|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Induction of apoptosis of human gastric carcinoma SGC-7901 cell line by 5,7-dihydroxy-8-nitrochrysin in vitro显示文摘AIM: To investigate the effect of 5, 7-dihydroxy-8- nitrochrysin (NOChR) on apoptosis of human gastric carcinoma SGC-7901 cell line. METHODS: SGC-7901 cells were cultured in vitro and the inhibitory effect of NOChR on proliferation of SGC-7901 cells was measured by using an MTT assay. NOChR-induced apoptosis rate of SGC-7901 cells was detected using flow cytometry (FCM) with PI staining. DNA ladder bands were observed by DNA agarose gel electrophoresis. The influence of NOChR on the proxisome proliferator-activated receptor-γ (PPARγ), Bcl-2 and Bax protein expression of SGC-7901 cells was analyzed by Western blot. RESULTS: MTT assay showed that NOChR markedly inhibited proliferation of SGC-7901 cells in a dose- dependent manner, and when IC50 was 4.14 μmol/L, the potency of NOChR was 10 times than that of lead compound, chrysin (ChR, IC50 was 40.56 μmol/L), and was similar to 5-fluorouracil (5-FU, IC50 was 4.51 μmol/L). FCM with propidium iodide (PI) staining demonstrated that the apoptosis rates of SGC-7901 cells treated with 1.25, 5.00 and 20.00 μmol/L NOChR for 48 h were 9.8% ± 0.2%, 36.8% ± 1.9% and 45.5% ± 3.5%, respectively, and were significantly higher when treated with 5.00 and 20.00 μmol/L NOChR than that with 20.00 μmol/L ChR (12.9% ± 1.5%). DNA agarose gel electrophoresis showed that treatment of SGC-7901 cells with 20.00 μmol/L NOChR for 48 h resulted in typical DNA ladder bands of DNA of SGC-7901 cells, which could be eliminated by treating with 10.00 μmol/L GW9662, a blocker of PPARγ. Western blot analysis revealed that after 24 h of treatment with 20.00 μmol/L NOChR, PPARgamma and Bax protein expression of SGC-7901 cells increased but Bcl-2 expression decreased; however, pre-incubation with 10.00 μmol/L GW9662 could efficiently antagonize and weaken the regulatory effect of 20.00 μmol/L NOChR on Bax and Bcl-2 protein expression of SGC-7901 cells. CONCLUSION: NOChR induces apoptosis of SGC-7901 cell lines by activating PPARγ and decreasing ratio of Bcl-2 to Bax. | Xiao-Hong Ai Xing Zheng Xiao-Qing Tang Li Sun Yang-Qin Zhang Yong Qin Hua-Qing Liu Hong Xia Jian-Guo Cao | 2007 | World Journal of Gastroenterology2007，13，28： | 22 |
| 2 | A novel stability prediction approach for thin-walled component milling considering material removing process显示文摘The milling stability of thin-walled components is an important issue in the aviation manufacturing industry, which greatly limits the removal rate of a workpiece. However, for a thin-walled workpiece, the dynamic characteristics vary at different positions. In addition, the removed part also has influence on determining the modal parameters of the workpiece. Thus,the milling stability is also time-variant. In this work, in order to investigate the time variation of a workpiece's dynamic characteristics, a new computational model is firstly derived by dividing the workpiece into a removed part and a remaining part with the Ritz method. Then, an updated frequency response function is obtained by Lagrange's equation and the corresponding modal parameters are extracted. Finally, multi-mode stability lobes are plotted by the different quadrature method and its accuracy is verified by experiments. The proposed method improves the computational efficiency to predict the time-varying characteristics of a thin-walled workpiece. | Jiahao SHI Qinghua SONG Zhanqiang LIU Xing AI | 2017 | Chinese Journal of Aeronautics2017，30，5： | 9 |
| 3 | Effects of targeting magnetic drug nanoparticles on human cholangiocarcinoma xenografts in nude mice显示文摘BACKGROUND:Targeting is a new therapeutic tool for malignant tumor as a result of combining nanotechnology with chemotherapeutics.The aim of our study was to investigate the effects of magnetic nanoparticles enveloping a chemotherapeutic drug on human cholangiocarcinoma xenografts in nude mice. METHODS:The human cholangiocarcinoma xenograft model was established in nude mice with the QBC939 cell line.The nude mice were randomly assigned to 7 groups. 0.9%saline or magnetic nanoparticles,including high (group 2),medium(group 4)and low(group 5)dosages, were given to nude mice through the tail vein 20 days after the QBC939 cell line was implanted.Calculations were made 35 days after treatment in order to compare the volumes,inhibition ratios and growth curves of the tumors in each group.Mice in each group were sacrificed randomly to collect tumor tissues and other organs for electron microscopy and pathological examination. RESULTS:The high and medium dosage groups were significantly different from the control group(P<0.05). The tumor inhibition ratios for the high,medium and low dosage groups were 39.6%,14.6%and 7.9%,respectively. The tumor growth curve of groups 5,4,and 2 changed slowly in turn.The high and medium groups showed cell apoptosis under an electron microscope.CONCLUSION:Magnetic nanoparticles can inhibit the growth of human cholangiocarcinoma xenografts in nude mice. | Tang, Tao Zheng, Jian-Wei Chen, Bo Li, Hong Li, Xi Xue, Ke-Ying Ai, Xing Zou, Sheng-Quan | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 8 |
| 4 | Characteristics of pulmonary inflammation in combined pulmonary fibrosis and emphysema显示文摘 | ZHAO Ying CUI Ai WANG Feng WANG Xiao-juan CHEN Xing JIN Mu-lan HUANG Ke-wu | 2012 | Chinese Medical Journal2012，，17： | 8 |
| 5 | CIVB flashback analysis of hydrogen flame based on azimuthal vorticity at mixing zone exit显示文摘Swirl-premixed combustion systems exhibit potential to meet future regulations on pollution emissions. However, combustion induced vortex breakdown(CIVB) flashback is frequently observed in these systems, especially for high hydrogen content fuel. In this study, a swirl-premixed burner with diverging centerbody was used to investigate CIVB flashback based on azimuthal vorticity at mixing zone exit. Through 2D axisymmetric model, it was found that there was a maximal azimuthal vorticity at mixing zone exit for each equivalence ratio. The physical meaning of these maximal azimuthal vorticity values was the minimally required azimuthal vorticity to trigger CIVB flashback. At the same time, the required azimuthal vorticity declined with the increase of equivalence ratio since turbulent burning velocity started to control flashback. Nevertheless, azimuthal vorticity offered by heat release increased with the increase of equivalence ratio, which promoted flame propagating upstream continually. | TIAN Xiao Jing XING Shuang Xi CUI Yu Feng FANG Ai Bing NIE Chao Qun | 2014 | Science China(Technological Sciences)2014，57，12： | 7 |
| 6 | Synthesis and application of a hydrophobic hypercrosslinked polymeric resin for removing VOCs from humid gas stream显示文摘恐水病的亢奋的 crosslinked 聚合树脂 LC-1 被准备并且描绘。LC-1 树脂的性质与商业亢奋的 crosslinked 聚合物 NDA-201 树脂的那些相比。另外, trichloroethylene (TCE ) 的动态吸附被调查到在在 303 K 的干燥、潮湿的条件下面的 LC-1 上, LC-1 拥有的结果表演高恐水病的性质和罐头把 TCE 从气体移开没有高湿度的效果,高效地流。 | Peng Liu Chao Long Hong Ming Qian Ying Li Ai Min Li Quan Xing Zhang | 2009 | Chinese Chemical Letters2009，20，4： | 7 |
| 7 | Relationship Between Thermal Shock Behavior and Cutting Performance of a Functionally Gradient Ceramic Tool显示文摘Based on the deep understanding of the requirements of cutting conditions on ceramic tools, a design model for functionally gradient ceramic tool materials with symmetrical composition distribution was presented in this paper, according to which an Al 2O 3-TiC functionally gradient ceramic tool material FG-1 was synthesized by powder-laminating and uniaxially hot-pressing technique. The thermal shock resistance of the Al 2O 3-TiC functionally gradient ceramics FG-1 was evaluated by water quenching and subsequent three-point bending tests of flexural strength diminution. Comparisons were made with results from parallel experiments conducted using a homogeneous Al 2O 3-TiC ceramics. Functionally gradient ceramics exhibited higher retained strength under all thermal shock temperature differences compared to homogeneous ceramics, indicating the higher thermal shock resistance. The experimental results were supported by the calculation of transient thermal stress field. The cutting performance of the Al 2O 3-TiC functionally gradient ceramic tool FG-1 was also investigated in rough turning the cylindrical surface of exhaust valve of diesel engine in comparison with that of a common Al 2O 3-TiC ceramic tool LT55. The results indicated that the tool life of FG-1 increased by 50 percent over that of LT55. Tool life of LT55 was mainly controlled by thermal shock cracking which was accompanied by mechanical shock. While tool life of FG-1 was mainly controlled by mechanical fatigue crack extension rather than thermal shock cracking, revealing the less thermal shock susceptibility of functionally gradient ceramics than that of common ceramics. | ZHAO Jun, AI Xing, HUANG Xin-ping (School of Mechanical Engineering, Shandong University, Jinan 250061, China) | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 6 |
| 8 | Comments on Thermal effect of holmium laser lithotripsy under ureteroscopy显示文摘To the Editor:We appreciate the work Wang et al[1]have done on thermal effect of holmium laser lithotripsy under ureteroscopy.Holmium laser is considered as the optimum lithotripter for ureteroscopy due to its effectiveness.[2]With the application of high-power laser system,the potential risk of ureter thermal injury increases.Several in-vitro and animal experiments have been carried out to assess temperature changes of lavage solution during laser activation recent years.To the best of our knowledge,this is the first human study revealing temperature changes of ureter lavage solution during holmium laser ureteroscopic lithotripsy. | Jing-Fei Teng Kai Wang Xing Ai | 2020 | Chinese Medical Journal2020，，1： | 4 |
| 9 | 太原大气二氧化碳浓度变化及传输特征分析显示文摘本文首次使用太原温室气体观测站2016–2018年大气CO2,PM2.5,PM1.0浓度等观测数据,分析了城市地区大气CO2浓度的月,日分布特征,周末效应,霾日与非霾日变化特征。分析表明,太原地区CO2浓度秋,冬季高于春,夏季;霾日高于非霾日;四季日变化特征均呈‘单峰单谷’型;工作日整体略高于非工作日,特别是早高峰浓度差明显。利用HYSPLIT后向轨迹模式分析得出,太原CO2浓度主要受局地源汇影响,水平扩散可降低其浓度,而小风天气则不利于CO2扩散。高空风向,风速与近地面有区别,SW-W-NW扇区近距离气团对太原四季CO2浓度抬升明显,太原区域CO2以本地贡献为主。 | ZHANG Fengsheng ZHU Lingyun YAN Shiming GAO Xing’ai PEI Kunning | 2020 | Atmospheric and Oceanic Science Letters2020，13，4： | 4 |
| 10 | Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China显示文摘Objective To study the optimal waist circumference(WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome(MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China. | HOU Xin Guo WANG Chuan MA Ze Qiang YANG Wei Fang WANG Ji Xiang LI Cheng Qiao WANG Yu Lian LIU Shu Min Hu Xiu Ping ZHANG Xiu Ping JIANG Mei WANG Wei Qing NING Guang ZHENG Hui Zhen MA Ai Xia SUN Yu SONG Jun LIN Peng LIANG Kai LIU Fu Qiang LI Wen Juan XIAO Juan GONG Lei WANG Mei Jian LIU Ji Dong YAN Fei YANG Jun Peng WANG Ling Shu TIAN Meng ZHAO Ru Xing JIANG Ling CHEN Li | 2014 | Biomedical and Environmental Sciences2014，27，5： | 3 |
| 11 | pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging显示文摘The emerging technique of photoacoustic imaging,especially in the near infra-red(NIR)window,permits high resolution,deep-penetration,clinically reliable sensing.However,few contrast agents are available that can specifically respond to intricate biological environments,and which are biodegradable and biocompatible.Herein,we in troduce a new class of pH-sensitive orga nic photoacoustic con trast age nt that operates in the second NIR window(NIR-II,960-1,700 nm),which is derived from the self-assembled charge-transfer nanocomplex(CTN)by 3,3',5,5'-tetramethylbenzidine(TMB)and its dication structure(TMB++).The unique NIR-ll-responsive CTN can specifically respond to pH change in the physiological range and allows noninvasive and sensitive visualization of the tumor acidic microenvironment(e.g.at pH5)in mice with higher signal-to-noise ratio.The CTN is biodegradable under physiological conditions(e.g.pH 7.4),which alleviates the biosafety concern of nan oparticle accumulati on in vivo.These results clearly show the pote ntial of the TMB/TMB++-based CTN as a promisi ng pH-activated and biodegradable molecular probe for specific tumor photoacoustic imaging in the NIR-II region. | Zhimin Wang Paul Kumar Upputuri Xu Zhen Ruochong Zhang Yuyan Jiang Xiangzhao Ai Zhijun Zhang Ming Hu Zhenyu Meng Yunpeng Lu Yuanjing Zheng Kanyi Pu Manojit Pramanik Bengang Xing | 2019 | Nano Research2019，12，1： | 3 |
| 12 | Intrauterine Intervention of Pulmonary Atresia at 26^th Gestational Week显示文摘To the Editor:Congenital heart diseases (CHDs)are the most common congenital structural anomalies in China.Most of them are curable after birth.However,some defects progress during fetal period,thus resulting in high neonatal mortality and morbidity. Pulmonary atresia with intact ventricular septum (PA/IVS)during fetal period is partly associated with right ventricle (RV)hypoplasia and its consequent hemodynamic deterioration,which limits the possibility of biventricular (BV)repair after birth.The 1-year survival of PA/IVS live births is around 70%,but the rate of BV outcome is around 30%.[1] | Quan-Sheng Xing Yue Sun Gang Luo Ai Zhang Tao-Tao Chen Si-Lin Pan | 2018 | Chinese Medical Journal2018，，23： | 3 |
| 13 | Partial Surface Damper to Suppress Vibration for Thin Walled Plate Milling显示文摘The material removal rate and required workpiece surface quality of thin-walled structure milling are greatly limited due to its severe vibration, which is directly associated with the dynamic characteristics of the system.Therefore, the suppression of vibration is an unavoidable problem during milling. A novel partial surface damping method is proposed to modify the mode of the thin walled cantilever plate and to suppress vibration during milling.Based on classical plate theory, the design criterion is analyzed and configuration of the partial surface damper is introduced, in which viscoelastic plate and constraining plate are attached to the surface of the plate to increase the system's natural frequency and loss factor. In order to obtain the energy expression of the cutting system, the Ritz method is used to describe the unknown displacements.Then, with Lagrange's equation, the natural frequency and loss factor are calculated. In addition, the plate is divided into a finite number of square elements, and the regulation of treated position is studied based on theoretic and experimental analysis. The milling tests are conducted to verify its damping performance and the experimental results show that with treatment of partial surface damper,the deformation of the bare plate is reduced from 0.27 mm to 0.1 mm, while the vibration amplitude of the bare plate is reduced from 0.08 mm to 0.01 mm. The proposed research provides the instruction to design partial surface damper. | Jiahao SHI Qinghua SONG Zhanqiang LIU Xing AI | 2017 | Chinese Journal of Mechanical Engineering2017，30，3： | 3 |
| 14 | Friction and wear behavior of Al2O3/TiB2 ceramic composite against cemented carbide in various atmosphere at elevated temperature显示文摘 | Deng Jianxin Ai Xing | 1996 | Wear1996，195，12： | 2 |
| 15 | Attachment of tyrosinase on mixed self-assembled monolayers for the construction of electrochemical biosensor显示文摘A 混合了 thioctic 酸(TCOOH ) 的自我装配的单层(SAM ) , thioctic 酸酰胺(TNH2 ) 被用来为制作生物传感器使 tyrosinase 不能调动。结果证明在 1:4 的比率从答案准备的混合 SAM 为在 tyrosinase 和底层之间的酶的反应提供了优秀微型环境。生物传感器为察觉到底层展出了快回答和高敏感。 | Xue Ping Ji Xian Rui Li Na Wang Rui Xing Ni Xiao Hong Liu Hua Ai Xiong | 2010 | Chinese Chemical Letters2010，21，10： | 2 |
| 16 | Wear behavior and mechanism of alumina based ceramic tools in machining of ferrous and nonferrous alloys显示文摘 | Deng Jianxin Ai Xing | 1998 | Tribology International1998，30，11： | 2 |
| 17 | Yhhu3813 is a novel selective inhibitor of c-Met kinase that inhibits c-Met-dependent neoplastic phenotypes of human cancer cells显示文摘 | Chang-xi HE Jing AI Wei-qiang XING Yi CHEN Hao-tian ZHANG Min HUANG You-hong HU Jian DING Mei-yu GENG | 2014 | Acta Pharmacologica Sinica2014，35，1： | 2 |
| 18 | Wear behavior and mechanisms of alumina based ceramic tools in machining of ferrous and nonferrous alloys 显示文摘 | Deng Jianxin Ai Xing | 1997 | Tribology International1997，30，11： | 2 |
| 19 | Research and development of rare-earth cemented carbides 显示文摘 | XU Chong-hai AI Xing HUANG Chuan-zhen | 2001 | International Journal of Refractory Metals & Hard Materials2001，19，3： | 1 |
| 20 | Preparation of a-alumina coated carbide tools by the solgel process显示文摘 | Chen Yuanchun Ai Xing Huang Chuanzhen | 2000 | Materials Science and Engineering A2000，288，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员