|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 2 | Cardiovascular efficacy and safety of dipeptidyl peptidase-4 inhibitors:A meta-analysis of cardiovascular outcome trials显示文摘BACKGROUND Dipeptidyl peptidase-4(DPP-4)inhibitors are a generally safe and well tolerated antidiabetic drug class with proven efficacy in type 2 diabetes mellitus(T2DM).Recently,a series of large,randomized controlled trials(RCTs)addressing cardiovascular outcomes with DPP-4 inhibitors have been published.AIM To pool data from the aforementioned trials concerning the impact of DPP-4 inhibitors on surrogate cardiovascular efficacy outcomes and on major cardiac arrhythmias.METHODS We searched PubMed and grey literature sources for all published RCTs assessing cardiovascular outcomes with DPP-4 inhibitors compared to placebo until October 2020.We extracted data concerning the following“hard”efficacy outcomes:fatal and non-fatal myocardial infarction,fatal and non-fatal stroke,hospitalization for heart failure,hospitalization for unstable angina,hospitalization for coronary revascularization and cardiovascular death.We also extracted data regarding the risk for major cardiac arrhythmias,such as atrial fibrillation,atrial flutter,ventricular fibrillation and ventricular tachycardia.RESULTS We pooled data from 6 trials in a total of 52520 patients with T2DM assigned either to DPP-4 inhibitor or placebo.DPP-4 inhibitors compared to placebo led to a non-significant increase in the risk for fatal and non-fatal myocardial infarction[risk ratio(RR)=1.02,95%CI:0.94-1.11,I2=0%],hospitalization for heart failure(RR=1.09,95%CI:0.92-1.29,I2=65%)and cardiovascular death(RR=1.02,95%CI:0.93-1.11,I2=0%).DPP-4 inhibitors resulted in a non-significant decrease in the risk for fatal and non-fatal stroke(RR=0.96,95%CI:0.85-1.08,I2=0%)and coronary revascularization(RR=0.99,95%CI:0.90-1.09,I2=0%),Finally,DPP-4 inhibitors demonstrated a neutral effect on the risk for hospitalization due to unstable angina(RR=1.00,95%CI:0.85-1.18,I2=0%).As far as cardiac arrhythmias are concerned,DPP-4 inhibitors did not significantly affect the risk for atrial fibrillation(RR=0.95,95%CI:0.78-1.17,I2=0%),while they were associated with a significant increase in the risk for atrial flutter,equal to 52%(RR=1.52,95%CI:1.03-2.24,I2=0%).DPP-4 inhibitors did not have a significant impact on the risk for any of the rest assessed cardiac arrhythmias.CONCLUSION DPP-4 inhibitors do not seem to confer any significant cardiovascular benefit for patients with T2DM,while they do not seem to be associated with a significant risk for any major cardiac arrhythmias,except for atrial flutter.Therefore,this drug class should not be the treatment of choice for patients with established cardiovascular disease or multiple risk factors,except for those cases when newer antidiabetics(glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors)are not tolerated,contraindicated or not affordable for the patient. | Dimitrios Ioannis Patoulias Aristi Boulmpou Eleftherios Teperikidis Alexandra Katsimardou Fotios Siskos Michael Doumas Christodoulos E Papadopoulos Vassilios Vassilikos | 2021 | World Journal of Cardiology2021，13，10： | 2 |
| 3 | Predicting strangulated small bowel obstruction:An old problem revisited显示文摘 | Tim J Lan T Vu Alexandra E | 2008 | Gastrointest Surg2008，13，1： | 1 |
| 4 | Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study显示文摘 | Sheila A Bingham Nicholas E Day Robert Luben Pietro Ferrari Nadia Slimani Teresa Norat Fran?oise Clavel-Chapelon Emmanuelle Kesse Alexandra Nieters Heiner Boeing Anne Tj?nneland Kim Overvad Carmen Martinez Miren Dorronsoro Carlos A Gonzalez Timothy J Key | 2003 | The Lancet2003，，9368： | 1 |
| 5 | Fragments of SLIT3 inhibit cellular migration 显示文摘 | Schubert T Alexandra E Anke Ruede | 2012 | International Journal of Molecular Medicine2012，30，： | 1 |
| 6 | Frey Procedure in Patients with Chronic Pancreatitis: Short and Long-term Outcome from a Prospective Study显示文摘 | Alexandra Roch Dorothée Brachet Emilie Lermite Patrick Pessaux Jean-Pierre Arnaud | 2012 | Journal of Gastrointestinal Surgery2012，，7： | 1 |
| 7 | HPLC/UV quantitation of retinal,retinol,and retinyl esters in serum and tissues显示文摘 | Maureen A K Alexandra E F Joseph L N | 2008 | Anal Biochem2008，378，1： | 1 |
| 8 | Evolution of Plant-Like Crystalline Storage Polysaccharide in the Protozoan Parasite Toxoplasma gondii Argues for a Red Alga Ancestry显示文摘 | Alexandra Coppin Jean-Stéphane Varré Luc Lienard David Dauvillée Yann Guérardel Marie-Odile Soyer-Gobillard Alain Buléon Steven Ball Stanislas Tomavo | 2005 | Journal of Molecular Evolution2005，，2： | 1 |
| 9 | Novel genes associated with biofilm formation of Actinobacillus pleuropneumoniae显示文摘 | Alexandra Grasteau Yannick D.N. Tremblay Josée Labrie Mario Jacques | 2011 | Veterinary Microbiology2011，，1： | 1 |
| 10 | Spontaneous intramedullary apoptosis is present in disorders other than myelodysplasia显示文摘 | Irvine M Karen Magill | 1998 | Experimental Hematology1998，26，： | 1 |
| 11 | Intramedullary nailing of metaphyseal distal tibial fractures 显示文摘 | Sean E Alexandra K Schwartz | 2005 | J Bone Joint Surg2005，87，： | 1 |
| 12 | Method for removing hy- popharyngeal salivary bypass tubes显示文摘 | Alexandra E Kejner Eben L Rosenthal | 2011 | The Laryngoscope2011，121，7： | 1 |
| 13 | Intram edallary nailing of metaphyseal distal tib ial fractures显示文摘 | Sean E Alexandra K Scbwart Z | 2005 | J Bone Joint Surg2005，87，51： | 1 |
| 14 | Genomic variation in the MAP3K5 gene is associated with &bgr;-thalassemia disease severity and hydroxyurea treatment efficacy显示文摘 | Christina Tafrali Arsinoi Paizi Joseph Borg Milena Radmilovic Marina Bartsakoulia Emily Giannopoulou Olga Giannakopoulou Maja Stojiljkovic-Petrovic Branka Zukic Konstantinos Poulas Eleana F Stavrou Polyxeni Lambropoulou Alexandra Kourakli Alexander E Feli | 2013 | Pharmacogenomics2013，，5： | 1 |
| 15 | Pyrrolizidine alkaloids from Gynura divaricata 显示文摘 | Erhard R Alexandra E Helmut W | 1996 | Planta Med1996，62，4： | 1 |
| 16 | Anthocyanins from Oxalis triangularis as potential food colorants显示文摘 | ALEXANDRA PAZMIN-O-DURAN E MONICA GIUSTIB WROLSTAD R E | 2001 | Food Chemistry2001，75，： | 1 |
| 17 | Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes显示文摘 | Alexandra E Juliette J Suan B | 2003 | Diabetes2003，52，1： | 1 |
| 18 | Development ofChemiluminescent ELISAs to DDT and It s Metabolites ir Food and Environmental Samples显示文摘 | Alexandra E Botchkareva Sergei A Eremin Angel Montoya el al | 2003 | Journal of Immunological Methods2003，283，： | 1 |
| 19 | Secondary organic aerasol formation from aromatic precursors 显示文摘 | Wipawee D Alexandra E Yosuke K | 2003 | Environmental Science and Technology2003，37，16： | 1 |
| 20 | A follow-up investigation of teaching presence in the SUNY Learning Network显示文摘 | Shea Peter Pickett Alexandra Pelt William E | 2003 | Journal of the Asynchronous Learning Network2003，7，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员