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| 1 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 2 | An interactive genetic algorithm-based framework for handling qualitative criteria in design optimization显示文摘 | Alexandra M B Jeremy R Ashutosh T | 2007 | Computers in Industry2007，58，： | 1 |
| 3 | Predicting strangulated small bowel obstruction:An old problem revisited显示文摘 | Tim J Lan T Vu Alexandra E | 2008 | Gastrointest Surg2008，13，1： | 1 |
| 4 | Late Glacial temperature and precipitation changes in tile lowland Neotropics by tandem measurement of lSO in biogenic carbonate and gypsum hydration water显示文摘 | DAVID A H ALEXANDRA V T CAMILLA J W | 2012 | Geochimica et Cosmochimica Acta2012，77，： | 1 |
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| 7 | Kawasaki Disease:Summary of the American Heart Association Guidelines显示文摘 | ALEXANDRA F STANFORD T | 2006 | American Family Physician2006，74，： | 1 |
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| 9 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 10 | Emerging Technologies for the Detection and Genetic Characterization of Protozoan Parasites显示文摘 | Paul T Monis Steven Giglio Alexandra R Keegan | 2005 | Trends in Parasitology2005，21，7： | 1 |
| 11 | On-line current monitoring and application of a finite element method to predict the level of static airgap eccentricity in three-phase induction motors 显示文摘 | William T T Alexandra B | 1998 | IEEE Transactions on Energy Conversion1998，13，4： | 1 |
| 12 | Intluenee of lutein supplementation on macular pigment, assessed with two objective techniques显示文摘 | TOS T J BERENDSCHOT M ALEXANDRA GOLDBOHM R WILHELMINA A KLOPPING A | 2000 | Investigative Ophthalmology & Visual Science2000，41，11： | 1 |
| 13 | Esophageal and small bowel obstruction by occupational bezoar:report of a case显示文摘 | T Alexandra M Konstantinos | 2003 | BMC Gastroenterology2003，3，： | 1 |
| 14 | Limited role of secretedaspartyl proteinases Sap1 to Sap6 in Candida albicans virulenceand host immune response in murine hematogenously dissemina-ted candidiasis显示文摘 | Alexandra C Ulrich L Luzia T | 2010 | Infect Immun2010，78，11： | 1 |
| 15 | Food scares and trust:a european study显示文摘 | MARIO M ALEXANDRA L BRUCE T W | 2008 | Journal of Agricultural Eco-nomics2008，59，1： | 1 |
| 16 | Theory of stimula- ted Raman scattering cancellation in wavelength-division- ultiplexed systems via spectral inversion 显示文摘 | Alexandra G G Demetrios N C Jean T | 1999 | Photonics Technology Letters1999，11，10： | 1 |
| 17 | Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of atype-1 polarized immune response显示文摘 | FOTIOS P P MARIA T ALEXANDRA K | 2004 | Blood2004，103，： | 1 |
| 18 | The glycemic index:methodology and clinical implication显示文摘 | WOLEVER T M S DAVID J A ALEXANDRA L J | 1991 | Am J Clin Nutr1991，54，： | 1 |
| 19 | Impact of age on treatment and outcomes after acute myocardial infarction,particularly in very elderly patients 显示文摘 | Ana TT Ruben R Alexandra T | 2011 | Revista Portuguesa de Cardiologia2011，30，12： | 1 |
| 20 | Nanoscale materials damage fish brains显示文摘 | Alexandra G Tiny T | 2004 | Science News2004，165，14： | 1 |
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