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| 1 | A bacterial effector protein uncovers a plant metabolic pathway involved in tolerance to bacterial wilt disease显示文摘Bacterial wilt caused by the soil-borne plant pathogen Ralstonia solanacearum is a devastating disease worldwide.Upon plant colonization,R.solanacearum replicates massively,causing plant wilting and death;collapsed infected tissues then serve as a source of inoculum.In this work,we show that the plant metabolic pathway mediated by pyruvate decarboxylases(PDCs)contributes to plant tolerance to bacterial wilt disease.Arabidopsis and tomato plants resp ond to R.solanacearum infection by in creasing PDC activity,and plants with deficient PDC activity are more susceptible to bacterial wilt.Treatment with either pyruvic acid or acetic acid(substrate and product of the PDC pathway,respectively)enhances plant tolerance to bacterial wilt disease.An effector protein secreted by R.solanacearum,RipAK,interacts with PDCs and inhibits their oligomerization and enzymatic activity.Collectively,our work reveals a metabolic pathway involved in plant resistance to biotic and abiotic stresses,and a bacterial virulence strategy to promote disease and the completion of the pathogenic life cycle. | Yaru Wang Achen Zhao Rafael J.L.Morcillo Gang Yu Hao Xue Jose S.Rufian Yuying Sang Alberto P.Macho | 2021 | Molecular Plant2021，14，8： | 3 |
| 2 | Intra-strain Elicitation and Suppression of Plant Immunity by Ralstonia solanacearum Type-III Effectors in Nicotiana benthamiana显示文摘Effector proteins delivered inside plant cells are powerful weapons for bacterial pathogens,but this exposes the pathogen to potential recognition by the plant immune system.Therefore,the effector repertoire of a given pathogen must be balanced for a successful infection.Ralstonia solanacearum is an aggressive pathogen with a large repertoire of secreted effectors.One of these effectors,RipE1,is conserved in most R.solanacearum strains sequenced to date.In this work,we found that RipE1 triggers immunity in N.benthamiana,which requires the immune regulator SGT1,but not EDS1 or NRCs.Interestingly,RipE1-triggered immunity induces the accumulation of salicylic acid(SA)and the overexpression of several genes encoding phenylalanine-ammonia lyases(PALs),suggesting that the unconventional PALmediated pathway is responsible for the observed SA biosynthesis.Surprisingly,RipE1 recognition also induces the expression of jasmonic acid(JA)-responsive genes and JA biosynthesis,suggesting that both SA and JA may act cooperatively in response to RipE1.We further found that RipE1 expression leads to the accumulation of glutathione in plant cells,which precedes the activation of immune responses.R.solanacearum secretes another effector,RipAY,which is known to inhibit immune responses by degrading cellular glutathione.Accordingly,RipAY inhibits RipE1-triggered immune responses.This work shows a strategy employed by R.solanacearum to counteract the perception of its effector proteins by plant immune system. | Yuying Sang Wenjia Yu Haiyan Zhuang Yali Wei Lida Derevnina Gang Yu Jiamin Luo Alberto P.Macho | 2020 | Plant Communications2020，1，4： | 2 |
| 3 | 拟南芥ABA受体PYL的十二重突变体揭示了PYL对ABA不依赖的渗透胁迫应答的抑制显示文摘文章简介ABA促进气孔关闭、生长抑制、休眠等胁迫应答,被称为'胁迫激素'。除胁迫应答之外,ABA信号是否参与调控其他生理过程尚不清楚。本研究构建了敲除所有ABA受体的PYL的十四重突变体,发现它极矮小且不育. | 赵杨 Zhengjing Zhang 高景慧 王鹏程 胡涛 Zegang Wang Yueh-Ju Hou Yizhen Wan Wenshan Liu Shaojun Xie Tianjiao Lu Liang Xue Yajie Liu Alberto P.Macho W.Andy Tao Ray A.Bressan 朱健康 | 2019 | 科学新闻2019，0，2： | 1 |
| 4 | JASMONATE-ZIM DOMAIN proteins engage Polycomb chromatin modifiers to modulate Jasmonate signaling in Arabidopsis显示文摘Jasmonate(JA)regulates various aspects of plant growth and development and stress responses,with prominent roles in male reproductive development and defenses against herbivores and necrotrophic pathogens.JASMONATE-ZIM DOMAIN(JAZ)proteins are key regulators in the JA signaling pathway and function to repress the expression of JA-responsive genes.Here,we show that JAZ proteins directly interact with several chromatin-associated Polycomb proteins to mediate repressive chromatin modifications at JA-responsive genes and,thus,their transcriptional repression in Arabidopsis.Genetic analyses revealed that the developmental defects,including anther and pollen abnormalities,resulting from loss or block of JA signaling were partially rescued by loss of Polycomb protein-mediated chromatin silencing(Polycomb repression).We further found that JAZ-mediated transcriptional repression during anther and pollen development requires Polycomb proteins at four key Regulatory loci.Analysis of genome-wide occupancy of a Polycomb factor and transcriptome reprogramming in response to JA revealed that Polycomb repression is involved in the repression of various JA-responsive genes.Taken together,our study reveals an important chromatin-based mechanism for JAZ-mediated transcriptional repression and JA signaling in plants. | Zicong Li Xiao Luo Yang Ou Huijun Jiao Li Peng Xing Fu Alberto P.Macho Renyi Liu Yuehui He | 2021 | Molecular Plant2021，14，5： | 1 |
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