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| 1 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 2 | Stress concentrations in a viscoelastic composite plate weak- ened by a triangular hole显示文摘 | Allam M N M Zenkour A M El-Mekawy H F | 2007 | Composite Structures2007，79，1： | 1 |
| 3 | Stress concentrations in a viscoelastic composite plate weakened by a triangular hole显示文摘 | ALLAM M N M ZENKOUR A M EL-MEKAWY H F | 2007 | Composite Structures2007，79，1： | 1 |
| 4 | Clinical value of im?munohistochemically detected lymphovascular space invasion in early stage cervical carcinoma显示文摘 | Lim CS Alexander-Sefre F Allam M | 2008 | Ann Surg Oncol2008，15，： | 1 |
| 5 | Moderate treadmill exerciserescues anxiety and depression-like behavior as well asmemory impairment in a rat model of posttraumatic stressdisorder显示文摘 | Patki G Li L Allam F | 2014 | Physiol Behav2014，130，10： | 1 |
| 6 | Antibody profile, interferon-gamma and nutritional status in cryptosporidial infection among school children显示文摘 | Allam A F Abou-Shousha S A Abou Shamaa L A | 2002 | Egypt Soc Parasitol2002，32，3： | 1 |
| 7 | Moderate treadmill exer- cise rescues anxiety and depression-like behavior as well as memory impairment in a rat model of posttrau- matic stress disorder显示文摘 | Patki G Li L Allam F | 2014 | Physiology and behavior2014，130，： | 1 |
| 8 | Pregnancy outcome after ovulation induction with aromatase inhibitors or clomiphene citrate in unexplained infertility 显示文摘 | BADAWY A SHOKEIR A ALLAM A F | 2009 | Acta Obstet Gynecol Scand2009，88，2： | 1 |
| 9 | Moderate treadmill exercise rescues anxiety and depression-like behavior as well as memory impairment in a rat model of post traumatic stress disorder显示文摘 | Patki G Li L Allam F | 2014 | Physiol Behav2014，130，： | 1 |
| 10 | Invasive pulmonary aspergillosis:retrospective case record review显示文摘 | ALLAM M F SERRANO D E L CASTILLO A DIAZ-MOLINA C | 2004 | Rev Iberoam Micol2004，21，1： | 1 |
| 11 | Computer tomography assess- ment of pedicle screw placement in lumbar and sacral spine: compar- ison between free-hand and O-ann based navigation techniques显示文摘 | Silbermann J Riese F Allam Y | 2011 | Eur Spine J2011，20，： | 1 |
| 12 | Synthesis of some new benzothiazole derivatives as potential antimicrobial and antiparasotic agents显示文摘 | Mahran M A El-nassry S M F Allam S R | 2003 | Pharmazie2003，58，8： | 1 |
| 13 | Stress concentrations in a viscoelastic composite plate weakened by a triangular hole显示文摘 | ALLAM M N M ZENKOUR A M EL-MEKAWY H F | 2007 | Composite Structures2007，79，1： | 1 |
| 14 | IL-23-producing CD68+macrophage-like cells predominate within an IL-17-polarized infiltrate in chronic periodontitis lesions显示文摘 | Allam JP Duan Y Heinemann F | 2011 | J Clin Periodontol2011，38，10： | 1 |
| 15 | Intramedullary fixation of failed plat-ed femoral diaphyseal fractures: are bone grafts necessary? 显示文摘 | EMARA K M ALLAM M F | 2008 | JTrauma2008，65，3： | 1 |
| 16 | Pneumatization of the temporal bone 显示文摘 | ALLAM A F | 1969 | Ann Otol Rhinol Laryngol1969，，3： | 1 |
| 17 | Computer tomog- raphy assessment of pediele screw placement in thoracic spine: comparison between free hand and a generic 3D-based navigation techniques显示文摘 | ALLAM Y SILBERMANN J RIESE F | 2013 | European Spine Journal2013，22，3： | 1 |
| 18 | Moderate treadmill exercise rescues anxiety and depression-like behavioras well as mem- ory impairment in a rat model of posttraumatic stressdisorder 显示文摘 | Patki G Li L Allam F | 2014 | Physiol Behav2014，130，： | 1 |
| 19 | Islanding detection method for DFIG wind turbines using artificial neural networks 显示文摘 | ABD-ELKADER A G ALLAM D F TAGELDIN E | 2014 | International Journal of Electrical Power & Energy Systems2014，，62： | 1 |
| 20 | Computer tomography as?sessment of pedicle screw placement in lumbar and sacral spine: comparison between free-hand and O-arm based navigation tech?niques显示文摘 | SilbermannJ Riese F Allam Y | 2011 | Eur SpineJ2011，20，6： | 1 |
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