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| 1 | mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan显示文摘AIM: To investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis stage.METHODS: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using Taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALT) level.RESULTS: The expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P < 0.04). When analyzing mi RNA expression in relation to fibrosis, levels of mi R-122 and mi R-221 showed negative correlations with fibrosis stage, and mi R-122 was found to correlate negatively and mi R-224 positively with LS values(all P < 0.05). ALT levels displayed a positive correlation with mi R-21(P < 0.04). Negative correlations were observed in the fibrosis samples of mixed etiology between mi R-122 and fibrosis stage and LS values(P < 0.05), and in the samples of chronic viral hepatitis, between mi R-221 and fibrosis stage(P < 0.01), whereas mi R-21 showed positive correlation with ALT values in the samples of autoimmune liver diseases(P < 0.03). The results also revealed a strong correlation between fibrosis stage and LS values(P < 0.01) when etiology of fibrosis was not taken into account.CONCLUSION: Reduced expression of mi R-122 in advanced fibrosis and its correlation with fibrosis stage and LS values seem to be characteristic of hepatic fibrosis of various etiologies. | Tünde Halász Gábor Horváth Gabriella Pár Klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai | 2015 | World Journal of Gastroenterology2015，21，25： | 11 |
| 2 | Therapeutic drug monitoring in patients with inflammatory bowel disease显示文摘Thiopurine analogs and anti-tumor necrosis factor(TNF)agents have dramatically changed the therapeutics of inflammatory bowel diseases(IBD),improving short and long-term outcomes.Unfortunately some patients do not respond to therapy and others lose response over time.The pharmacokinetic properties of these drugs are complex,with high inter-patient variability.Thiopurine analogs are metabolized through a series of pathways,which vary according to the patients’pharmacogenetic profile.This profile largely determines the ratios of metabolites,which are in turn associated with likelihoods of clinical efficacy and/or toxicity.Understanding these mechanisms allows for manipulation of drug dose,aiming to reduce the development of toxicity while improving the efficacy of treatment.The efficacy of anti-TNF drugs is influenced by many pharmacodynamic variables.Several factors may alter drug clearance,including the concomitant use of immunomodulators(thiopurine analogs and methotrexate),systemic inflammation,the presence of anti-drug antibodies,and body mass.The treatment of IBD has evolved with the understanding of the pharmacologic profiles of immunomodulating and TNF-inhibiting medications,with good evidence for improvement in patient outcomesobserved when measuring metabolic pathway indices.The role of routine measurement of metabolite/drug levels and antibodies warrants further prospective studies as we enter the era of personalized IBD care. | Andres J Yarur Maria T Abreu Amar R Deshpande David H Kerman Daniel A Sussman | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 3 | Cell Therapy Based on Adipose Tissue-Derived Stromal Cells Promotes Physiological and Pathological Wound Healing显示文摘 | T G. Ebrahimian F Pouzoulet C Squiban V Buard M André B Cousin P Gourmelon M Benderitter L Casteilla R Tamarat | 2009 | Arteriosclerosis, Thrombosis, and Vascular Biology2009，，4： | 2 |
| 4 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 5 | The global carbon budget 1959-2011显示文摘 | QuéréC L Andres R J Boden T | 2013 | Earth System Science Data2013，5，： | 1 |
| 6 | Emergence and evolution of the circadian rhythm of melatonin in children 显示文摘 | Ardura J Gutierrez R Andres J Agapito T | 2003 | Horm Res2003，59，2： | 1 |
| 7 | The User Action Framework: A Reliable Founda- tion for Usability Engineering Support Tools 显示文摘 | ANDRE T S HARTSON H R BELZ S M | 2001 | International Journal of Human-Computer Studies2001，54，1： | 1 |
| 8 | Nanostructure of nafion membrane at different states of hydration: an IR and Raman study显示文摘 | Gruger A André Régis Schmatko T | 2001 | Vibrational Spectroscopy2001，26，： | 1 |
| 9 | Coulomb staircase at room temperature in a self-assembled molecular nanostructure显示文摘 | Andres R P Bein T Dorogi M | 1996 | Science1996，272，： | 1 |
| 10 | Phase Ⅲ,randomized,double-blind,placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant,advanced breast cancer (BOLERO-3)显示文摘 | O' Regan R Ozguroglu M Andre F Toi M Jerusalem G Wilks S Isaacs C Xu B Masuda N Arena FP Yardley D Yap YS Mukhopadhyay P Douma S El-Hashimy M Taran T Sahmoud T Lebwohl D Gianni L | | 0，，15： | 1 |
| 11 | Phylogenetic relationships among domesticated and wild species of Cucurbita (Cucurbitaceae) inferred from a mitochondrial gene:Implications for cro Pplant evolution and areas of origin 显示文摘 | Sanjur O I Piperno D R Andres T C | 2002 | PNAS2002，99，1： | 1 |
| 12 | Pesticide Residues and Vertical Integration in Florida Strawberries and Tomatoes显示文摘 | Kilmer R Andre A Stevens T | | 0，，17： | 1 |
| 13 | Synthesis and Characterization of Star Polymers Made from Simple, Multifunctional Initiators 显示文摘 | D R Robello A Andre T A McCovick | 2002 | Macromolecules2002，35，25： | 1 |
| 14 | Fibre-optic pesticide biosensor based on covalently immobilized acetylcholinesterase and thymol blue显示文摘 | Andres R T Narayanaswamy R | 1997 | Talanta1997，44，： | 1 |
| 15 | Fibre-optic pesticide biosensor based on covalently immobilized acetylcholinesterase and thymol blue 显示文摘 | Andres R T Narayanaswamy R | 1997 | Talanta1997，44，： | 1 |
| 16 | Multi-site evaluation of IKONOS data for classification of tropical coral reef environments显示文摘 | Serge Andréfou?t Philip Kramer Damaris Torres-Pulliza Karen E Joyce Eric J Hochberg Rodrigo Garza-Pérez Peter J Mumby Bernhard Riegl Hiroya Yamano William H White Mayalen Zubia John C Brock Stuart R Phinn Abdulla Naseer Bruce G Hatcher Frank E Muller-Karg | 2003 | Remote Sensing of Environment2003，，1： | 1 |
| 17 | 显示文摘 | Bein T Dorogi M | 1996 | Science1996，272，： | 1 |
| 18 | Stabilization of foams with inorganic colloidal particles显示文摘 | Gonzenbach U T Studart Andre R Tervoort Elena | 2006 | Langmuir2006，22，10： | 1 |
| 19 | Fibre -optie pesticide biosensor based on covalently immobilized acetylcholinesterase and thymol blue 显示文摘 | Andres R T Narayanaswamy R | 1997 | Talanta1997，44，： | 1 |
| 20 | Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK显示文摘 | Neufert Clemens Becker Christoph Türeci ?zlem Waldner Maximilian J Backert Ingo FIoh Katharina Atreya lmke Leppkes Moritz Jefremow Andre Vieth Michael Schneider-Stock Regine Klinger Patricia Greten Florian R Threadgill David W Sahin Ugur Ne | 2013 | Journal of Clinical Investigation2013，，4： | 1 |
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