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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 3 | Application of purge and trap extraction and gas chromatography for determination of minor esters in cider显示文摘 | ROBERTO R M NOEM P G ANA G H | 2005 | Journal of chromatography A2005，1069，2： | 1 |
| 4 | Thidiazuron promotes in vitro plant regeneration of Arachis correntina (Leguminosae) via organogenesis显示文摘 | Erika M HebeY R Ana M G | 2004 | Journal of Plant Growth Regulation2004，23，2： | 1 |
| 5 | Structural and optical properties of polypropylene-montmorillonite nanocomposites显示文摘 | Lucilene B P Ana T M Thiago R G | 2007 | Materials Science and Engineering A2007，447，12： | 1 |
| 6 | Kinetic characterization of secretory transport of a new ciprofloxacin derivative ( CNV97100 ) across Caco-2 cell monolayers显示文摘 | Ana R G Lin H M Hu M | 2002 | Pharm Sci2002，91，12： | 1 |
| 7 | Density, heat capacity and thermal conductivity of liquid egg products 显示文摘 | Jane s R Coimbra Ana L G Luis A M | 2006 | Joumal of Food Engineering2006，74，： | 1 |
| 8 | Toxicity ofcadmium in Japanese quail:evaluation of body weight,hepatic and renal function,and cellular immune re-sponse显示文摘 | Sant'Ana M G Moraes R Bernardi M M | 2005 | Environ Res2005，99，2： | 1 |
| 9 | Segmenting wine consumers according to their involvement with appellations of origin 显示文摘 | Carmen R S Miguel C B Ana G F | 2006 | Journal of Brand Management2006，13，45： | 1 |
| 10 | Arabidopsis and tobacco plants ectopically expressing the soybean antiquitin-like ALDH7 gene display enhanced tolerance to drought,salinity,and oxidative stress显示文摘 | Simone M R Maxuel O A Ana P S G Fabio M D Maria C B P Elizabeth P B F | | 0，，： | 1 |
| 11 | Trypsin from viscera of vermiculated sailfin catfish, Pterygoplichthys disjunctivus, Weber, 1991:Its purification and characterization显示文摘 | Ana G V Juan C R Elisa M V | 2013 | Food Chem2013，141，2： | 1 |
| 12 | Thermal protection of β-carotene in re- assembled casein micelles during different processing technologies applied in food industry 显示文摘 | Maria S Carolina G F Ana M R | 2013 | Food Chemistry2013，138，： | 1 |
| 13 | An improved flow injection system for spectrophotometric determination of molybdenum and tungsten in tool steels显示文摘 | Ana P G Gervasio I Paula R Fortes Silvia R P Meneses | 2006 | Talanta2006，69，： | 1 |
| 14 | Effects of soybean Kunitz trypsin inhibitor on the cotton boll weevil (Anthonomus grandis)显示文摘 | FRANCOA O L DIASB S C MAGALHA_ESD C P MONTEIROA ANA C S JR C B MELOE F R OLIVEIRA-NETOA O B MONNERATA R G GROSSI-DE-SA M F | 2004 | Phytochernistry2004，65，1： | 1 |
| 15 | Volatile composition,emission pattern,and localization of floral scent emission in Mirabilis jalapa(Nyctaginaceae)显示文摘 | UTA E J ANA G URSULAS R R | 2005 | American Journal of Botany2005，92，1： | 1 |
| 16 | Energy efficiency in the European union: what can be learned from the joint application of directional distance functions and slacks-based measures? 显示文摘 | ROBERTO G DAVID C ANA R G | 2014 | Applied Energy2014，132，： | 1 |
| 17 | Structure,atomistic simulations,and phase transition of stoichiometric yeelimite显示文摘 | Ana C Angeles G D T Enrique R L | 2013 | Chemistry of Materials2013，25，9： | 1 |
| 18 | Interactions of Acetobacter diazotrophicus with an amylolytie yeast in nitrogen-free batch culture显示文摘 | ENIO H C VERONICA M R ANA C G S JOHANNA D | 1993 | FEMS Microbiol Leters1993，106，： | 1 |
| 19 | The yeast HAL1 gene improves salt tolerance of transgenic tomatol 显示文摘 | Carmina G Ana M R Carmen M B | 2000 | Plant Physiology2000，123，1： | 1 |
| 20 | Disappearance of azoxystrobin,pyrimethanil, cyprodinil, and fludioxonil on tomatoes in a greenhouse显示文摘 | VINCENZO L G ALBERTO A ANA A D R I | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
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