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| 1 | Drain amylase value as an early predictor of pancreatic fistula after cephalic duodenopancreatectomy显示文摘AIM:To determine predictors of clinically relevant pancreatic fistulas(CRPF)by measuring drain fluid amylase(DFA)in the early postoperative period.METHODS:This prospective clinical study included382 patients with periampullary tumors that were surgically resected at our department between March 2005and October 2012.A cephalic duodenopancreatectomy (DP)was performed on all patients.Two closed suction drains were placed at the end of the surgery.The highest postoperative DFA value was recorded and analyzed during the first three postoperative days and on subsequent days if the drains were kept longer.Pancreatic fistula(PF)was classified according to the International Study Group of Pancreatic Fistula(ISGPF)criteria.Postoperative complications were defined according to the Dindo-Clavien classification.All data were statistically analyzed.The optimal thresholds of DFA levels on the first,second and third postoperative days were estimated by constructing receiver operating curves,generated by calculating the sensitivities and specificities of the DFA levels.The DFA level limits were used to differentiate between the group without PF and the groups with biochemical pancreatic fistula(BPF)and CRPF.RESULTS:Pylorus-preserving duodenopancreatectomy was performed on 289(75.6%)patients,while the remaining patients underwent a classic Whipple procedure(CW).The total incidence of PF was 37.7%(grade A22.8%,grade B 11.0%and grade C 3.9%).Soft pancreatic texture(SPT)was present in 58.3%of patients who developed PF.Mortality was 4.2%.The median DFA value on the first postoperative day(DFA1)in patients who developed PF was 4520 U/L(range 350-99000 U/L)for grade A fistula(BPF)with a SPT and a diameter of the main pancreatic duct(MPD)of≤3 mm.For grade B/C(CRPF),the median DFA1 value was 8501 U/L(range377-92060 U/L)with a SPT and MPD of≤3 mm.These values were significantly higher when compared to the patients who did not have PF(122;range 5-37875 U/L).The upper limit of DFA values for the first 3 postoperative days in the examined stages of PF were:DFA1 1200U/L for the BPF and CRPF;DFA3 350 U/L for BPF and DFA3 800 U/L for CRPF.The determined values were highly significant and demonstrated a reliable diagnostic test for both BPF and CRPF.CONCLUSION:DFA1≥1200 U/L is an important predictive factor for PF of any degree.The trend of DFA3(decrease of<50%)compared to DFA1 is a significant factor in the differentiation of CRPF from transient BPF. | Vladimir D Dugalic Djordje M Knezevic Vladan N Obradovic Miroslava G Gojnic-Dugalic Slavko V Matic Aleksandra R Pavlovic-Markovic Predrag D Dugalic Srbislav M Knezevic | 2014 | World Journal of Gastroenterology2014，20，26： | 7 |
| 2 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 3 | The efficacyof hypertonic solutions sailne nasal irrigation for chronic sinonasal symptoms显示文摘 | David R Thomas P Aleksandra Z | 2005 | Otolaryngology-Head and Neck Surgery2005，133，1： | 1 |
| 4 | Characterization of chitosan/montmorillonite membranes as ad sorbents for Bezactiv Orange V-3R dye显示文摘 | Nesic Aleksandra R Velickovic Sava J Antonovic Dusan G | 2012 | Journal of Hazard- ous Materials2012，209，3： | 1 |
| 5 | The application of Scanning Electronic Microscopy:The study of the surface of the upper layers of dyed polyester fibre samples in the ostacet yellow E-LSR显示文摘 | MILENA N M MILOVAN M P ALEKSANDRA R Z | 2004 | FACTA Universitis ( Physics Chemistry and Technology )2004，3，1： | 1 |
| 6 | The efficacy of hypertonic solutions sailne nasal irri-gationfor chronic sinonasal symptoms显示文摘 | DAVLD R THOMAS P ALEKSANDRA Z | 2005 | Otolaryngol Head Neck Surg2005，133，： | 1 |
| 7 | Effect of multiple transverse modes in self-mixing sensors based on vertical-cavity surface-emitting lasers 显示文摘 | Tucker John R Rakic Aleksandra D O'Brien Christopher J | 2007 | Applied Optics(S0003-6935)2007，46，4： | 1 |
| 8 | The efficacy of hypertonic solutions saline nasal irrigationfor chronic sinonasal symptoms 显示文摘 | David R Thomas P Aleksandra Z | 2005 | Otolaryngology-Head and Neck Surgely2005，133，1： | 1 |
| 9 | The efficacy of hypertonic solutions sailne nasal irrigationf or chronic sinonasal symptoms显示文摘 | David R Thomas P Aleksandra Z | 2005 | Otolaryngology-Head and Neck Surgely2005，133，1： | 1 |
| 10 | Enriched environment influences brain-derived neurotrophic factor levels in rat forebrain after focal stroke显示文摘 | Li RZ Anette R Aleksandra W | 2001 | Neuroscience Letters2001，305，： | 1 |
| 11 | The adsorption of sulphate,hydrogenchromate and dihydrogenphosphate anions on surfactant-modified clinoptilolite显示文摘 | Aleksandra D V Magdalena R Tomas evic-Canovic Aleksan dra S D Vera T D | 2000 | Applied Clay Science2000，17，： | 1 |
| 12 | Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial显示文摘 | Robert Pirker Jose R Pereira Aleksandra Szczesna Joachim von Pawel Maciej Krzakowski Rodryg Ramlau Ihor Vynnychenko Keunchil Park Chih-Teng Yu Valentyn Ganul Jae-Kyung Roh Emilio Bajetta Kenneth O’Byrne Filippo de Marinis Wilfried Eberhardt Thomas Goddeme | 2009 | The Lancet2009，，9674： | 1 |
| 13 | Colorectal cancer screening in a low-incidence area: general invitation versus family risk targeting: a comparative study from Montenegro显示文摘 | Nikola Panic Thomas R?sch Brigita Smolovic Miodrag Radunovic Mirko Bulajic Aleksandra Pavlovic-Markovic Zoran Krivokapic Srdjan Djuranovic Tatjana Ille Milutin Bulajic | 2015 | European Journal of Gastroenterology & Hepatology2015，，10： | 1 |
| 14 | The application of Scanning Electronic Microscopy:The study of the surface of the upper layers of dyed polyester fibre samples in the ostacet yellow E-L5R,FACTA Universities显示文摘 | Milena N M Milovan M P Aleksandra R Z | 2004 | Physics Chemistry and Technology2004，3，1： | 1 |
| 15 | The efficacy of hypertonic solutions saline nasal irrigationfor chronic sinonasal syrnptorrks 显示文摘 | David R Thomas P Aleksandra Z | 2005 | Otolaryngology - head and Neck Surgely2005，133，1： | 1 |
| 16 | Ethyl xanthate adsorption and adsorption kinetics on lead-modified galena and sphalerite under flotation conditions 显示文摘 | Dusiea R V Predrag M L Aleksandra A R | 2006 | Colloids and Surfaces' A: Physicochemical and Engineering Aspects2006，279，123： | 1 |
| 17 | The adsorption of sulphate,hydrogenchromate and dihydrogenphosphate anions on surfactant-modified clinoptilolite显示文摘 | Aleksandra D Vujakovic Magdalena R Tomasevic-Canovic Aleksandra S Dakovic | 2000 | Applied Clay Science2000，17，： | 1 |
| 18 | The influence of oxygen on radiation-induced structural and functional changes in glyceraldehydes-3-phosphate dehydrogenase and latate dehydrogenase显示文摘 | Aleksandra R Eligiusz S Michal B | 2012 | Radiat Phys Chem2012，81，7： | 1 |
| 19 | Surfactant modified zeolites--new efficient adsorbents for Mycotoxins 显示文摘 | Magdalena T C Aleksandra D George R | 2003 | Microporous and Mesoporous Materials2003，61，17： | 1 |
| 20 | Labour Costs and FDI Flows into Central and Eastern European Countries:A Survey of the Literature and Empirical Evidence显示文摘 | MARKUS L ALEKSANDRA R | 2008 | Structural Change and Economic Dynamics2008，，19： | 1 |
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