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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Induction of G250-targeted and T-cell-mediated antitumor activity against renal cell carcinoma using a chimeric fusion protein consisting of G250 and granulocyte/monocyte-colony stimulating factor显示文摘 | Cho-Lea T Amnon Z Allan P | 2001 | Cancer Res2001，61，21： | 1 |
| 3 | Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function 显示文摘 | Tanya P Amnon P Isabelle P | 2000 | J Clin Invest2000，106，11： | 1 |
| 4 | Observation of amplified phase-conjugate reflection and optical parametric oscillation by degenerate four-wave mixing in a transparent medium显示文摘 | David M P Dan F Amnon Y | 1978 | Applied Physics Letters1978，33，1： | 1 |
| 5 | Coaxial configuration of the dielectric Cherenkov maser显示文摘 | Amnon F William G M | 1990 | IEEE Trans on Plasma Science1990，18，6： | 1 |
| 6 | The effect of material degradation on bond properties of FRP reinforcing bars in concrete显示文摘 | Lawrence C B Moshe P Amnon K | 1998 | ACI Mater J1998，95，3： | 1 |
| 7 | 控释植入剂在心血管疾病中的应用显示文摘药物的副作用常常妨碍各种心血管疾病的治疗,例如利用心得安、利多卡因或乙胺碘呋酮进行抗心律失常的治疗时,由于会产生与药物有关的心脏和全身的副作用而使治疗复杂化。应用控释植入剂就可以避免这类问题。本文中所要讨论的是在心血管系统内的病灶区,用这种局部的给药方法在用药部位产生局部的高浓度,而全身的药物浓度则较低,可以既达到疗效又避免了副作用。药物可被混合在一种控释系统中,在基质中作为分散物,或作为“贮存”(reservoir)的片心。广泛应用的非降解基质聚合物有乙烯乙酸乙烯酯、硅橡胶和聚亚胺酯。将生物降解骨架材料用于控释植入剂常常是有利的。 | Robert J Levy Thomas P Johnston Amnon Sintov 周干南 | 1991 | 药学进展1991，15，1： | 1 |
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