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| 1 | Involvement of 90-kuD ribosomal S6 kinase in collagen type Ⅰ expression in rat hepatic fibrosis显示文摘AIM: To investigate the relationship between 90-kuD ribosomal S6 kinase (p90RSK) and collagen type □expression during the development of hepatic fibrosis in vivo and in vitro.METHODS: Rat hepatic fibrosis was induced by intraperitoneal injection of dimethylnitrosamine. The protein expression and cell location of p90RSK and their relationship with collagen type □were determined by co-immunofluoresence and confocal microscopy. Subsequently, RNAi strategy was employed to silence p90RSK mRNA expression in HSC-T6, an activated hepatic stellate cell (HSC) line. The expression of collagen type □in HSC-T6 cells was assessed by Western blotting and real-time polymerase chain reaction. Furthermore, HSCs were transfected with expression vectors or RNAi constructs of p90RSK to increase or decrease the p90RSK expression, then collagen type □promoter activity in the transfected HSCs was examined by reporter assay. Lastly HSC-T6 cells transfected with p90RSK siRNA was treated with or without platelet-derived growth factor (PDGF)-BB at a final concentration of 20 μg/L and the cell growth was determined by MTS conversion.RESULTS: In fibrotic liver tissues, p90RSK was overexpressed in activated HSCs and had a significant positive correlation with collagen type □levels.In HSC-T6 cells transfected with RNAi targeted to p90RSK, the expression of collagen type □was down-regulated (61.8% in mRNA, P < 0.01, 89.1% in protein, P < 0.01). However, collagen type □promoter activity was not increased with over-expression of p90RSK and not decreased with low expression either, compared with controls in the same cell line (P = 0.076). Furthermore, p90RSK siRNA exerted the inhibition of HSC proliferation, and also abolished the effect of PDGF on the HSC proliferation.CONCLUSION: p90RSK is over-expressed in activated HSCs and involved in regulating the abnormal expression of collagen type □through initiating the proliferation of HSCs. | Miao-Fang Yang Jun Xie Xiao-Yi Gu Xiao-Hua Zhang Andrew K Davey Shuang-Jie Zhang Ji-Ping Wang Ren-Min Zhu | 2009 | World Journal of Gastroenterology2009，15，17： | 3 |
| 2 | Prognostic value of Her-2/neu and clinicopathologic factors for evaluating progression and disease-specific death in Chinese men with prostate cancer显示文摘背景 Her-2/neu 基因 overexpression 在几恶意被发现了,并且与差的预后被联系;当它在前列腺癌症( PCa )的 tumorigenesis 和前进的角色仍然是 controversial.This 时,学习试图为疾病前进和PCa特定的 death.Methods Her-2/neu 蛋白质表示与 PCa 在 对待antiandrogen 的中国人评估 Her-2/neu 蛋白质表示和 clinicopathologic 因素的预示的价值在收集的标本用 immunohistochemistry ( IHC )被决定从 124 前列腺活体检视和从七前列腺 canc 的前列腺( TURP ) | ZHANG Yi-fen GUAN Yang-bo YANG Bin WU Hong-yan DAI Yu-tian ZHANG Shuang-jie WANG Ji-ping Shailendra Anoopkumar-Dukie Andrew K Davey SUN Ze-yu | 2011 | Chinese Medical Journal2011，，24： | 2 |
| 3 | The cardioprotective effect of isosteviol on rats with heart ischemia-reperfusion injury显示文摘 | Deyi Xu Yongfang Li Jiping Wang Andrew K. Davey Shuangjie Zhang Allan M. Evans | 2006 | Life Sciences2006，，4： | 1 |
| 4 | High-performance liquid chromatography spectrometric analysis of trans -resveratrol in rat plasma显示文摘 | Hui He Xijing Chen Guangji Wang Jiping Wang Andrew Keith Davey | 2005 | Journal of Chromatography B2005，，2： | 1 |
| 5 | Sex Determination in Freshwater Eels and Management Options for Manipulation of Sex显示文摘 | Andrew J. H. Davey Donald J. Jellyman | 2005 | Reviews in Fish Biology and Fisheries (-)2005，，1： | 1 |
| 6 | IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts显示文摘 | Kathryn E. Hamilton Felicite K. Noubissi Prateek S. Katti Christopher M. Hahn Sonya R. Davey Emma T. Lundsmith Andres J. Klein-Szanto Andrew D. Rhim Vladimir S. Spiegelman Anil K. Rustgi | 2013 | Carcinogenesis2013，，11： | 1 |
| 7 | Are all 5HT3 receptor antagonists the same显示文摘 | Andrews Pl Bhandari P Davey PT | 1992 | Eur J Cancey1992，28，1： | 1 |
| 8 | An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles显示文摘 | Spomenka Simovic He Hui Yunmei Song Andrew K. Davey Thomas Rades Clive A. Prestidge | 2010 | Journal of Controlled Release2010，，3： | 1 |
| 9 | Investigating the long‐term legacy of drought and warming on the soil microbial community across five E uropean shrubland ecosystems显示文摘 | Johannes Rousk Andrew R. Smith Davey L. Jones | 2013 | Glob Change Biol2013，，12： | 1 |
| 10 | Specificity of early-career general practitioners’problem formulations in patients presenting with dizziness:a cross-sectional analysis显示文摘Objectives Dizziness is a common and challenging clinical presentation in general practice.Failure to determine specific aetiologies can lead to significant morbidity and mortality.We aimed to establish frequency and associations of general practitioner(GP)trainees’(registrars’)specific vertigo provisional diagnoses and their non-specific symptomatic problem formulations.Design A cross-sectional analysis of Registrar Clinical Encounters in Training(ReCEnT)cohort study data between 2010 and 2018.ReCEnT is an ongoing,prospective cohort study of registrars in general practice training in Australia.Data collection occurs once every 6 months midtraining term(for three terms)and entails recording details of 60 consecutive clinical consultations on hardcopy case report forms.The outcome factor was whether dizziness-related or vertigo-related presentations resulted in a specific vertigo provisional diagnosis versus a non-specific symptomatic problem formulation.Associations with patient,practice,registrar and consultation independent variables were assessed by univariate and multivariable logistic regression.Setting Australian general practice training programme.The training is regionalised and delivered by regional training providers(RTPs)(2010-2015)and regional training organisations(RTOs)(2016-2018)across Australia(from five states and one territory).Participants All general practice registrars enrolled with participating RTPs or RTOs undertaking GP training terms.Results 2333 registrars(96%response rate)recorded 1734 new problems related to dizziness or vertigo.Of these,546(31.5%)involved a specific vertigo diagnosis and 1188(68.5%)a non-specific symptom diagnosis.Variables associated with a non-specific symptom diagnosis on multivariable analysis were lower socioeconomic status of the practice location(OR 0.94 for each decile of disadvantage,95%CIs 0.90 to 0.98)and longer consultation duration(OR 1.02,95%CIs 1.00 to 1.04).A specific vertigo diagnosis was associated with performing a procedure(OR 0.52,95%CIs 0.27 to 1.00),with some evidence for seeking information from a supervisor being associated with a non-specific symptom diagnosis(OR 1.39,95%CIs 0.92 to 2.09;p=0.12).Conclusions Australian GP registrars see dizzy patients as frequently as established GPs.The frequency and associations of a non-specific diagnosis are consistent with the acknowledged difficulty of making diagnoses in vertigo/dizziness presentations.Continuing emphasis on this area in GP training and encouragement of supervisor involvement in registrars’diagnostic processes is indicated. | Jocelyn Ledger Amanda Tapley Christopher Levi Andrew Davey Mieke van Driel Elizabeth G Holliday Jean Ball Alison Fielding Neil Spike Kristen FitzGerald Parker Magin | 2021 | Family Medicine and Community Health2021，9，4： | 0 |
| 11 | Absolute cardiovascular risk assessment by Australian early-career general practitioners: a cross-sectional study显示文摘Objective To determine the prevalence and associations of general practice registrars’performing absolute cardio-vascular risk(ACVR)assessment(ACVRa).Design A cross-sectional study employing data(2017–2018)from the Registrar Clinical Encounters in Training project,an ongoing inception cohort study of Australian GP registrars.The outcome measure was whether an ACVRa was performed.Analyses employed univariable and multivariable regression.Analysis was conducted for all patient problems/diagnoses,then for an‘at-risk’population(specific problems/diagnoses for which ACVRa is indicated).Setting Three GP regional training organisations(RTOs)across three Australian states.Participants GP registrars training within participating RTOs.Results 1003 registrars(response rate 96.8%)recorded details of 69105 problems either with Aboriginal and/or Torres Strait patients aged 35 years and older or with non-Indigenous patients aged 45 years and older.Of these problems/diagnoses,1721(2.5%(95%CI 2.4%to 2.6%))involved an ACVRa.An ACVRa was‘plausibly indicated’in 10384 problems/diagnoses.Of these,1228(11.8%(95%CI 11.2%to 12.4%))involved ACVRa.For‘all problems/diagnoses’,on multivariable analysis female gender was associated with reduced odds of ACVRa(OR 0.61(95%CI 0.54 to 0.68)).There was some evidence for Aboriginal and/or Torres Strait Islander people being more likely to receive ACVRa(OR 1.40(95%CI 0.94 to 2.08),p=0.10).There were associations with variables related to continuity of care,with reduced odds of ACVRa:if the patient was new to the registrar(OR 0.65(95%CI 0.57 to 0.75)),new to the practice(OR 0.24(95%CI 0.15 to 0.38))or the problem was new(OR 0.68(95%CI 0.59 to 0.78));and increased odds if personal follow-up was organised(OR 1.43(95%CI 1.24 to 1.66)).For‘ACVRa indicated’problems/diagnoses,findings were similar to those for‘all problems/diagnoses’.Association with Aboriginal and/or Torres Strait Islander status,however,was significant at p<0.05(OR 1.60(95%CI 1.04 to 2.46))and association with female gender was attenuated(OR 0.88(95%CI 0.77 to 1.01)).Conclusion Continuity of care is associated with registrars assessing ACVR,reinforcing the importance of care continuity in general practice.Registrars’assessment of an individual patient’s ACVR is targeted to patients with individual risk factors,but this may entail ACVRa underutilisation in female patients and younger age groups. | Toby Morgan Anna Ralston Andrew Davey Elizabeth G Holliday Mark Nelson Alison Fielding Mieke van Driel Amanda Tapley Dominica Moad Jean Ball Jennifer Presser Neil Spike Parker Magin | 2023 | Family Medicine and Community Health2023，11，3： | 0 |
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