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| 1 | 纤维母细胞生长因子对复合皮肤移植成活和收缩的影响显示文摘我们曾报道应用同基因表层皮片(IE)和同种异基因真皮(AD)组成复合皮肤移植物(CSG)可一次完成全层皮肤缺损的永久性修复。但由于IE不能及时获得足够血运,IE常有部分坏死,CSG后期收缩仍较明显。在本研究中我们进一步用纤维母细胞生长因子(FGF)预先处理AD获得较好效果。经观察17周表明,FGF组皮片坏死率和坏死面积较对照组明显下降(P<0.05);FGF组CSG收缩较对照组明显减轻(P<0.001);皮片坏死面积与皮片最终面积呈负相关(r=-0.450,P<0.05)。实验预示,完全成活的CSG后期收缩较移植同等厚度的IE为轻。观察2年,AD未被排斥。 | 方承辉 Robb E C 于光曙 Alexander J W Warden G D | 1993 | 中华整形烧伤外科杂志1993，9，1： | 6 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing显示文摘前列腺癌症是全球癌症相关的死亡的一个领先的原因,但是试图改善诊断并且开发新奇治疗被重要耐心的异质惊讶。在最近的年里,到几百个前列腺瘤的下一代的定序的应用程序定义新奇分子的子类型并且描绘了位于疾病开始和前进下面的广泛的 genomic 错误。在诊所观察的异质是由与复杂性流行的一处分子的风景的 underpinned,现在是清楚的,在 genomic 重新整理和稀罕变化联合放大 transcriptomic 差异的地方。这评论把我们前列腺癌症 ‘ 的当前的理解; omic 的包括拷贝数字变化的哨兵角色, oncogenic 熔化基因, chromothripsis 的潜在的影响,和在定义联系变化的子类型的突破的成长光谱。增加的证据建议损害经常在特定的细胞的功能和发信号的小径上集成的那 genomic,还周期性的基因错误显得稀罕。因此,我们继续定义单个瘤染色体,是批评的,特别在他们的表示 transcriptome 的上下文。仅仅通过到瘤可变性罐头的瘤的改进描述,我们前进到精确治疗和个性化的肿瘤学的年龄。 | Alexander W Wyatt Fan Mo Yuzhuo Wang Colin C Collins | 2013 | Asian Journal of Andrology2013，15，3： | 5 |
| 4 | Next generation patient-derived prostate cancer xenograft models显示文摘对为前列腺癌症的更有效的治疗学的途径有批评需要。然而,在这个区域的研究被缺乏严重妨碍了临床上相关,在疾病的 vivo 模型试验性。这评论特别地基于 patients’ 的 subrenal 囊 grafting 集中于前列腺癌症异种皮移植模型的发展;进 nonobese 糖尿病 / 严重的肿瘤组织联合了 immunodeficient (NOD/SCID ) 老鼠。这种技术允许可移植的、导出病人的癌症织物异种皮移植线的成功的开发从不仅好攻击变形,而且从局部性的前列腺癌症纸巾。异种皮移植被发现了保留原来的恶意的关键生物性质,包括组织病理学说、分子的特征,肿瘤异质,对雄激素脱离的反应和变形能力。因此,他们是高度临床上相关并且在细胞、分子的层次,为个性化的癌症治疗屏蔽的药和现出症状之前的潜的药为前列腺癌症前进的研究提供珍贵工具测试的功效;特别当模型的一块面板习惯于盖子时许多疾病。这些异种皮移植模型能因此被看作前列腺癌症的下一代的模型。 | Dong Lin Hui Xue Yuwei Wang Rebecca Wu Akira Watahiki Xin Dong Hongwei Cheng Alexander W Wyatt Colin C Collins Peter W Gout Yuzhuo Wang | 2014 | Asian Journal of Andrology2014，16，3： | 4 |
| 5 | 使用二甲双胍的禁忌证 证据显示应该修改二甲双胍的禁忌证显示文摘在英国前瞻性糖尿病研究(UNPOS)中,2型糖尿病患者被随机分入二甲双胍、磺酰脲类或胰岛素强化治疗组,3组患者取得了相似的血糖控制效果,微血管并发症终点事件显著降低。该项研究显示,肥胖患者使用二甲双胍治疗可以降低心血管事件的发生,二甲双胍治疗组的患者没有低血糖事件。 | G C Jones J P Macklin W D Alexander 李玉秀 | 2003 | 英国医学杂志中文版2003，6，3： | 2 |
| 6 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 7 | Distribution of P, K, Ca, Mg, B, Cu, Mn and Zn in peanut lines near maturity 显示文摘 | Hallock D L Martens D C Alexander M W | 1971 | Agronomy Journal1971，63，2： | 1 |
| 8 | Synthesis of a-hydroxyphosphonates phosphonates using a solid supported base 显示文摘 | Alexander C W Albiniak P A Gibson L R | 2000 | Phosphorus Sulfur and Silicon ( S1042-6507 )2000，167，： | 1 |
| 9 | Enzymes of energy metabolism in the bradyzoites and tachyzoites of Toxoplasma gondii显示文摘 | Denton H Roberts C W Alexander J | 1996 | FEMS Microbiol Lett1996，137，1： | 1 |
| 10 | Thickness dependence of dielectric loss in SrTiO3thin films显示文摘 | LI H C SI W D ALEXANDER D W | 1998 | Appl Phys Lett1998，73，4： | 1 |
| 11 | Membranous glomerulonephritis is a manifestation of IgG4-related disease 显示文摘 | Alexander M P Larsen C P Gibson I W | 2013 | Kidney international2013，83，3： | 1 |
| 12 | A comprehensive map of the porcine genome 显示文摘 | Rohrer G A Alexander L J Hu Z Smith T P L Keele JW Beattie C W | 1996 | Genome Res1996，6，： | 1 |
| 13 | Manufacturing Technology 显示文摘 | Alexander J M Brewer R C Rowe G W | 1999 | Tribology Transactions1999，59，2： | 1 |
| 14 | Enabling scalable spectral clustering for image segmentation显示文摘 | Frederick T Alexander W David A C | 2010 | Pattern Recognition2010，43，12： | 1 |
| 15 | Positive and nega- tive impacts of specialty malts on beer foam: a comparison of various ce- real products for their foaming properties显示文摘 | ALEXANDER L C JUSTIN K A CHARLES W B | 2013 | J Sei Food Agr2013，93，9： | 1 |
| 16 | Sex- associated hormones and immunity to protozoan parasites显示文摘 | Walker W Alexander J | 2001 | Clin Microbiol2001，14，： | 1 |
| 17 | Cassini star tracking and identification architecture显示文摘 | Valerie C Thomas James W Alexander | 2000 | Proceedings of SPIE2000，2221，： | 1 |
| 18 | Analysis of im-mune responses directed toward a recombinant early secretoryantigenic target six-kilodalton protein-culture filtrate protein10fusion protein in Mycobacterium bovis-infected cattle显示文摘 | ALEXANDER C MAUE W RAY W | 2005 | Infect Immun2005，73，10： | 1 |
| 19 | Usage of smart antenna for cancelling neighboring base-station interferences in wireless CDMA communicaions显示文摘 | YE W C BAR N ALEXANDER M H | 1997 | IEEE Signals Systems & Computers1997，1998，1： | 1 |
| 20 | North - South R&D Spillovers 显示文摘 | DAVID T C ELHANAN H ALEXANDER W H | 1997 | The Economic Journal1997，107，： | 1 |
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