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| 1 | Opposite Interplay Between the Canonical WNT/β-Catenin Pathway and PPAR Gamma: A Potential Therapeutic Target in Gliomas显示文摘In gliomas, the canonical Wingless/Int(WNT)/b-catenin pathway is increased while peroxisome proliferator-activated receptor gamma(PPAR-c) is downregulated.The two systems act in an opposite manner. This review focuses on the interplay between WNT/b-catenin signaling and PPAR-c and their metabolic implications as potential therapeutic target in gliomas. Activation of the WNT/bcatenin pathway stimulates the transcription of genes involved in proliferation, invasion, nucleotide synthesis,tumor growth, and angiogenesis. Activation of PPAR-c agonists inhibits various signaling pathways such as the JAK/STAT, WNT/b-catenin, and PI3 K/Akt pathways,which reduces tumor growth, cell proliferation, cell invasiveness, and angiogenesis. Nonsteroidal anti-inflammatory drugs, curcumin, antipsychotic drugs, adiponectin,and sulforaphane downregulate the WNT/b-catenin pathway through the upregulation of PPAR-c and thus appear to provide an interesting therapeutic approach for gliomas.Temozolomide(TMZ) is an antiangiogenic agent. The downstream action of this opposite interplay may explain the TMZ-resistance often reported in gliomas. | AlexANDre Vallée Yves Lecarpentier Rémy Guillevin Jean-Noёl Vallée | 2018 | Neuroscience Bulletin2018，34，3： | 7 |
| 2 | High-resolution multimodal flexible coherent Raman endoscope显示文摘Coherent Raman scattering microscopy is a fast,label-free,and chemically specific imaging technique that shows high potential for future in vivo optical histology.However,the imaging depth in tissues is limited to the sub-millimeter range because of absorption and scattering.Realization of coherent Raman imaging using a fiber endoscope system is a crucial step towards imaging deep inside living tissues and providing information that is inaccessible with current microscopy tools.Until now,the development of coherent Raman endoscopy has been hampered by several issues,mainly related to the fiber delivery of the excitation pulses and signal collection.Here,we present a flexible,compact,coherent Raman,and multimodal nonlinear endoscope(4.2mm outer diameter,71mm rigid length)based on a resonantly scanned hollow-core Kagomé-lattice double-clad fiber.The fiber design enables distortion-less,background-free delivery of femtosecond excitation pulses and back-collection of nonlinear signals through the same fiber.Sub-micrometer spatial resolution over a large field of view is obtained by combination of a miniature objective lens with a silica microsphere lens inserted into the fiber core.We demonstrate high-resolution,high-contrast coherent anti-Stokes Raman scattering,and second harmonic generation endoscopic imaging of biological tissues over a field of view of 320μm at a rate of 0.8 frames per second.These results pave the way for intraoperative label-free imaging applied to real-time histopathology diagnosis and surgery guidance. | Alberto Lombardini Vasyl Mytskaniuk Siddharth Sivankutty Esben Ravn Andresen Xueqin Chen Jérôme Wenger Marc Fabert Nicolas Joly Frédéric Louradour Alexandre Kudlinski Hervé Rigneault | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 3 | Astrocytes in the cerebral cortex play a role in the spontaneous motor recovery following experimental striatal hemorrhage显示文摘Intracerebral hemorrhage(ICH)is a stroke subtype caused by spontaneous rupture of small vessels and bleeding into the brain parenchyma,resulting in cell death and sensorimotor deficits.Despite the greater prevalence of the ischemic form of stroke(87%),ICH has the highest mortality rate of all stroke subtypes.The striatum is the most affected structure in hemorrhagic stroke(35–70%),followed by cere- | Juliana Dalibor Neves Régis Gemerasca Mestriner Carlos Alexandre Netto | 2018 | Neural Regeneration Research2018，13，1： | 3 |
| 4 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 5 | Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice显示文摘The mammalian epididymis not only plays a fun dame ntal role in the maturati on of spermatozoa,but also provides protecti on agai nst various stressors.The foremost among these is the threat posed by oxidative stress,which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids,proteins,and nucleic acids.In mice,the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5(GPX5)as a major luminal scavenger in the proximal caput epididymidal segment.Accordingly,the loss of GPX5^-/-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx57 mice.To explore the underlying mechanism,we have conducted transcriptomic analysis of caput epididymidal epithelial cells from aged(13 months old)Gpx5^-/-m mice.This analysis revealed the dysregulation of several thousand epididymal mRNA transcripts,in eluding the downregulation of a subgroup of piRNA pathway gen es,in aged Gpx5^-/-mice.In agreeme nt with these fin dings,we also observed the loss of piRNAs,which potentially bind to the P-element-induced wimpy testis(PlWI)-like proteins PIWIL1 and PIWIL2.The absence of these piRNAs was correlated with the elevated mRNA levels of their putative gene targets in the caput epididymidis of Gpx5^-/-mice.Importantly,the oxidative stress response genes tend to have more targeting piRNAs,and many of them were among the top increased genes upon the loss of GPX5^-/-.Taken together,our findings suggest the existence of a previously uncharacterized somatic piRNA pathway in the mammalian epididymis and its possible invoIvement in the aging and oxidative stress-mediated responses. | Chen Chu Lu Yu Joelle Henry-Berger Yan-Fei Ru Ayhan Kocer Alexandre Champroux Zhi-Tong Li Miao He Sheng-Song Xie Wu-Bin Ma Min-Jie Ni Zi-Mei Ni Yun-Li Guo Zhao-Liang Fei Lan-Tao Gou Qiang Liu Samanta Sharma Yu Zhou Mo-Fang Liu Charlie Degui Chen Andrew L Eamens Brett Nixon Yu-Chuan Zhou Joel R Drevet Yong-Lian Zhang | 2020 | Asian Journal of Andrology2020，22，6： | 2 |
| 6 | Seizure outcome after surgery for epilepsy due to focal cortical dysplastic lesions 显示文摘 | Alexandre V Walz R Bianchin MM | 2006 | Seizure2006，15，6： | 1 |
| 7 | PI3K-FRAP/mTOR path-way is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival显示文摘 | Alexandre C Claude R David G | 2002 | Hepatology2002，3，： | 1 |
| 8 | Seizure outcome after surgery for epilepsy due to focal cortical dysplastie lesions 显示文摘 | Alexandre V Jr Walz R Bianchin M M | 2006 | Seizure2006，15，6： | 1 |
| 9 | Complications of Scoliosis Surgery in Prader-Willi Syndrome显示文摘 | Franck Accadbled Thierry Odent Alexandre Moine Edouard Chau Christophe Glorion Gwenaelle Diene Jér?me Sales de Gauzy | 2008 | Spine2008，，4： | 1 |
| 10 | Phytoliths as palaeoenvironmental indicators, West Side Middle Awash Val- ley, Ethiopia显示文摘 | Barboni D Bonnefille R Alexandre A | 1999 | Palaeogeography Palaeoclimatology Palae- oeeology1999，152，： | 1 |
| 11 | The numerical computation of near-wall turbulent flow over a steep hill 显示文摘 | Juliana B R Loureiro Alexandre T P Alho Atila P Silva Freire | 2008 | Journal of Wind Engineering and Industrial Aerodynamics2008，96，： | 1 |
| 12 | Poly(ethylene-co vinyl acetate)/clay Nanocomposites: Effect of Clay Nature and Organic Modifiers on Morphology,Mechanical and Thermal Properties显示文摘 | Peeterbroeck S Alexandre M Jerome R | 2005 | Polymer Degradation and Stability2005，，90： | 1 |
| 13 | Marine fish larvae feeding formulated diets or live pery 显示文摘 | Personle R J Alexandre J C Thebaud L | 1993 | J World Aquac- ult Soc1993，24，21： | 1 |
| 14 | Hard elastic carbon thin films form linking of carbon nanoparticles显示文摘 | Amaratunga G A J Chhowalla M Kiely C J Alexandrou I Aharonov R Devenish R M | 1996 | Nature (London)1996，383，： | 1 |
| 15 | The role of system dynamics in project management显示文摘 | Alexandre R | 1996 | International Journal of Project Management1996，14，4： | 1 |
| 16 | Comparison between anaerobic threshold determined by ventilatory variables and blood lactate response in cyclists 显示文摘 | ALEXANDRE H O LEANDRO R A HERBERT G S | 2006 | Rev Bras Med Esporte2006，12，1： | 1 |
| 17 | Glucuronoxylomannan of Cryptococcus neoformans exacerbates in vitro yeast cell growth by interleukin 10-dependent inhibition of CD4+ T lymphocyte responses显示文摘 | Mariano Andrade R Monteiro Almeida G Alexandre DosReis G | 2003 | Cell Immunol2003，222，2： | 1 |
| 18 | The use of microRNAs as re{erence genes for quantitative polymerase chain reaction in soybean 显示文摘 | Franccli R K Francismar C M Alexandre L N | 2010 | Analytical Biochemistry2010，406，2： | 1 |
| 19 | An improved rice transformation system using biolistic method 显示文摘 | Li L C Qu R D Alexandre D K | 1993 | Plant Cell Reports1993，12，： | 1 |
| 20 | Existence of infinitely many homoclinic orbits in Hamiltonian systems显示文摘 | Steven Dewitte Dominique Crommelynck Sabri Mekaoui Alexandre Joukoff Eric Séré | 1992 | Mathematische Zeitschrift1992，，1： | 1 |
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