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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Laser in situ keratomileusis for myopia and astigmatism: safety and efficacy显示文摘 | Alan Sugar Christopher J Rapuano William W Culbertson David Huang Gary A Varley Peter J Agapitos Vincent P de Luise Douglas D Koch | 2002 | Ophthalmology2002，，1： | 2 |
| 3 | A test method for wash-off pressure sensitive adhesives显示文摘 | BRYAN D L ALAN D R P | 1996 | International Journal of Adhesion and Adhesives1996，16，1： | 1 |
| 4 | Deposition of anatase on the surface of activated carbon显示文摘 | AMJAD H E S ALAN P N HAFID A D | 2004 | Surface Coatings Technology2004，187，23： | 1 |
| 5 | Fiber grating sensors显示文摘 | Alan D K Michael A D Heather J P | 1997 | J Lightwave Technol1997，15，8： | 1 |
| 6 | Airway compromise due to laryngopharyngeal edema after anterior cervical spine surgery 显示文摘 | Mark A P Jessica P A Alan H D | 2013 | J Clin Anesth2013，25，1： | 1 |
| 7 | Assessment of stability of slopes under drawdown conditions显示文摘 | ALANE P GRIFFITHS D V | 2000 | Journal of G-eetechnical and Geoenvironmental Engineering2000，126，5： | 1 |
| 8 | The effect of early treatment by cerivastatin on the serum level of C-reactive protein, interleukin-6, and interleukin-8 in the patients with unstable angina and non-Q-wave myocardial infarction 显示文摘 | Ostadal P Alan D Hajek P | 2003 | Mol Cell Biochem2003，246，12： | 1 |
| 9 | Effect of Sur- face Finish on Gear Tooth Friction 显示文摘 | Britton R D Elcoate C D Alanou M P | 2000 | Journal of tribology2000，122，1： | 1 |
| 10 | The impact of complications on outcomes after resection for esophageal and gastroesophageal junction carcinoma显示文摘 | Nabil P Rizk Peter B Bach Deborah Schrag Manjit S Bains Alan D Turnbull Martin Karpeh Murray F Brennan Valerie W Rusch | 2004 | Journal of the American College of Surgeons2004，，1： | 1 |
| 11 | Ultrathin multifunctional oxide coatings for lithium ion batteries显示文摘 | Xiao X Lu P Alan D | 2011 | Advanced Materials2011，23，34： | 1 |
| 12 | Determination of dissolved organic nitrogen in natural waters using high-temperature catalytic oxidation显示文摘 | E1-Sayed A B Eric P A Alan D T | 2003 | Trends in analytical chemistry2003，22，11： | 1 |
| 13 | A novel seri es of 2,5-substituted tryptamine derivative as vascular 5-HT 1B/D recepto r antagonists显示文摘 | Gerar P Molone Alan D Robertson Graeme R Martin | 1997 | J Med Chem1997，40，： | 1 |
| 14 | Detection of intensification in global-and continental-scale hydrological cycles: Temporal scale of evaluation 显示文摘 | Alan D Z Justin S Edwin P M | 2003 | Journal of Climate2003，16，： | 1 |
| 15 | The effect of medial meniscectomy and coronal plane angulation on in vitro load transmission in the canine stifle joint 显示文摘 | Alan P N Anderson D R | 1989 | Orthopaedic Research1989，7，： | 1 |
| 16 | Phylogeny, mor- phology and pathogenicity of diaporthe and phomopsis spe- cies on almond in Portugal 显示文摘 | Eugenio L F D Jorge M S Alan J L P | 2010 | Fungal Diversity2010，44，： | 1 |
| 17 | Anti-Xa activity of enoxaparinand nadroparin in patients with acute coronary syndrome 显示文摘 | Ostadal P Alan D Vejvoda J | 2008 | ExpClin Cardiol2008，13，： | 1 |
| 18 | Iterafive minimization techniques for ab initio total-energy calculations: molecular dynamics and conjugate gradients 显示文摘 | PAYNE M C TETER M P ALAN D C | 1992 | Rev Mod Phys1992，64，： | 1 |
| 19 | Ultra-drawing of polyamides:the hydrogen bond barrier显示文摘 | AALDRIK R P PAUL S ALAN D E | 1990 | Polymer commuications1990，31，： | 1 |
| 20 | Fluvastatin in the first-line therapy of acute coronary syndrome:results of the multicenter,randomized,double-blind,placebo-controlled trial (the FACS-trial)显示文摘 | Ostadal P Alan D Vejvoda J | | 0，，： | 1 |
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