|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Viral hepatitis:Innovations and expectations显示文摘Viral hepatitis is a significant health problem worldwide,associated with morbidity and mortality.Hepatitis B,C,D,and occasionally E viruses(HBV,HCV,HDV,and HEV)can evolve in chronic infections,whereas hepatitis A virus(HAV)frequently produces acute self-limiting hepatitis.In the last years,different studies have been performed to introduce new antiviral therapies.The most important goal in the treatment of viral hepatitis is to avoid chronic liver disease and complications.This review analyzes currently available therapies,in particular for viruses associated with chronic liver disease.The focus is especially on HBV and HCV therapies,investigating new drugs already introduced in clinical practice and clinical trials.We also describe new entry inhibitors,developed for the treatment of chronic HDV and HBV and currently available treatments for HEV.The last drugs introduced have shown important efficacy in HCV,with achievable target HCV elimination by 2030.Concurrently,renewed interest in curative HBV therapies has been registered;current nucleotide/nucleoside analogs positively impact liver-related complications,ensuring high safety and tolerability.Novel approaches to HBV cure are based on new antivirals,targeting different steps of the HBV life cycle and immune modulators.The improved knowledge of the HDV life cycle has facilitated the development of some direct-acting agents,as bulevirtide,the first drug conditionally approved in Europe for HDV associated compensated liver disease.Further studies are required to identify a new therapeutic approach in hepatitis E,especially in immunosuppressed patients. | Simona Leoni Alberto Casabianca Benedetta Biagioni Ilaria Serio | 2022 | World Journal of Gastroenterology2022，28，5： | 3 |
| 2 | 2,5-Dimethyl- 1H- pyrrole-3,4-dicarbaldehyde as a precolumn derivatization reagent for HPLC/UV detection of amino acids显示文摘 | Gatti Rita Gioia Maria Grazia Leoni Alberto | 2010 | Journal of Pharmaceutical and Biomedical Analysis2010，，530： | 1 |
| 3 | Determination of estragole in fennel herbal teas by HS-SPME and GC-MS显示文摘 | Giulia Basaglia Jessica Fiori Alberto Leoni | 2014 | Analytical Letters2014，47，2： | 1 |
| 4 | Electronic nose and chiral-capillary electrophoresis in evaluation of the quality changes in commercial green tea leaves during a long-term storage显示文摘 | Mara Mirasoli Roberto Gotti Massimo Di Fusco Alberto Leoni Carolina Colliva Aldo Roda | 2014 | Talanta2014，，： | 1 |
| 5 | Synthesis and antitumor activity of a new class of pyrazolo pyrrolo diazepinone analogues of pyrrolo benzodiazepines 显示文摘 | Pier Fiovanni Baraldi Alberto Leoni Barbara Cacerari | 1994 | J Med Chem1994，37，： | 1 |
| 6 | Language switching mechanisms in simultaneous interpreters: an ERP study显示文摘 | Alice Mado Proverbio Giuliana Leoni Alberto Zani | 2004 | Neuropsychologia2004，，12： | 1 |
| 7 | Language Switching Mechanisms in Simultaneous Interpreters: an ERP Study显示文摘 | Proverbio Alice Mado Giuliana Leoni and Alberto Zani | 2004 | Neuropsychologia2004，，12： | 1 |
| 8 | Some remarks on the engineering application of the fatigue crack growth approach under nonzero mean loads显示文摘著名疲劳裂缝生长(FCG ) 曲线是二参数的依赖者。压力紧张因素 K 和负担比率 R 的范围是通常使用描述这些曲线的参数。为设计目的,这些曲线的数学表示应该在起始、最后的裂缝尺寸之间是综合的以便为压力和生活获得安全因素。首先,把 FCG 曲线的依赖归结为仅仅一个参数是必要的。K 几乎总是被选择并且处于这些条件,看作了裂缝驱动力。用从文学的试验性的数据,现在的纸显示出怎么用传统的沃克途径和更最近的统一途径执行多重回归分析。那么获得的关联图形地在三种尺寸被分析。为裂缝在经常的振幅的名字的压力下面成长在的裂缝生长分析的数字例子光滑并且 notched 几何学被执行,作为可得到的试验性的数据的假定一个相同材料部件。裂缝尺寸的产生曲线对周期(vs. N ) 的数字然后被比较。二个模型近似在两几何学给一样(vs. N ) 曲线。行为之间的差别(vs. N ) 弯在光滑并且 notched 几何学被加亮,并且为这些特别行为的原因被讨论。 | Jorge Alberto Rodriguez DURAN Ronney Mancebo BOLOY Rafael Raider LEONI | 2015 | Frontiers of Mechanical Engineering2015，10，3： | 0 |
| 9 | 一英里观景塔显示文摘该方案命名为"一英里观景塔(The Mile),这个一英里高的垂直公园与观景平台,是由Carlo Ratti Associati与德国工程师Schlaich Bergerman以及英国设计工作室Atmos联合设计。该方案的灵感来自于设计师的愿望,"一英里"不仅是人类永恒的追求垂直海拔高度,它还解决了我们人类需要从不同的角度去看世界。 | Carlo Ratti Giovanni de Niederhusern Emma Greer Saverio Panata Alberto Bottero Gary di Silvio Andrea Galli Pietro Leoni Monica Lve Schlaich Bergermann 白骐鸣 | 2016 | 现代装饰2016，0，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员