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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Arsenic determination by ICP-QMS with octopole collision/reaction cell overcome of matrix effects under vented and pressurized cell conditions显示文摘 | Mireia C Manuela H Monica I | 2011 | Talanta2011，85，： | 1 |
| 3 | Elevated jugular venous oxygen saturation after severe head injury显示文摘 | Manuela C Alex B Claudia S | 1999 | J Neurosurg1999，90，1： | 1 |
| 4 | Analytical procedures for the determination of organotin compounds in sediment and biota : a critical review 显示文摘 | Manuela A Josep- Maria B Ramom C | 1997 | Analytiea Chemica Acta1997，，788： | 1 |
| 5 | Phenolic profile characteriza-tion of pomegranate(Punica granatum)juice by high-performance liquid chromatography with diode array detection coupled to an electrospray ion trap mass analyzer显示文摘 | Enrique S Manuela C C José M S | | 0，，30： | 1 |
| 6 | Gene func tion and expression level influence the insertion/fixation dy namics of distinct transposon families in mammalian introns 显示文摘 | MANUELA S GIORGIA M GIACOMO P C | 2006 | Genome Biol2006，7，12： | 1 |
| 7 | Towards the bio-production of trans-carveol and carvone from limonene:induction after cell growth on limonene and toluene显示文摘 | Carla C C R de carvalho M Manuela R da Fonseca | | 0，，： | 1 |
| 8 | Growth, photosynthesis and water-use efficiency of two C4 Sahelian grasses subjected to water deficits显示文摘 | Maroco P Pereira S Manuela C M | 2000 | Journal of Arid Environments2000，45，： | 1 |
| 9 | Molecular cloning and tissue expression of an insect farnesyl diphosphate synthase显示文摘 | Manuela C G Franck C | 1999 | Eur J Biothem1999，262，2： | 1 |
| 10 | A practical approach for fish freshness determinations using a portable electronic nose显示文摘 | Manuela O C Gabriela V Gustavo P | 2001 | Sensors and Actuators B2001，80，： | 1 |
| 11 | Multiple intracrani-al lesion in head injury:clinicalconsiderations,prognostic-factors,manageme and results in 95patient显示文摘 | Manuela C Marco L Rolando C | 2001 | SurgNeu-rol2001，56，2： | 1 |
| 12 | Among pregnant women with bacterial vaginosis, the hydrolytic enzymes sialidase and prolidase are positively associated with interleukin- 1β显示文摘 | Sabina C Jennifer FC Manuela DS | 2008 | Am J Obstet Gynecol2008，198，1： | 1 |
| 13 | Multiple intracranial lesios in head inury:clinicaal considerations,prognostic factors,management,and results in 95 patients显示文摘 | MANUELA C MARCO L ROLANDO C | 2001 | Surg Neurol2001，56，2： | 1 |
| 14 | Prevalence and bio - di- versity of Brettanomyces bruxellensis in wine from Northwestern Italy 显示文摘 | Simona C Kalliopi R Manuela G | 2010 | AmJEnolViticuh2010，61，4： | 1 |
| 15 | Long-term results of gemcitabine plus oxaliplatin with and without rituximab as salvage treatment for transplant-ineligible patients with refractory/relapsing B-cell lymphoma显示文摘 | Gaetano C Gaetana C Manuela A | 2009 | Cancer Chemother Pharmacol2009，64，5： | 1 |
| 16 | Cognitive recovery after delayed carbon mono-xide encephalopathy显示文摘 | Leonardo C Manuela B Paola F | 2005 | Clin Neurol Neurosurg2005，107，4： | 1 |
| 17 | β-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies 显示文摘 | Manuela B Carlo B Vanni C | 2003 | Biochem Pharmacol2003，65，3： | 1 |
| 18 | Among pregnant women with bacterial vaginosis, the hydrolytic enzymes sialidase and prolidase are positively associatedwith interleukin-1β显示文摘 | Sabina C Jennifer FC Manuela DS | 2008 | Am J Obstet Gynecol2008，198，1： | 1 |
| 19 | Electrical conductivity of self-monitoring CFRC 显示文摘 | Manuela C Raffaele Z | 2005 | Cement & Concrete Composites2005，27，： | 1 |
| 20 | Taenia solium and Taenia ovis: Stage-specific expression of the vaccine antigen genes, TSOL18, TSOL16, and homologues, in oncospheres 显示文摘 | Gauci C G Manuela R Robert H | 2006 | Experimental Parasitology2006，，： | 1 |
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