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| 1 | Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3显示文摘AIM: To investigate the inhibitory role and the underlying mechanisms of sorafenib on signal transducer and activator of transcription 3 (STAT3) activity in hepatocellular carcinoma (HCC).METHODS: Human and rat HCC cell lines were treated with sorafenib. Proliferation and STAT3 dephosphorylation were assessed. Potential molecular mechanisms of STAT3 pathway inhibition by sorafenib were evaluated. In vivo antitumor action and STAT3 inhibition were investigated in an immunocompetent orthotopic rat HCC model.RESULTS: Sorafenib decreased STAT3 phosphorylationat the tyrosine and serine residues (Y705 and S727), but did not affect Janus kinase 2 (JAK2) and phosphatase shatterproof 2 (SHP2), which is associated with growth inhibition in HCC cells. Dephosphorylation of S727 was associated with attenuated extracellular signal-regulated kinase (ERK) phosphorylation, similar to the effects of a mitogen-activated protein kinase (MEK) inhibitor U0126, suggesting that sorafenib induced S727 dephosphorylation by inhibiting MEK/ERK signaling. Meanwhile, sorafenib could also inhibit Akt phosphorylation, and both the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and Akt knockdown resulted in Y705 dephosphorylation, indicating that Y705 dephosphorylation by sorafenib was mediated by inhibiting the PI3K/Akt pathway. Finally, in the rat HCC model, sorafenib signifi cantly inhibited STAT3 activity, reducing tumor growth and metastasis.CONCLUSION: Sorafenib inhibits growth and metastasis of HCC in part by blocking the MEK/ERK/STAT3 and PI3K/Akt/STAT3 signaling pathways, but independent of JAK2 and SHP2 activation. | Fang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian ZhouFang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian Zhou, Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai 200032, China Author contributions: Gu FM, Li QL and Gao Q contributed equally to this work Gu FM and Li QL performed the experi- ments and interpretation of the data and statistical analysis Zhou J and Gao Q contributed to the conception and design of the study Gu FM, Gao Q, Li QL and Zhou J wrote the manuscript Jiang JH, Huang XY, Pan JF and Fan J made substantial contri- bution to the design and conception of the study and interpreta- tion of data all authors read and approved the f inal manuscript. | 2011 | World Journal of Gastroenterology2011，17，34： | 18 |
| 2 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 3 | 慢性再生障碍性贫血的中医药治疗及用药经验谈显示文摘邀请中华中医药学会内科血液病专业委员会的专家教授 ,讨论慢性再生障碍性贫血的中医辨治方法与用药经验。专家们提出 ,本病病机为肾精亏损、脾失健运、脏气失调、瘀阻髓络、热毒内伏和湿浊蕴结 ,治疗以补肾健脾、益髓生血、抑肝泻火、活血化瘀、利湿化浊、清热养阴、凉血止血为主。 | Hematopathy Committee of All China Chinese Medicine Association | 2002 | 上海中医药杂志2002，36，10： | 15 |
| 4 | Mobile Ubiquitous Service Environment显示文摘The Mobile Ubiquitous Service Environment (MUSE),established through the coordination and integration of mobile telecommunications and ubiquitous network,in the pursuit of Always Best Experience (ABE),represents the major development trend for the next generation mobile wireless network. Research on MUSE will involve the integration of the computing model system,service platform system,operating system and terminal structure system,all of which involve exploration and innovation of a new networking structure,its control and management as well as way of measuring. The change in network resources triggers the change in network computing models. To let readers have a basic understanding of MUSE,this lecture introduces it in four sections. This section focuses on the development and demand analysis of the service platform. | Zhang Ping,Ji Yang,Feng Zhiyong (Research Center for Wireless New Technology,Beijing University of Posts and Telecommunications,Beijing 100876,China) The Mobile Ubiquitous Service Environment (MUSE),established through the coordination and integration of mobile telecommunications and ubiquitous network,in the pursuit of Always Best Experience (ABE),represents the major development trend for the next generation mobile wireless network. Research on MUSE will involve the integration of the computing model system,service platform system,operating system and terminal structure system,all of which involve exploration and innovation of a new networking structure,its control and management as well as way of measuring. The change in network resources triggers the change in network computing models. To let readers have a basic understanding of MUSE,this lecture introduces it in four sections. This section focuses on the development and demand analysis of the service platform. | 2007 | ZTE Communications2007，5，2： | 10 |
| 5 | Quantum phase transition and entanglement in Li atom system显示文摘By use of the exact diagonalization method, the quantum phase transition and en- tanglement in a 6-Li atom system are studied. It is found that entanglement appears before the quantum phase transition and disappears after it in this exactly solvable quantum system. The present results show that the von Neumann entropy, as a measure of entanglement, may reveal the quantum phase transition in this model. | SI LiMing1 & HOU JiXuan2 1 Department of Electronic Engineering, School of Information Science and Technology, Beijing Institute of Technology, Beijing 100081, China 2 Laboratoire de Chimie, UMR 5182 CNRS, Ecole Normale Supérieure de Lyon, 46, Allée d’Italie, F-69364 Lyon Cedex 07, France | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，11： | 6 |
| 6 | 欧、美、亚一些国家体育测验制度与健身计划综述(摘要)显示文摘通过对国外健身计划综述比较研究,得出各国政府都很重视增强国民体质的研究工作,并关注体育与社会活动的联系。各国制订的健身计划目的明确,都是服从于本国政治、经济在不同时期的发展以及民众健康的需要的。各国体育测验制度经不断修订,已日趋完善。各国的健康计划或措施,均把体育健身活动作为预防疾病、增强国民健康水平的重要内容之一。 | Information research group of 'healthy plan for all in China' written by Yao Yuwu | 1994 | 天津体育学院学报1994，9，2： | 4 |
| 7 | New Development of China-Russia-India Triangle显示文摘Since 2001, positive improvement has occurred in the trianglerelationship between China, Russia and India. The foreignministers of the three nations met in Russia recently, symbolizingthe launching of substantive triangular cooperation. | Ma Jiali is Research Professor at CICIR. He specializes in South Asian security, especially in India’s foreign policy. He is the author of three books, such as Pay Close Attention to India: A Rising Power which is very influential. He was one of the delegates for Track Two Dialogue between China and India for all of four rounds and a delegate for Track Two Dialogue between China, Russia and India. He is also a member of Eminent Persons Group Forum between China and India. | 2005 | Contemporary International Relations2005，15，7： | 4 |
| 8 | Low temperature induces oocytes p34^(cdc2) synthesis and accumulation-the acquisition of competence to resume meiosis in toad oocytes显示文摘Full grown oocytes derived from Bufo Bufo gargarizans rearing at high temperature environment (24℃),never underwent GVBD after progesterone treatment. No p34cdc2, H1 kinase activity was detected in the oocytes after progesterone stimulation or OA microinjection; Western blotting analysis showed that the level of p3cdc2, and p33 in the oocytes are significantly lower than those in the oocytes derived from the hibernating toads (below 10 ℃). 25S-Met incorporation analysis showed that when the oocytes were incubated at 6℃, synthesis of about thirty defferent polypeptides was promoted or induced, including p34cdc2 and some other p13suc1-binding proteins. All these results indicated that a low temperature environment is essential for the oocytes of Bufo Bufo gargarizans to express and store some cell cycle drivers and its regulators, and to gain the maturation competence. These results will also provide a new clue for explaining the molecular mechanisms why gametogenesis of some organisms depends on a relative low temperature and how to maintain the geographical distribution of some animals. | LU JI NING ZHENG GU HONG SHENG CHUANG JU LIU JIA KE TSO (Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China)(To whom all correspondence should be addressed, present address: Shanghai Institute of Planned Parenthood | 1996 | Cell Research1996，6，2： | 3 |
| 9 | Some Physical Properties of CuTlSe Alloy显示文摘The structure and optical properties of Cu0.1Tl2Se3 alloy was studied. X-ray analysis showed that the polycrystalline powder consists of a mixture of two phases Cu3jTlSe2 (monoclinic) and TISe (tetragonal). Chalcopyrite phase CuTISe2 can be obtained by annealing the powder at 250’C for 1 h. Thin film with a monoclinic phase of Cu3TlSe2 was obtained for the thick film (0.7 um). The optical parameters a, n, k, e’ and e' and the energy gap were calculated. The thermoelectric power measurements showed that S has a positive polarity over the whole range of temperature. | A.Abdel All Physics Department, Faculty of Science , Helwan University, Cairo, Egypt K.A.Sharaf Physics Department, Faculty of Science, Al-Azhar University for Girls, Cairo, Egypt A.Elshafie Physics Department, Faculty of Science, Menoufia University, She | 2001 | Journal of Materials Science & Technology2001，17，2： | 2 |
| 10 | BLIND AND INTERNET显示文摘BLINDANDINTERNETBLINDANDINTERNETZhaoGuanglu(ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing100730China)In... | Qin-zhang Ding(The Department of Neuropsychiatry.Second Affiliated Hospital of Hebei Medical UniversityShijiazhuang. Heibe, 050000 China)In china a and all of the world, it is always using cloth bands to restrain activities of thelimbs in the patient | 1995 | Chinese Journal of Biomedical Engineering(English Edition)1995，4，4： | 2 |
| 11 | Redefined nomenclature of members of the carcinoembryonic antigen family显示文摘 | Collaborative work of all groups finalized at a CEA/PSG workshop held in Ratzeburge Germany | 1999 | Exp Cell Res1999，252，： | 1 |
| 12 | Parametric between brickwall and supporting beam 显示文摘 | Hossain M M Rahman M study of composite action A All S S | 2000 | Journal of Civil Engineering2000，28，1： | 1 |
| 13 | 我国稻瘟病菌生理小种研究显示文摘 | All China Coorporation of Research on Physiological Races of Pyricularia oryzae | 1980 | 植物病理学报1980，，02： | 1 |
| 14 | nephrolithotomy complications using tth mdified clavien grading system: looking for a standard显示文摘 | Ahmet Tefekli Mert All Karadag Kadir Classification of percutaneous Tepeler | 2008 | Eur urol2008，，53： | 1 |
| 15 | 显示文摘 | Cllao -C'hang_ l~en']ing 'Liu 'Qian ' et 'all -Effect of oral and maxillofacial trauma after oxidation potential water in- terrupted oral spray | 2009 | Chinese Journal of nursing2009，44，1： | 1 |
| 16 | The san Antonio Heart Study显示文摘 | Wel hi Gaskill SP Haffner SM et ak Effect of diabetes and level of glyeemla and all - cauze and cardiovaleular mortality | 1998 | Diabetes Care1998，21，7： | 1 |
| 17 | Fibrinolytic Therapy Trialists(FTT) Collaborative Group显示文摘 | Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1 000 patients | 1994 | Lancet1994，343，8893： | 1 |
| 18 | 我国稻瘟病菌生理小种研究显示文摘 | All China Coorporation of Research on Physiological Races of Pyricularia oryzae | 1980 | 植物病理学报1980，，02： | 1 |
| 19 | 我国小麦赤霉病穗部镰刀菌种类、分布及致病性显示文摘 | All China Corporation of Research on Wheat Scab | 1984 | 上海师范学院学报(自然科学版)1984，，03： | 1 |
| 20 | Pleiotropic effects ofstatins in distal human pulmonary artery smooth muscle cells 显示文摘 | All OF Growcott EJ Butrous GS | 2011 | Respir Res2011，12，1： | 1 |
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