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| 1 | Current and future pharmacological therapies for managing cirrhosis and its complications显示文摘Due to the restrictions of liver transplantation,complication-guided pharmacological therapy has become the mainstay of long-term management of cirrhosis.This article aims to provide a complete overview of pharmacotherapy options that may be commenced in the outpatient setting which are available for managing cirrhosis and its complications,together with discussion of current controversies and potential future directions.PubMed/Medline/Cochrane Library were electronically searched up to December 2018 to identify studies evaluating safety,efficacy and therapeutic mechanisms of pharmacological agents in cirrhotic adults and animal models of cirrhosis.Non-selective betablockers effectively reduce variceal re-bleeding risk in cirrhotic patients with moderate/large varices,but appear ineffective for primary prevention of variceal development and may compromise renal function and haemodynamic stability in advanced decompensation.Recent observational studies suggest protective,haemodynamically-independent effects of beta-blockers relating to reduced bacterial translocation.The gut-selective antibiotic rifaximin is effective for secondary prophylaxis of hepatic encephalopathy;recent small trials also indicate its potential superiority to norfloxacin for secondary prevention of spontaneous bacterial peritonitis.Diuretics remain the mainstay of uncomplicated ascites treatment,and early trials suggest alpha-adrenergic receptor agonists may improve diuretic response in refractory ascites.Vaptans have not demonstrated clinical effectiveness in treating refractory ascites and may cause detrimental complications.Despite initial hepatotoxicity concerns,safety of statin administration has been demonstrated in compensated cirrhosis.Furthermore,statins are suggested to have protective effects upon fibrosis progression,decompensation and mortality.Evidence as to whether proton pump inhibitors cause gut-liver-brain axis dysfunction is conflicting.Emerging evidence indicates that anticoagulation therapy reduces incidence and increases recanalisation rates of non-malignant portal vein thrombosis,and may impede hepatic fibrogenesis and decompensation.Pharmacotherapy for cirrhosis should be implemented in accordance with up-to-date guidelines and in conjunction with aetiology management,nutritional optimisation and patient education. | David Kockerling Rooshi Nathwani Roberta Forlano Pinelopi Manousou Benjamin H Mullish Ameet Dhar | 2019 | World Journal of Gastroenterology2019，25，8： | 16 |
| 2 | EUS-guided FNA for diagnosis of solid pancreatic neoplasms: a meta-analysis显示文摘 | Michael Jonathan Hewitt Mark J.W. McPhail Lucia Possamai Ameet Dhar Panagiotis Vlavianos Kevin J. Monahan | 2012 | Gastrointestinal Endoscopy2012，，2： | 5 |
| 3 | Risk-adjustment in hepatobiliarypancreatic surgery显示文摘AIM: The present study evaluates the performance of the POSSUM, the American Society of Anesthetists (ASA),APACHE and Childs classification in predicting mortality and morbidity in hepatopancreaticobiliary (HPB) surgery.We describe especially the limitations and advantages of risk in stratifying the patients.METHODS: We investigated 177 randomly chosen patients undergoing eledive complex HPB surgery in a single institution with a total of 71 pre-operative and intra-operative risk factors.Primary endpoint was in-hospital mortality and morbidity.Ordered logistic regression analysis was used to identify individual predictors of operative morbidity and mortality.RESULTS: The operative mortality in the series was 3.95% .This compared well with the p-POSSUM and APACHE predicted mortality of 4.31% and 4.29% respectively. Postoperative complications amounted to 45% with 24 (13.6%)patients having a major adverse event. On multivariate analysis the pre-operative POSSUM physiological score (OR = 1.18,P = 0.009) was superior in predicting complications compared to the ASA (P = 0.108), APACHE (P = 0.117)or Childs classification (P = 0.136). In addition, serum sodium, creatinine, international normalized ratio (INR),pulse rate, and intra-operative blood loss were independent risk factors. A combination of the POSSUM variables and INR offered the optimal combination of risk factors for risk prognostication in HPB surgery.CONCLUSION: Morbidity for elective HPB surgery can be accurately predicted and applied in everyday surgical practice as an adjunct in the process of informed consent and for effective allocation of resources for intensive and high-dependency care facilities. | Hemant M Kocher Paris P Tekkis Palepu Gopal Ameet G Patel Simon Cottam Irving S Benjamin | 2005 | World Journal of Gastroenterology2005，11，16： | 3 |
| 4 | 图书馆的用户休验(摘要)显示文摘1什么是用户体验?
“用户体验”(UserExperience,UX)这个词起源于网络可用性评价和应用程序接口设计领域。过去几年,其他一些服务导向的行业,如销售业和零售服务业,用这个词来描述理想的客户体验的整套设计方法。最近,创新者们将这种体验的设计应用在了图书馆。 | Robert Fox(著) Ameet Doshi(著) 刘小玲(编译) 宋丹辉(编译) | 2011 | 图书情报工作动态2011，，8： | 2 |
| 5 | How Gaming Could Improve Infonnation Literacy 显示文摘 | Ameet Doehi | 2006 | Computers in Libraries2006，，5： | 1 |
| 6 | Serum analysis of tryptophan catabolism pathway: Correlation with Crohn’s disease activity显示文摘 | Nitin K. Gupta Ameet I. Thaker Navya Kanuri Terrence E. Riehl Christopher W. Rowley William F. Stenson Matthew A. Ciorba | 2011 | Inflamm Bowel Dis2011，，7： | 1 |
| 7 | Pedicled thinned deep inferior epigastric artery perforator flap for perineal reconstruction:a preliminary report显示文摘 | Fang BR Ameet H Li XF | 2011 | J Plast Reconstr Aesthet Surg2011，64，： | 1 |
| 8 | Pancreatic interstitial pH in human and feline chronic pancreatitis显示文摘 | Ameet G. Patel Mark T. Toyama Carlos Alvarez Thanh N. Nguyen Peter U. Reber Stanley W. Ashley Howard A. Reber | 1995 | Gastroenterology1995，，5： | 1 |
| 9 | Just the right tweet at just the right time显示文摘 | Ameet Doshi | 2012 | Reference ServicesReview2012，，2： | 1 |
| 10 | The effect of bovine colostrum supplementation on exercise performance in elite field hockey players显示文摘 | Hoffman Z Ameets R Verlaan G | 2002 | Int J Sport Nutr2002，12，4： | 1 |
| 11 | Gut Hormone Profiles Following Bariatric Surgery Favor an Anorectic State, Facilitate Weight Loss, and Improve Metabolic Parameters显示文摘 | Carel W. le Roux Simon J. B. Aylwin Rachel L. Batterham Cynthia M. Borg Frances Coyle Vyas Prasad Sandra Shurey Mohammad A. Ghatei Ameet G. Patel Stephen R. Bloom | 2006 | Annals of Surgery2006，，1： | 1 |
| 12 | The role of beroptic laryngoscopy in infants with stridor 显示文摘 | MARISSA B AMEET K HAYTHAM K | 2000 | International Journal of Pediatric Otorhinolaryngology2000，55，： | 1 |
| 13 | The Effect of Bovine Colostrum Supplementation on Exercise Performance in Elite Field Hockey Players显示文摘 | HOFFMAN Z AMEETS R VERLAAN G | 2002 | Int J Sport Nutr2002，12，4： | 1 |
| 14 | Life-threatening upper gastrointestinal tract bleeding caused by ruptured extrahepatic pseudoaneurysm after pancreatoduodenectomy显示文摘 | Peter U. Reber Hans U. Baer Ameet G. Patel Jürgen Triller Markus W. Büchler | 1998 | Surgery1998，，1： | 1 |
| 15 | The role of fibreoptic laryngoscopy in infants with stridor 显示文摘 | Marissa B Ameet K Haytham K | 2000 | International Journal of Pediatric Otorhinolaryngology2000，55，： | 1 |
| 16 | Biliopancreatic diversion in rats is associated with intestinal hypertrophy and with increased GLP-1, GLP-2 and PYY levels显示文摘 | Cynthia M. Borg MD MRCS Carel W. Roux MB PhD Mohammad A. Ghatei PhD Stephen R. Bloom FRCP DSc Ameet G. Patel FRCS | 2007 | Obesity Surgery2007，，9： | 1 |
| 17 | Pedicled thinned deep inferior epigastric artery perforator flap for perineal reconstruction: a pre- liminary report 显示文摘 | Fang BR Ameet H Li XF | 2011 | J Plast Reconstr Aesthet Surg2011，64，12： | 1 |
| 18 | Single and Multiple Incision Laparoscopic Adjustable Gastric Banding: a matched comparison显示文摘 | Saurav Chakravartty Beth Murgatroyd David Ashton Ameet Patel | 2012 | Obesity Surgery2012，，11： | 1 |
| 19 | Effect of Ethanol on Pancreatic Interstitial pH and Blood Flow in Cats with Chronic Pancreatitis显示文摘 | Mark T. Toyama Ameet G. Patel Thanh Nguyen Stanley W. Ashley Howard A. Reber | 1997 | Annals of Surgery1997，，： | 1 |
| 20 | Adaptive wavelets for characterizing magnetic flux leakage signals from pipeline inspection 显示文摘 | Ameet Joshi Lalita Udpa Satish Udpa | 2006 | IEEE Tras on Magnetics2006，42，10： | 1 |
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