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| 1 | Modulating effects of acyl-CoA synthetase 5-derived mitochondrial Wnt2B palmitoylation on intestinal Wnt activity显示文摘AIM:To investigate the role of acyl-CoA synthetase 5(ACSL5)activity in Wnt signaling in intestinal surface epithelia.METHODS:Several cell lines were used to investigate the ACSL5-dependent expression and synthesis of Wnt2B,a mitochondrially expressed protein of the Wnt signaling family.Wnt activity was functionally assessed with a luciferase reporter assay.ACSL5-related biochemical Wnt2B modifications were investigatedwith a modified acyl-exchange assay.The findings from the cell culture models were verified using an Apcmin/+mouse model as well as normal and neoplastic diseased human intestinal tissues.RESULTS:In the presence of ACSL5,Wnt2B was unable to translocate into the nucleus and was enriched in mitochondria,which was paralleled by a significant decrease in Wnt activity.ACSL5-dependent S-palmitoylation of Wnt2B was identified as a molecular reason for mitochondrial Wnt2B accumulation.In cell culture systems,a strong relation of ACSL5 expression,Wnt2B palmitoylation,and degree of malignancy were found.Using normal mucosa,the association of ACSL5 and Wnt2B was seen,but in intestinal neoplasias the mechanism was only rudimentarily observed.CONCLUSION:ACSL5 mediates antiproliferative activities via Wnt2B palmitoylation with diminished Wnt activity.The molecular pathway is probably relevant for intestinal homeostasis,overwhelmed by other pathways in carcinogenesis. | Christina Klaus Ursula Schneider Christian Hedberg Anke K Schütz Jürgen Bernhagen Herbert Waldmann Nikolaus Gassler Elke Kaemmerer | 2014 | World Journal of Gastroenterology2014，20，40： | 4 |
| 2 | Truncating mutations in Peutz-Jeghers syndrome are associated with more polyps, surgical interventions and cancers显示文摘 | Heidi Salloch Anke Reinacher-Schick Karsten Schulmann Christian Pox J?rg Willert Andrea Tannapfel Stefan Heringlake Timm O. Goecke Stefan Aretz Susanne Stemmler Wolff Schmiegel | 2010 | International Journal of Colorectal Disease2010，，1： | 2 |
| 3 | Growth behaviour of a spore forming probiotic strain in the gastrointestinal tract of broilers chicken and piglets显示文摘 | Anke J W Vanien 0 Simon | 2001 | Architech Animal Nutrition2001，，54： | 1 |
| 4 | A review of CETP and its rela- tion to atherosclerosis 显示文摘 | Greetje J Anke H Erik S | 2004 | J Lipid Res2004，45，11： | 1 |
| 5 | Hemodynamic assessment of acute stroke using dynamic single-slice computed tomographic perfusion imaging显示文摘 | Joachim R Lars J Anke F | 2000 | Arch Neurol2000，57，： | 1 |
| 6 | In vivo high-resolution magnetic resonance elastography of the uterine corpus and cervix显示文摘 | Xuyuan Jiang Patrick Asbach Kaspar-Josche Streitberger Anke Thomas Bernd Hamm Jürgen Braun Ingolf Sack Jing Guo | 2014 | European Radiology2014，，： | 1 |
| 7 | Procyanidins from Myrothamnus flabellifolia 显示文摘 | Anke J Petereit F Engelhardt C | 2008 | Nat Prod Res2008，22，14： | 1 |
| 8 | A novel oxidative cleavage of the steroidal skeleton 显示文摘 | Rolf J Anke M F Ekkehard W | 1999 | Chem Eur J1999，5，： | 1 |
| 9 | Ternperature effects on the radiation response of MOS devices显示文摘 | Schw ank J R Sexton F W Fleetwood D M | 1988 | IEEE T rans N ucl Sci1988，35，6： | 1 |
| 10 | Type Ⅲ interferon (IFN) induces a type Ⅰ IFN-Like response in a restricted subset of cells through signaling pathways Involving both the Jak-STAT pathway and the mito- gen-activated protein kinases 显示文摘 | Zhou Z Hamming O J Ank N | 2007 | J Virol2007，81，14： | 1 |
| 11 | Effects of irradiation temperature on MOS radiation response显示文摘 | Shaneyfelt M R Schw ank J R Fleetwood D M | 1998 | IEEE T rans N ud Sci1998，45，3： | 1 |
| 12 | Expression of type Ⅲ IFN in the vaginal mucosa is mediated primarily by DCs and displays stronger dependence on NF-κB than type Ⅰ IFNs显示文摘 | Iversen MB Ank N Melchjorsen J | 2010 | J Virol2010，84，9： | 1 |
| 13 | Selection, Characterization and X-ray Structure of Anti-ampicillin Single-chain Fv Fragments from Phage-displayed Murine Antibody Libraries显示文摘 | J?rg Burmester Silvia Spinelli Luisa Pugliese Anke Krebber Annemarie Honegger Sabine Jung Bernhard Schimmele Christian Cambillau Andreas Plückthun | 2001 | Journal of Molecular Biology2001，，3： | 1 |
| 14 | Chemical-induced apoptotoc cell death in tomato cells:involvement of caspase-like proteases显示文摘 | ANKE J De JONG FRANK A H | 2000 | Planta2000，211，： | 1 |
| 15 | Characterzation of chitinases able to rescue somatic embryos of the temperature-sensitive carrot variantts11显示文摘 | Kragh Karsten M Hendriks Theo de Jong Anke J | | 0，，03： | 1 |
| 16 | Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis 显示文摘 | Jens-Michael J Regina FH Anke B | 2004 | J Invest Dermato12004，122，6： | 1 |
| 17 | Effect of interleukin (IL) - 12 and IL--15 on activated natural killer(ANK) and antibody -de- pendent cellular cytotoxicity ( ADCC ) in HIV infection 显示文摘 | Lin S J Roberts R L Ank B J | 1998 | J Clin lmmunol1998，18，5： | 1 |
| 18 | Antibiotics from basidiomycetes显示文摘 | Kupka J Anke T Giannetti B M | 1951 | Arch Microbiol1951，130，3： | 1 |
| 19 | Expression oftype III 1FN in the vaginal mucosa is mediated primarily byDCs and displays stronger dependence on NF-kB than type IIFNs显示文摘 | Iversen MB Ank N Melchjorsen J | 2010 | J Virol2010，84，： | 1 |
| 20 | Chemical - induced apoptotic cell death in tomato cells: involvement of caspase-like proteases显示文摘 | Anke J J Frank A H Elena T Y | | 0，，： | 1 |
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