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| 1 | Hepatitis B and immunosuppressive therapies for chronic inflammatory diseases: When and how to apply prophylaxis, with a special focus on corticosteroid therapy显示文摘Currently immunosuppressive and biological agentsare used in a more extensive and earlier way in patients with inflammatory bowel disease, rheumatic or dermatologic diseases. Although these drugs have shown a significant clinical benefit, the safety of these treatments is a challenge. Hepatitis B virus(HBV) reactivations have been reported widely, even including liver failure and death, and it represents a deep concern in these patients. Current guidelines recommend to preemptive therapy in patients with immunosuppressants in general, but preventive measures focused in patients with corticosteroids and inflammatory diseases are scarce. Screening for HBV infection should be done at diagnosis. The patients who test positive for hepatitis B surface antigen, but do not meet criteria for antiviral treatment must receive prophylaxis before undergoing immunosuppression, including corticosteroids at higher doses than prednisone 20 mg/d during more than two weeks. Tenofovir and entecavir are preferred than lamivudine because of their better resistance profile in long-term immunosuppressant treatments. There is not a strong evidence, to make a general recommendation on the necessity of prophylaxis therapy in patients with inflammatory diseases that are taking low doses of corticosteroids in short term basis or low systemic bioavailability corticosteroids such as budesonide or beclomethasone dipropionate. In these cases regularly HBV DNA monitoring is recommended, starting early antiviral therapy if DNA levels begin to rise. In patients with occult or resolved hepatitis the risk of reactivation is much lower, and excepting for Rituximab treatment, the prophylaxis is not necessary. | Pilar López-Serrano Elsa de la Fuente Briongos Elisa Carrera Alonso Jose Lázaro Pérez-Calle Conrado Fernández | 2015 | World Journal of Hepatology2015，7，3： | 4 |
| 2 | Pain-temperature lelation in the application of local anaesthesia显示文摘 | Perula LA Fiaja LE | 1993 | Rr J plast surg1993，46，1： | 1 |
| 3 | Comparison of the clinical efficacy and safety of carbamide peroxide and hydrogen peroxide in at-home bleaching gels显示文摘 | Alonso de la Pea V Balboa Cabrita O | 2006 | Quintessence Int2006，37，7： | 1 |
| 4 | Value of a sec- ond transurethral resection in the assessment and treatment of patients with bladder tumor显示文摘 | OJEA CA NUNEZ LA ALONSO RA | 2001 | Actas Urol Esp2001，25，3： | 1 |
| 5 | Gout and risk of Parkinson disease : a prospective study 显示文摘 | Alonso A Rodriguez LA Logroscino G | 2007 | Neurology2007，69，： | 1 |
| 6 | Gout and risk of Parkin- son disease : A prospective study 显示文摘 | Alonso A Rodriguez LA Logroscino G | 2007 | Neurology2007，69，17： | 1 |
| 7 | Nasal provocation test (NPT)with aspirin:a sensitive and safe method to diagnose aspirin-induced asthma(AIA) 显示文摘 | Alonso LA Martinez CC Dominguez OJ | 2002 | Allergy2002，57，： | 1 |
| 8 | Nucleotide sequence of the genomic RNA of pepper mild mottle virus,a resistance-breaking tobamovirus in pepper显示文摘 | Alonso E Garcia-Luque I de la Cruz A | 1991 | J Gen Virol1991，72，： | 1 |
| 9 | Role of SOX family of transcription factors in central nervous system tumors显示文摘 | de la Rocha A M Sampron N Alonso M M | 2014 | Cancer Res2014，4，4： | 1 |
| 10 | Gout and risk of Parkinson disease: a prospective study 显示文摘 | Alonso A Rodriguez LA Logroscino G | 2007 | Neu rology2007，69，17： | 1 |
| 11 | Periodontal 5'-deiodination on forced-induced root resorption-the protective effect of thyroid hormone administration 显示文摘 | Vazquez-Landaverde LA Rojas-Huidobro R Alonso Gallegos- Corona M | 2002 | Eur J Orthod2002，24，4： | 1 |
| 12 | Carnitine concentrations in dialysed and undialysed patients with chronic renal insufficiency显示文摘 | Rodriguez-Segade S Alonso de la Pena C Paz M | 1986 | Ann Clin Biochem1986，23，6： | 1 |
| 13 | Role of New Functional MRI Techniques in the Diagnosis, Staging, and Followup of Gynecological Cancer: Comparison with PET-CT显示文摘 | Elena Alvarez Moreno Mar Jimenez de la Pe?a Raquel Cano Alonso David C. Howlett | 2012 | Radiology Research and Practice2012，，： | 1 |
| 14 | Age of sitting unsupported and independent walking in very low birth weight preterm infants with normal motor development at 2 years显示文摘 | Marin Gabriel MA Pallás Alonso CR De La Cruz Bértolo J | | 0，，11： | 1 |
| 15 | Role of interleukin - lbeta in the control of neuroepithelial proliferation and differentiation of the spinal cord during development显示文摘 | de la Mano A Gato A Alonso MI | 2007 | Cytokine2007，2，： | 1 |
| 16 | Prevalence and Factors Associated With Circadian Blood Pressure Patterns in Hypertensive Patients显示文摘 | Alejandro de la Sierra Josep Redon José R. Banegas Julián Segura Gianfranco Parati Manuel Gorostidi Juan J. de la Cruz Javier Sobrino José L. Llisterri Javier Alonso Ernest Vinyoles Vicente Pallarés Antonio Sarría Pedro Aranda Luis M. Ruilope | 2009 | Hypertension2009，，3： | 1 |
| 17 | Microbleed Burden and Hematoma Expansion in Acute Intracerebral Hemorrhage显示文摘 | Martí-fàbregas Joan Delgado-mederos Raquel Granell Esther Morenas Rodríguez Estrella Marín Lahoz Juan Dinia Lavinia Carrera David Pérez De La Ossa Natalia Sanahuja Jordi Sobrino Tomás De Arce Ana María Alonso De Leci?ana María | 2013 | European Neurology . 2013 (3-4)2013，，3： | 1 |
| 18 | Gout and risk of Parkinson disease: a prospective study 显示文摘 | Alonso A Rodriguez LA Logroscino G | 2007 | Neurology2007，69，17： | 1 |
| 19 | Role of SOX family of transcription factors in central nervous system tumors 显示文摘 | de la Rocha AM Sampron N Alonso MM | 2014 | Am J Cancer Res2014，4，4： | 1 |
| 20 | Characterization of the Drosophila melanogaster mitochondrial proteome显示文摘 | Alonso J Rodriguez JM Baena-Lopez LA | 2005 | J proteome Res2005，4，5： | 1 |
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