 and 2009 under the inorganic fertilizer(NP and NPK)treatments.The average yield between 2001 and 2009 under the NP,NPK,NPKM,and M treatments(compared with the CK treatment)increased by 38,115,383,and 381%,respectively,for wheat and 348,891,2738,and 1845%,respectively,for maize.Different long-term fertilization treatments significantly changed coarse free particulate(cf POC),fine free particulate(ff POC),intramicroaggregate particulate(i POC),and mineral-associated(m SOC)organic carbon fractions.In the experimental years of 2001 and 2009,soil fractions occurred in the following order for all treatments:m SOC>cf POC>i POC>ff POC.All fractions were higher under the manure application treatments than under the inorganic fertilization treatments.Compared to the inorganic fertilization treatments,manure input enhanced the stocks of SOC and total N in the surface layer(0–20 cm)but decreased SOC and N in the deep soil layer(80–100 cm).This reveals the efficiency of manure in increasing yield productivity and decreasing risk of vertical loss of nutrients,especially N,compared to inorganic fertilization treatments.The findings provide opportunities for understanding deep soil C and N dynamics,which could help mitigate climate change impact on agricultural production and maintain soil health. | Muhammad QASWAR LI Dong-chu HUANG Jing HAN Tian-fu Waqas AHMED Sehrish ALI Muhammad Numan KHAN Zulqarnain Haider KHAN XU Yong-mei LI Qian ZHANG Hui-min WANG Bo-ren Ahmad TAUQEER | 2022 | Journal of Integrative Agriculture2022，21，3： | 2 |
| 3 | Diapir structure and its constraint on gas hydrate accumulation in the Makran accretionary prism, offshore Pakistan显示文摘The Makran accretionary prism is located at the junction of the Eurasian Plate,Arabian Plate and Indian Plate and is rich in natural gas hydrate(NGH)resources.It consists of a narrow continental shelf,a broad continental slope,and a deformation front.The continental slope can be further divided into the upper slope,middle slope,and lower slope.There are three types of diapir structure in the accretionary prism,namely mud diapir,mud volcano,and gas chimney.(1)The mud diapirs can be grouped into two types,namely the ones with low arching amplitude and weak-medium activity energy and the ones with high arching amplitude and medium-strong activity energy.The mud diapirs increase from offshore areas towards onshore areas in general,while the ones favorable for the formation of NGH are mainly distributed on the middle slope in the central and western parts of the accretionary prism.(2)The mud volcanoes are mainly concentrated along the anticline ridges in the southern part of the lower slope and the deformation front.(3)The gas chimneys can be grouped into three types,which are located in piggyback basins,active anticline ridges,and inactive anticline ridges,respectively.They are mainly distributed on the middle slope in the central and western parts of the accretionary prism and most of them are accompanied with thrust faults.The gas chimneys located at different tectonic locations started to be active at different time and pierced different horizons.The mud diapirs,mud volcanoes,and gas chimneys and thrust faults serve as the main pathways of gas migration,and thus are the important factors that control the formation,accumulation,and distribution of NGH in the Makran accretionary prism.Mud diapir/gas chimney type hydrate develop in the middle slope,mud volcano type hydrate develop in the southern lower slope and the deformation front,and stepped accretionary prism type hydrate develop on the central and northern lower slope.The middle slope,lower slope and deformation front in the central and western parts of the Makran accretionary prism jointly constitute the NGH prospect area. | Zhen Zhang Gao-wen He Hui-qiang Yao Xi-guang Deng Miao Yu Wei Huang Wei Deng Syed Waseem Haider Naimatullah Sohoo Noor Ahmed Kalhoro | 2020 | China Geology2020，3，4： | 2 |
| 4 | Neuropeptide y and neuropeptide y y5 receptor interaction restores impaired growth potential of aging bone marrow stromal cells 显示文摘 | Haider HKh Ahmed RP | 2011 | Rejuvenation Res2011，14，4： | 1 |
| 5 | Knowledge,attitudes and practices related to cystic echinococcosis endemicity in Pakistan显示文摘Background:Cystic echinococcosis(CE)is a human and animal health problem in many endemic areas worldwide.It is considered a neglected zoonotic disease caused by the larval form(hydatid cyst)of Echinococcus spp.tapeworm.There are limited studies on echinococcosis in Pakistan.Methods:A cross-sectional survey was conducted to find out recent knowledge,attitudes and practices on the occurrence of cystic echinococcosis in butchers and dog owners in both urban and rural areas of Rawalpindi/Islamabad regions,Pakistan.The quantitative data was collected in the form of questionnaires to investigate the knowledge and awareness of CE among community members and their routine practices that were behind the factors involved in hydatid cyst infection.The practices and infrastructure of abattoirs/butcher shops and their role in transmission of cystic echinococcosis were also evaluated in the present study.Results:The participants involved in the study were dog owners and people who kept animals.A total of 400 people were interviewed and 289 questionnaires were received.The results showed that only 4.1%of people have heard about the disease,and 58.1%were closely associated with dogs.Sixty-three percent of dogs in study area were consuming uncooked organs(e.g.liver,lung,etc.)of slaughtered animals,while 100%of dogs at butcher shops were consuming uncooked organs.Home slaughtering was common in 20.06%.Among butchers,32.3%had heard about zoonoses and 7.61%knew about CE.The statistical analysis showed that there was highly significant difference(P<0.05)among most of the practices that were associated with the prevalence of CE.Conclusions:It was concluded from the present study that,the knowledge and awareness of CE among people of Rawalpindi/Islamabad were low.Because of dogs and poor knowledge of CE among community members and butchers,the transmission of echinococcosis is facilitated.Therefore,there is urgent need to strengthen awareness and health education among people,as well as proper practices related to the CE not only in the study area,but also in other areas of Pakistan. | Aisha Khan Kashf Naz Haroon Ahmed Sami Simsek Muhammad Sohail Afzal Waseem Haider Sheikh Saeed Ahmad Sumaira Farrakh Wu Weiping Guan Yayi | 2018 | Infectious Diseases of Poverty2018，7，1： | 1 |
| 6 | Transcriptional profiling of young and old mesenchymal stem cells in response to oxygen deprivation and reparability of the infarcted myocardium 显示文摘 | Jiang S Kh Haider H Ahmed RP | 2008 | J Mol Cell Cardiol2008，44，3： | 1 |
| 7 | Prospects and challenges of future HVDC Super Grids with modular multilevel converters 显示文摘 | AHMED N HAIDER A VAN HERTEM D | 2011 | in Power Electronics and Applications (EPE 2011) Proceedings of the 2011 - 14th European Conference on2011，，： | 1 |
| 8 | Reprogramming of skeletal myoblasts for induction of pluripotency for tumor - free cardiomyogenesis in the infarcted heart显示文摘 | AHMED R P HAIDER H K BUCCINI S | 2011 | Circ Res2011，109，1： | 1 |
| 9 | Transcriptional profiling of young and old mesenchymal stem cells in response to oxygen deprivation and reparability of the infarcted myocardium 显示文摘 | Jiang S Kh Haider H Ahmed RP | 2008 | J Mol Cell Cardiol2008，44，： | 1 |
| 10 | Hereditary hemochromatosis:Temporal trends,sociodemographic characteristics,and independent risk factor of hepatocellular cancer–nationwide population-based study显示文摘BACKGROUND Hereditary hemochromatosis(HH)has an increased risk of hepatocellular cancer(HCC)both due to genetic risks and iron overload as iron overload can be carcinogenic;HH impacts the increasing risk of HCC,not only through the development of cirrhosis but concerning hepatic iron deposition,which has been studied further recently.AIM To evaluate HH yearly trends,patient demographics,symptoms,comorbidities,and hospital outcomes.The secondary aim sheds light on the risk of iron overload for developing HCC in HH patients,independent of liver cirrhosis complications.The study investigated HH(without cirrhosis)as an independent risk factor for HCC.METHODS We analyzed data from National Inpatient Sample(NIS)Database,the largest national inpatient data collection in the United States,and selected HH and HCC cohorts.HH was first defined in 2011 International Classification of Disease-9th edition(ICD-9)as a separate diagnosis;the HH cohort is extracted from January 2011 to December 2019 using 275.01(ICD-9)and E83.110(ICD-10)diagnosis codes of HH.Patients were excluded from the HH cohort if they had a primary or secondary diagnostic code of cirrhosis(alcoholic,non-alcoholic,and biliary),viralhepatitis,alcoholic liver disease,non-alcoholic fatty liver disease(NAFLD),and non-alcoholic steatohepatitis(NASH).We removed these patients from the HH cohort to rule out bias or ICD-10 diagnostic errors.The HCC cohort is selected from January 2011 to December 2019 using the ICD-9 and ICD-10 codes of HCC.We selected a non-HCC cohort with the 1:1 fixed ratio nearest neighbor(greedy)propensity score method using the patients'age,gender,and race.We performed multivariate analysis for the risk factors of HCC in the HCC and non-HCC matched cohort.We further analyzed HH without cirrhosis(removing HH patients with a diagnosis of cirrhosis)as an independent risk factor of HCC after adjusting all known risk factors of HCC in the multivariate model.RESULTS During the 2011-2019 period,a total of 18031 hospitalizations with a primary or secondary diagnosis of HH(excluding liver diseases)were recorded in the NIS database.We analyzed different patients’characteristics,and we found increments in inpatient population trend with a Ptrend<0.001 and total hospital cost of care trend from$42957 in 2011 to$66152 in 2019 with a Ptrend<0.001 despite no change in Length of Stay over the last decade.The multivariate analyses showed that HH without cirrhosis(aOR,28.8;95%CI,10.4–80.1;P<0.0001),biliary cirrhosis(aOR,19.3;95%CI,13.4–27.6;P<0.0001),non-alcoholic cirrhosis(aOR,17.4;95%CI,16.5–18.4;P<0.0001),alcoholic cirrhosis(aOR,16.9;95%CI,15.9–17.9;P<0.0001),hepatitis B(aOR,12.1;95%CI,10.85–13.60;P<0.0001),hepatitis C(aOR,8.58;95%CI,8.20–8.98;P<0.0001),Wilson disease(aOR,4.27;95%CI,1.18–15.41;P<0.0001),NAFLD or NASH(aOR,2.96;95%CI,2.73–3.20;P<0.0001),alpha1-antitrypsin deficiency(aOR,2.10;95%CI,1.21–3.64;P<0.0001),diabetes mellitus without chronic complications(aOR,1.17;95%CI,1.13–1.21;P<0.0001),and blood transfusion(aOR,1.80;95%CI,1.69–1.92;P<0.0001)are independent risk factor for liver cancer.CONCLUSION Our study showed an increasing trend of in-hospital admissions of HH patients in the last decade.These trends were likely related to advances in diagnostic approach,which can lead to increased hospital utilization and cost increments.Still,the length of stay remained the same,likely due to a big part of management being done in outpatient settings.Another vital part of our study is the significant result that HH without cirrhosis is an independent risk factor for HCC with adjusting all known risk factors.More prospective and retrospective large studies are needed to re-evaluate the HH independent risk in developing HCC. | Maryam Bilal Haider Ali Al Sbihi Ahmed Jamal Chaudhary Syed M Haider Ahmed Iqbal Edhi | 2022 | World Journal of Hepatology2022，14，9： | 1 |
| 11 | Metal complexes of saccharin显示文摘 | Haider S Z Malik K M A Ahmed K J | 1985 | Inorg Synth1985，23，： | 1 |
| 12 | Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo显示文摘 | Samir Attoub Olivier Sperandio Haider Raza Kholoud Arafat Suhail Al‐Salam Mahmood Ahmed Al Sultan Maha Al Safi Takashi Takahashi Abdu Adem | 2013 | Fundam Clin Pharmacol2013，，5： | 1 |
| 13 | Relationship of brain tryp- tophan and serotonin in improving cognitive performance in rats 显示文摘 | Khaliq S Haider S Ahmed S P | 2006 | Pak J Pharm Sci2006，19，1： | 1 |
| 14 | 碳纳米管指数拉伸曲面上Darcy-Forchheimer流动的数值处理(英文)显示文摘本文对碳水纳米流体的二维流动进行了数值模拟。流体是由指数扩展曲面引起的。本文用Darcy-Forchheimer方法描述了渗透空间中的黏性液体。通过适当的变换,将偏微分方程的后续排列转化为常微分框架。采用NDSolve程序建立了控制框架的数值排布。考察了不同参数对温度和速度的影响,并对表面摩擦和传热速率进行监测。 | Tasawar HAYAT Farwa HAIDER Taseer MUHAMMAD Ahmed ALSAEDI | 2019 | Journal of Central South University2019，26，4： | 1 |
| 15 | Long-term tryptophan administration enhances cognitive performance and increases 5HT metabolism in the hippocampus of female rats 显示文摘 | Haider S Khaliq S Ahmed SP | 2006 | Amino Acids2006，31，4： | 1 |
| 16 | Sonic hedgehog genedelivery to the rodent heart promotes angiogenesis via iNOS/Netrin-l/PKC Pathway 显示文摘 | Ahmed RP Haider KH Shujia J | 2010 | PLoS One2010，5，1： | 1 |
| 17 | Relationship of brain tryptophan and serotonin in improving cognitive performance in rats显示文摘 | Khaliq S Haider S Ahmed SP | 2006 | Pak J Pharm Sci2006，19，1： | 1 |
| 18 | Survival impact of surgical resection of primary tumor in patients with stage IV colorectal cancer: Results from a large population‐based cohort study显示文摘 | Shahid Ahmed Anne Leis Anthony Fields Selliah Chandra‐Kanthan Kamal Haider Riaz Alvi Bruce Reeder Punam Pahwa | 2014 | Cancer2014，，5： | 1 |
| 19 | Cardiac tumorgenic potential of induced pluripotent stem cells in an immunocompetent host with myocardial infarction显示文摘 | Rafeeq PH Ahmed Muhammad Ashraf Stephanie Buccini Jiang Shujia Husnain Kh Haider | 2011 | Regen. Med2011，，： | 1 |
| 20 | Multifunctional transition and temperature-responsive contact lenses显示文摘Smart contact lenses have recently gained traction due to their functionalization as noninvasive diagnostic and therapeutic wearables that can address several ocular diseases.Herein,multifunctional contact lenses exhibiting UV-transition and temperature-responsive capabilities were developed utilizing chromogenic materials that were integrated simultaneously into poly(2-hydroxyethyl methacrylate)(pHEMA)contact lenses.The functionalities of the contact lenses were optically evaluated in both their activated and non-activated states.Transition contact lenses offered excellent UV and blue light blocking capabilities(~45%)at their inactive states.When activated via UV exposure,the transparent lenses darkened instantaneously and absorbed portions of the visible light spectrum.The absorption intensity and transient discoloration of the transition lenses relied primarily on the utilized photochromic material.Likewise,the temperature-responsive contact lenses exhibited distinct colorimetric variations in response to temperature changes within the physiological range(33-38℃).The maximum sensitivity of the thermochromic lens was 8%transmitted light per Celsius degree shift.Physiochemical and morphological analysis indicated the adequacy of the contact lenses.Hence,the multifunctional contact lenses can be deployed as smart wearables to manage ophthalmic deficiencies that are deterred by UV radiations and variations in ocular surface temperature. | Ahmed E.Salih Haider Butt | 2023 | Light(Science & Applications)2023，12，12： | 0 |
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