4篇
您的检索式：作者名="Andrew Hopkinson"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Concise Review: Evidence for CD34 as a Common Marker for Diverse Progenitors显示文摘 | Laura E. Sidney Matthew J. Branch Siobhán E. Dunphy Harminder S. Dua Andrew Hopkinson | 2014 | Stem Cells2014，，6： | 1 |
| 2 | Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model显示文摘BACKGROUND An in vitro injury model mimicking a corneal surface injury was optimised using human corneal epithelial cells(hCEC).AIM To investigate whether corneal-stroma derived stem cells(CSSC) seeded on an amniotic membrane(AM) construct manifests an anti-inflammatory, healing response.METHODS Treatment of hCEC with ethanol and pro-inflammatory cytokines were compared in terms of viability loss, cytotoxicity, and pro-inflammatory cytokine release, in order to generate the in vitro injury. This resulted in an optimal injury of 20%(v/v) ethanol for 30 s with 1 ng/mL interleukin-1(IL-1) beta. Co-culture experiments were performed with CSSC alone and with CSSC-AM constructs.The effect of injury and co-culture on viability, cytotoxicity, IL-6 and IL-8 production, and IL1 B, TNF, IL6, and CXCL8 mRNA expression were assessed.RESULTS Co-culture with CSSC inhibited loss of hCEC viability caused by injury. Enzyme linked immunosorbent assay and polymerase chain reaction showed a significant reduction in the production of IL-6 and IL-8 pro-inflammatory cytokines, and reduction in pro-inflammatory cytokine mRNA expression during co-culture with CSSC alone and with the AM construct. These results confirmed the therapeutic potential of the CSSC and the possible use of AM as a cell carrier for application to the ocular surface.CONCLUSION CSSC were shown to have a potentially therapeutic anti-inflammatory effectwhen treating injured hCEC, demonstrating an important role in corneal regeneration and wound healing, leading to an improved knowledge of their potential use for research and therapeutic purposes. | Mariana Lizeth Orozco Morales Nagi M Marsit Owen D McIntosh Andrew Hopkinson Laura E Sidney | 2019 | World Journal of Stem Cells2019，11，2： | 1 |
| 3 | Use of iron-based technologies in contaminated land and groundwater remediation: A review显示文摘 | Andrew B. Cundy Laurence Hopkinson Raymond L.D. Whitby | 2008 | Science of the Total Environment2008，，1： | 1 |
| 4 | NICE指南更新概要:慢性阻塞性肺疾病的诊断和管理显示文摘慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)具有高发病率和高病死率,在英国被确诊为COPD的共有130万人。COPD也是常见的住院原因之一。虽然英国国家医疗服务体系(National Health Service,NHS)已将呼吸系统疾病纳入其长期计划的优先范畴,但是英国皇家内科医师学会COPD审查项目却显示整个医疗体系仍存在大量缺陷,包括肺康复治疗、戒烟治疗和流感疫苗等方面均未落实到位。 | Nicholas S Hopkinson Andrew Molyneux Joshua Pink Marie C Harrisingh 颜佳扬(译者) 林辉煌(译者) 姜红妮(审校者) 瞿介明(审校者) | 2020 | 英国医学杂志中文版2020，23，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员