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| 1 | Conjugated polyelectrolytes for label-free visual detection of heparin显示文摘Conjugated polyelectrolytes (CPEs),with electron-delocalized backbones and charged ionic side chains,are unique sensory materials for the construction of optical biosensors.In this feature article,CPE-based visual detection of heparin is summarized.Three CPE-based heparin probes,including ratiometric,light-up and colormetric probes,are discussed in terms of molecular design,detection selectivity and quantification capability.The work summarized here provides fundamental guidelines for CPE-based label-free visual sensing. | PU KanYi ZHAN RuoYu LIANG Jing LIU Bin | 2011 | Science China Chemistry2011，54，4： | 3 |
| 2 | pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging显示文摘The emerging technique of photoacoustic imaging,especially in the near infra-red(NIR)window,permits high resolution,deep-penetration,clinically reliable sensing.However,few contrast agents are available that can specifically respond to intricate biological environments,and which are biodegradable and biocompatible.Herein,we in troduce a new class of pH-sensitive orga nic photoacoustic con trast age nt that operates in the second NIR window(NIR-II,960-1,700 nm),which is derived from the self-assembled charge-transfer nanocomplex(CTN)by 3,3',5,5'-tetramethylbenzidine(TMB)and its dication structure(TMB++).The unique NIR-ll-responsive CTN can specifically respond to pH change in the physiological range and allows noninvasive and sensitive visualization of the tumor acidic microenvironment(e.g.at pH5)in mice with higher signal-to-noise ratio.The CTN is biodegradable under physiological conditions(e.g.pH 7.4),which alleviates the biosafety concern of nan oparticle accumulati on in vivo.These results clearly show the pote ntial of the TMB/TMB++-based CTN as a promisi ng pH-activated and biodegradable molecular probe for specific tumor photoacoustic imaging in the NIR-II region. | Zhimin Wang Paul Kumar Upputuri Xu Zhen Ruochong Zhang Yuyan Jiang Xiangzhao Ai Zhijun Zhang Ming Hu Zhenyu Meng Yunpeng Lu Yuanjing Zheng Kanyi Pu Manojit Pramanik Bengang Xing | 2019 | Nano Research2019，12，1： | 3 |
| 3 | Water-soluble light-emitting nanoparticles prepared by non-covalent bond self-assembly of a hydroxyl group functionalized oligo(p-phenyleneethynylene) with different water-soluble polymers显示文摘Water-soluble light-emitting nanoparticles were prepared from hydroxyl group functionalized oligos(p-phenyleneethynylene) (OHOPEL) and water-soluble polymers(PEG,PAA,and PG) by non-covalent bond self-assembly.Their structure and optoelectronic properties were investigated through dynamic light scattering(DLS) ,UV and PL spectroscopy.The optical properties of OHOPEL-based water-soluble nanoparticles exhibited the same properties as that found in OHOPEL films,indicating the existence of interchain-aggregation of OHOPELs in the nanoparticles.OHOPEL-based nanoparticles prepared from conjugated oligomers show smaller size and lower dispersity than nanoparticles from conjugated polymers,which means that the structures of water-soluble nanoparticles are linked to the conjugated length.Furthermore,the OHOPEL/PG and OHOPEL/PAA systems produced smaller particles and lower polydispersity than the OHOPEL/PEG system,indicating that there may exist influence of the strength of non-covalent bonds on the size and degree of dispersity of the nanoparticles. | Lu XiaoMei Fan QuLi Zhang GuangWei Pu KanYi Huang Wei | 2010 | Science China Chemistry2010，53，5： | 3 |
| 4 | A smart supramolecular phototherapeutics for specific cancer therapy显示文摘Phototherapeutics provides opportunities for cancer therapy because of its high spatiotemporal controllability and minimal invasiveness. For example, photodynamic therapeutics,often termed as photosensitizer (PS), can be administered to the patients with subsequent exposure to a specific light that leads to the death of the disease cells via oxidative damage.However, the efficacy of traditional PS has been limited by several issues including poor tumor specificity, fast renal clearance, and phototoxic side effect on normal tissues [1]. | Kanyi Pu | 2018 | Science China Chemistry2018，61，11： | 3 |
| 5 | Development of optical nanoprobes for molecular imaging of reactive oxygen and nitrogen species显示文摘 | Xu Zhen Kanyi Pu | 2018 | Nano Research2018，11，10： | 2 |
| 6 | Ultrasound-guided delivery of microRNA loaded nanoparticles into cancer显示文摘 | Tzu-Yin Wang Jung Woo Choe Kanyi Pu Rammohan Devulapally Sunitha Bachawal Steven Machtaler Sayan Mullick Chowdhury Richard Luong Lu Tian Butrus Khuri-Yakub Jianghong Rao Ramasamy Paulmurugan Jürgen K. Willmann | 2015 | Journal of Controlled Release2015，，： | 1 |
| 7 | Excimer-based Activatable Fluorescent Sensor for Sensitive Detection of Alkaline Phosphatase显示文摘The accurate detection of related biomarkers at early stage is crucial in diagnosis and therapy of cancer.Small molecule fluorescence probes stand out acting as efficient tools to detect biomolecules,especially biomacromolecules.Herein,a new probe that features excimer formation has been designed to detect cancer-related biomarker alkaline phosphatase(ALP).The probe shows high sensitivity to ALP with a low limit detection of 0.13 U/L and high selectivity with resistance to the interference in the complex physiological system.Furthermore,this probe presents good biocompatibility with negligible cytotoxicity and displays remarkable cell imaging functions,which allows for its application in biosystems.Theoretical simulation validates the high affinity of the probe with ALP and depicts the details of the interaction modes,which provides the possible mechanisms underlying the efficient detection of the probe in atomic level.The study of synthesis,properties and applications of the activatable emissive excimers not only enriches the tools to detect ALP,but also provides a new strategy to comprehend the pathogenic mechanism of enzyme-related diseases. | YUAN Fang LI Yang CHEN Zhenjuan ZHANG Jianjian NING Lulu YANG Xiao-Feng PU Kanyi | 2021 | Chemical Research in Chinese Universities2021，37，4： | 0 |
| 8 | Chemiluminescence:From mechanism to applications in biological imaging and therapy显示文摘Chemiluminescence(CL)is an emission phenomenon induced by chemical reaction.Different from the photoluminescence,CL is free from external excitation source,which is expected to show great advantages such as higher signal-to-background ratio(SBR)in bioimaging,and deeper tissue penetration in photodynamic therapy(PDT).This review introduces the theoretical aspects of CL mechanism,such as classification,energy consideration and chemiexcited/photoexcited states.Application of CL in bioimaging is highlighted.In particular,the approaches to modulate the brightness and the wavelength of CL are summarized,which are two fundamental parameters in bioimaging.Finally,the application of CL in PDT is introduced.The potential challenges and perspectives of CL in bioimaging and therapy are also discussed. | Zhijia Wang Jiaguo Huang Jingsheng Huang Bingran Yu Kanyi Pu Fu-Jian Xu | 2021 | Aggregate2021，2，6： | 0 |
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