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| 1 | Recent development on synthetic biological devices treating bladder cancer显示文摘Synthetic biology is an emerging field focusing on engineering genetic devices and biomolecular systems for a variety of applications from basic biology to biotechnology and medicine.Thanks to the tremendous advances in genomics and the chemical synthesis of DNA in the past decade,scientists are now able to engineer genetic devices and circuits for cancer research and intervention,which offer promising therapeutic strategies for cancer treatment.In this article,we provide a systemic review on recent development achieved by the synthetic biologists,oncologists and clinicians of one National“973”Plan.We expand the synthetic biology toolkits involving DNA,RNA and protein bio-parts to explore various issues in cancer research,such as elucidation of mechanisms and pathways,creation of new diagnostic tools and invention of novel therapeutic approaches.We claimed that the Chinese synthetic biologists are promoting the basic research productions of tumor synthetic biology into the clinic. | Zhicong Chen Anbang He Yuchen Liu Weiren Huang Zhiming Cai | 2016 | Synthetic and Systems Biotechnology2016，1，4： | 4 |
| 2 | Adult-repopulating lymphoid potential of yolk sac blood vessels is not confined to arterial endothelial cells显示文摘During embryogenesis,hematopoietic stem progenitor cells(HSPCs)are believed to be derived from hemogenic endothelial cells(HECs).Moreover,arterial feature is proposed to be a prerequisite for HECs to generate HSPCs with lymphoid potential.Although the molecular basis of hematopoietic stem cell-competent HECs has been delicately elucidated within the embryo proper,the functional and molecular characteristics of HECs in the extraembryonic yolk sac(YS)remain largely unresolved.In this study,we initially identified six molecularly different endothelial populations in the midgestational YS through integrated analysis of several single-cell RNA sequencing(scRNA-seq)datasets and validated the arterial vasculature distribution of Gja5+ECs using a Gja5-EGFP reporter mouse model.Further,we explored the hemogenic potential of different EC populations based on their Gja5-EGFP and CD44 expression levels.The hemogenic potential was ubiquitously detected in spatiotemporally different vascular beds on embryonic days(E)8.5–E9.5 and gradually concentrated in CD44-positive ECs from E10.0.Unexpectedly,B-lymphoid potential was detected in the YS ECs as early as E8.5 regardless of their arterial features.Furthermore,the capacity for generating hematopoietic progenitors with in vivo lymphoid potential was found in nonarterial as well as arterial YS ECs on E10.0–E10.5.Importantly,the distinct identities of E10.0–E10.5 HECs between YS and intraembryonic caudal region were revealed by further scRNA-seq analysis.Cumulatively,these findings extend our knowledge regarding the hemogenic potential of ECs from anatomically and molecularly different vascular beds,providing a theoretical basis for better understanding the sources of HSPCs during mammalian development. | Chaojie Wang Yandong Gong Anbang Wei Tao Huang Siyuan Hou Junjie Du Zongcheng Li Junliang Wang Bing Liu Yu Lan | 2021 | Science China(Life Sciences)2021，64，12： | 3 |
| 3 | ECO-ENVIRONMENT REHABILITATION AND ECONOMIC DEVELOPMENT OF THE MIDDLE REACHES OF THE YARLUNG ZANGBO RIVER FOR WEST DEVELOPMENT | Liu Shuzhen, Wen Anbang, Fan Jianrong, Zhou Lin and Zhu Pingyi (Chengdu Institute of Mountain Hazards and Environment, Chinese Academy of Sciences & Ministry of Water Resources, PRC, Chengdu 610041, China) | 2002 | Natural Disaster Reduction in China2002，，1： | 1 |
| 4 | P4S10 modified lithium anode for enhanced performance of lithium–sulfur batteries显示文摘To address the corrosion and dendrite issues of lithium metal anodes, a protective layer was ex-situ constructed by P4S10 modification. It was determined by X-ray photoelectron spectroscopy and Raman spectra that the main constituents of the protective layer were P4S10, Li3PS4 and other LixPySztype derivatives. The protective layer was proved to be effective to stabilize the interphase of lithium metal. With the modified Li anodes, symmetric cells could deliver stable Li plating/stripping for 16000 h;Li–S batteries exhibited a specific capacity of 520 m A h g-1 after 200 cycles at 1000 m A g-1 with average Coulombic efficiency of 97.9%. Therefore, introducing LixPySzbased layer to protect Li anode provides a new strategy for the improvement of Li metal batteries. | Meng Li Xiaojun Liu Qian Li Zhaoqing Jin Weikun Wang Anbang Wang Yaqin Huang Yusheng Yang | 2020 | Journal of Energy Chemistry2020，29，2： | 1 |
| 5 | A naked-eye colorimetric sensor for chloroform显示文摘A phenoxazine based molecule termed SP has been synthesized and used as selective sensor for halogenated solvents. This molecule shows selective fast response towards halogenated solvent via naked-eye detectable chromism. SP shows colorless solution when dissolved in most solvents initially but changes to blue color in chloroform under UV irradiation(λ = 365 nm) within 5 s. The luminescence spectra of SP in halogenated solvent show a large bathochromic shift(> 100 nm) with 60-fold enhanced emission intensity compared to that in halogen-free solvents. It is also worth mentioning that the photoinduced reaction between SP molecule and the halogenated solvents occurred. Based on the detailed NMR, fluorescence and mass spectra, the possible radical reaction mechanism was proposed.Different from the majority of solvatochromic sensors that based on the polarity of solvents for detection of halogenated solvents, our sensor system worked in a special | Kai Sheng Haifeng Lu Anbang Sun Yanmin Wang Yuantao Liu Feng Chen Wenchao Bian Yang Li Rui Kuang Di Sun | 2019 | Chinese Chemical Letters2019，30，4： | 0 |
| 6 | Advances and outlook of TE-PCM system:a review显示文摘This review reports the most recent developments of thermoelectric(TE)system coupled with phase change material(PCM)and its promising integration options within various PCM deployment and structure design.These innovative TE coupled with PCM(TE-PCM)systems provide heat/cold energy with additional electric power which implies better harnessing of multiform energy.Fundamentals of TE-PCM system including thermoelectric effect are presented along with a basic mathematical formulation of the physical problem.The classification principles and configuration types of such systems are also summarized.The most representative studies related to the utilization of TE-PCM system in diversified application scenarios and their compatibility with other energy systems have been comprehensively reviewed and analyzed,including the component and structure optimization.In-depth analysis of the main technical and operational challenges in the future has been carried out,and the prospective development of more efficient TEPCM system and its hybrid configurations are projected based on the current technological level. | Anbang Liu Huaqing Xie Zihua Wu Yuanyuan Wang | 2022 | Carbon Neutrality2022，1，1： | 0 |
| 7 | Definition and verification of novel metastasis and recurrence related signatures of ccRCC: A multicohort study显示文摘Background:Cancer metastasis and recurrence remain major challenges in renal carcinoma patient management.There are limited biomarkers to predict the metastatic probability of renal cancer,especially in the early-stage subgroup.Here,our study applied robust machine-learning algorithms to identify metastatic and recurrence-related signatures across multiple renal cancer cohorts,which reached high accuracy in both training and testing cohorts.Methods:Clear cell renal cell carcinoma(ccRCC)patients with primary or metastatic site sequencing information from eight cohorts,including one outhouse cohort,were enrolled in this study.Three robust machine-learning algorithms were applied to identify metastatic signatures.Then,two distinct metastatic-related subtypes were identified and verified;matrix remodeling associated 5(MXRA5),as a promising diagnostic and therapeutic target,was investigated in vivo and in vitro.Results:We identified five stable metastasis-related signatures(renin,integrin subunit beta-like 1,MXRA5,mesenchyme homeobox 2,and anoctamin 3)from multicenter cohorts.Additionally,we verified the specificity and sensibility of these signatures in external and out-house cohorts,which displayed a satisfactory consistency.According to these metastatic signatures,patients were grouped into two distinct and heterogeneous ccRCC subtypes named metastatic cancer subtype 1(MTCS1)and type 2(MTCS2).MTCS2 exhibited poorer clinical outcomes and metastatic tendencies than MTCS1.In addition,MTCS2 showed higher immune cell infiltration and immune signature expression but a lower response rate to immune blockade therapy than MTCS1.The MTCS2 subgroup was more sensitive to saracatinib,sunitinib,and several molecular targeted drugs.In addition,MTCS2 displayed a higher genome mutation burden and instability.Furthermore,we constructed a prognosis model based on subtype biomarkers,which performed well in training and validation cohorts.Finally,MXRA5,as a promising biomarker,significantly suppressed malignant ability,including the cell migration and proliferation of ccRCC cell lines in vitro and in vivo.Conclusions:This study identified five robust metastatic signatures and proposed two metastatic probability clusters with stratified prognoses,multiomics landscapes,and treatment options.The current work not only provided new insight into the heterogeneity of renal cancer but also shed light on optimizing decision‐making in immunotherapy and chemotherapy. | Aimin Jiang Qingyang Pang Xinxin Gan Anbang Wang Zhenjie Wu Bing Liu Peng Luo Le Qu Linhui Wang | 2022 | Cancer Innovation2022，1，2： | 0 |
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