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| 1 | Expression of Interleukin-26 is upregulated in inflammatory bowel disease显示文摘AIM To investigate interleukin(IL)-26 expression in the inflamed mucosa of patients with inflammatory bowel disease(IBD) and the function of IL-26. METHODS Human colonic subepithelial myofibroblasts(SEMFs) were isolated from colon tissue surgically resected. The expression of IL-26 protein and its receptor complex was analyzed by immunohistochemistry. The gene expression induced by IL-26 was evaluated by realtime polymerase chain reaction. Intracellular signaling pathways were evaluated by immunoblotting and specific small interfering(si) RNA transfection. RESULTS The m RNA and protein expression of IL-26 were significantly enhanced in the inflamed mucosa of patients with IBD. IL-26 receptor complex was expressed in colonic SEMFs in vivo and in vitro. IL-26 stimulated the m RNA expression of IL-6 and IL-8 in colonic SEMFs. The inhibitors of mitogen-activated protein kinases and phosphoinositide 3-kinase, and si RNAs for signal transducers and activator of transcription 1/3, nuclear factor-kappa B and activator protein-1 significantly reduced the m RNA expression of IL-6 and IL-8 induced by IL-26.CONCLUSION These results suggest that IL-26 plays a role in the pathophysiology of IBD through induction of inflammatory mediators. | Makoto Fujii Atsushi Nishida Hirotsugu Imaeda Masashi Ohno Kyohei Nishino Shigeki Sakai Osamu Inatomi Shigeki Bamba Masahiro Kawahara Tomoharu Shimizu Akira Andoh | 2017 | World Journal of Gastroenterology2017，23，30： | 8 |
| 2 | Cap polyposis refractory to Helicobacter pylori eradication treated with endoscopic submucosal dissection显示文摘Cap polyposis is a rare intestinal disorder. Characteristic endoscopic findings are multiple inflammatory polypoid lesions covered by caps of fibrous purulent exudate. Although a specific treatment has not been established, some studies have suggested that eradication therapy for Helicobacter pylori(H. pylori) is effective. We report a case of a 20-year-old man with cap polyposis presenting with hematochezia. Colonoscopy showed the erythematous polyps with white caps from the sigmoid colon to rectum. Histopathological findings revealed elongated, tortuous, branched crypts lined by hyperplastic epithelium with a mild degree of fibromusculosis in the lamina propria. Although H. pylori eradication was instituted, there was no improvement over six months. We then performed en bloc excision of the polyps by endoscopic submucosal dissection(ESD), which resulted in complete resolution of symptoms. ESD may be a treatment option for cap polyposis refractory to conservative treatments. We review the literature concerning treatment for cap polyposis and clinical outcomes. | Masaki Murata Mitsushige Sugimoto Hiromitsu Ban Taketo Otsuka Toshiro Nakata Masahide Fukuda Osamu Inatomi Shigeki Bamba Ryoji Kushima Akira Andoh | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，10： | 5 |
| 3 | Usefulness of the clip-flap method of endoscopic submucosal dissection: A randomized controlled trial显示文摘AIM To prospectively investigate the efficacy and safety of clipflap assisted endoscopic submucosal dissection(ESD) for gastric tumors.METHODS From May 2015 to October 2016, we enrolled 104 patients with gastric cancer or adenoma scheduled for ESD at Shiga University of Medical Science Hospital. We randomized patients into two subgroups using the minimization method based on location of the tumor(upper, middle or lower third of the stomach), tumor size(< 20 mm or > 20 mm) and ulcer status: ESD using an endoclip(the clip-flap group) and ESD without an endoclip(the conventional group). Therapeutic efficacy(procedure time) and safety(complication: Gastrointestinal bleeding and perforation) were assessed. RESULTS En bloc resection was performed in all patients. Four patients had delayed bleeding(3.8%) and two had perforation(1.9%). No significant differences in en bloc resection rate(conventional group: 100%, clip flap group: 100%), curative endoscopic resection rate(conventional group: 90.9%, clip flap group: 89.8%, P = 0.85), procedure time(conventional group: 70.8 ± 46.2 min, clip flap group: 74.7 ± 53.3 min, P = 0.69), area of resected specimen(conventional group: 884.6 ± 792.1 mm^2, clip flap group: 1006.4 ± 1004.8 mm^2, P = 0.49), delayed bleeding rate(conventional group: 5.5%, clip flap group: 2.0%, P = 0.49), or perforation rate(conventional group: 1.8%, clip flap group: 2.0%, P = 0.93) were found between the two groups. Lessexperienced endoscopists did not show any differences in procedure time between the two groups.CONCLUSION For patients with early-stage gastric tumors, the clipflap method has no advantage in efficacy or safety compared with the conventional method. | Hiromitsu Ban Mitsushige Sugimoto Taketo Otsuka Masaki Murata Toshiro Nakata Hiroshi Hasegawa Osamu Inatomi Shigeki Bamba Akira Andoh | 2018 | World Journal of Gastroenterology2018，24，35： | 4 |
| 4 | Efficacy of additional treatment with azathioprine in a patient with prednisolone-dependent gastric sarcoidosis显示文摘Gastric sarcoidosis with noncaseating granuloma is rare. Although corticosteroid produces a dramatic clinical response, it is unknown whether azathioprine show efficacy in prednisolone-dependent cases. Here, we report a case of gastric sarcoidosis in a 25-year-old man with severe epigastlargia. Gastroendoscopy revealed multiple map-like ulcerations. Histological examination showed multiple noncaseating granulomatous lesions in gastric mucosa, which were incompatible with diagnoses of Crohn's disease or tuberculosis. He was started on prednisolone at 30 mg/d, and his symptoms improved within 7-d. The prednisolone was gradually tapered by 5 mg every 2-wk, but oral azathioprine at 50 mg was added after symptoms recurred at tapered dose of 10 mg. Endoscopy 4-wk later showed healing ulcers, and, lymphocytic infiltration was absent. The efficacy of additional azathioprine in gastric sarcoidosis is not well defined. Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases. | Masaki Murata Mitsushige Sugimoto Yoshihiro Yokota Hiromitsu Ban Osamu Inatomi Shigeki Bamba Ryoji Kushima Akira Andoh | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 5 | Epithelial expression of interleukin‐37b in inflammatory bowel disease显示文摘 | H. Imaeda K. Takahashi T. Fujimoto E. Kasumi H. Ban S. Bamba H. Sonoda T. Shimizu Y. Fujiyama A. Andoh | 2013 | Clin Exp Immunol2013，，3： | 2 |
| 6 | Surveillance and treatment for second primary cancer in the gastric tube after radical esophagectomy显示文摘 | Takeo Bamba Shin-ichi Kosugi Manabu Takeuchi Masaaki Kobayashi Tatsuo Kanda Atsushi Matsuki Katsuyoshi Hatakeyama | 2010 | Surgical Endoscopy2010，，6： | 2 |
| 7 | Application of novel magnified single balloon enteroscopy for a patient with Cronkhite-Canada syndrome显示文摘We present a case of Cronkhite-Canada syndrome(CCS) in which the entire intestine was observed using a prototype of magnifying single-balloon enteroscope(SIF Y-0007, Olympus). CCS is a rare, non-familial gastrointestinal polyposis with ectodermal abnormalities. To our knowledge, this is the first report showing magnified intestinal lesions of CCS. A 73-year-old female visited our hospital with complaints of diarrhea and dysgeusia. The blood test showed mild anemia and hypoalbuminemia. The esophagogastroduodenoscopy and colonoscopy revealed diffuse and reddened sessile to semi-pedunculated polyps, resulting in the diagnosis of CCS. In addition to the findings of conventional balloon-assisted enteroscopy or capsule endoscopy, magnifying observation revealed tiny granular structures, non-uniformity of the villus, irregular caliber of the loop-like capillaries, scattered white spots in the villous tip, and patchy redness of the villus. Histologically, the scattered white spots and patchy redness of the villus reflect lymphangiectasia and bleeding to interstitium, respectively. | Masaki Murata Shigeki Bamba Kenichiro Takahashi Hirotsugu Imaeda Atsushi Nishida Osamu Inatomi Tomoyuki Tsujikawa Ryoji Kushima Mitsushige Sugimoto Akira Andoh | 2017 | World Journal of Gastroenterology2017，23，22： | 2 |
| 8 | Melatonin promotes cardiomyocyte proliferation and heart repair in mice with myocardial infarction via miR-143-3p/Yap/Ctnnd1 signaling pathway显示文摘The neonatal heart possesses the ability to proliferate and the capacity to regenerate after injury;however,the mechanisms underlying these processes are not fully understood.Melatonin has been shown to protect the heart against myocardial injury through mitigating oxidative stress,reducing apoptosis,inhibiting mitochondrial fission,etc.In this study,we investigated whether melatonin regulated cardiomyocyte proliferation and promoted cardiac repair in mice with myocardial infarction(MI),which was induced by ligation of the left anterior descending coronary artery.We showed that melatonin administration significantly improved the cardiac functions accompanied by markedly enhanced cardiomyocyte proliferation in MI mice.In neonatal mouse cardiomyocytes,treatment with melatonin(1μM)greatly suppressed miR-143-3p levels.Silencing of miR-143-3p stimulated cardiomyocytes to re-enter the cell cycle.On the contrary,overexpression of miR-143-3p inhibited the mitosis of cardiomyocytes and abrogated cardiomyocyte mitosis induced by exposure to melatonin.Moreover,Yap and Ctnnd1 were identified as the target genes of miR-143-3p.In cardiomyocytes,inhibition of miR-143-3p increased the protein expression of Yap and Ctnnd1.Melatonin treatment also enhanced Yap and Ctnnd1 protein levels.Furthermore,Yap siRNA and Ctnnd1 siRNA attenuated melatonin-induced cell cycle re-entry of cardiomyocytes.We showed that the effect of melatonin on cardiomyocyte proliferation and cardiac regeneration was impeded by the melatonin receptor inhibitor luzindole.Silencing miR-143-3p abrogated the inhibition of luzindole on cardiomyocyte proliferation.In addition,both MT1 and MT2 siRNA could cancel the beneficial effects of melatonin on cardiomyocyte proliferation.Collectively,the results suggest that melatonin induces cardiomyocyte proliferation and heart regeneration after MI by regulating the miR-143-3p/Yap/Ctnnd1 signaling pathway,providing a new therapeutic strategy for cardiac regeneration. | Wen-ya Ma Rui-jie Song Bin-bin Xu Yan Xu Xiu-xiu Wang Hong-yue Sun Shuai-nan Li Shen-zhen Liu Mei-xi Yu Fan Yang Dan-yu Ye Rui Gong Zhen-bo Han Ying Yu Djibril Bamba Ning Wang Zhen-wei Pan Ben-zhi Cai | 2021 | Acta Pharmacologica Sinica2021，42，6： | 2 |
| 9 | A novel technique using hydrophilic polymers to promote axonal fusion显示文摘The management of traumatic peripheral nerve injury remains a considerable concern for clinicians.With minimal innovations in surgical technique and a limited number of specialists trained to treat peripheral nerve injury,outcomes of surgical intervention have been unpredictable.The inability to manipulate the pathophysiology of nerve injury(i.e.,Wallerian degeneration) has left scientists and clinicians depending on the slow and lengthy process of axonal regeneration(~1 mm/day).When axons are severed,the endings undergo calcium-mediated plasmalemmal sealing,which limits the ability of the axon to be primarily repaired.Polythethylene glycol(PEG) in combination with a bioengineered process overcomes the inability to fuse axons.The mechanism for PEG axonal fusion is not clearly understood,but multiple studies have shown that a providing a calcium-free environment is essential to the process known as PEG fusion.The proposed mechanism is PEG-induced lipid bilayer fusion by removing the hydration barrier surrounding the axolemma and reducing the activation energy required for membrane fusion to occur.This review highlights PEG fusion,its past and current studies,and future directions in PEG fusion. | Ravinder Bamba D.Colton Riley Nathaniel D.Kelm Mark D.Does Richard D.Dortch Wesley P.Thayer | 2016 | Neural Regeneration Research2016，11，4： | 2 |
| 10 | Butyrate stimulates IL-32α expression in human intestinal epithelial cell lines显示文摘AIM: To investigate the effects of butyrate on interleukin (IL)-32α expression in epithelial cell lines. METHODS: The human intestinal epithelial cell lines HT-29, SW480, and T84 were used. Intracellular IL- 32α was determined by Western blotting analyses. IL- 32α mRNA expression was analyzed by real-time poly-merase chain reaction. RESULTS: Acetate and propionate had no effects on IL-32α mRNA expression. Butyrate significantly enhanced IL-32α expression in all cell lines. Butyrate also up-regulated IL-1β-induced IL-32α mRNA expression. Butyrate did not modulate the activation of phosphatidylinositol 3-kinase (PI3K), a mediator of IL- 32α expression. Like butyrate, trichostatin A, a histone deacetylase inhibitor, also enhanced IL-1β-induced IL- 32α mRNA expression.CONCLUSION: Butyrate stimulated IL-32α expression in epithelial cell lines. An epigenetic mechanism, such as histone hyperacetylation, might be involved in the action of butyrate on IL-32α expression. | Ayako Kobori Shigeki Bamba Hirotsugu Imaeda Hiromitsu Ban Tomoyuki Tsujikawa Yasuharu Saito Yoshihide Fujiyama Akira Andoh | 2010 | World Journal of Gastroenterology2010，16，19： | 2 |
| 11 | Essential oil of Eupatorium odoratum显示文摘 | BAMBA D BESSIER J M MARION C | 1993 | Planta Medica1993，59，2： | 2 |
| 12 | Severity of gastric mucosal atrophy affects the healing speed of post-endoscopic submucosal dissection ulcers显示文摘AIM To investigate factors associated with the healing of endoscopic submucosal dissection(ESD)-induced ulcers.METHODS We enrolled 132 patients with gastric tumors scheduled for ESD. Following ESD, patients were treated with daily lansoprazole 30 mg or vonoprazan 20 mg. Ulcer size was endoscopically measured on the day after ESD and at 4 and 8 wk. The gastric mucosa was endoscopically graded according to the Kyoto gastritis scoring system. We assessed the number of patients with and without a 90% reduction in ulcer area at 4 wk post-ESD and scar formation at 8 wk, and looked for risk factors for slower healing.RESULTS The mean size of gastric tumors and post-ESD ulcers was 17.4 ± 12.1 mm and 32.9 ± 13.0 mm. The meanreduction rates in ulcer area were 90.4% ± 0.8% at 4 wk and 99.8% ± 0.1% at 8 wk. The reduction rate was associated with the Kyoto grade of gastric atrophy at 4 wk(A0: 97.9% ± 0.6%, A1: 93.4% ± 4.1%, and A2: 89.7% ± 1.0%, respectively). In multivariate analysis, the factor predicting 90% reduction at 4 wk was gastric atrophy(Odds ratio: 5.678, 95%CI: 1.190-27.085, P = 0.029).CONCLUSION The healing speed of post-ESD ulcers was associated with the degree of gastric mucosal atrophy, and Helicobacter pylori eradication therapy is required to perform at younger age. | Taketo Otsuka Mitsushige Sugimoto Hiromitsu Ban Toshiro Nakata Masaki Murata Atsushi Nishida Osamu Inatomi Shigeki Bamba Akira Andoh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，5： | 2 |
| 13 | Effectiveness of combined anticoagulant therapy for extending portal vein thrombosis in Crohn’s disease显示文摘 | Dr. Tomoyuki Tsujikawa M.D. Ph.D. Takashi Ihara M.D. Masaya Sasaki M.D. Ph.D. Hisayuki Inoue M.D. Ph.D. Yoshihide Fujiyama M.D. Ph.D. Tadao Bamba M.D. Ph.D | 1996 | Diseases of the Colon & Rectum1996，，7： | 2 |
| 14 | Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice显示文摘 | Atsuhiro Ogawa Akira Andoh Yoshio Araki Tadao Bamba Yoshihide Fujiyama | 2003 | Clinical Immunology2003，，： | 2 |
| 15 | Pedunculated gastric tube interposition in an esophageal cancer patient with prepyloric adenocarcinoma显示文摘Gastric carcinoma is one of the malignancies that are most frequently associated with esophageal carcinoma.We describe herein our device for advanced esophageal cancer associated with early gastric cancer in the antrum.A 57-year-old man presenting with dysphagia and upper abdominal pain was admitted to our hospital.Preoperative examinations revealed locally advanced squamous cell carcinoma (SCC) of the middle thoracic esophagus (T3N0M0 Stage ⅡA) and mucosal signetring cell carcinoma of the gastric antrum (T1N0M0 Stage ⅠA).Although the gastric tumor appeared to be an intramucosal carcinoma,its margin was obscure,so endoscopic en-bloc resection was considered inadequate.We chose surgical resection of the gastric tumor as well as the esophageal SCC after neoadjuvant chemotherapy with 5-fluorouracil and cisplatin for advanced esophageal cancer.Following transthoracic esophagectomy with three-field lymph node dissection,the gastric carcinoma was removed by gastric antrectomy,which preserved the right gastroepiploic vessels,and a pedunculated short gastric tube was used as the esophageal substitute.Twenty-eight months after the surgery,the patient is well with no evidence of cancer recurrence.Because it minimizes surgical stress and organ sacrifice,gastric tube interposition is a potentially useful technique for esophageal cancer associated with localized early gastric cancer. | Tatsuo Kanda Yu Sato Kazuhito Yajima Shin-ichi Kosugi Atsushi Matsuki Takashi Ishikawa Takeo Bamba Hajime Umezu Tsutomu Suzuki Katsuyoshi Hatakeyama | 2011 | World Journal of Gastrointestinal Oncology2011，3，5： | 2 |
| 16 | A metabolomic approach to lung cancer显示文摘 | Suya Hori Shin Nishiumi Kazuyuki Kobayashi Masakazu Shinohara Yukihisa Hatakeyama Yoshikazu Kotani Naoya Hatano Yoshimasa Maniwa Wataru Nishio Takeshi Bamba Eiichiro Fukusaki Takeshi Azuma Tadaomi Takenawa Yoshihiro Nishimura Masaru Yoshida | 2011 | Lung Cancer2011，，2： | 2 |
| 17 | Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis显示文摘 | Ayako Kobori Yuhki Yagi Hirotsugu Imaeda Hiromitsu Ban Shigeki Bamba Tomoyuki Tsujikawa Yasuharu Saito Yoshihide Fujiyama Akira Andoh | 2010 | Journal of Gastroenterology2010，，10： | 2 |
| 18 | Multiple carcinoids in the duodenum, pancreas and stomach accompanied with type A gastritis: A case report显示文摘我们报导多重十二指肠、胰腺、胃的良性肿瘤的一个案例。A 67- 岁女人为十二指肠的良性肿瘤的治疗进入我们的医院。实验室测试表明病人与 macrocytic 和 hypergastrinemia 被联系,并且类型 A 胃炎被 gastrofiberscopy 显示出。在外科期间,另一个肿瘤顺便说一下在胰的头被发现。在十二指肠和胰的肿瘤被胰头十二指肠切除术完全切除并且 immunohistologically 作为促胃液素诊断了 -- 并且生产血清素的良性肿瘤分别地。病理学的检查表明除了非常发现的良性肿瘤,有无临床症状的良性肿瘤,其一是内分泌的房间 micronest,在胃和十二指肠定位了。在十二指肠,胰,和胃的肿瘤词法上从对方显示出不同特征并且免疫化学上。尽管没有权威的证据被获得了,某种基因异例可能涉及了这种情况,并且 hypergastrinemia 可以由于十二指肠的 gastrinoma 导致多重胃的良性肿瘤。 | Takeo Bamba Shin-ichi Kosugi Tatsuo Kanda Toshihiro Tsubono Yasuo Sakai Nobuyuki Musha Noriko Ishihara Katsuyoshi Hatakeyama | 2007 | World Journal of Gastroenterology2007，13，15： | 2 |
| 19 | Relationship between expression of cyclin D1 and impaired liver regeneration observed in fibrotic or cirrhotic rats显示文摘 | Kato A Bamba H Shinohara M | 2005 | J Gastroenterol Hepatol2005，20，8： | 1 |
| 20 | Prostaglandins up-regulate vascular endothelial growth factor production distict pathways in differentiated U937 cells显示文摘 | Bamba H Ota S Kato A | 2000 | Biochem Biophys Res Commun2000，273，2： | 1 |
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