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| 1 | Identification of ta-siRNAs and Cis-nat-siRNAs in Cassava and Their Roles in Response to Cassava Bacterial Blight显示文摘Trans-acting small interfering RNAs (ta-siRNAs) and natural cis-antisense siRNAs (cis-nat-siRNAs) are recently discovered small RNAs (sRNAs) involved in post-transcriptional gene silencing. ta-siRNAs are transcribed from genomic loci and require processing by microRNAs (miRNAs). cis-nat-siRNAs are derived from antisense RNAs produced by the simultaneous transcription of overlapping antisense genes. Their roles in many plant processes, including pathogen response, are mostly unknown. In this work, we employed a bioinformatic approach to identify ta-siRNAs and cis-nat-siRNAs in cassava from two sRNA libraries, one constructed from healthy cassava plants and one from plants inoculated with the bacterium Xanthomonas axonopodis pv.manihotis (Xam). A total of 54 possible ta-siRNA loci were identified in cassava, including a homolog of TAS3, the best studied plant ta-siRNA. Fifteen of these loci were induced, while 39 were repressed in response to Xam infection. In addition, 15 possible cis-natural antisense transcript (cis-NAT) loci producing siRNAs were identified from overlapping antisense regions in the genome,and were found to be differentially expressed upon Xam infection. Roles of sRNAs were predicted by sequence complementarity and our results showed that many sRNAs identified in this work might be directed against various transcription factors. This work represents a significant step toward understanding the roles of sRNAs in the immune response of cassava. | Andrés Quintero Alvaro L. Pérez-Quintero Camilo López | 2013 | Genomics, Proteomics & Bioinformatics2013，11，3： | 4 |
| 2 | Analyzing predictors of graft survival in patients undergoing liver transplantation with donors aged 70 years and over显示文摘AIM To increase the number of available grafts.METHODS This is a single-center comparative analysis performed between April 1986 and May 2016. Two hundred and twelve liver transplantation(LT) were performed with donors ≥ 70 years old(study group). Then, we selected the first cases that were performed with donors < 70 years old immediately after the ones that were performed with donors ≥ 70 years old(control group).RESULTS Graft and patient survivals were similar between both groups without increasing the risk of complications, especially primary non-function, vascular complications and biliary complications. We identified 5 risk factors as independent predictors of graft survival: recipient hepatitis C virus(HCV)-positivity [hazard ratio(HR) = 2.35; 95% confidence interval(CI): 1.55-3.56; P = 0.00]; recipient age(HR = 1.04; 95%CI: 1.02-1.06; P = 0.00); donor age X model for end-stage liver disease(D-MELD)(HR = 1.00; 95%CI: 1.00-1.00; P = 0.00); donor value of serum glutamic-pyruvic transaminase(HR = 1.00; 95%CI: 1.00-1.00; P = 0.00); and donor value of serum sodium(HR = 0.96; 95%CI: 0.94-0.99; P = 0.00). After combining D-MELD and recipient age we obtained a new scoring system that we called DR-MELD(donor age X recipient age X MELD). Graft survival significantly decreased in patients with a DR-MELD score ≥ 75000, especially in HCV patients(77% vs 63% at 5 years in HCV-negative patients, P = 0.00; and 61% vs 25% at 5 years in HCV-positive patients; P = 0.00). CONCLUSION A DR-MELD ≥ 75000 must be avoided in order to obtain the best results in LT with donors ≥ 70 years old. | Oscar Caso-Maestro Carlos Jiménez-Romero Iago Justo-Alonso Jorge Calvo-Pulido David Lora-Pablos Alberto Marcacuzco-Quinto Félix Cambra-Molero Alvaro García-Sesma Marina Pérez-Flecha Carlos Munoz- Arce Carmelo Loinaz-Segurola Alejandro Manrique-Municio | 2018 | World Journal of Gastroenterology2018，24，47： | 2 |
| 3 | The history of hair transplantation 显示文摘 | JAE P PAULO G ALVARO Z | 2008 | Am J Cosmet Surg2008，25，4： | 1 |
| 4 | A rapid TLC scanning method for the determination of patulin in apple products 显示文摘 | Silvana V Alvaro V Cerdeiras P | 1999 | Journal of Planar Chromatography1999，12，4： | 1 |
| 5 | Deformation and phase shift in amplitude modulation atomic force microscopy显示文摘 | Alvaro S P Ricardo Amplitude G | 2001 | Surface Science2001，471，： | 1 |
| 6 | Ah receptor signals cross-talk with multiple developmental pathways显示文摘 | Alvaro P Craig R T Ying X | 2005 | Biochemical Pharmac2005，69，2： | 1 |
| 7 | Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial显示文摘 | Shamir R Mehta Jean-Francois Tanguay John W Eikelboom Sanjit S Jolly Campbell D Joyner Christopher B Granger David P Faxon Hans-Jurgen Rupprecht Andrzej Budaj Alvaro Avezum Petr Widimsky Philippe Gabriel Steg Jean-Pierre Bassand Gilles Montalescot Carlos | 2010 | The Lancet2010，，9748： | 1 |
| 8 | Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial显示文摘 | Shamir R Mehta Jean-Francois Tanguay John W Eikelboom Sanjit S Jolly Campbell D Joyner Christopher B Granger David P Faxon Hans-Jurgen Rupprecht Andrzej Budaj Alvaro Avezum Petr Widimsky Philippe Gabriel Steg Jean-Pierre Bassand Gilles Montalescot Carlos | 2010 | The Lancet2010，，9748： | 1 |
| 9 | A novel process for recovery of fermentation-derived succinic acid显示文摘 | Alvaro O Abraham J Y Lars P B Carl T L Dennis J M | 2011 | Separation and Purification Technology2011，83，： | 1 |
| 10 | Application of artificial neural networks to the prediction of the antioxidant activity of essential oils in two experimental in vitro models显示文摘 | ALVARO C C JOSE M P | | 0，，1： | 1 |
| 11 | Comparison between radiological and masopharyngolaryngoscopic assessment of adenoid tissue volume in mouth breathing children显示文摘 | Edmir AL Karen CLA Alvaro P J | 2005 | Rev Bras Otorrinolaringol2005，71，1： | 1 |
| 12 | Estrogens stimulate prohferation of intrahepatic bihary epithelium in rats 显示文摘 | Alvaro D Alpini G Onori P | 2000 | Gastroenterology2000，119，6： | 1 |
| 13 | A rapid TLC-scanning method for the determination of patulin in apple products显示文摘 | Silvana V Alvaro V Cerdeiras P | 1999 | Journal of Planar Chromato graphy1999，12，4： | 1 |
| 14 | Coagels from alkanoyl-6-O-ascorbic acid derivatives as drug carriers : Structure and rheology 显示文摘 | Santiago P Alvaro J K Laura F | 2003 | Farmaco2003，58，： | 1 |
| 15 | Crystalline nanostructures of heavy metal iodides显示文摘 | Laura Fornaro Ivana Aguiar María Pérez Barthaburu Alvaro Olivera Isabel Galain Maia Mombrú | 2014 | Journal of Crystal Growth2014，，： | 1 |
| 16 | Modification of Darcy's law for the threshold pressure gradient显示文摘 | ALVARO P FARUK C | 1999 | Journal of Petroleum Science and Engineering1999，22，4： | 1 |
| 17 | Graphene oxide as an acid catalyst for the room temperature ring opening of epoxides 显示文摘 | Dhakshinamoorthy A Alvaro M Concepcion P | 2012 | Chemical Communications2012，48，： | 1 |
| 18 | Estrogens stimulate proliferation of intrahepatic biliary epithelium in rats 显示文摘 | Alvaro D Alpini G Onori P | 2000 | Gastroenterology2000，119，6： | 1 |
| 19 | Intracellular pathways mediating estrogen-induced cholangiocyte proliferation in the rat显示文摘 | Alvaro D Onori P Metalli VD | 2002 | Hepatol2002，36，2： | 1 |
| 20 | Prevalence of thermoduric bacteria and spores on 10 midwest dairy farms显示文摘 | KIMBERLY P B SANJEEV A ALVARO G | 2014 | J Dairy Sci2014，97，11： | 1 |
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