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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Response to radiofrequency ablation of pulmonary tumours: a prospective, intention-to-treat, multicentre clinical trial (the RAPTURE study)显示文摘 | Riccardo Lencioni Laura Crocetti Roberto Cioni Robert Suh Derek Glenn Daniele Regge Thomas Helmberger Alice R Gillams Andrea Frilling Marcello Ambrogi Carlo Bartolozzi Alfredo Mussi | 2008 | Lancet Oncology2008，，7： | 2 |
| 3 | Management of Evans syndrome显示文摘 | Alice N Irene R | 2006 | Br J Haematol2006，132，2： | 1 |
| 4 | Effects of low levels of Ciprofloxacin on a chemostat model of the human colonic microflora 显示文摘 | CARMAN R J MARY ALICE WOODBURN | 2001 | Regulat Toxicol Pharmacol2001，，33： | 1 |
| 5 | Ciprofloxacin at low levels disrupts colonization resistance of human fecal microflora growing in chemostats显示文摘 | CARMAN R J MARY ALICE SIMON | 2004 | Regular Toxicol Pharmacol2004，，40： | 1 |
| 6 | Herbivory,Mowing and Herbicides Differently Affect Production and Nutrient Allocation of Alternanthera Philoxeroides显示文摘 | SHON S S ALICE G Y JOHN R U | 2007 | Aquatic Botany2007，86，1： | 1 |
| 7 | CTdatabase: aknowledge-base of high-throughput and curated data oncancer-testis antigens显示文摘 | Luiz G A Noboru J S Alice R O | | Nucleic Acids R e s0，37，： | 1 |
| 8 | The effect of cues on gait vari- ability-reducing the attentional cost of walking in people with Parkinson's disease 显示文摘 | Katherine B Lynn R Alice N | 2008 | Parkinsonism Relat Disord2008，14，4： | 1 |
| 9 | Children's emotional attributions to self versus others an exploration of an assumption underlying projective techniques显示文摘 | Carter Alice S | 1982 | Journal of Consulting and Clinical Psychology1982，，5： | 1 |
| 10 | Quench theThirst: Lessons From Clinical Thirst Trials 显示文摘 | Arai Shoshana R Butzlaff Alice Stotts Nancy A | 2013 | Bioiogical research fornursing2013，，： | 1 |
| 11 | How Changing the Focus of Attention Affects Performance, Kinematics, and Electromyography in Dart Throwing 显示文摘 | Keith R L David E S Alice F H | 2010 | Human Movement Science2010，29，： | 1 |
| 12 | Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies显示文摘 | Celeste Leigh Pearce Claire Templeman Mary Anne Rossing Alice Lee Aimee M Near Penelope M Webb Christina M Nagle Jennifer A Doherty Kara L Cushing-Haugen Kristine G Wicklund Jenny Chang-Claude Rebecca Hein Galina Lurie Lynne R Wilkens Michael E Carney Mar | 2012 | Lancet Oncology2012，，： | 1 |
| 13 | Thyroid Status, Cardiovascular Risk, and Mortality in Older Adults 显示文摘 | Anne R Linda P Alice M | 2006 | JAMA2006，295，： | 1 |
| 14 | Testing a Psychological Contract Measure in a Swiss Employment Context显示文摘 | R SABINE R ANETTE W ALICE I | 2009 | Swiss Journal of Psychology2009，68，4： | 1 |
| 15 | Comparision of the therapeutic of epotin beta and epoetin alfa in maintenance phase hemodialysis patients显示文摘 | Alice L Galil R Sumith C | 2011 | Renal Failure2011，33，3： | 1 |
| 16 | Impact of thrombolysis, intra-aortic balloon pump counterpulsation, and their combination in cardiogenic shock complicating acute myocardial infarction: a report from the SHOCK Trial Registry显示文摘 | Timothy A Sanborn Lynn A Sleeper Eric R Bates Alice K Jacobs Jean Boland John K French Jo Dens Vladimir Dzavik Sebastian T Palmeri John G Webb Mark Goldberger Judith S Hochman | 2000 | Journal of the American College of Cardiology2000，，： | 1 |
| 17 | Why caution should be applied when interpreting and promoting findings from Mendelian randomisation studies显示文摘Introduction In their article entitled‘Investigating genetic causal relationships between blood pressure and anxiety,depressive symptoms,neuroticism and subjective well-being’,Cai and colleagues1 presented the results of a two-sample Mendelian randomisation2(MR)study examining associations between blood pressure traits(systolic,diastolic,hypertension and pulse pressure)and psychological traits(anxiety,depression,neuroticism and subjective well-being).After correction for multiple testing. | Alice R Carter Abigail Fraser Laura D Howe Sian Harris Amanda Hughes | 2023 | General Psychiatry2023，36，4： | 1 |
| 18 | Cobalt-and Platinum-rich Ferromanganese Crusts and Associated Substrate Rocks from the Marshall Island显示文摘 | Schwab William C Davis Alices | 1988 | Marine Geology1988，78，34： | 1 |
| 19 | Asso- ciations of total and high-molecular-weight adiponectin with all-cause and cardiovascular mortality in older persons: The Cardiovascular Health Study 显示文摘 | KIZER J R BENKESER D ALICE M | 2012 | Cir- culation2012，126，： | 1 |
| 20 | Herbivory, mowing and herbicides differently affect production and nutrient allocation of ahernanthera philoxeroides 显示文摘 | Shon S Schooler Alice G Yeates John R U Wilson | 2007 | Aquat Bot2007，86，： | 1 |
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