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| 1 | Triptolide induces Sertoli cell apoptosis in mice via ROS/JNK-dependent activation of the mitochondrial pathway and inhibition of Nrf2-mediated antioxidant response显示文摘Triptolide (TP ) ,氧化 diterpene,举办许多有益的 pharmacodynamic 活动但是它的临床的应用程序由于严重阴囊的损害被限制。这研究试图描出在 vitro 并且在 vivo 的导致 TP 的阴囊的损害的分子的机制。TP (5-50000 nmol/L ) dose-dependently 减少了有在 24 h 的 669.5-269.45 nmol/L 的 IC 50 价值的 TM4 Sertoli 房间的生存能力。TP (125, 250,和 500 nmol/L ) dose-dependently 在 TM4 房间增加了 ROS, JNK 的 phosphorylation, mitochondrial 机能障碍和内在的 apoptosis 小径的激活的累积。这些过程被合作处理与抗氧化剂 N 乙酰半胱氨酸稀释(NAC, 1 mmol/L ) 。而且, TP 处理从细胞质禁止了 Nrf2 的 translocation 进原子核以及下游的基因 NAD (P) H quinone 的表示 oxidoreductase1 (NQO1 ) ,过氧化氢酶(猫) 和 hemeoxygenase 1 (HO-1 ) ,因此对氧化应力废除调停 Nrf2 的防卫机制。而且, Nrf2 击倒的 siRNA 显著地加强了 TM4 房间的导致 TP 的 apoptosis。从在 vitro 实验的上述结果进一步在 TP 的口头的管理以后在雄的老鼠被验证(30, 60,和 120 mg 吗? | Yu WANG Su-han GUO Xue-jun SHANG Li-sha YU Jian-wei ZHU Ang ZHAO Yan-fen ZHOU Guo-hua AN Qi ZHANG BO MA | 2018 | Acta Pharmacologica Sinica2018，39，2： | 22 |
| 2 | Inhibitory effects of antisense RNA of HAb18G/CD147 on invasion of hepatocellular carcinoma cells in vitro显示文摘AIM: To study the inhibitory effects of antisense RNA of HAb18G/CD147 on invasion of hepatocellular carcinoma (HCC) cells in vitro.METHODS: Antisense RNA of HAb18G/CD147 vector PCIasHAb18G was constructed by reversely inserting HAb18G/CD147 cDNA to eukaryotic expression vector PCI-neo. The HCC cell line HHCC was transfected by PCI-asHAb18G via cation liposome. Expression of HAb18G/CD147 of transfected cells selected by G418 (geneticin) was observed by immunohistochemical SP staining and FACS (fluorescence activated cell sorting). Gelatin zymography was used to determine the effect of PCI-asHAb18G on reducing secretions of MMP2 and MMP-9 of the transfected cells. Boyden chamber was employed to test the invasion of HCC cells in vitro.RESULTS: The construction of antisense RNA vector PCIasHAb18G was verified correct by partial nucleotide sequencing and restricted endonuclease digestion. The expression of HAb18G/CD147 in transfected HHCC was inhibited by PCI-asHAb18G. Secretions of MMP-2 and MMP9 of transfected HHCC were reduced and the invasion of transfected HHCC was inhibited compared to HHCC,respectively.CONCLUSION: Invasion of HCC cells can be inhibited by antisense RNA of HAb18G/CD147. HAb18G/CD147 may be used as a potential target of drugs for anti-invasion and metastasis of HCC. | Yu Li Peng Shang Ai-Rong Qian Li Wang Yong Yang Zhi-Nan Chen, Department of Cell Biology, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China | 2003 | World Journal of Gastroenterology2003，9，10： | 22 |
| 3 | Differentiation of Renal Oncocytoma and Renal Clear Cell Carcinoma Using Relative CT Enhancement Ratio显示文摘 | An Ren Feng Cai Yan-Ning Shang En-Sen Ma Zhen-Guo Huang Wu Wang Yan Lu Xue-Zhe Zhang | 2015 | Chinese Medical Journal2015，，2： | 20 |
| 4 | Modern pollen rain in the Lake Qinghai basin, China显示文摘Lake Qinghai is the largest inland brackish lake in China and lies within the NE Tibetan Plateau. Our study shows that pollen assemblages in each vegetation belt are significantly correlated with the vegetation types of this area. Among the herbaceous and shrubby pollen assemblages, Artemisia is over-represented, while Poaceae, Cyperaceae and Polygonaceae are under-represented. Artemisia/ Chenopodiaceae (A/C) ratios with the regional vegetation characteristic can be used as a proper index to reconstruct the history of vegetation and climate in Lake Qinghai basin. Modern pollen in the lake mainly comes from the nearby vegetation, controlled by the directions and velocity of the wind. The distribution of modern pollen in Lake Qinghai tends to be similar in most part of the lake. The difference of pollen sedimentation process in the lake can be potentially influenced by the focusing function of the lake, river streams, and lake current. | SHANG Xue LI XiaoQiang AN ZhiSheng JI Ming ZHANG HongBin | 2009 | Science China Earth Sciences2009，52，10： | 15 |
| 5 | Serum N-glycan markers for diagnosing liver fibrosis induced by hepatitis B virus显示文摘BACKGROUND Hepatitis B virus (HBV) infection is the primary cause of hepatitis with chronic HBV infection,which may develop into liver fibrosis,cirrhosis and hepatocellular carcinoma.Detection of early-stage fibrosis related to HBV infection is of great clinical significance to block the progression of liver lesion.Direct liver biopsy is regarded as the gold standard to detect and assess fibrosis;however,this method is invasive and prone to clinical sampling error.In order to address these issues,we attempted to find more convenient and effective serum markers for detecting HBV-induced early-stage liver fibrosis.AIM To investigate serum N-glycan profiling related to HBV-induced liver fibrosis and verify multiparameter diagnostic models related to serum N-glycan changes.METHODS N-glycan profiles from the sera of 432 HBV-infected patients with liver fibrosis were analyzed.Significant changed N-glycan levels (peaks)(P <0.05) in differentfibrosis stages were selected in the modeling group,and multiparameter diagnostic models were established based on changed N-glycan levels by logistic regression analysis.The receiver operating characteristic (ROC) curve analysis was performed to evaluate diagnostic efficacy of N-glycans models.These models were then compared with the aspartate aminotransferase to platelet ratio index (APRI),fibrosis index based on the four factors (FIB-4),glutamyltranspeptidase platelet albumin index (S index),GlycoCirrho-test,and GlycoFibro-test.Furthermore,we combined multiparameter diagnostic models with alanine aminotransferase (ALT) and platelet (PLT) tests and compared their diagnostic power.In addition,the diagnostic accuracy of N-glycan models was also verified in the validation group of patients.RESULTS Multiparameter diagnostic models constructed based on N-glycan peak 1,3,4and 8 could distinguish between different stages of liver fibrosis.The area under ROC curves (AUROCs) of Model A and Model B were 0.890 and 0.752,respectively differentiating fibrosis F0-F1 from F2-F4,and F0-F2 from F3-F4,and surpassing other serum panels.However,AUROC (0.747) in Model C used for the diagnosis of F4 from F0-F3 was lower than AUROC (0.795) in FIB-4.In combination with ALT and PLT,the multiparameter models showed better diagnostic power (AUROC=0.912,0.829,0.885,respectively) when compared with other models.In the validation group,the AUROCs of the three combined models (0.929,0.858,and 0.867,respectively) were still satisfactory.We also applied the combined models to distinguish adjacent fibrosis stages of 432patients (F0-F1/F2/F3/F4),and the AUROCs were 0.917,0.720 and 0.785.CONCLUSION Multiparameter models based on serum N-glycans are effective supplementary markers to distinguish between adjacent fibrosis stages of patients caused by HBV,especially in combination with ALT and PLT. | Xi Cao Qing-Hua Shang Xiao-Ling Chi Wei Zhang Huan-Ming Xiao Mi-Mi Sun Gang Chen Yong An Chun-Lei Lv Lin Wang Yue-Min Nan Cui-Ying Chen Zong-Nan Tan Xue-En Liu Hui Zhuang | 2020 | World Journal of Gastroenterology2020，26，10： | 12 |
| 6 | Prevention and control of HIV/AIDS in China:lessons from the past three decades显示文摘In the past 37 years,human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS)has undergone various major transmission routes in China,with the world most complex co-circulating HIV-1 subtypes,even the prevalence is still low.In response to the first epidemic outbreak of HIV in injecting drug users and the second one by illegal commercial blood collection,China issued the Anti-Drug Law and launched the Blood Donation Act and nationwide nucleic acid testing,which has avoided 98,232 to 211,200 estimated infections and almost ended the blood product-related infection.China has been providing free antiretroviral therapy(ART)since 2003,which covered>80%of the identified patients and achieved a viral suppression rate of 91%.To bend the curve of increasing the disease burden of HIV and finally end the epidemic,China should consider constraining HIV spread through sexual transmission,narrowing the gaps in identifying HIV cases,and the long-term effectiveness and safety of ART in the future. | Jun-Jie Xu Meng-Jie Han Yong-Jun Jiang Hai-Bo Ding Xi Li Xiao-Xu Han Fan Lv Qing-Feng Chen Zi-Ning Zhang Hua-Lu Cui Wen-Qing Geng Jing Zhang Qi Wang Jing Kang Xiao-Lin Li Hong Sun Ya-Jing Fu Ming-Hui An Qing-Hai Hu Zhen-Xing Chu Ying-Jie Liu Hong Shang | 2021 | Chinese Medical Journal2021，，23： | 9 |
| 7 | Influence of weight management on the prognosis of steatohepatitis in chronic hepatitis B patients during antiviral treatment显示文摘Background:Although concomitant nonalcoholic steatohepatitis(NASH)is common in chronic hepatitis B(CHB),the impact of viral factors on NASH and the outcome of CHB patients concomitant with NASH remain unclear.We aimed to investigate the outcomes of NASH in CHB patients receiving antiviral treatment.Methods:In the post-hoc analysis of a multicenter trial,na?ve CHB patients receiving 72-week entecavir treatment were enrolled.We evaluated the biochemical,viral and histopathological responses of these patients.The histopathological features of NASH were also evaluated,using paired liver biopsies at baseline and week 72.Results:A total of 1000 CHB patients were finally enrolled for analysis,with 18.2%of whom fulfilling the criteria of NASH.A total of 727 patients completed entecavir antiviral treatment and received the second biopsy.Serum HBe Ag loss,HBe Ag seroconversion and HBV-DNA undetectable rates were similar between patients with or without NASH(P>0.05).Among patients with NASH,the hepatic steatosis,ballooning,lobular inflammation scores and fibrosis stages all improved during follow-up(all P<0.001),46%(63/136)achieved NASH resolution.Patients with baseline body mass index(BMI)≥23 kg/m2(Asian criteria)[odds ratio(OR):0.414;95%confidence interval(95%CI):0.190-0.899;P=0.012]and weight gain(OR:0.187;95%CI:0.050-0.693;P=0.026)were less likely to have NASH resolution.Among patients without NASH at baseline,22(3.7%)developed NASH.Baseline BMI≥23 kg/m2(OR:12.506;95%CI:2.813-55.606;P=0.001)and weight gain(OR:5.126;95%CI:1.674-15.694;P=0.005)were predictors of incident NASH.Conclusions:Lower BMI and weight reduction but not virologic factors determine NASH resolution in CHB.The value of weight management in CHB patients during antiviral treatment deserves further evaluation. | Xiu-Juan Chang Yi-Wen Shi Jing Wang Hua-Bao Liu Yan Chen Xiao-Ning Zhu Yong-Ping Chen Zu-Jiang Yu Qing-Hua Shang Lin Tan Qin Li Li Jiang Guang-Ming Xiao Liang Chen Wei Lu Xiao-Yu Hu Qing-Hua Long Lin-Jing An Zi-Yuan Zou Vincent Wai-Sun Wong Yong-Ping Yang Jian-Gao Fan | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，5： | 8 |
| 8 | Characteristics of dry friction backward whirl—A self-excited oscillation in rotor-to-stator contact systems显示文摘In this paper,the response characteristics of dry friction backward whirl of a general rotor/stator model,which accounts for both the dynamics of the rotor and the stator as well as the friction and the deformation at the contact surfaces,are investigated.The existence boundaries and the whirl frequencies of the dry friction backward whirl are determined analytically.It is found that there are two or three existence boundaries of the dry friction backward whirl that usually form two existence regions,either standing completely separately,or overlapping each other partly,or one containing the other completely,depending upon the system parameters.The whirl frequencies in the two existence regions are quite different and may jump between the lower and the higher values with the variation of the rotating speed.The results have been found to have good correspondence in the related rotor/stator rubbing experiments. | JIANG Jun,SHANG ZhiYong & HONG Ling MOE Key Laboratory of Strength and Vibration,Xi’an Jiaotong University,Xi’an 710049,China | 2010 | Science China(Technological Sciences)2010，53，3： | 8 |
| 9 | Molecular network-based intervention brings us closer to ending the HIV pandemic显示文摘Precise identification of HIV transmission among populations is a key step in public health responses.However,the HIV transmission network is usually difficult to determine.HIV molecular networks can be determined by phylogenetic approach,genetic distance-based approach,and a combination of both approaches.These approaches are increasingly used to identify transmission networks among populations,reconstruct the history of HIV spread,monitor the dynamics of HIV transmission,guide targeted intervention on key subpopulations,and assess the effects of interventions.Simulation and retrospective studies have demonstrated that these molecular network-based interventions are more cost-effective than random or traditional interventions.However,we still need to address several challenges to improve the practice of molecular network-guided targeting interventions to finally end the HIV epidemic.The data remain limited or difficult to obtain,and more automatic real-time tools are required.In addition,molecular and social networks must be combined,and technical parameters and ethnic issues warrant further studies. | Xiaoxu Han Bin Zhao Minghui An Ping Zhong Hong Shang | 2020 | Frontiers of Medicine2020，14，2： | 7 |
| 10 | Developing potent PROTACs tools for selective degradation of HDAC6 protein显示文摘Dear Editor, Histone deacetylases (HDACs) are a family of enzymes that remove acetyl groups on histone and non-histone proteins, thereby playing a vital role in the modulation of gene expression and protein activity. Eighteen HDACs have been identified in human and subdivided into four classes including I, II (Ila, lib), III and IV (Seto et al., 2014). Among them, HDAC6 is a unique lib HD AC with dominant cytoplasmic localization and two functional catalytic domains. Besides the functions for deacetylation of histone, and modulation of a-tubulin, HSP90 and cortactin, HDAC6 also participates in protein trafficking and degradation, cell shape and migration (Valenzuela-Fernandez et al., 2008). The deregulation of HDAC6 is related to various diseases, such as neurodegenerative diseases, cancer and pathological autoimmune response (Batchu et al., 2016). Hence, it is especially important for directly controlling cellular HDAC6 protein levels to achieve therapeutic purposes. The traditional approaches of red u ci ng cellular protein levels mainly rely on genetic modifications, such as RNA interference, transcription activator-like effector nucleases, recombination-based gene knockout and clustered regularly interspaced short palindromic repeats (CRISPR-Cas9)(Boettcher et al., 2015). However, these approaches have failed to a certain degree to achieve acute and reversible changes of gene function. Furthermore, the complications of potential genetic compensation and/or spontaneous mutations arising in geneknockout models may lead to misinterpretations (Davisson etal., 2012;El-Brolosy etal., 2017). Therefore, it is urgent for developing a rapid, robust, and reversible approach to directly modulate HDAC6 protein levels. | Zixuan An Wenxing Lv Shang Su Wei Wu Yu Rao | 2019 | Protein & Cell2019，10，8： | 7 |
| 11 | Gastric hepatoid adenocarcinoma: A computed tomography report of six cases显示文摘We describe the computed tomography(CT)imaging findings in six cases(five males and one female;age range 61-78 years;mean age 67.3 years)with histologically proven hepatoid adenocarcinoma of the stomach(HAS).Five of the six patients had elevated serum alpha-fetoprotein levels.The most common type of gross appearance HAS on CT is a polypoid mass(83%,5/6).The most common contrast enhancement pattern was heterogeneous.All six patients had a regional lymphadenopathy larger than 6 mm in its short axis.Liver metastases(n=3)were noted.Venous tumor thrombosis was identified in the portal vein(n=2)of the regions near primary gastric tumors or metastatic masses.Our findings suggest in an elderly,male patients with a large heterogeneous enhancement tumor,the presence of distant metastases,regional lymphadenopathy and characteristically increased serum alphafetoprotein levels indicates a high likelihood of HAS. | An Ren Feng Cai Yan-Ning Shang En-Sen Ma Zhen-Guo Huang Wu Wang Jie Luo | 2014 | World Journal of Gastroenterology2014，20，40： | 6 |
| 12 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 13 | Reconstruction of plasmoid and traveling compression region in the near-Earth magnetotail显示文摘Cluster spacecraft observed an earthward flowing plasmoid along with a travelling compression region(TCR)structure in southern plasma sheet boundary layer(PSBL)at 21:09 UT of September 19,2001.We have reconstructed the two-dimensional topology of the magnetic field structure observed by C1 using Grad-Shafranov reconstruction method.Results show that C1passed through part of a plasmoid,which compressed the lobe magnetic field and formed a TCR.The size of the whole plasmoid structure in X direction is estimated to be about 3 RE.Furthermore,using multi-spacecraft observations,we have found some detailed information about this structure.First,C1 observed bi-streaming electron components,which supports our suggestion that the spacecraft passed through closed field lines.Second,a small magnetic field perturbation within this plasmoid accompanied by slight decrease in electron flux suggests that a flux rope core might exist at the center of the plasmoid. | LU Shang Wen ZONG Qiu Gang VOGIATZIS Ioannis WANG Yong Fu TIAN An Min | 2015 | Science China(Technological Sciences)2015，58，2： | 4 |
| 14 | The clock system for LHAASO WCDA based on reduced White Rabbit显示文摘Due to the large scale of Water Cherenkov Detector Array in Large High Altitude Air Shower Observatory, the frontend digitization is imperative.Thus a clock distribution system is desired,which broadcasts the synchronous clock signals with low jitter to the frontend electronics distributed in the field of 90 000 m^2.The White Rabbit protocol provides an option,which has been approved to achieve sub-ns accuracy and ps jitter in the synchronization of around 1 000 nodes in the order of 10 km.But the hierarchy of the original is too complex for Large High Altitude Air Shower Observatory application.Thus we proposed a reduced scheme based on the White Rabbit protocol.The validation circuit shows that the clock skew due to the fiber length difference can be adjusted to less than 25 ps and the clock jitter is less than 62 ps. | LI Cheng LIU Shubin SHANG Linfeng CAO Ping AN Qi | 2012 | Nuclear Science and Techniques2012，23，4： | 3 |
| 15 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 16 | Pulse source-system model and its amplitude versus frequency characteristics显示文摘The pulse contains most of information on the body health. In recent years, scholars,both at home and abroad, have been greatly interested in studying human pulse information using the modern scientific technology and methods. In this paper, we study the features and the physical process of pulse signal gcncration and initially establish a pulse source-system model on the basis of the information theory, the system theory and the acoustical theory. The model is proved to be rational by experimental testing and the new signal analysis techniques-the Cepstrum and Liftering Techniques. In this paper, the structures and features of the pulse acoustical-spectral diagrams are analysed for the first time and several conclusions on the physiological features of the pulse transmission system are drawn. | WANG Binghe DONG Yanwu TU Haiying WU Shengju SHANG Zhiyuan TONG Jie JIN Xiuchan WANG Ruie(Applied Acoustics Institute Shaanxi Normal University, Xi’ an 710062)ZHANG Xiaomin WANG Haiyan XIANG Jinglin(Northwestern Polylechnical Uaiversity. Xi’ an 71 | 1995 | Chinese Journal of Acoustics1995，14，3： | 3 |
| 17 | 茂金属催化剂催化苯乙烯间规聚合 Ⅰ.Cp Ti(CH_2SiMe_3)_3/B(C_6F_5)_3催化体系显示文摘考察了新型催化剂Cp*Ti(CH2SiMe3)3/B(C6F5)3催化苯乙烯间规聚合的性能.结果表明,Cp*Ti(CH2SiMe3)3与B(C6F5)3等摩尔混合可形成高活性的催化剂,催化活性高达(0.7~1.37)×107g/(mol2·h),聚苯乙烯的间规度为95%以上.B(C6F5)3/Ti摩尔比不等于1时,其催化活性和间规立构选择性都明显降低.Al(i-Bu)3的加入不仅显著提高催化活性和间规立构选择性,而且还提高了间规聚苯乙烯的相对分子量.最佳聚合温度为343K.在c(St)=0.44~6.56mol/L范围内,苯乙烯聚合速率对苯乙烯单体呈一级反应,苯乙烯转化率和间规聚苯乙烯的相对分子量随反应时间的增加而提高. | Xu Guangxue, Liu Shuiping, Lin Shang′an(Institute of Polymer Science, Zhongshan University, Guangzhou 510275) | 1998 | 催化学报1998，19，3： | 3 |
| 18 | Synthesis, Characterization and Thermal Decomposition Mechanism of Cetyltrimethyl Ammonium Tetrathiotungstate显示文摘合成,描述和 cetyltrimethyl 铵 tetrathiotungstate (CTriMATT ) 的热解机制此处被学习。同样综合的 CTriMATT 被元素的分析描绘, X 射线衍射(XRD ) , Fourier 变换红外线(英尺红外) ,紫外可见(紫外力) 系列。结果证明同样综合的 CTriMATT 有高纯净和好 crystallinity。烷基组的介绍导致了 W-S 债券的拉长的颤动乐队的移动降低波数,当它没在 WS 的位置上有影响时(2 ?) 。Thermogravimetric 分析(TG ) ,差热分析(DTA ) 并且在揭示的 situ XRD 描述,那 CTriMATT 开始在氮在 423 点分解 K 并且最后被变换成 WS2。另外,在在氮的 673 K 的 CTriMATT 的分解产物被 N2 吸附(赌注) 和扫描电子显微检查法(SEM ) 描绘。结果证明有更高的比表面积的 WS2,和毛孔体积能在氮从 CTriMATT 的热解被获得。给词调音:Cetyltrimethyl 铵 tetrathiotungstate;合成;描述;热解;机制; | Gaojun An Yunqi Liu Yongming Chai Hongyan Shang Chenguang Liu | 2006 | Journal of Natural Gas Chemistry2006，15，2： | 3 |
| 19 | A Study of Schemes for Internet Data Transmission Based on CATV Networks显示文摘In this paper, an idea of transmitting of the Internet data is presented. The methods, which could transmit the data on the CATV network, are discussed at the same time. | SHANG Feng, NIE Min (Telecommunication Department of Xi’an Institute of Posts and Telecommunications, Xi’an 710061, P.R. China) | 2001 | The Journal of China Universities of Posts and Telecommunications2001，8，4： | 3 |
| 20 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
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