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| 1 | Outcome in obscure gastrointestinal bleeding after capsule endoscopy显示文摘AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions. | Alex Caas-Ventura Lucia Márque Xavier Bessa Josep Maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 4 |
| 2 | Management of hepatitis C in patients with chronic kidney disease显示文摘Hepatitis C virus(HCV) infection is highly prevalent among chronic kidney disease(CKD) subjects under hemodialysis and in kidney transplantation(KT) recipients, being an important cause of morbidity and mortality in these patients. The vast majority of HCV chronic infections in the hemodialysis setting are currently attributable to nosocomial transmission. Acute and chronic hepatitis C exhibits distinct clinical and laboratorial features, which can impact on managementand treatment decisions. In hemodialysis subjects, acute infections are usually asymptomatic and anicteric; since spontaneous viral clearance is very uncommon in this context, acute infections should be treated as soon as possible. In KT recipients, the occurrence of acute hepatitis C can have a more severe course, with a rapid progression of liver fibrosis. In these patients, it is recommended to use pegylated interferon(PEG-IFN) in combination with ribavirin, with doses adjusted according to estimated glomerular filtration rate. There is no evidence suggesting that chronic hepatitis C exhibits a more aggressive course in CKD subjects under conservative management. In these subjects, indication of treatment with PEG-IFN plus ribavirin relies on the CKD stage, rate of progression of renal dysfunction and the possibility of a preemptive transplant. HCV infection has been associated with both liver disease-related deaths and cardiovascular mortality in hemodialysis patients. Among those individuals, low HCV viral loads and the phenomenon of intermittent HCV viremia are often observed, and sequential HCV RNA monitoring is needed. Despite the poor tolerability and suboptimal efficacy of antiviral therapy in CKD patients, many patients can achieve sustained virological response, which improve patient and graft outcomes. Hepatitis C eradication before KT theoretically improves survival and reduces the occurrence of chronic graft nephropathy, de novo glomerulonephritis and post-transplant diabetes mellitus. | Roberto J Carvalho-Filho Ana Cristina CA Feldner Antonio Eduardo B Silva Maria Lucia G Ferraz | 2015 | World Journal of Gastroenterology2015，21，2： | 4 |
| 3 | High aluminum concentration and initial establishment of Handroanthus impetiginosus : clues about an Al non-resistant species in Brazilian Cerrado显示文摘Cerrado soils are acidic and nutrient-poor,with high content of solubilized Al 3+.Plants growing in these conditions may display adaptations to cope with high aluminum concentrations especially during early developmental stages.We investigated leaf nutritional status,and photosynthetic and growth characteristics during the initial establishment of Handroanthus impetiginosus(Mart.Ex Dc.)Mattos,a secondary tree species distributed in the Brazilian Cerrado.Our goal was to understand leaf-level traits related to diff erent aluminum concentrations.H.impetiginosus plants were cultivated in four diff erent aluminum sulfate concentrations:0,1,2,and 4 mM Al,for 40 days.We performed analyses of growth,leaf gas exchange,chloroplast pigment content,and leaf mineral nutrients.We observed a linear increase of Al leaf content as a function of Al concentration in the nutrient solution.Plants grown in 1 mM Al showed a remarkable increase of K leaf content,net photosynthesis,stomatal conductance,and transpiration,while in 4 mM Al there were reductions of N,P,and K contents,gas exchange characteristics,and height.H.impetiginosus did not have mechanisms of avoidance,compartmentalization,or resistance to high Al concentrations.Indeed,this species showed a hormetic response,with low Al concentrations stimulating and high Al concentrations inhibiting plant responses. | Ane Marcela das Chagas Mendon ca Jean Marcel Sousa Lira Ana Luiza de Oliveira Vilela Daniel Amorim Vieira Nayara Cristina de Melo Joao Paulo Rodrigues Alves Delfi no Barbosa | 2020 | Journal of Forestry Research2020，31，6： | 1 |
| 4 | Clinical e- valuation of the effects of low-intensity laser (GaA1As) on wound healing after gingivoplasty in humans显示文摘 | DDamante CA Greghi SL Sant'Ana AC | 2004 | J Appl Oral Sci2004，12，2： | 1 |
| 5 | Effect of changing intestinal flow rate on a measurement of intestinal perme- ability显示文摘 | FINE K D SANTA ANA CA PORTER J L | 1995 | Gastroenterology1995，108，4： | 1 |
| 6 | Development of a lavage solution associated with minimal water and electrolyte absorption or secretion显示文摘 | Davis GR Santa Ana CA Morawski SG Fordtran JS | 1980 | Gastroenterology1980，78，51： | 1 |
| 7 | Osmotic effects of polyethylene glycol显示文摘 | Emmett M Santa Ana CA | 1988 | Gastroenterology1988，94，： | 1 |
| 8 | Steatosis recovery after treatment with a balanced sunflower or olive oil-based diet: Involvement of perisinusoidal stellate cells显示文摘AIM: To analyze the relationship between perisinusoidal stellate cell (PSC) activation and the dietary fat quantity and composition in the treatment of hepatic steatosis.METHODS: Using an experimental rat model of steatosis based on the intake of a hyperlipidic diet (14% fat as olive oil or sunflower oil, HL-O and HL-S, respectively), we analyzed the liver's capability of recovery after the treatment with a normal-lipidic diet (5% fat as olive oil or sunflower oil, NL-O and NL-S, respectively) by immunocytochemical and Western blot analysis of glial fibrillary acidic protein (GFAP) expression in PSCs, collagen quantification and serum aminotransferase determination.RESULTS: The fatty infiltration in the steatotic livers decreased after the treatment with both NL diets, indicating liver recovery. This decrease was accompanied with a lower collagen deposition and aminotransferase level as well as changes in the PSC population that increased the GFAP expression. The above-mentioned effects were more pronounced in animals fed on NL-O based diet. CONCLUSION: Treatment with a balanced dietenriched in olive oil contributes to the liver recovery from a stea totic process. The PSC phenotype is a marker of this hepatic-recovery model. | Raquel Hernández Esther Martínez-Lara Ana Cauelo Ma Luisa del Moral Santos Blanco Eva Siles Ana Jiménez Juan ngel Pedrosa Ma ngeles Peinado | 2005 | World Journal of Gastroenterology2005，11，47： | 1 |
| 9 | Turning on the microscope turret: a new view for the study of brassinosteroid signaling in plant development显示文摘 | Norma Fàbregas Ana I. Ca?o‐Delgado | 2014 | Physiol Plantarum2014，，2： | 1 |
| 10 | Gastrointestinal absorption of calcium from milk and calcium salts显示文摘 | Sheikh MS Santa Ana CA Niear MJ | 1987 | New Engl J Med1987，317，9： | 1 |
| 11 | Osmotic effects of polyethylene glycol 显示文摘 | Scheller LR Emmett M Santa Ana CA | 1998 | Gastroenterology1998，94，： | 1 |
| 12 | Develop-ment of a lavage solution associated with minimal water and electrolyte ab- sorption or secretion 显示文摘 | Divas GR santa Ana CA Marawski SG | 1980 | Gastroenter-ology1980，78，51： | 1 |
| 13 | Increased ALK Gene Copy Number and Amplification are Frequent in Non-small Cell Lung Cancer显示文摘 | Marta Salido Lara Pijuan Luz Martínez-Avilés Ana B. Galván Israel Ca?adas Ana Rovira Montserrat Zanui Alejandro Martínez Raquel Longarón Francisco Sole Sergio Serrano Beatriz Bellosillo Murry W. Wynes Joan Albanell Fred R. Hirsch Edurne Arriola | 2011 | Journal of Thoracic Oncology2011，，1： | 1 |
| 14 | Oxidative stress parameters in unmediated and treated bipolar subjects during initial manic episode:A possible role for lithium antioxidant effects显示文摘 | Rodrigo MV Ana CA Carlos IV | 2007 | Neurosci Lett2007，421，1： | 1 |
| 15 | Development of a layage solution associated with minimal water and electrolyte absorption or secretion显示文摘 | Santa Ana CA Morawski SG | 1980 | Gastroenterology1980，78，51： | 1 |
| 16 | Development of a lavage solution associated with minimal water and electrolyte absorption or secretion 显示文摘 | Davis GR Santa Ana CA Morawski SG | 1980 | Gastroenterology1980，78，51： | 1 |
| 17 | Composition of the Essential Oils of Ocimum canum, O. gratissimum and O. minimum显示文摘 | Ana Martins Lígia Salgueiro Roser Vila Félix Tomi Salvador Ca?igueral Joseph Casanova António da Cunha Tomás Adzet | 1999 | Planta Med1999，，02： | 1 |
| 18 | Histomorphometricstudy of the healing of human oral mueosa after gingivoplasty and low-level laser therapy 显示文摘 | Damante CA Greghi SL Sant~Ana AC | 2004 | Lasers Surg Med2004，35，5： | 1 |
| 19 | Development of a lavage solution associated with minimal water and electrolyte absorption or secretion显示文摘 | Davis GR Santa Ana CA Morawski SG | 1980 | Gastroenterology1980，78，51： | 1 |
| 20 | Development of a lavage solution associated with minimal water and electrolyte absorption or secretion显示文摘 | Davis GR Santa Ana CA Morawski SG | 1980 | Gastroenterology1980，78，51： | 1 |
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