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| 1 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 2 | GRAIN LENGTH AND AWN 1 negatively regulates grain size in rice显示文摘Grain size is an important factor determining yield in rice. Here, we identified a recessive mutant gene, grain length and awn 1 (gla1), which caused a significant increase in grain length and weight, and was associated with long awns. The gla1 mutation was mapped to a single-nucleotide polymorphism in a gene encoding a cytoplasmically-localized mitogen-activated protein kinase (MAPK) phosphatase. Overexpression of GLA1 caused a decrease in grain length, and the GLA1 protein interacted with OsMAPK6. These results suggest that GLA1 may serve as a negative regulator of the OsMAPKK4-OsMAPK6 cascade, controlling grain size via the dephosphorylation of OsMAPK6. | Tao Wang Ting Zou Zhiyuan He Guoqiang Yuan Tao Luo Jun Zhu Yueyang Liang Qiming Deng Shiquan Wang Aiping Zheng Huainian Liu Lingxia Wang Ping Li Shuangcheng Li | 2019 | Journal of Integrative Plant Biology2019，61，10： | 7 |
| 3 | Effects of long-term fertilization with different substitution ratios of organic fertilizer on paddy soil显示文摘In recent years,the abuse of chemical fertilizers has caused numerous environmental problems,such as soil acidification and compaction.Replacing chemical fertilizers with organic fertilizers can effectively alleviate these problems.However,the effects of alternative organic fertilizers remain unclear.To explore the effects of organic fertilizer substitution on rice yield and paddy soil physicochemical properties and bacterial community structure,we conducted a 5-year experiment using different proportions of organic fertilizer substitution in a double-cropping rice field in Jiangxi,China.Our results showed that replacing chemical fertilizers with organic fertilizers can reduce soil acidification,increase soil organic matter content,nutrient contents,and enzyme activities,improve soil physicochemical properties and microbial community,and enhance soil metabolism.Appropriate organic substitution also had positive effects on rice production.These findings enhance our understanding of the effects of different alternative organic fertilization methods and have important theoretical significance for the promotion of the use of organic fertilizers in the future. | Weifeng SONG Aiping SHU Jiai LIU Wenchong SHI Mingcong LI Wenxue ZHANG Zuzhang LI Guangrong LIU Fusheng YUAN Shuxin ZHANG Zengbing LIU Zheng GAO | 2022 | Pedosphere2022，32，4： | 7 |
| 4 | Less and shrunken pollen 1(LSP1) encodes a member of the ABC transporter family required for pollen wall development in rice(Oryza sativa L.)显示文摘Pollen fertility is an agronomic trait that strongly influences rice yield. Recent studies have revealed that the development of the pollen wall is required for pollen fertility and is regulated by several genes. However, the mechanisms underlying pollen and pollen wall development in rice remain largely unknown. In the present study, a point mutation in a gene on chromosome 1 was identified that resulted in the production of less and shrunken pollen(LSP) and led to defects in pollen wall formation. This gene was named LSP1 and was found to encode a member of the adenosine triphosphate-binding cassette(ABC)transporter G subfamily, OsABCG3. Two other loss-of-function mutants of LSP1/OsABCG3,generated using CRISPR/Cas9 technology, showed the same male sterile phenotype. The LSP1/OsABCG3 gene showed a spatio-temporal expression pattern in the developing anthers, and is an ortholog of the Arabidopsis genes At ABCG1 and At ABCG16, which play an important role in pollen wall development. Mutation of LSP1/OsABCG3 affected the expression of several genes involved in pollen and pollen wall formation. These results suggest that LSP1/OsABCG3 is critical for normal pollen fertility and shed light on the molecular mechanisms underlying rice pollen wall development. | Tao Luo Ting Zou Guoqiang Yuan Zhiyuan He Wenjie Li Yang Tao Miaomiao Liu Dan Zhou Hongfeng Zhao Jun Zhu Yueyang Liang Qiming Deng Shiquan Wang Aiping Zheng Huainian Liu Lingxia Wang Ping Li Shuangcheng Li | 2020 | The Crop Journal2020，8，3： | 4 |
| 5 | Self-immolative micellar drug delivery:The linker matters显示文摘Redox-responsive polymer-drug conjugate micelles are excellent nanoscale vehicles for self-immolative intracellular drug delivery.To covalently connect the polymer and drug,disulfide-bearing linkers,such as 3,3'-dithiodipropionic acid (DDPA) and 4,4'-dithiodibutyric add (DDBA),are used.In this paper,we report the influence of linker length on the therapeutic outcome of redox-sensitive conjugate micelles.Curcumin was selected as the model drug and it was conjugated to a multivalent methoxy poly(ethylene glycol)-polylysine copolymer with DDPA or DDBA as the linker.The obtained two polymer-curcumin conjugates were amphiphilic and could self-assemble into micelles that have a hydrodynamic diameter less than 100 nm.The loading of curcumin in both micelles was above 20% (w/w).Irrespective of the linker type,micelle disassembly was observed due to the collapse of the disulfide bond in a reducing environment.However,the rate of curcumin release was much faster with the DDBA linker than with the DDPA linker as the side product was a 5-membered ring with a low ring strain.The linker length-induced variation of curcumin release kinetics caused a significant difference in the intracellular drug concentration and a higher cytotoxicity was witnessed in three model cell lines (HeLa,PC3,and 4T1) for the micelles with a DDBA linker compared to those containing a DDPA linker.As expected,this phenomenon was also observed in HeLa tumor-bearing nude mice in vivo.The current work highlights the significance of linker length in engineering redox-responsive on-demand delivery systems. | Xuan Meng Min Gao Jian Deng Di Lu Aiping Fan Dan Ding Deling Kong Zheng Wang Yanjun Zhao | 2018 | Nano Research2018，11，12： | 2 |
| 6 | Innovative color jet 3D printing of levetiracetam personalized paediatric preparations显示文摘3D printing is a promising technology used in the fabrication of complex oral dosage delivery pharmaceuticals.This study first reports an innovative color jet 3D printing(CJ-3DP)technology to produce colorful cartoon levetiracetam pediatric preparations with high accuracy and reproducibility.For this study,the ideal printing ink consisted of 40%(v/v)isopropanol aqueous solution containing 0.05%(w/w)polyvinylpyrrolidone and 4%(w/w)glycerin,which was satisfied with scale-up of the production.The external and internal spatial structures of the tablets were designed to control the appearance and release,and cartoon tablets with admirable appearances and immediate release characteristics were printed.The dosage model showed a good linear relationship between the model volume and the tablet strength(r>0.999),which proved the potential of personalized administration.The surface roughness indicated that the appearance of the CJ-3DP tablets was significantly better than the first listed 3D printed drug(Spritam R).Moreover,the scanning electron microscopy and porosity results further showed that the tablets have a structure of loose interior and tight exterior,which could ensure good mechanical properties and rapid dispersion characteristics simultaneously.In conclusion,the innovative CJ-3DP technology can be used to fabricate personalized pediatric preparations for improved compliance.Due to the stable formulation and fabrication process,this technology has the potential in scale-up production. | Zengming Wang Xiaolu Han Ruxin Chen Jingru Li Jing Gao Hui Zhang Nan Liu Xiang Gao Aiping Zheng | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，3： | 2 |
| 7 | Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) inhibits platelet apoptosis in immune-induced bone marrow failure through mitochondrial pathway显示文摘OBjECTIVE: To investigate the effect of Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) on the platelet number in immune-induced bone marrow failure(BMF) and its mechanism of mitochondrial apoptotic pathway.METHODS: Immune-induced BMF model, established in mice, was randomly divided into four groups: normal control group without BMF, BMF control group, cyclosporine(CSA) group and flavone group(n = 10 in each group). Mice were given0.027 g/kg cyclosporine or 0.2 g/kg flavone lavage daily in either the cyclosporine or flavone group respectively. Platelet count, mitochondrial transmembrane potential(ΔΨm), cytochrome C(Cyt C), phosphatidylserine(PS), changes of calcium ion(Ca^(2+)),and protein expression of mitochondrial apoptotic pathway including B-cell lymphoma-2(bcl-2) Homologous Antagonist-Killer Protein(Bak), bcl-2-associated X protein(Bax), caspase-3, caspase-8, and caspase-9 were examined and compared.RESULTS: Compared with the normal control group, the BMF group had significantly lower levels of platelet count, ΔΨm, and expressions of caspase family proteins as well as higher levels of Cyt C, PS,Ca^(2+), and expressions of Bak and Bax(all P < 0.05).Compared with the BMF group, the CSA and flavone groups had significantly higher ΔΨm and expressions of caspase family proteins(all P < 0.05)whereas the levels of Cyt C, PS, Ca^(2+), and expressions of Bak and Bax were reduced(all P < 0.05).More importantly, the flavone group had higher levels of Cyt C, Ca^(2+)and expressions of Bak and Bax compared with the CSA group(all P < 0.05), while the levels of PS and caspase family proteins were reduced(all P < 0.05).CONCLUSION: Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) significantly increases the platelet number and prevents its apoptosis through mitochondrial pathway. | Jiang Yiling Zheng Qin Zhang Aiping Cui Lele Xia Lemin Luo Meihong | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 2 |
| 8 | Pu-erh tea: A review of a healthful brew显示文摘Pu-erh tea has been used for thousands of years to treat metabolic diseases.Recognized in Shen Nong's Herbal Classic,a compendium kept by the first traditional Chinese practitioners,it is still highly valued for its hypocholesterolemic and hypolipidemic effects.This review reports the processing and bioactive components of pu-erh tea.Recent human and animal studies of pu-erh tea and its potential therapeutic mechanisms have also been summarized.The interaction of liver and gut microbiome regulates the puerh tea biotransformation and endogenous metabolism,and thus contributes to the health benefits. | Wei Jia Cynthia Rajani Aiping Lv Tai-Ping Fan Xiaojiao Zheng | 2022 | Journal of Traditional Chinese Medical Sciences2022，9，2： | 2 |
| 9 | An Imported Case of BA.2 Lineage of Omicron Variant COVID-19—Guangdong Province,China,December 28,2021显示文摘On December 19,2021,a 31-year-old male boarded a flight from Bhubaneswar,India to Mumbai,India,and then another flight from Mumbai to Muscat,Oman.On December 24,he returned from Muscat to Guangzhou by airplane and was transferred to a centralized isolation hotel in Foshan.He was sampled on the third day of the quarantine,and the result returned to be coronavirus disease 2019(COVID-19)positive on December 27,2021.He was transported to the Guangzhou Eighth People’s Hospital for isolated treatment by negative pressure ambulance on the same day.The case had two lungs focal inflamed according to the chest CT examination. | Qianfang Guo Ruhan A Lijun Liang Xiang Zhao Aiping Deng Yao Hu Zhonghua Zheng Lirong Zou Cao Chen Baisheng Li | 2022 | China CDC weekly2022，4，5： | 2 |
| 10 | Effects of missing marker and segregation distortion on QTL mapping in F2 populations显示文摘 | Luyan Zhang Shiquan Wang Huihui Li Qiming Deng Aiping Zheng Shuangcheng Li Ping Li Zhonglai Li Jiankang Wang | 2010 | Theoretical and Applied Genetics2010，，6： | 2 |
| 11 | Duplication and expression analysis of multicopy miRNA gene family members in Arabidopsis and rice显示文摘理解扩大多拷贝 microRNA (miRNA ) 在植物的家庭,我们局部性从到他们的染色体的 Arabidopsis 和米饭的报导 miRNA 基因,分别地并且从 Arabidopsis 观察了 117 miRNA 基因中的那 37% 个,从米饭的 173 miRNA 基因中的 35% 个是在染色体的部分复制。为了描绘表示多样化是否多发生在植物之中,拷贝 miRNA 家庭成员,我们设计了在 Arabidopsis 和米饭从 10 个家庭指向 48 位预言的 miRNA 先锋的 PCR 教材。从 RT-PCR 数据的结果建议在一样的 miRNA 家庭以内的成员的抄录先锋在不同表示层次是在场的。另外,尽管 miR160 和 miR162 序列在 Arabidopsis 和米饭被保存,我们发现这些基因的表示模式在二种之间不同。这些数据建议那表达式多样化发生了在多拷贝 miRNA 家庭,在植物增加我们 miRNAs 的表达式规定的理解。 | Danhua Jiang Changsong Yin Aiping Yu Xiaofan Zhou Wanqi Liang Zheng Yuan Yun Xu Qingbo Yu Tieqiao Wen Dabing Zhang | 2006 | Cell Research2006，16，5： | 2 |
| 12 | Twodimensions data slicing algorithm,a New Approach inMining Rules of Literature in Traditional ChineseMedicine显示文摘 | Guang Zheng Hongtao Guo Aiping Lu | 2011 | CCIS Springer-Verlag Berlin Heidelberg2011，237，： | 1 |
| 13 | Effects of missing marker and segregation distortion on QTL mapping in F2 populations显示文摘 | Luyan Zhang Shiquan Wang Huihui Li Qiming Deng Aiping Zheng Shuangcheng Li Ping Li Zhonglai Li Jiankang Wang | 2010 | Theoretical and Applied Genetics2010，，6： | 1 |
| 14 | Discrete de- rivative: a data slicing algorithm for exploration of sharing biological networks between rheumatoid arthritis and coro- nary heart disease显示文摘 | Guang Zheng Hongtao Guo Aiping Lu | 2011 | BioData Min2011，23，4： | 1 |
| 15 | 2011 IEEE International Conference on Bioinfor matics and Biomedicine Workshops显示文摘 | Zheng Guang Jiang Miao Lu Aiping Exploring the biological basis of deficiency pattern in rheumatoid arthritis through text mining | 2011 | BIBMW2011，，： | 1 |
| 16 | Association study between methylenetetrahydrofolate reductase polymorphisms and unexplained recurrent pregnancy loss: A meta-analysis显示文摘 | Yunlei Cao Jianhua Xu Zhaofeng Zhang Xianliang Huang Aiping Zhang Jian Wang Qiupeng Zheng Lingyuan Fu Jing Du | 2013 | Gene2013，，2： | 1 |
| 17 | Fab-rication of microreactors for dehydrogenation to benzene显示文摘 | Ji Fang Zheng Aiping | 2000 | Sensors and Actuators2000，71，3： | 1 |
| 18 | Surface modification of ePTFE vascular grafts with O-carboxymethychitosan显示文摘 | ZHU Aiping ZHANG Ming ZHANG Zheng | 2004 | Polym Int2004，53，1： | 1 |
| 19 | Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles显示文摘Immunotherapy has revolutionized the landscape of cancer treatment.However,single immunotherapy only works well in a small subset of patients.Combined immunotherapy with antitumor synergism holds considerable potential to boost the therapeutic outcome.Nevertheless,the synergistic,additive or antagonistic antitumor effects of combined immunotherapies have been rarely explored.Herein,we established a novel combined cancer treatment modality by synergizing p21-activated kinase 4(PAK4)silencing with immunogenic phototherapy in engineered extracellular vesicles(EVs)that were fabricated by coating M1 macrophage-derived EVs on the surface of the nano-complex cores assembled with si RNA against PAK4 and a photoactivatable polyethyleneimine.The engineered EVs induced potent PAK4 silencing and robust immunogenic phototherapy,thus contributing to effective antitumor effects in vitro and in vivo.Moreover,the antitumor synergism of the combined treatment was quantitatively determined by the Compu Syn method.The combination index(CI)and isobologram results confirmed that there was an antitumor synergism for the combined treatment.Furthermore,the dose reduction index(DRI)showed favorable dose reduction,revealing lower toxicity and higher biocompatibility of the engineered EVs.Collectively,the study presents a synergistically potentiated cancer treatment modality by combining PAK4 silencing with immunogenic phototherapy in engineered EVs,which is promising for boosting the therapeutic outcome of cancer immunotherapy. | Mei Lu Haonan Xing Wanxuan Shao Pengfei Wu Yuchuan Fan Huining He Stefan Barth Aiping Zheng Xing-Jie Liang Yuanyu Huang | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 1 |
| 20 | Preparation and characterization of insulin-loaded bioadhesive PLGA nanoparticles for oral administration显示文摘 | Xiaoyan Zhang Muzhen Sun Aiping Zheng Deying Cao Yunqi Bi Jianxu Sun | 2012 | European Journal of Pharmaceutical Sciences2012，，5： | 1 |
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