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| 1 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | Soil microbial community patterns related to the history and intensity of grazing in submontane ecosystems 显示文摘 | Richard D B Angela C J David L J | 2001 | Soil Biology and Biochemistry2001，33，： | 1 |
| 3 | Bio?degradation and bio-sorption of antibiotics and non-ster?oidal anti-inflammatory drugs using immobilized cell process显示文摘 | Tsung H Y Angela Y C L Sri Chandana P | 2011 | Chemosphere2011，84，9： | 1 |
| 4 | Extended safety and effi- cacy studies of a live attenuated double leucine and pantothenate auxotroph of Mycobacterium tubericulosis as a vaccine candidate 显示文摘 | Samantha L Keith G Angela C | 2011 | Vaccine2011，29，： | 1 |
| 5 | Physical and mechanical properties of peanut protein films显示文摘 | Chin C L Angela M Tellez G M | 2004 | Lebensm2004，37，： | 1 |
| 6 | The respiration rate of composting pig manure 显示文摘 | Angela L C Claire T Adrian G W | 2004 | Compost Science & Utilization2004，12，2： | 1 |
| 7 | Human amniotic fluid-derived stem cells are rejected after transplantation in the myocardium of normal, ischemic, immuno-suppressed or immuno-deficient rat 显示文摘 | Angela C Sveva B Michela P Saverio S Andrea C Lisa G Jenny T Martina P Elisabetta L Gino G Igor V Emanuele C Annalisa A Laura I Giovanni F Z Anthony A Paolo D C and Saverio S | 2007 | Journal of Molecular and Cellular Cardiology2007，42，4： | 1 |
| 8 | Tile Relation- ship between Cultural Intelligence and Performance with the Mediating Eft~et of Culture Shock : A Case from Phil- ippine Laborers in Taiwan 显示文摘 | ANGELA S C YI - CHUN L AIRIN S | 2011 | International Journal of Intercultural Relations2011，，2： | 1 |
| 9 | Environmental Flow Requirements of Fish in Lesotho Rivers Using the DRIFT Methodology显示文摘 | Angela H Arthington Johan L Rall C Mark J K | 2003 | River Research and Applications2003，19，： | 1 |
| 10 | Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 显示文摘 | Marco C Leonardo P Francesco L Orazio N Paolo P Angela S Saverio C Angelo C | 2013 | Bio Med Chem2013，21，： | 1 |
| 11 | Removal of pharmaceuticals in secondary wastewater treatment processes in Taiwan 显示文摘 | ANGELA Y C L YU T SHAIK KL | 2009 | Journal of Hazardous Materials2009，108，1： | 1 |
| 12 | Successive bouts of cycling stimulates genes associated with mitochondrial biogenesis显示文摘 | Dumke C L Mark Davis J Angela Murphy E | 2009 | Eur J Appl Physiol2009，107，4： | 1 |
| 13 | Physical and mechanical properties of peanut protein films显示文摘 | Chin C L Angela M Tellez G M | 2004 | Lebensm2004，37，： | 1 |
| 14 | HIV integration site selection:Analysis by massively parallel pyrosequencing reveals association with epigenetic modifications显示文摘 | ANGELA C JEREMY L | 2007 | Genome Res2007，17，： | 1 |
| 15 | The respiration rate of composting pig manu:显示文摘 | Angela L C Claire T Adrian G W | 2004 | Compost Science Utilization2004，12，2： | 1 |
| 16 | MR imaging features of solid pseudopapillary tumor of the pancreas in adult and pediatric patients显示文摘 | Vito C Koenraad JM Angela L | 2003 | AJR2003，181，2： | 1 |
| 17 | Analysis of occupational accidents in Portugal between1992 and 2001显示文摘 | Angela C Macedo Inês L Silva | 2005 | Safety Science2005，43，5： | 1 |
| 18 | Forage and breed effects on behavior and temperament of pregnant beef heifers显示文摘Background: Integration of behavioral observations with traditional selection schemes may lead to enhanced animal well-being and more profitable forage-based cattle production systems.Brahman-influenced(BR;n = 64) and Gelbvieh × Angus(GA;n = 64) heifers consumed either toxic endophyte-infected tall fescue(E+) or one of two nontoxic endophyte-infected tall fescue(NT) cultivars during two yr.Heifers were weighed at midpoint and termination of grazing.Grazing behavior(grazing,resting in the shade,lying,or standing without grazing) was recorded(n = 13 visual observations per yr in June and July) for each pasture.During yr 2,exit velocity(EV) and serum prolactin(PRL) were determined.Results: Grazing behavior was influenced(P < 0.05) by an interaction between fescue cultivar and breed type.Gelbvieh × Angus heifers assigned to E+ pastures had the lowest percentage of animals grazing and the largest percentage of animals resting in the shade.Brahman-influenced heifers had faster EV(P < 0.001) than GA heifers(0.52 vs.0.74 ± 0.04 s/m,respectively).Body weight(BW) was affected(P < 0.01) by an interaction of tall fescue cultivar and d,and an interaction of tall fescue cultivar and breed type.Heifers grazing NT pastures were heavier(P < 0.01) than heifers grazing E+ pastures at midpoint and termination.Gelbvieh × Angus heifers grazing NT pastures were heavier(P < 0.01) than GA and BR heifers grazing E+ and BR heifers grazing NT pastures.An interaction of forage cultivar and breed type occurred on serum PRL(P < 0.01).Conclusion: Collectively fescue cultivar,EV,and concentrations of serum PRL were associated with grazing behavior.Heifers grazing NT pastures were observed to be grazing more than heifers assigned to E+ pastures,regardless of breed type,which may have contributed to changes in BW and average daily gain(ADG) in heifers.Integration of behavioral observations along with traditional selection schemes may lead to enhanced animal well-being and more profitable forage-based cattle production systems. | Angela R Mays Michael L Looper Benjamin C Williamson Kenneth P Coffey Wayne K Coblentz Glen E Aiken Charles F Rosenkrans Jr | 2013 | Journal of Animal Science and Biotechnology2013，4，3： | 1 |
| 19 | The effect of raltegravir on the glucuronidation of lamotrigine显示文摘 | MATTHIJS L ANGELA C VERWEY-VAN | 2009 | J Clin Pharmacol2009，49，10： | 1 |
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