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| 1 | Optically stimulated luminescence dosimeter based on CaS:Eu,Sm显示文摘Alkaline earth sulfides (MgS,CaS and BaS) crystal doped with rare-earth ions is an optically stimulated luminescence dosimeter with very high sensitivity,short time constant of the optically stimulated luminescence (OSL) separated perfectly from the stimulation.In this paper,an OSL dosimeter is described.It has linear dose response from 0.01 to 1000 Gy.The equipment,relatively simple and small in size is promising for applications in space exploration and for high dose irradiation and dangerous irradiation conditions. | LIU Yanping CHEN Zhaoyang BA Weizhen FAN Yanwei GUO Qi YU Xuefeng CHANG Aiming LU Wu DU Yanzhao | 2008 | Nuclear Science and Techniques2008，19，2： | 4 |
| 2 | Coesite eclogite fades meta-morphic tectonite: Evidence for ultrahigh pressure deformation显示文摘An ultrahigh pressure ductile shear melange crops out on the beach of Yangkou Bay near Qingdao City. The melange is composed of weakly deformed blocks in a highly ductilly flow mylonites. Ultrahigh pressure meta-morphic (UHPM) tectonite includes strongly deformed ec-logite and mylonitized eclogite. Coesite occurs in the tectonite as both interstitial mineral and inclusions in garnet and omphacite, indicating that the deformation took place in the stability field of coesite (800-850°C, >30 GPa) in the upper mantle. Coesite is rounded or short prismatic grains with undulatory extinction, and often fractured, suggesting brittle deformation. Garnet is also characterized by brittle fractures and sometimes necked and slightly elongated. Omphacite is elongated, with long axis preferred orientation. Undulatory extinction, subgrains and dynamically recrystallized grains suggest plastic flow of omphacite. Ultrahigh pressure meta-morphic tectonite was probably formed in the ductile shear zone during the early | ZHAO Zhongyan, FANG Aiming & YU LiangjunLTE Lab, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China | 2002 | Chinese Science Bulletin2002，47，16： | 3 |
| 3 | Detection of Variants of B.1.617 Lineage from Five Returning Chinese Nationals at a Guangxi-Vietnam Border Port——Guangxi Zhuang Autonomous Region,China,April 2021显示文摘A 47-year-old male(Patient A)passenger from Vietnam whose nucleic acid results for coronavirus disease 2019(COVID-19),also known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),were positive at Pingxiang Customs on April 29,2021,and subsequently confirmed by Guangxi CDC laboratories on April 30. | Ning Kang Yinpin Liu Fuyin Bi Jing Wang Huafeng Chen Jing Wang Zhenli Liang Min Chen Guangwu Wei Aiming Li Yonghong Li Bao Lu Zhenling Jiang Yi Tan Ge Zhong Mei Lin Yu Ju | 2021 | China CDC weekly2021，3，30： | 3 |
| 4 | Adsorptive removal of arsenate and orthophosphate anions by mesoporous alumina 显示文摘 | Mi-Jin Yu Xiong Li Wha-Seung Aim | 2008 | Microporous and Mesoporous Materials2008，113，13： | 1 |
| 5 | Requirement for distinct Janus kinases and STAT proteins in T cell proliferation versus IFN-gamma production following IL-12 stimulation显示文摘 | Aim H J Tomura M Yu W G | 1998 | J Immunol1998，161，11： | 1 |
| 6 | Glucosamine, a naturally occurring amino monosaccharide, inhibits A549and H446 cell proliferation by blocking G1/S transition显示文摘 | Yinghua Ju Aiming Yu Xiuhua Sun Didi Wu Hongkai Zhang | 2013 | Molecular Medicine Reports2013，，3： | 1 |
| 7 | Recent advances in RNA structurome显示文摘RNA structures are essential to support RNA functions and regulation in various biological processes. Recently, a range of novel technologies have been developed to decode genome-wide RNA structures and novel modes of functionality across a wide range of species. In this review, we summarize key strategies for probing the RNA structurome and discuss the pros and cons of representative technologies. In particular, these new technologies have been applied to dissect the structural landscape of the SARS-CoV-2 RNA genome. We also summarize the functionalities of RNA structures discovered in different regulatory layers-including RNA processing, transport, localization, and mRNA translation-across viruses, bacteria, animals, and plants. We review many versatile RNA structural elements in the context of different physiological and pathological processes(e.g., cell differentiation, stress response, and viral replication). Finally, we discuss future prospects for RNA structural studies to map the RNA structurome at higher resolution and at the single-molecule and single-cell level, and to decipher novel modes of RNA structures and functions for innovative applications. | Bingbing Xu Yanda Zhu Changchang Cao Hao Chen Qiongli Jin Guangnan Li Junfeng Ma Siwy Ling Yang Jieyu Zhao Jianghui Zhu Yiliang Ding Xianyang Fang Yongfeng Jin Chun Kit Kwok Aiming Ren Yue Wan Zhiye Wang Yuanchao Xue Huakun Zhang Qiangfeng Cliff Zhang Yu Zhou | 2022 | Science China(Life Sciences)2022，65，7： | 1 |
| 8 | Involvement of protein kinase B/AKT in early development of mouse fertilized eggs显示文摘 | Chen Feng Aiming Yu Bingzhi Yu | 2007 | Biolreprod2007，77，3： | 1 |
| 9 | Coagulation and fibrinolytic indices during the first trimester of pregnancy in women with polycystic ovary syndrome显示文摘 | Yu S Aiming W Ying S | 2013 | Reprod Sci2013，20，11： | 1 |
| 10 | Membrane Science显示文摘 | Zhao Changsheng Yu Binyu Qian Boshi Wei Qiang Yang Kaiguang Zhang Aiming | 2008 | 310 : 382008，310，： | 1 |
| 11 | Plant and animal positive-sense single-stranded RNA viruses encode small proteins important for viral infection in their negative-sense strand显示文摘Positive-sense single-stranded RNA(+ssRNA)viruses,the most abundant viruses of eukaryotes in nature,require the synthesis of negative-sense RNA(-RNA)using their genomic(positive-sense)RNA(+RNA)as a template for replication.Based on current evidence,viral proteins are translated via viral+RNAs,whereas-RNA is considered to be a viral replication intermediate without coding capacity.Here,we report that plant and animal+ssRNA viruses contain small open reading frames(ORFs)in their-RNA(reverse ORFs[rORFs]).Using turnip mosaic virus(TuMV)as a model for plant+ssRNA viruses,we demonstrate that small proteins encoded by rORFs display specific subcellularlocalizations,and confirm the presence of rORF2 in infected cells through mass spectrometry analysis.The protein encoded by TuMV rORF2 forms punctuate granules that are localized in the perinuclear region and co-localized with viral replication complexes.The rORF2 protein can directly interact with the viral RNA-dependent RNA polymerase,and mutation of rORF2 completely abolishes virus infection,whereas ectopic expression of rORF2 rescues the mutant virus.Furthermore,we show that several rORFs in the-RNA of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have the ability to suppress type l interferon production and facilitate the infection of ve-sicular stomatitis virus.In addition,we provide evidence that TuMV might utilize internal ribosome entry sites to translate these small rORFs.Taken together,these findings indicate that the-RNA of+ssRNA vi-ruses can also have the coding capacity and that small proteins encoded therein play critical roles in viral infection,revealing a viral proteome larger than previously thought. | Pan Gong Qingtang Shen Mingzhen Zhang Rui Qiao Jing Jiang Lili Su Siwen Zhao Shuai Fu Yu Ma Linhao Ge Yaqin Wang Rosa Lozano-Durán Aiming Wang Fangfang Li Xueping Zhou | 2023 | Molecular Plant2023，16，11： | 0 |
| 12 | Improving the Ability of Predictive Thinking显示文摘Improving the ability of predictive thinking is conducive in seeking the future and mastering initiative.In order to improve the ability of predictive thinking,it is necessary to strengthen the spirit of active exploration to give full play to people's subjective initiative.Scientific methodology is the basis for improving this ability.It is necessary to learn and apply dialectical materialist methodology and to master advanced methods in specific subject areas.A deep and broad knowledge system is the fundamental for the development of predictive thinking,hence a deep professional knowledge system and a broad multifield knowledge reserve must be formed.The development of science and technology provides traction in discovering new forecasting directions,more advanced tools for forecasting research,and philosophical epistemological guidance for forecasting.Therefore,there is a need to pay great attention to the development of science and technology. | Aiming Yu | 2021 | Journal of Contemporary Educational Research2021，5，7： | 0 |
| 13 | Three new shRNA expression vectors targeting the CYP3A4 coding sequence to inhibit its expression显示文摘RNA interference(RNAi)is useful for selective gene silencing.Cytochrome P4503A4(CYP3A4),which metabolizes approximately 50% of drugs in clinical use,plays an important role in drug metabolism.In this study,we aimed to develop a short hairpin RNA(shRNA)to modulate CYP3A4 expression.Three new shRNAs(S1,S2 and S3)were designed to target the coding sequence(CDS)of CYP3A4,cloned into a shRNA expression vector,and tested in different cells.The mixture of three shRNAs produced optimal reduction(55%)in CYP3A4 CDS-luciferase activity in both CHL and HEK293 cells.Endogenous CYP3A4 expression in HepG2 cells was decreased about 50%at both mRNA and protein level after transfection of the mixture of three shRNAs.In contrast,CYP3A5 gene expression was not altered by the shRNAs,supporting the selectivity of CYP3A4 shRNAs.In addition,HepG2 cells transfected with CYP3A4 shRNAs were less sensitive to Ginkgolic acids,whose toxic metabolites are produced by CYP3A4.These results demonstrate that vector-based shRNAs could modulate CYP3A4 expression in cells through their actions on CYP3A4 CDS,and CYP3A4 shRNAs may be utilized to define the role of CYP3A4 in drug metabolism and toxicity. | Siyun Xu Yongsheng Xiao Li Li Lushan Yu Huidi Jiang Aiming Yu Su Zeng | 2014 | Acta Pharmaceutica Sinica B2014，4，5： | 0 |
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