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| 1 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 2 |
| 4 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 5 | Unfrozen water contents of submarine permafrost determined by nuclear magnetic resonance 显示文摘 | Tice A R Anderson D M Sterrett K F | 1981 | Engineering Geology1981，18，： | 2 |
| 6 | Managing soil moisture on waste burial sites in add regions 显示文摘 | Anderson J E Nowak R S Ratzlaff T D | 1992 | Journal of Environmental Quality1992，22，1： | 1 |
| 7 | Efficacyand safety of a new vaginal contraceptive antimicrobialformulation containing high molecular weight poly(sodi-um4-styrenesulfon-ate)显示文摘 | Zaneveld L J Waller D P Anderson R A | 2002 | Biol Reprod2002，66，： | 1 |
| 8 | Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer:National Surgical Adjuvant Breast and Bowel Project Protocol B-27显示文摘 | BEAR H D ANDERSON S SMITH R E | 2006 | J Clin Oncol2006，24，13： | 1 |
| 9 | Naphthalene and benzene degradation under Fe(Ⅲ)-reducing conditions in petroleum-contaminated aquifers显示文摘 | Anderson R T Lovley D R | 1999 | Bioremediation Journal1999，3，2： | 1 |
| 10 | Character- ization,dynamics, and ecological impacts of harmful Cochlodini- um polykrikoides blooms on eastern Long Island, NY USA 显示文摘 | GOBLER C J BERRY D L ANDERSON O R | 2008 | Harmful Algae2008，7，： | 1 |
| 11 | Thin Poly- imide Films Prepared by Ionic Self-assembly显示文摘 | Anderson M R Davis R M Taylor C D | 2001 | Lang- muir2001，17，： | 1 |
| 12 | I Rach unkova and C C Tisdell, Solvability of discrete Neumann boundary value problems 显示文摘 | Anderson D R | 2007 | J Math Anal Appl2007，，331： | 1 |
| 13 | Age differences in online processing of video:An eye movement study显示文摘 | KIRKORIAN H L ANDERSON D R KEEN R | | 0，，02： | 1 |
| 14 | Derivation of a simple clinical model to categorize patients probalfility of pulmonary embolism:increasing the models utility with the SimpliRed D-Dimmer显示文摘 | Wells P S Anderson D R Rodger M | 2000 | Thromb Haemost2000，83，： | 1 |
| 15 | A revision of bloom's taxonomy: An overview 显示文摘 | Krathwohl D R Anderson L | 2002 | Theory Into Practice2002，，41： | 1 |
| 16 | Linking leaf chlorophyll fluorescence properties tophysiological responses for detection of salt and drought stress in coastal plant species显示文摘 | Naumman L C Young D R Anderson J E | 2007 | Physiologia Plantarura2007，131，： | 1 |
| 17 | Exercise-based cardiac rehabilitation for coronary heart disease: cochrane systematic review and Meta-analysis 显示文摘 | Anderson L Oldridge N Thompson D R | 2016 | Journal of the American College of Cardiology2016，67，1： | 1 |
| 18 | Measuring disparities in sanitation access:does the measure matter?显示文摘 | Rheingans R Anderson J D Luyendijk R | 2014 | Tropical Medicine and International Health2014，19，1： | 1 |
| 19 | Studies into the formation of dioxins in the sintering process used in the iron and steel industry: characterization of isomer profiles in particulate and gaseous Emissions显示文摘 | WANG T S ANDERSON D R THOMPSON D | 2003 | Chemosphere2003，51，7： | 1 |
| 20 | Multiple solutions and eigenvalues for third - order right focal boundary value problems 显示文摘 | ANDERSON D R DAVIS J M | 2002 | J Math Anal Appl2002，267，： | 1 |
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