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| 1 | Outcomes of robotic vs laparoscopic hepatectomy:A systematic review and meta-analysis显示文摘AIM: To perform a systematic review and metaanalysis on robotic-assisted vs laparoscopic liver resections.METHODS: A systematic literature search was performed using Pub Med, Scopus and the Cochrane Library Central. Participants of any age and sex, who underwent robotic or laparoscopic liver resection were considered following these criteria:(1) studies comparing robotic and laparoscopic liver resection;(2) studies reporting at least one perioperative outcome; and(3) if more than one study was reported by the same institute, only the most recent was included. The primary outcome measures were set for estimated blood loss, operative time, conversion rate, R1 resection rate, morbidity and mortality rates, hospital stay and major hepatectomy rates.RESULTS: A total of 7 articles, published between 2010 and 2014, fulfilled the selection criteria. The laparoscopic approach was associated with a significant reduction in blood loss and lower operative time(MD = 83.96, 95%CI: 10.51-157.41, P = 0.03; MD = 68.43, 95%CI: 39.22-97.65, P < 0.00001, respectively). No differences were found with respect to conversion rate, R1 resection rate, morbidity and hospital stay.CONCLUSION: Laparoscopic liver resection resulted in reduced blood loss and shorter surgical times compared to robotic liver resections. There was no difference in conversion rate, R1 resection rate, morbidity and length of postoperative stay. | Roberto Montalti Giammauro Berardi Alberto Patriti Marco Vivarelli Roberto Ivan Troisi | 2015 | World Journal of Gastroenterology2015，21，27： | 22 |
| 2 | Robot-assisted laparoscopic vs open gastrectomy for gastric cancer:Systematic review and meta-analysis显示文摘AIM To evaluate the potential effectiveness of robot-assisted gastrectomy(RAG) in comparison to open gastrectomy(OG) for gastric cancer patients.METHODS A comprehensive systematic literature search using PubM ed,EMBASE,and the Cochrane Library was carried out to identify studies comparing RAG and OG in gastric cancer.Participants of any age and sex were considered for inclusion in comparative studies of the two techniques independently from type of gastrectomy.A meta-analysis of short-term perioperative outcomes was performed to evaluate whether RAG is equivalent to OG.The primary outcome measures were set for estimated blood loss,operative time,conversion rate,morbidity,and hospital stay.Secondary among postoperative complications,wound infection,bleeding and anastomotic leakage were also analysed.RESULTS A total of 6 articles,5 retrospective and 1 randomized controlled study,involving 6123 patients overall,with 689(11.3%) cases submitted to RAG and 5434(88.7%) to OG,satisfied the eligibility criteria and were included in the meta-analysis.RAG was associated with longer operation time than OG(weighted mean difference 72.20 min;P < 0.001),but with reduction in blood loss and shorter hospital stay(weighted mean difference-166.83 mL and-1.97 d respectively;P < 0.001).No differences were found with respect to overall postoperative complications(P = 0.65),wound infection(P = 0.35),bleeding(P = 0.65),and anastomotic leakage(P = 0.06).The postoperative mortality rates were similar between the two groups.With respect to oncological outcomes,no statistical differences among the number of harvested lymph nodes were found(weighted mean difference-1.12;P = 0.10).CONCLUSION RAG seems to be a technically valid alternative to OG for performing radical gastrectomy in gastric cancer resulting in safe complications. | Stefano Caruso Alberto Patriti Franco Roviello Lorenzo De Franco Franco Franceschini Graziano Ceccarelli Andrea Coratti | 2017 | World Journal of Clinical Oncology2017，8，3： | 23 |
| 3 | Laparoscopic and robot-assisted gastrectomy for gastric cancer: Current considerations显示文摘Radical gastrectomy with an adequate lymph-adenectomy is the main procedure which makes it possible to cure patients with resectable gastric cancer(GC). A number of randomized controlled trials and meta-analysis provide phase Ⅲ evidence that laparoscopic gastrectomy is technically safe and that it yields better short-term outcomes than conventional open gastrectomy for early-stage GC. While laparoscopic gastrectomy has become standard therapy for early-stage GC, especially in Asian countries such as Japan and South Korea, the use of minimally invasive techniques is still controversial for the treatment of more advanced tumours, principally due to existing concerns about its oncological adequacy and capacity to carry out an adequately extended lymphadenectomy. Some intrinsic drawbacks of the conventional laparoscopic technique have prevented the worldwide spread of laparoscopic gastrectomyfor cancer and, despite technological advances in recent year, it remains a technically challenging procedure. The introduction of robotic surgery over the last ten years has implied a notable mutation of certain minimally invasive procedures, making it possible to overcome some limitations of the traditional laparoscopic technique. Robot-assisted gastric resection with D2 lymph node dissection has been shown to be safe and feasible in prospective and retrospective studies. However, to date there are no high quality comparative studies investigating the advantages of a robotic approach to GC over traditional laparoscopic and open gastrectomy. On the basis of the literature review here presented, robot-assisted surgery seems to fulfill oncologic criteria for D2 dissection and has a comparable oncologic outcome to traditional laparoscopic and open procedure. Robot-assisted gastrectomy was associated with the trend toward a shorter hospital stay with a comparable morbidity of conventional laparoscopic and open gastrectomy, but randomized clinical trials and longer follow-ups are needed to evaluate the possible influence of robot gastrectomy on GC patient survival. | Stefano Caruso Alberto Patriti Franco Roviello Lorenzo De Franco Franco Franceschini Andrea Coratti Graziano Ceccarelli | 2016 | World Journal of Gastroenterology2016，22，25： | 23 |
| 4 | Robot-assisted laparoscopic gastrectomy for gastric cancer显示文摘Phase Ⅲ evidence in the shape of a series of randomized controlled trials and meta-analyses has shown that laparoscopic gastrectomy is safe and gives better short-term results with respect to the traditional open technique for early-stage gastric cancer. In fact, in the East laparoscopic gastrectomy has become routine for early-stage gastric cancer. In contrast, the treatment of advanced gastric cancer through a minimally invasive way is still a debated issue, mostly due to worries about its oncological efficacy and the difficulty of carrying out an extended lymphadenectomy and intestinal reconstruction after total gastrectomy laparoscopically. Over the last ten years the introduction of robotic surgery has implied overcoming some intrinsic drawbacks found to be present in the conventional laparoscopic procedure. Robotassisted gastrectomy with D2 lymphadenectomy has been shown to be safe and feasible for the treatment of gastric cancer patients. But unfortunately, most available studies investigating the robotic gastrectomy for gastric cancer compared to laparoscopic and open technique are so far retrospective and there have not been phase Ⅲ trials. In the present review we looked at scientific evidence available today regarding the new high-tech surgical robotic approach, and we attempted to bring to light the real advantages of robot-assisted gastrectomy compared to the traditional laparoscopic and open technique for the treatment of gastric cancer. | Stefano Caruso Franco Franceschini Alberto Patriti Franco Roviello Mario Annecchiarico Graziano Ceccarelli Andrea Coratti | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，1： | 4 |
| 5 | Multicentric Study on Robotic Tumor-Specific Mesorectal Excision for the Treatment of Rectal Cancer显示文摘 | Alessio Pigazzi Fabrizio Luca Alberto Patriti Manuela Valvo Graziano Ceccarelli Luciano Casciola Roberto Biffi Julio Garcia-Aguilar Jeong-Heum Baek | 2010 | Annals of Surgical Oncology2010，，6： | 1 |
| 6 | Robot-assisted laparoscopic total and partial gastric resection with D2 lymph node dissection for adenocarcinoma显示文摘 | Alberto Patriti Graziano Ceccarelli Raffaele Bellochi Alberto Bartoli Alessandro Spaziani Lelio Zitti Luciano Casciola | 2008 | Surgical Endoscopy2008，，12： | 1 |
| 7 | Robotic choledochoduodenostomy for complicated common bile duct stones-a video vignette显示文摘Despite that endoscopic retrograde cholangiopancreatography(ERCP) has become the gold standard in the treatment of benign biliary obstruction, bilioenteric anastomosis still represents a valid option to treat the increasing number of patients with recalcitrant obstruction, and/or altered anatomy after digestive surgery [1,2]. Minimally invasive techniques have become the standard of care for the surgery of the biliary tract in specialized centers [2,3]. | Francesco Guerra Filippo Petrelli Alberto Patriti | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，3： | 1 |
| 8 | c-Met targeting in advanced gastric cancer: An open challenge显示文摘 | Luigi Marano Rita Chiari Alessio Fabozzi Ferdinando De Vita Virginia Boccardi Giandomenico Roviello Roberto Petrioli Daniele Marrelli Franco Roviello Alberto Patriti | 2015 | Cancer Letters2015，，1： | 1 |
| 9 | Robot-assisted laparoscopic total and partial gastric resection with D2 lymph node dissection for adenocarcinoma显示文摘 | Alberto Patriti Graziano Ceccarelli Raffaele Bellochi Alberto Bartoli Alessandro Spaziani Lelio Zitti Luciano Casciola | 2008 | Surgical Endoscopy2008，，12： | 1 |
| 10 | Multicentric Study on Robotic Tumor-Specific Mesorectal Excision for the Treatment of Rectal Cancer显示文摘 | Alessio Pigazzi Fabrizio Luca Alberto Patriti Manuela Valvo Graziano Ceccarelli Luciano Casciola Roberto Biffi Julio Garcia-Aguilar Jeong-Heum Baek | 2010 | Annals of Surgical Oncology2010，，6： | 1 |
| 11 | Robot-assisted laparoscopic total and partial gastric resection with D2 lymph node dissection for adenocarcinoma显示文摘 | Alberto Patriti Graziano Ceccarelli Raffaele Bellochi Alberto Bartoli Alessandro Spaziani Lelio Zitti Luciano Casciola | 2008 | Surgical Endoscopy2008，，12： | 1 |
| 12 | Immune response activation following hyperthermic intraperitoneal chemotherapy for peritoneal metastases:A pilot study显示文摘BACKGROUND Hyperthermic intraperitoneal chemotherapy(HIPEC)for peritoneal metastases(PM)is considered to be feasible,safe and to improve survival.AIM To investigate whether an immune response is activated following HIPEC for PM.METHODS Six patients were enrolled in this study.Peripheral blood samples were obtained from each patient prior to(day 0)and post-procedure(day 30),and used to evaluate the number of CD3+total,CD3+/CD4+T-Helper,CD3+/CD8+cytotoxic T,CD3+/CD56+natural killer and CD19+B lymphocyte numbers,and CD4+:CD8+T lymphocyte ratios.RESULTS The total numbers of CD3+,CD3+/CD4+T-Helper,CD3+/CD8+cytotoxic T,CD3+/CD56+natural killer and CD19+B lymphocytes,and CD4+:CD8+lymphocyte ratios were increased in all but one patient 30 d following the cytoreductive surgery-HIPEC procedure,and these increases were significant(P≤0.05)for CD3+/CD4+T Helper and CD3+/CD8+cytotoxic T lymphocyte numbers.CONCLUSION This report provides the first evidence that HIPEC exhibits immunomodulating activity in PM patients,resulting in generalized activation of the adaptive immune response.Moreover,the majority of lymphocyte populations increased following HIPEC and continued to be elevated several weeks following the procedure,consistent with a potential authentic immunomodulating effect rather than a normal inflammatory response,to be fully characterised in future studies. | Giammaria Fiorentini Donatella Sarti Alberto Patriti Emilio Eugeni Francesco Guerra Francesco Masedu Andrew Reay Mackay Stefano Guadagni | 2020 | World Journal of Clinical Oncology2020，11，6： | 0 |
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