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| 1 | Usefulness of biodegradable stents constructed of poly-l-lactic acid monofilaments in patients with benign esophageal stenosis显示文摘AIM: To report 13 patients with benign esophageal stenosis treated with the biodegradable stent. METHODS: We developed a Ultraflex-type stent by knitting poly-l-lactic acid monofilaments. RESULTS: Two cases were esophageal stenosis caused by drinking of caustic liquid, 4 cases were due to surgical resection of esophageal cancers, and 7 cases were patients with esophageal cancer who received the preventive placement of biodegradable stents for post- endoscopic mucosal dissection (ESD) stenosis. The preventive placement was performed within 2 to 3 d after ESD. In 10 of the 13 cases, spontaneous migration of the stents occurred between 10 to 21 d after placement. In these cases, the migrated stents were excreted with the feces, and no obstructive complications were experienced. In 3 cases, the stents remained at the proper location on d 21 after placement. No symptoms of re-stenosis were observed within the follow-up period of 7 mo to 2 years. Further treatment with balloon dilatation or replacement of the biodegradable stent was not required. CONCLUSION: Biodegradable stents were useful for the treatment of benign esophageal stenosis, particularly for the prevention of post-ESD stenosis. | Yasuharu Saito Toyohiko Tanaka Akira Andoh Hideki Minematsu Kazunori Hata Tomoyuki Tsujikawa Norihisa Nitta Kiyoshi Murata Yoshihide Fujiyama | 2007 | World Journal of Gastroenterology2007，13，29： | 30 |
| 2 | Mucosal cytokine network in inflammatory bowel disease显示文摘Inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn's disease (CD) are characterized by ongoing mucosal inflammation in which dysfunction of the host immunologic response against dietary factors and commensal bacteria is involved. The chronic in-flammatory process leads to disruption of the epithelial barrier, and the formation of epithelial ulceration. This permits easy access for the luminal microbiota and dietary antigens to cells resident in the lamina pro-pria, and stimulates further pathological immune cell responses. Cytokines are essential mediators of the interactions between activated immune cells and non-immune cells, including epithelial and mesenchymal cells. The clinical efficacy of targeting TNF-α clearly indicates that cytokines are the therapeutic targets in IBD patients. In this manuscript, we focus on the bio-logical activities of recently-reported cytokines [Inter-leukin (IL)-17 cytokine family, IL-31 and IL-32], which might play a role through interaction with TNF-α in the pathophysiology of IBD. | Akira Andoh Yuhki Yagi Makoto Shioya Atsushi Nishida Tomoyuki Tsujikawa Yoshihide Fujiyama | 2008 | World Journal of Gastroenterology2008，14，33： | 21 |
| 3 | Usefulness of bispectral monitoring of conscious sedation during endoscopic mucosal dissection显示文摘AIM: To assess the usefulness of bispectral index (BIS) monitoring in order to carry out endoscopic submucosal dissection (ESD) safely and with patients' satisfaction. METHODS: Three hundred sixty-six patients with an early-stage neoplasm of the digestive tract were enrolled. The BIS monitor (A-1050: Aspect medical systems/NIHON KOHDEN, Tokyo, Japan) was used. The appropriate sedative condition was set at 55 to 75 BIS levels (BIS value) during the endoscopic procedures. RESULTS: Among 366 cases, 13 were accompanied by adverse events during and/or after ESD. All episodes occurred in cases with BIS value between 56 and 65. Hypotension was observed in four cases, and bradycardia in six. Respiratory distress was observed in two cases with chronic pulmonary obstructive disease. All patients with adverse events were able to leave the hospital without extension of the hospitalization. CONCLUSION: BIS monitoring is useful to safely perform ESD. A BIS value of 70 to 75 is suitable for ESD. | Kazunori Hata Akira Andoh Kiyoyuki Hayafuji Atsuhiro Ogawa Tamio Nakahara Tomoyuki Tsujikawa Yoshihide Fujiyama Yasuharu Saito | 2009 | World Journal of Gastroenterology2009，15，5： | 9 |
| 4 | Therapeutic approaches targeting intestinal microflora in inflammatory bowel disease显示文摘煽动性的肠疾病, ulcerative,和 Crohn 是疾病,是在的未知病原学的长期的肠的混乱在遗传上易受影响的个人,,粘膜免疫系统向共栖的细菌显示出异常回答。胃肠道开发了机灵的机制与它的自体同源的微植物群共存,但是在病原的感染被清除以后,很快对与它的共栖的细菌入侵病原体然后回来到动态平衡作出回应。在这紧调整的动态平衡的混乱的情况下,长期的肠的发炎可以被导致。当其它也没有影响或有一个保护的行动时,以前的研究证明一些共栖的细菌是有害的。另外,每位主人有遗传上坚定的回答到有害、保护的细菌的种类。这些建议微植物群的不平衡的那治疗学的操作能影响健康和疾病。这评论处于内脏健康和疾病集中于新卓见进共栖的细菌的角色,并且在天生、适应的有免疫力的相互作用介绍最近的调查结果。调制肠的微植物群的平衡和他们行动的潜在的机制的治疗学的途径也被讨论。 | Akira Andoh Yoshihide Fujiyama | 2006 | World Journal of Gastroenterology2006，12，28： | 9 |
| 5 | 摄入石墨烯量子点的家蚕可直接吐出力学性能增强的蚕丝(英文)显示文摘家蚕蚕丝具有细腻、光鲜以及优良的力学特性,因而在诸多领域中都有广泛应用.许多科学家对提高家蚕蚕丝力学性能的研究非常感兴趣.本工作中,我们通过血管注射的方式给家蚕幼虫注入了石墨烯量子点(GQDs),并且得到了力学性能增强的蚕丝. GQDs可通过淋巴循环进入到家蚕的丝腺器官并影响家蚕的纺丝过程.研究发现,当家蚕的GQDs摄入量为0.6μg/头时,家蚕蚕丝的断裂强度、断裂伸长率以及韧性模量可分别增强到原来的2.74, 1.33和3.62倍.广角X射线散射(WAXS)结果表明GQDs-蚕丝中的β-折叠纳米晶体的尺寸比起空白蚕丝有所降低,红外光谱结果表明GQDs限制了丝素蛋白中无规则卷曲或者α-螺旋结构向β-折叠结构的构象转变.β-折叠结构的尺寸及含量的变化可能是引起蚕丝力学性能增强的原因所在.我们还对GQDs的毒性以及单头家蚕摄入GQDs的安全限进行了评估,结果发现家蚕摄入GQDs的上限为30.0μg/头.使家蚕直接摄入GQDs获得力学性能增强的蚕丝的方法为生产高强度蚕丝提供了一种有潜力的途径. | 马琳 Maxwell Akologo Akurugu Vivian Andoh 刘海燕 宋江超 武国华 李龙 | 2019 | Science China Materials2019，62，2： | 8 |
| 6 | Expression of Interleukin-26 is upregulated in inflammatory bowel disease显示文摘AIM To investigate interleukin(IL)-26 expression in the inflamed mucosa of patients with inflammatory bowel disease(IBD) and the function of IL-26. METHODS Human colonic subepithelial myofibroblasts(SEMFs) were isolated from colon tissue surgically resected. The expression of IL-26 protein and its receptor complex was analyzed by immunohistochemistry. The gene expression induced by IL-26 was evaluated by realtime polymerase chain reaction. Intracellular signaling pathways were evaluated by immunoblotting and specific small interfering(si) RNA transfection. RESULTS The m RNA and protein expression of IL-26 were significantly enhanced in the inflamed mucosa of patients with IBD. IL-26 receptor complex was expressed in colonic SEMFs in vivo and in vitro. IL-26 stimulated the m RNA expression of IL-6 and IL-8 in colonic SEMFs. The inhibitors of mitogen-activated protein kinases and phosphoinositide 3-kinase, and si RNAs for signal transducers and activator of transcription 1/3, nuclear factor-kappa B and activator protein-1 significantly reduced the m RNA expression of IL-6 and IL-8 induced by IL-26.CONCLUSION These results suggest that IL-26 plays a role in the pathophysiology of IBD through induction of inflammatory mediators. | Makoto Fujii Atsushi Nishida Hirotsugu Imaeda Masashi Ohno Kyohei Nishino Shigeki Sakai Osamu Inatomi Shigeki Bamba Masahiro Kawahara Tomoharu Shimizu Akira Andoh | 2017 | World Journal of Gastroenterology2017，23，30： | 8 |
| 7 | Nutrition status and Helicobacter pylori infection in patients receiving hemodialysis显示文摘Chronic kidney disease(CKD) patients receiving hemodialysis(HD) often develop gastrointestinal abnormalities over their long treatment period. In general, prognosis in such patients is poor due to the development of protein-energy wasting(PEW). Therefore, it is important to clarify the etiology of PEW and to establish better strategies to deal with this condition. Chronic Helicobacter pylori(H. pylori) infection in the gastric mucosa has a close association with not only the development of peptic ulcer disease and gastric cancer, but is also associated with abnormal plasma and gastric mucosal ghrelin levels that are seen in malnutrition. It is unclear whether H. pylori infection of the gastric mucosa is directly associated with prognosis in HD patients by affecting ghrelin levels. Recent studies show that the prevalence of H. pylori infection in HD patients is significantly lower than in subjects with normal renal function. In the natural history of H. pylori infection in HD patients, the prevalence of infection decreases as the length of time on HD increases. The severity of gastric mucosal atrophy has been suggested as the major determinant of ghrelin levels in these patients, and eradication therapy of H. pylori improves nutritional status by increasing serum cholinesterase and cholesterol levels, especially in patients with mildto-moderate gastric mucosal atrophy. Prompt H. pylori eradication to inhibit the progress of gastric atrophy may be required to prevent this decrease in ghrelin levels and subsequent PEW and improve the prognosis of HD patients by improving their nutritional status. | Mitsushige Sugimoto Hideo Yasuda Akira Andoh | 2018 | World Journal of Gastroenterology2018，24，15： | 7 |
| 8 | Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis:A multicenter study in Japan显示文摘BACKGROUND Rapid urinary trypsinogen-2 dipstick test and levels of urinary trypsinogen-2 and trypsinogen activation peptide(TAP) concentration have been reported as prognostic markers for the diagnosis of acute pancreatitis.AIM To reconfirm the validity of all these markers in the diagnosis of acute pancreatitis by undertaking a multi-center study in Japan.METHODS Patients with acute abdominal pain were recruited from 17 medical institutions in Japan from April 2009 to December 2012. Urinary and serum samples were collected twice, at enrollment and on the following day for measuring target markers. The diagnosis and severity assessment of acute pancreatitis were assessed based on prognostic factors and computed tomography(CT) Grade of the Japanese Ministry of Health, Labour, and Welfare criteria.RESULTS A total of 94 patients were enrolled during the study period. The trypsinogen-2 dipstick test was positive in 57 of 78 patients with acute pancreatitis(sensitivity,73.1%) and in 6 of 16 patients with abdominal pain but without any evidence of acute pancreatitis(specificity, 62.5%). The area under the curve(AUC) score of urinary trypsinogen-2 according to prognostic factors was 0.704, which was highest in all parameter. The AUC scores of urinary trypsinogen-2 and TAP according to CT Grade were 0.701 and 0.692, respectively, which shows higher than other pancreatic enzymes. The levels of urinary trypsinogen-2 and TAP were significantly higher in patients with extended extra-pancreatic inflammation as evaluated by CT Grade.CONCLUSION We reconfirmed urinary trypsinogen-2 dipstick test is useful as a marker for the diagnosis of acute pancreatitis. Urinary trypsinogen-2 and TAP may be considered as useful markers to determine extra-pancreatic inflammation in acute pancreatitis. | Hiroaki Yasuda Keisho Kataoka Yoshifumi Takeyama Kazunori Takeda Tetsuhide Ito Toshihiko Mayumi Shuji Isaji Tetsuya Mine Motoji Kitagawa Seiki Kiriyama Junichi Sakagami Atsushi Masamune Kazuo Inui Kenji Hirano Ryukichi Akashi Masamichi Yokoe Yoshio Sogame Kazuichi Okazaki Chie Morioka Yasuyuki Kihara Shigeyuki Kawa Masao Tanaka Akira Andoh Wataru Kimura Isao Nishimori Junji Furuse Isao Yokota Tooru Shimosegawa | 2019 | World Journal of Gastroenterology2019，25，1： | 7 |
| 9 | Eubacterium limosum ameliorates experimental colitis and metabolite of microbe attenuates colonic inflammatory action with increase of mucosal integrity显示文摘瞄准:为了检验真细菌类高级轿车的效果,加(E。高级轿车和) 在结肠的上皮的房间线在试管内上,并且到评估 E 的效果。试验性的大肠炎上的高级轿车和。方法:E。高级轿车和被接种厌氧的联盟者和它的代谢物被获得。E 的生长 stimulatory 效果。T84 房间上的高级轿车和代谢物被 IL-6 生产被 SUDH 活动,和反煽动性的效果评估。在象受体 4 一样的使用费(TLR4 ) 的 mRNA 的变化被实时 PCR 评估。大肠炎被用 2.0% 葡聚糖硫酸钠喂 BALB/C 老鼠导致。这些老鼠收到了任何一个 5% lyophilized E。高级轿车和(n = 7 ) 或控制节食(n = 7 ) 。在大肠炎正式就职,临床、组织学的分数,冒号长度,和盲肠的有机酸层次以后的七天是坚定的。结果:E。高级轿车和在 0.25, 1.0, 0.025 和 0.07 mmol/L 生产了丁酸盐,醋酸盐,丙酸盐,和 lactate,分别地在里面中等。在这集中,每酸没有生长在 T84 细胞上刺激活动;然而,当这些酸在上述层次一起被混合时,它比控制显示出显著地高的活动。除了 lactate,这些酸显著地在就 0.1 mmol/L 稀释了 IL-6 生产。在 TNF-alpha 刺激下面,另外,丁酸盐稀释了 TLR4 mRNA 的生产。有 E 的处理。高级轿车和显著地随盲肠的丁酸盐层次的增加稀释了大肠炎的临床、组织学的分数,与控制组相比。结论:E。高级轿车和能改善试验性的结肠的发炎。部分地, E 的代谢物。高级轿车和,丁酸盐,增加粘膜正直和表演经由 TLR4 的粘膜防卫系统的反煽动性的行动调整。 | Osamu Kanauchi Masanobu Fukuda Yoshiaki Matsumoto Shino Ishii Toyokazu Ozawa Makiko Shimizu Keiichi Mitsuyama Akira Andoh | 2006 | World Journal of Gastroenterology2006，12，7： | 6 |
| 10 | 越南山茶×金花茶杂交种的子叶培养显示文摘开黄花的金花茶C,Chrysantha(二倍体)与其他物种的种间杂交,在用种子培育杂交种植株上的尝试己被证明是不成功的在我们的杂交试验中,将越南山茶(六倍体)和金花茶进行五次人工控制授粉处理,成功地获得了含有三粒可育的种子的两个成熟蒴果。将这些可育的种子的成熟子叶置于BA3mg/L+NAA1.0mg/L的MS培养基上进行离体培养,经过六个月时间的缓慢增殖,把它转移到椰乳10%+GA_3 1mg/L的MS培养基上,子叶表面形成大量的浅黄色或浅绿色的芽点。这些发生出来的芽只有4.3%(6/138)形成5厘米以上的带叶小植株发育成苗。由根的分生细胞的核形态特征可以看出,这此新生植株是越南山茶和金花茶的杂交种。 | SHINSAKU NADAMITSU YOSHIAKI ANDOH KATSUHIKO KONDO NICHIHARU SEGAWA 薛原 | 1991 | 广西林业科技1991，20，4： | 5 |
| 11 | Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the inferior common bile duct显示文摘A carcinoma displaying undifferentiated features with dense lymphoplasmacytic infiltration is defined as a lymphoepithelioma-like carcinoma(LEC),and some of LEC is associated with Epstein-Barr virus(EBV).All of the 13 previously reported cases of LEC of the biliary system were intrahepatic in location.Herein,we describe the first case of LEC of the inferior common bile duct.A 68-year-old Japanese man,who had been previously treated for hepatocellular carcinoma using microwave coagulation therapy,was found to have tumors of the common bile duct and pancreas head.Histopathological study of the resected tumor showed solid or cohesive nests of large undifferentiated cells with irregular large vesicular nuclei and nucleoli.Around the tumor cell nests,dense lymphoplasmacytic infiltration was observed.Focal glandular differentiation(approximately 5%) was also present.These histopathological features corresponded morphologically to LEC.Immunohistochemically,the tumor cells were positive for cytokeratin(CK) 7,CK 19 and CA19-9,but negative for CK 20 and Hep Par 1.In situ hybridization for Epstein Barr virus early small RNAs disclosed no nuclear signal in tumor cells.Therefore,a diagnosis of non-EBV-associated LEC of the inferior common bile duct was made.Although the prognosis of the biliary LEC is thought to be better than that of conventional cholangiocarcinoma,the differences in prognosis between EBV-positive and-negative cases have not yet been established.Therefore,additional case studies will be needed to clarify the clinicopathological features of LEC of the biliary tract. | Mitsuaki Ishida Tsuyoshi Mori Hisanori Shiomi Shigeyuki Naka Tomoyuki Tsujikawa Akira Andoh Yasuharu Saito Yoshimasa Kurumi Fumiyoshi Kojima Machiko Hotta Tohru Tani Yoshihide Fujiyama Hidetoshi Okabe | 2011 | World Journal of Gastrointestinal Oncology2011，3，7： | 5 |
| 12 | Cap polyposis refractory to Helicobacter pylori eradication treated with endoscopic submucosal dissection显示文摘Cap polyposis is a rare intestinal disorder. Characteristic endoscopic findings are multiple inflammatory polypoid lesions covered by caps of fibrous purulent exudate. Although a specific treatment has not been established, some studies have suggested that eradication therapy for Helicobacter pylori(H. pylori) is effective. We report a case of a 20-year-old man with cap polyposis presenting with hematochezia. Colonoscopy showed the erythematous polyps with white caps from the sigmoid colon to rectum. Histopathological findings revealed elongated, tortuous, branched crypts lined by hyperplastic epithelium with a mild degree of fibromusculosis in the lamina propria. Although H. pylori eradication was instituted, there was no improvement over six months. We then performed en bloc excision of the polyps by endoscopic submucosal dissection(ESD), which resulted in complete resolution of symptoms. ESD may be a treatment option for cap polyposis refractory to conservative treatments. We review the literature concerning treatment for cap polyposis and clinical outcomes. | Masaki Murata Mitsushige Sugimoto Hiromitsu Ban Taketo Otsuka Toshiro Nakata Masahide Fukuda Osamu Inatomi Shigeki Bamba Ryoji Kushima Akira Andoh | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，10： | 5 |
| 13 | Novel Biodegradable Stents for Benign Esophageal Strictures Following Endoscopic Submucosal Dissection显示文摘 | Yasuharu Saito Toyohiko Tanaka Akira Andoh Hideki Minematsu Kazunori Hata Tomoyuki Tsujikawa Norihisa Nitta Kiyoshi Murata Yoshihide Fujiyama | 2008 | Digestive Diseases and Sciences2008，，2： | 4 |
| 14 | Usefulness of the clip-flap method of endoscopic submucosal dissection: A randomized controlled trial显示文摘AIM To prospectively investigate the efficacy and safety of clipflap assisted endoscopic submucosal dissection(ESD) for gastric tumors.METHODS From May 2015 to October 2016, we enrolled 104 patients with gastric cancer or adenoma scheduled for ESD at Shiga University of Medical Science Hospital. We randomized patients into two subgroups using the minimization method based on location of the tumor(upper, middle or lower third of the stomach), tumor size(< 20 mm or > 20 mm) and ulcer status: ESD using an endoclip(the clip-flap group) and ESD without an endoclip(the conventional group). Therapeutic efficacy(procedure time) and safety(complication: Gastrointestinal bleeding and perforation) were assessed. RESULTS En bloc resection was performed in all patients. Four patients had delayed bleeding(3.8%) and two had perforation(1.9%). No significant differences in en bloc resection rate(conventional group: 100%, clip flap group: 100%), curative endoscopic resection rate(conventional group: 90.9%, clip flap group: 89.8%, P = 0.85), procedure time(conventional group: 70.8 ± 46.2 min, clip flap group: 74.7 ± 53.3 min, P = 0.69), area of resected specimen(conventional group: 884.6 ± 792.1 mm^2, clip flap group: 1006.4 ± 1004.8 mm^2, P = 0.49), delayed bleeding rate(conventional group: 5.5%, clip flap group: 2.0%, P = 0.49), or perforation rate(conventional group: 1.8%, clip flap group: 2.0%, P = 0.93) were found between the two groups. Lessexperienced endoscopists did not show any differences in procedure time between the two groups.CONCLUSION For patients with early-stage gastric tumors, the clipflap method has no advantage in efficacy or safety compared with the conventional method. | Hiromitsu Ban Mitsushige Sugimoto Taketo Otsuka Masaki Murata Toshiro Nakata Hiroshi Hasegawa Osamu Inatomi Shigeki Bamba Akira Andoh | 2018 | World Journal of Gastroenterology2018，24，35： | 4 |
| 15 | Efficacy of additional treatment with azathioprine in a patient with prednisolone-dependent gastric sarcoidosis显示文摘Gastric sarcoidosis with noncaseating granuloma is rare. Although corticosteroid produces a dramatic clinical response, it is unknown whether azathioprine show efficacy in prednisolone-dependent cases. Here, we report a case of gastric sarcoidosis in a 25-year-old man with severe epigastlargia. Gastroendoscopy revealed multiple map-like ulcerations. Histological examination showed multiple noncaseating granulomatous lesions in gastric mucosa, which were incompatible with diagnoses of Crohn's disease or tuberculosis. He was started on prednisolone at 30 mg/d, and his symptoms improved within 7-d. The prednisolone was gradually tapered by 5 mg every 2-wk, but oral azathioprine at 50 mg was added after symptoms recurred at tapered dose of 10 mg. Endoscopy 4-wk later showed healing ulcers, and, lymphocytic infiltration was absent. The efficacy of additional azathioprine in gastric sarcoidosis is not well defined. Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases. | Masaki Murata Mitsushige Sugimoto Yoshihiro Yokota Hiromitsu Ban Osamu Inatomi Shigeki Bamba Ryoji Kushima Akira Andoh | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 16 | Exercise,microglia,and beyond–workout to communicate with microglia显示文摘Microglia are brain-resident immune cells that use their ramified processes to survey the brain parenchyma.They maintain brain homeostasis by mediating immune responses through cytokine release,phagocytosing pathogens and protein aggregation(Salter et al.,2017).Furthermore,in both healthy and disease states,microglia interacting with neurons regulate synaptic formation,elimination and plasticity(Salter et al.,2017).It is thought that these functions may be altered by environmental stimuli such as lifestyle,stress,infection and air pollution,the effects of which may result in brain dysfunction and the development of neurodegenerative diseases(Branchi et al.,2014;Hanamsagar et al.,2017). | Megumi Andoh Ryuta Koyama | 2020 | Neural Regeneration Research2020，15，11： | 3 |
| 17 | Epithelial expression of interleukin‐37b in inflammatory bowel disease显示文摘 | H. Imaeda K. Takahashi T. Fujimoto E. Kasumi H. Ban S. Bamba H. Sonoda T. Shimizu Y. Fujiyama A. Andoh | 2013 | Clin Exp Immunol2013，，3： | 2 |
| 18 | Application of novel magnified single balloon enteroscopy for a patient with Cronkhite-Canada syndrome显示文摘We present a case of Cronkhite-Canada syndrome(CCS) in which the entire intestine was observed using a prototype of magnifying single-balloon enteroscope(SIF Y-0007, Olympus). CCS is a rare, non-familial gastrointestinal polyposis with ectodermal abnormalities. To our knowledge, this is the first report showing magnified intestinal lesions of CCS. A 73-year-old female visited our hospital with complaints of diarrhea and dysgeusia. The blood test showed mild anemia and hypoalbuminemia. The esophagogastroduodenoscopy and colonoscopy revealed diffuse and reddened sessile to semi-pedunculated polyps, resulting in the diagnosis of CCS. In addition to the findings of conventional balloon-assisted enteroscopy or capsule endoscopy, magnifying observation revealed tiny granular structures, non-uniformity of the villus, irregular caliber of the loop-like capillaries, scattered white spots in the villous tip, and patchy redness of the villus. Histologically, the scattered white spots and patchy redness of the villus reflect lymphangiectasia and bleeding to interstitium, respectively. | Masaki Murata Shigeki Bamba Kenichiro Takahashi Hirotsugu Imaeda Atsushi Nishida Osamu Inatomi Tomoyuki Tsujikawa Ryoji Kushima Mitsushige Sugimoto Akira Andoh | 2017 | World Journal of Gastroenterology2017，23，22： | 2 |
| 19 | Butyrate stimulates IL-32α expression in human intestinal epithelial cell lines显示文摘AIM: To investigate the effects of butyrate on interleukin (IL)-32α expression in epithelial cell lines. METHODS: The human intestinal epithelial cell lines HT-29, SW480, and T84 were used. Intracellular IL- 32α was determined by Western blotting analyses. IL- 32α mRNA expression was analyzed by real-time poly-merase chain reaction. RESULTS: Acetate and propionate had no effects on IL-32α mRNA expression. Butyrate significantly enhanced IL-32α expression in all cell lines. Butyrate also up-regulated IL-1β-induced IL-32α mRNA expression. Butyrate did not modulate the activation of phosphatidylinositol 3-kinase (PI3K), a mediator of IL- 32α expression. Like butyrate, trichostatin A, a histone deacetylase inhibitor, also enhanced IL-1β-induced IL- 32α mRNA expression.CONCLUSION: Butyrate stimulated IL-32α expression in epithelial cell lines. An epigenetic mechanism, such as histone hyperacetylation, might be involved in the action of butyrate on IL-32α expression. | Ayako Kobori Shigeki Bamba Hirotsugu Imaeda Hiromitsu Ban Tomoyuki Tsujikawa Yasuharu Saito Yoshihide Fujiyama Akira Andoh | 2010 | World Journal of Gastroenterology2010，16，19： | 2 |
| 20 | Severity of gastric mucosal atrophy affects the healing speed of post-endoscopic submucosal dissection ulcers显示文摘AIM To investigate factors associated with the healing of endoscopic submucosal dissection(ESD)-induced ulcers.METHODS We enrolled 132 patients with gastric tumors scheduled for ESD. Following ESD, patients were treated with daily lansoprazole 30 mg or vonoprazan 20 mg. Ulcer size was endoscopically measured on the day after ESD and at 4 and 8 wk. The gastric mucosa was endoscopically graded according to the Kyoto gastritis scoring system. We assessed the number of patients with and without a 90% reduction in ulcer area at 4 wk post-ESD and scar formation at 8 wk, and looked for risk factors for slower healing.RESULTS The mean size of gastric tumors and post-ESD ulcers was 17.4 ± 12.1 mm and 32.9 ± 13.0 mm. The meanreduction rates in ulcer area were 90.4% ± 0.8% at 4 wk and 99.8% ± 0.1% at 8 wk. The reduction rate was associated with the Kyoto grade of gastric atrophy at 4 wk(A0: 97.9% ± 0.6%, A1: 93.4% ± 4.1%, and A2: 89.7% ± 1.0%, respectively). In multivariate analysis, the factor predicting 90% reduction at 4 wk was gastric atrophy(Odds ratio: 5.678, 95%CI: 1.190-27.085, P = 0.029).CONCLUSION The healing speed of post-ESD ulcers was associated with the degree of gastric mucosal atrophy, and Helicobacter pylori eradication therapy is required to perform at younger age. | Taketo Otsuka Mitsushige Sugimoto Hiromitsu Ban Toshiro Nakata Masaki Murata Atsushi Nishida Osamu Inatomi Shigeki Bamba Akira Andoh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，5： | 2 |
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