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| 1 | Progress on the total synthesis of natural products in China:From 2006 to 2010显示文摘This paper summarizes the progress on the total syntheses of natural products accomplished in China's Mainland during the period from 2006 to 2010.The overview focuses on the first total synthesis of natural products of contemporary interest including alkaloids,cyclopeptides and cyclic depsipeptides,macrolides,terpenoids and steroids,saponins and glycosides.The development of novel synthetic strategies and methodologies,and application of new selective synthetic methods in the total syntheses of natural products are included as well. | CHEN Jie WANG AiE HUO HaoHua HUANG PeiQiang | 2012 | Science China Chemistry2012，55，7： | 8 |
| 2 | A novel and versatile method for the enantioselective syntheses of tropane alkaloids显示文摘A full account of the novel and flexible approach to hydroxylated 8-azabicyclo[3,2,1]octan-3-ones and 9-azabicyclo[3,3,1]nonan-3-ones is presented.Using keto-lactams as the starting materials,this two-step method consists of silyl enol ether formation with TBDMSOTf,lactam activation with Tf2O/DTBMP,and halide-promoted cyclization.Radical dechlorination of the resulting 1-halotropan-3-ones led to the corresponding hydroxylated tropan-3-ones,which can be hydrogenated to yield3,6-dihydroxytropanes.Starting from optically active keto-lactams,the method has been applied to the enantioselective syntheses of(+)-(1S,3S,5R,6S)-pervilleine C(6),(+)-(1S,3R,5S,6R)-valeroidine(3),(+)-(1S,3S,5R,6S)-dibenzoyloxytropane(8),and(+)-(1S,3S,5R,6S)-merredissine(9). | MAO ZhongYi HUANG SuYu GAO LongHui WANG AiE HUANG PeiQiang | 2014 | Science China Chemistry2014，57，2： | 3 |
| 3 | The func- tionality of milk powder and its relationship to chocolatemass processing, in particular the effect of milk powder manufacturing and composition on the physical properties of chocolate masses 显示文摘 | ATI'AIE H BREITSCHUH B BRAUN P | 2003 | Int J Food Sci Technol2003，38，3： | 1 |
| 4 | A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA显示文摘 | HUTVAGNER G MCLACHLAN J PASQUINELLI AIE | 2001 | Sci- ence2001，293，： | 1 |
| 5 | Worldwide survey of damage from swallowing multiple magnets显示文摘 | OESTREICH AIE | 2009 | Pediatr Radiol2009，39，2： | 1 |
| 6 | A Comparative Study ofPatients’ and Nurses’ Perceptions of the Quality of NursingServices, Satisfaction and Intent to Revisit the Hospital: AQuestionnaire Survey显示文摘 | Mi Aie Leea Young-Hee Yom | 2007 | Int J Nurs Stud2007，44，4： | 1 |
| 7 | Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis显示文摘 | Takahashi L Aie D | 1998 | Arthritis Rheum1998，41，6： | 1 |
| 8 | Numerical simulations of oblique-angle penetration by deformable projectiles into concrete targets显示文摘 | Yan Liu Aie Ma Fenglei Huang | 2008 | International Journal of Impact Engineering2008，，3： | 1 |
| 9 | Mutational dynamics of the SARS coronavirus in cell culture and human populations iso- lated in 2003 显示文摘 | Vega VB Ruan Y Liu J Lee WH Wei CL Se-Thoe SY Tang KF Zhang T Kolatkar PR Ooi EE Ling AIE Stan- ton LW Long PM Liu ET | 2004 | BMC Infect Dis2004，4，： | 1 |
| 10 | Epoxidized soybean oil as a potential source of high - temperature lubricants 显示文摘 | AIE)HVARYU A ERHAN S Z | 2002 | Ind Crops Prod2002，15，3： | 1 |
| 11 | Pyrolytic decomposition and model-free kinetics analysis of mixture of polypropylene ( PP ) and low-density polyethylene ( LDPE ) 显示文摘 | Chowlu Aie Cheng King Reddy P Karthik Ghoshal A K | 2009 | ThermochimicaActa2009，485，： | 1 |
| 12 | Acromioclavicular joint reconstruction using anchor sutures~ Surgical technique and prelimina- ry results显示文摘 | Basyoni Y E1-Ganainy AIE Aboul-Saad M | 2010 | Acta Orthop Belg2010，76，3： | 1 |
| 13 | Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases 显示文摘 | Straimer J Lee MC Lee AH Zeitler B Williams AIE Pearl JR Zhang L Rebar EJ Gregory PD Llinds M Urnov FD Fidock DA | 2012 | Nat Methods2012，9，10： | 1 |
| 14 | The survivability of patients with cervical cancer of IIB stage显示文摘 | Kryzhanivs'ka AIe Diakiv IB | 2014 | Lik Sprava2014，，56： | 1 |
| 15 | Warthin, s tumor muhicentricy and increasing incidence in women显示文摘 | Lamelas J Terry JH Jr Alfonso AIE | 1987 | AM J Surg1987，，1： | 1 |
| 16 | Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response 显示文摘 | Sundrud MS Koralov SB Feuerer M Calado DP Kozhaya AIE Rhule-Smith A Lefebvre RE Unutmaz D Mazitschek R Waldner H Whitman M Keller T Rao A | 2009 | Science2009，324，5932： | 1 |
| 17 | A Mouse Model of Vitiligo Induced by Monobenzone显示文摘 | Zhu Yiping Wang Suiquan Xu Aie | 2013 | Exp Dermatol2013，22，7： | 1 |
| 18 | Nuevos registros de macrohongos (Basidiomycota) para Colombia procedentes de un bosque seco tropical显示文摘 | PALACIO M GUTII~RREZ Y FRANCO-MOLANO AIE | 2014 | Actual Biol2014，37，102： | 1 |
| 19 | Artificial intelligence-based non-invasive tumorsegmentation, grade stratification and prognosisprediction for clear-cell renal-cell carcinoma显示文摘Due to the complicated histopathological characteristics of clear-cell renal-cell carcinoma(ccRcC),non-invasive prognosis before operative treatment is crucial in selecting the appropriate treatment.A total of 126345 computerized tomography(cT)images from four independent patient cohorts were included for analysis in this study.We propose a V Bottieneck multi-resolution and focus-organ network(VB-MrFo-Net)using a cascade framework for deep learning analysis.The VB-MrFo-Net achieved better performance than VB-Net in tumor segmentation,with a Dice score of 0.87.The nuclear-grade prediction model performed best in the logistic regression classifier,with area under curve values from 0.782 to 0.746.Survival analysis revealed that our prediction model could significantly distinguish patients with high survival risk,with a hazard ratio(HR)of 2.49[95%confidence interval(CI):1.13-5.45,P=0.023]in the General cohort.Excellent performance had also been verified in the Cancer Genome Atlas cohort,the Clinical Proteomic Tumor Analysis Consortium cohort,and the Kidney Tumor Segmentation Challenge cohort,with HRs of 2.77(95%CI:1.58-4.84,P=0.0019),3.83(95%CI:1.22-11.96,P=0.029),and 2.80(95%CI:1.05-7.47,P=0.025),respectively.In conclusion,we propose a novel VB-MrFo-Net for the renal tumor segmentation and automatic diagnosis of ccRcc.The risk stratification model could accurately distinguish patients with high tumor grade and high survival risk based on non-invasive CT images before surgical treatments,which couid provide practical advicefordecidingtreatmentoptions. | Siteng Chen Dandan Song Lei Chen Tuanjie Guo Beibei Jiang Aie Liu Xianpan Pan Tao Wang Heting Tang Guihua Chen Zhong Xue Xiang Wang Ning Zhang Junhua Zheng | 2023 | Precision Clinical Medicine2023，6，3： | 0 |
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