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| 1 | Inflammatory pseudotumor of the liver and peripheral eosinophilia in autoimmune pancreatitis显示文摘AIM: Inflammatory pseudotumor (IPT) of the liver is a rare benign lesion, the etiology of which remains obscure.It is not associated with any particular diseases apart from phlebitis and Crohn's disease.METHODS: A middle-aged male with hepatic IPT and peripheral eosinophilia associated with autoimmune pancreatitis (AIP) was selected for this study and review of literature.RESULTS: A 59-year-old male was admitted with obstructive jaundice, marked eosinophilia (1 343/mm3)and hypergammaglobulinemia (4 145 mg/dL). Imaging techniques revealed dilatation of the intrahepatic bile duct,stenosis of the common bile duct with diffuse wall thickening, gallbladder wall thickening, irregular narrowing of the pancreatic duct, and swelling of the pancreatic parenchyma. Multiple liver masses were also demonstrated and diagnosed as IPT by biopsy specimens. Six months later, the abnormal features of the biliary tree remarkably improved by the oral administration of prednisolone, and the liver masses disappeared. The swelling of the pancreatic head also improved. The peripheral eosinophil count normalized. IPT associated with AIP, as we know,has not been reported in the literature. The clinical features of the present case mimicked those of pancreatic cancer with liver metastasis. This case deserves to be documented to prevent misdiagnosis of similar cases. | Naoki Sasahira Takao Kawabe Akira Nakamura Kenji Shimura Haruhisa Shimura Ei Itobayashi Manabu Asada Yasushi Shiratori Masao Omata | 2005 | World Journal of Gastroenterology2005，11，6： | 2 |
| 2 | Nitrous Oxide Induces Paradoxical Electroencephalographic Changes After Tracheal Intubation During Isoflurane and Sevoflurane Anesthesia显示文摘 | Yutaka Oda Katsuaki Tanaka Tadashi Matsuura Ichiro Hase Kiyonobu Nishikawa Akira Asada | 2006 | Anesthesia & Analgesia2006，，4： | 1 |
| 3 | DNA methylation of angiotensin Ⅱ receptor gene in nonalcoholic steatohepatitis-related liver fibrosis显示文摘AIM To clarify whether Agtr1 a methylation is involved in the development of nonalcoholic steatohepatitis(NASH)-related liver fibrosis in adult rats.METHODS A choline-deficient amino acid(CDAA) diet model was employed for methylation analysis of NASH-related liver fibrosis.Agtr1 a methylation levels were measured in the livers of CDAA- and control choline-sufficient amino acid(CSAA)-fed rats for 8 and 12 wk using quantitative methylation-specific PCR.Hepatic stellate cells(HSCs) were isolated by collagenase digestion of the liver,followed by centrifugation of the crude cell suspension through a density gradient.Agtr1 a methylation and its gene expression were also analyzed during the activation of HSCs.RESULTS The mean levels of Agtr1 a methylation in the livers of CDAA-fed rats(11.5% and 18.6% at 8 and 12 wk,respectively) tended to be higher(P = 0.06 and 0.09,respectively) than those in the livers of CSAA-fed rats(2.1% and 5.3% at 8 and 12 wk,respectively).Agtr1 a was not methylated at all in quiescent HSCs,but was clearly methylated in activated HSCs(13.8%,P < 0.01).Interestingly,although Agtr1 a was hypermethylated,the Agtr1 a m RNA level increased up to 2.2-fold(P < 0.05) in activated HSCs compared with that in quiescent HSCs,suggesting that Agtr1 a methylation did not silence its expression but instead had the potential to upregulate its expression.These findings indicate that Agtr1 a methylation and its upregulation of gene expression are associated with the development of NASH-related liver fibrosis.CONCLUSION This is the first study to show that DNA methylation is potential y involved in the regulation of a renin-angiotensin system-related gene expression during liver fibrosis. | Kiyoshi Asada Yosuke Aihara Hiroaki Takaya Ryuichi Noguchi Tadashi Namisaki Kei Moriya Masakazu Uejima Mitsuteru Kitade Tsuyoshi Mashitani Kosuke Takeda Hideto Kawaratani Yasushi Okura Kosuke Kaji Akitoshi Douhara Yasuhiko Sawada Norihisa Nishimura Kenichiro Seki Akira Mitoro Junichi Yamao Hitoshi Yoshiji | 2016 | World Journal of Hepatology2016，8，28： | 1 |
| 4 | Dexmedetomidine Decreases the Convulsive Potency of Bupivacaine and Levobupivacaine in Rats: Involvement of α2-Adrenoceptor for Controlling Convulsions显示文摘 | Katsuaki Tanaka Yutaka Oda Tomoharu Funao Ryota Takahashi Naoya Hamaoka Akira Asada | 2005 | Anesthesia & Analgesia2005，，3： | 1 |
| 5 | Effect of simvastatin on steroid-induced osteonecrosis evidenced by the serum lipid level and hepatic cytochrome P4503A in a rabbit model显示文摘 | Kentaro Iwakiri Yutaka Oda Yasunori Kaneshiro Hiroyoshi Iwaki Toshiaki Masada Akio Kobayashi Akira Asada Kunio Takaoka | 2008 | Journal of Orthopaedic Science2008，，5： | 1 |
| 6 | MHC class I-related chain B gene polymorphism is associated with virologicalresponse to pegylated interferon plus ribavirin therapy in patients with chronichepatitis C infection显示文摘 | Ayumi Asada Makoto Shioya Rie Osaki Takashi Nishimura Takayuki Takeuchi Yoshiaki Okumura Akira Andoh | 2015 | Biomedical Reports2015，，2： | 1 |
| 7 | 开腹手术所致手术中氧化应激反应的预防显示文摘背景有观点认为,各种活性氧成分早期即参与了手术应激和损伤,但尚未得到证实;医疗手段对氧化应激反应的作用也不明确。方法测定血中氢过氧化物的水平,作为细胞损伤的氧化应激指标;同时测定血浆铁还原能力,作为总抗氧化能力的指标。拟行乙状结肠切除术的患者分为4组:七氰烷麻醉下开腹乙状结肠切除术组;七氟烷麻醉下腹腔镜乙状结肠切除术组;丙泊酚麻醉下开腹乙状结肠切除术组;丙泊酚麻醉下腹腔镜乙状结肠切除术组。结果七氟烷开腹乙状结肠切除术组患者的血浆铁还原能力显着降低,由387mmol/L降至153mmol/L,氢过氧化物水平没有变化,这表明手术中患者的氧化应激反应有所增加。氢过氧化物,是一种典型的细胞氧化产物,它并没有明显变化,可能是由于手术中增加的氧化应澈反应还不足以损伤细胞。七氟烷腹腔镜乙状结肠切除术组中,氢过氧化物水平和铁还原能力都没有明显改变,表明腹腔镜手术不会增加手术的氧化应激反应。丙泊酚麻醉2个组,氢过氧化物术毕都明显下降,分别为120±73UCarr和144±107UCarr(1UCarr=0.8mg/L H2O2)。结论开腹手术会增加手术中的氧化应激反应,腹腔镜手术则不会;丙泊酚作为抗氧化剂能够有效地减少手术中的氧化应激反应。 | Masahiko Tsuchiya Eisuke F. Sato Masayasu Inoue Akira Asada 任盈(译) 米卫东(校) | 2010 | 麻醉与镇痛2010，，1： | 0 |
| 8 | Molecular Evolution of the Cytochrome b Gene in Geographically Isolated Populations of Oryzias Latipes显示文摘 | Nobuhiko Asada Akira Hirai Taiki Hamada Eri Sato Akio Moriyama Tetsuro Takeuchi | 2011 | Journal of Life Sciences2011，5，4： | 0 |
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