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| 1 | Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics显示文摘The potential for the positive manipulation of the gut microbiome through the introduction of beneficial microbes, as also known as probiotics, is currently an active area of investigation. The FAO/WHO define probiotics as live microorganisms that confer a health benefit to the host when administered in adequate amounts. However, dead bacteria and bacterial molecular components may also exhibit probiotic properties. The results of clinical studies have demonstrated the clinical potential of probiotics in many pathologies, such as allergic diseases, diarrhea, inflammatory bowel disease and viral infection. Several mechanisms have been proposed to explain the beneficial effects of probiotics, most of which involve gene expression regulation in specific tissues, particularly the intestine and liver. Therefore, the modulation of gene expression mediated by probiotics is an important issue that warrants further investigation. In the present paper, we performed a systematic review of the probiotic-mediated modulation of gene expression that is associated with the immune system and inflammation. Between January 1990 to February 2014, Pub Med was searched for articles that were published in English using the Me SH terms 'probiotics ' and ' gene expression ' combined with 'intestines', 'liver', 'enterocytes', 'antigen-presenting cells', 'dendritic cells', 'immune system', and 'inflammation'. Two hundred and five original articles matching these criteria were initially selected, although only those articles that included specific gene expression results(77) were later considered for this review and separated into three major topics: the regulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver. Particular strains of Bifidobacteria, Lactobacilli, Escherichia coli, Propionibacterium, Bacillus and Saccharomyces influence the gene expression of mucins, Toll-like receptors, caspases, nuclear factor-κB, and interleukins and lead mainly to an anti-inflammatory response in cultured enterocytes. In addition, the interaction of commensal bacteria and probiotics with the surface of antigenpresenting cells in vitro results in the downregulation of pro-inflammatory genes that are linked to inflammatory signaling pathways, whereas other anti-inflammatory genes are upregulated. The effects of probiotics have been extensively investigated in animal models ranging from fish to mice, rats and piglets. These bacteria induce a tolerogenic and hyporesponsive immune response in which many genes that are related to the immune system, in particular those genes expressing anti-inflammatory cytokines, are upregulated. By contrast, information related to gene expression in human intestinal cells mediated by the action of probiotics is scarce. There is a need for further clinical studies that evaluate the mechanism of action of probiotics both in healthy humans and in patients with chronic diseases. These types of clinical studies are necessary for addressing the influence of these microorganisms in gene expression for different pathways, particularly thosethat are associated with the immune response,and to better understand the role that probiotics might have in the prevention and treatment of disease. | Julio Plaza-Diaz Carolina Gomez-Llorente Luis Fontana Angel Gil | 2014 | World Journal of Gastroenterology2014，20，42： | 12 |
| 2 | Malignant colorectal polyps显示文摘Nowadays, the number of cases in which malignant colorectal polyps are removed is increasing due to colorectal cancer screening programmes. Cancerous polyps are classified into non-invasive high grade neoplasia (NHGN), when the cancer has not reached the muscularis mucosa, and malignant polyps, classed as T1, when they have invaded the submucosa. NHGN is considered cured with polypectomy, while the prognosis for malignant polyps depends on various morphological and histological factors. The prognostic factors include, sessile or pedunculated morphology of the polyp, whether partial or en bloc resection is carried out, the degree of differentiation of the carcinoma, vascular or lymphatic involvement, and whether the polypectomy resection margin is tumor free. A malignant polyp at T1 is considered cured with polypectomy ifit is a pedunculated polyp (Ip of the Paris classification), it has been completely resected, it is not poorly differentiated, the resection edge is not affected by the tumor and there is no vascular or lymphatic involvement. The sessile malignant polyp (Is of the Paris classification) at T1 is considered not cured with polypectomy. Only in some cases (e.g. older people with high surgical risk) local excision(polypectomy or endoscopic submucosal dissection or conventional endoscopic mucosal resection) is considered the definitive treatment. | Luis Bujanda Angel Cosme Ines Gil Juan I Arenas-Mirave | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 3 | Lactobacillus rhamnosus and its cell-free culture supernatant differentially modulate inflammatory biomarkers in Escherichia coli -challenged human dendritic cells显示文摘 | Miriam Bermudez-Brito Sergio Mu?oz-Quezada Carolina Gomez-Llorente Fernando Romero Angel Gil | 2014 | British Journal of Nutrition2014，，10： | 1 |
| 4 | Quantitative one-step real-time RT-PCR for the fast detection of the four genotypes of PPRV显示文摘 | Olivier Kwiatek Djénéba Keita Patricia Gil Jovita Fernández-Pinero Miguel Angel Jimenez Clavero Emmanuel Albina Genevieve Libeau | 2010 | Journal of Virological Methods2010，，2： | 1 |
| 5 | A note on the connection between fuzzy numbers and random intervals显示文摘 | Maria Angeles Gil | 1992 | Statistics & Probability Letters1992，13，2： | 1 |
| 6 | Dietary trans fatty acids in early life a review显示文摘 | ]Elvira Larque Salvador Zamora Angel Gil | 2001 | Early Human Development2001，65，： | 1 |
| 7 | Sources, isolation, characterisation and evaluation of probiotics – CORRIGENDUM显示文摘 | Luis Fontana Miriam Bermudez-Brito Julio Plaza-Diaz Sergio Mu?oz-Quezada Angel Gil | 2013 | British Journal of Nutrition2013，，4： | 1 |
| 8 | Role of Nucleotides in intestinal development and repair:implications for infant nutrition 显示文摘 | Uauy R Richard Quan Angel Gil | 1994 | Journal of Nutrition1994，，124： | 1 |
| 9 | Radioembolization using 90Y-resin microspheres for patients with advanced hepatocellular carcinoma显示文摘 | Bruno Sangro Jose I. Bilbao Jose Boan Antonio Martinez-Cuesta Alberto Benito Javier Rodriguez Angel Panizo Belen Gil Mercedes Inarrairaegui Ignacio Herrero Jorge Quiroga Jesus Prieto | 2006 | International Journal of Radiation Oncology, Biology, Physics2006，，3： | 1 |
| 10 | Influence of administration of long-chain polyunsaturated fatty acids on process of histological recovery in liver cirrhosis produced by oral intake of thioacetamide显示文摘 | Isabel Fernández BSc Isabel Torres PhD Eliane Moreira PhD Luis Fontana PhD Angel Gil PhD Antonio Rios PhD | 1996 | Digestive Diseases and Sciences1996，，1： | 1 |
| 11 | 门诊成人社区获得性肺炎的危险因素:生活方式和共病条件(NEUMO-ES-RISK项目)显示文摘背景社区获得性肺炎(CAP)风险在初级保健中的信息是有限的。我们评估了不同生活方式和共病条件作为初级保健成人CAP的危险因素。方法一项回顾性观察对照研究。使用国家初级保健数据监测系统检索了2009至2013年在西班牙初级保健部门诊断的成人CAP病例。匹配年龄和匹配性别的对照组采用发病率密度抽样(比例2∶1)。以百分比和比值比来表示关联分析。为了避免偏倚效应,建立二项回归模型。结果51 139例患者和102 372例对照组做比较。平均年龄为61.4(19.9)岁。危险因素与CAP的显著相关性如下:艾滋病[比值比(95%可信区间)5.21(4.35~6.27)]、慢性阻塞性肺病(COPD)[2.97(2.84~3.12)]、哮喘[2.16(2.07~2.26)]、吸烟[1.96(1.91~2.02)]和口腔卫生问题[1.45(1.41~1.49)]。患者组中有危险因素存在的平均患病率为82.2%,对照组为69.2%。CAP患病率的增加与危险因素和年龄的累积有关:1个危险因素时,在18~60岁老人中的风险相关性是1.42,在>60岁人中是1.57;2个危险因素时,是1.88和2.35;≥3个危险因素时,是3.11和4.34。结论成人CAP初级保健中的危险因素普遍较高。主要与危险因素相关的是艾滋病、COPD、哮喘、吸烟、口腔卫生问题。我们的风险叠加结果可以帮助临床医生确定肺炎风险较高的患者。 | Irene Rivero-Calle Miriam Cebey-López Jacobo Pardo-Seco José Yuste Esther Redondo Diego A Vargas Enrique Mascarós Jose Luis Díaz-Maroto Manuel Linares-Rufo Isabel Jimeno Angel Gil Jesus Molina Daniel Ocana Federico Martinón-Torres 崔晓霞(译) | 2019 | 英国医学杂志中文版2019，22，8： | 1 |
| 12 | Dietary trans fatty acids in early life: a review显示文摘 | Elvira Larque Salvador Zamora Angel Gil | 2001 | Early Human Development2001，65，： | 1 |
| 13 | Colorectal cancer prognosis twenty years later显示文摘AIM:To evaluate changes in colorectal cancer(CRC) survival over the last 20 years.METHODS:We compared two groups of consecutive CRC patients that were prospectively recruited:Group Ⅰincluded 1990 patients diagnosed between 1980 and 1994.GroupⅡincluded 871 patients diagnosed in 2001.RESULTS:The average follow up time was 21 mo(1-229)for GroupⅠand 50 mo(1-73.4)for GroupⅡ.Overall median survival was significantly longer in Group Ⅱthan in GroupⅠ(73 mo vs 25 mo,P<0.001)and the difference was significant for all tumor stages.Post surgical mortality was 8% for GroupⅠand 2% for Group Ⅱ(P<0.001).Only 17% of GroupⅠpatients received chemotherapy compared with 50% of GroupⅡpatients(P<0.001).CONCLUSION:Survival in colorectal cancer patients has doubled over the past 20 years.This increase seems to be partly due to the generalization in the administration of chemotherapy and to the decrease of post surgical mortality. | Luis Bujanda Cristina Sarasqueta Elisabeth Hijona Lander Hijona Angel Cosme Ines Gil Jose Luis Elorza Jose I Asensio Santiago Larburu José M Enríquez-Navascués Rodrigo Jover Francesc Balaguer Xavier Llor Xavier Bessa Montserrat Andreu Artemio Paya Antoni Castells Gastrointestinal Oncology Group of the Spanish Gastroenterological Association | 2010 | World Journal of Gastroenterology2010，16，7： | 0 |
| 14 | Effects of Trifoliate Interstocks on Growth and Yield of Mexican Lime Trees显示文摘 | Victor Manuel Medina-Urrutia Marciano Manuel Robles-Gonzalez Miguel Angel Manzanilla-Ramirez JoseJoaquin Velazquez-Monreal Jaime Eduardo Reyes-Hernandez Gil Virgen-Calleros Elizabeth Fernandez-Rivera | 2014 | Journal of Agricultural Science and Technology(B)2014，4，7： | 0 |
| 15 | Poly-contextural Logic: New Resource for Transdisciplinary Research in Sociology显示文摘 | Miguel Angel Briceflo Gil | 2011 | Journal of Sociology Study2011，1，2： | 0 |
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