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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Potential role of metabolomics in diagnosis and surveillance of gastric cancer显示文摘Gastric cancer is one of the deadliest cancers worldwide, and is especially prevalent in Asian countries. With such high morbidity and mortality, early diagnosis is essential to achieving curative intent treatment and long term survival. Metabolomics is a new field of study that analyzes metabolites from biofluids and tissue samples. While metabolomics is still in its infancy, there are numerous potential applications in oncology, specifically early diagnosis. Only a few studies in the literature have examined metabolomics' role in gastric cancer. Various fatty acid, carbohydrate, nucleic acid, and amino acid metabolites have been identified that distinguish gastric cancer from normal tissue and benign gastric disease. However, findings from these few studies are at times conflicting. Most studies demonstrate some relationship of cancer cells to the Warburg Effect, in that glycolysis predominates with conversion of pyruvate to lactate. This is one of the most consistent findings across the literature. There is less consistency in metabolomic signature with respect to nucleic acids, lipids and amino acids. In spite of this, metabolomics holds some promise for cancer surveillance but further studies are necessary to achieve consistency and validation before it can be widely employed as a clinical tool. | Angela W Chan Richdeep S Gill Daniel Schiller Michael B Sawyer | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 3 | Human Spermicidal Activity of Passiflora edulis Extract显示文摘Objective To evaluate the spermicidal activity of Passiflora edulis extract on human spermatozoa. Methods Human spermatozoa were incubated with P. edulis extracts and their motility and viability were evaluated; additionally, the cytotoxic effect of the extracts was evaluated by the tetrazolium bromide (MTT) reduction assay. Results The motility and viability were decreased immediately after treatment with a 21% dilution of the supernatant of the extract of P. edulis (P<0.001). No cytotoxic effect of the extracts studied was found on proliferation of MDBK and VERO cells. Conclusion These results may open the way for the use of P. edulis as a spermicidal product with less adverse effects. | Angela M.Alvarez-Gómez1 Wálter Cardona-Maya1 Jorge Forero Angela P.Cadavid | 2010 | Journal of Reproduction and Contraception2010，21，2： | 2 |
| 4 | Relationshhips between environmental organochlorine contaminant residues, plasma corticosterone concentrations and intermediary metabolic enzyme activities in Great Lakes Herring Gull embryos 显示文摘 | ANGELA L THOMOS W MOON S | 1999 | Environmental Health Perspectives1999，107，3： | 1 |
| 5 | Methanol removal efficiency and bacterial diversity of an activated carbon biofilter显示文摘 | Callie W B Adriana P Angela S Lindner | 2009 | Bioresour Techn2009，100，24： | 1 |
| 6 | 显示文摘 | Kameron R J Gbenga A O Angela K W | 2011 | Journal of Haz- ardous Materials2011，186，1： | 1 |
| 7 | Cardiac HCN chan-nels,structure,function,and modulation显示文摘 | Martin B Angela S Christian W | 2002 | Trends inCardiovascular Medicine2002，12，5： | 1 |
| 8 | Inhibition of the LKB1–AMPK pathway by the Epstein–Barr virus‐encoded LMP1 promotes proliferation and transformation of human nasopharyngeal epithelial cells显示文摘 | Angela Kwok‐Fung Lo Kwok‐Wai Lo Chun‐Wai Ko Lawrence S Young Christopher W Dawson | 2013 | J Pathol2013，，3： | 1 |
| 9 | Children sport shoes a systematic review of current显示文摘 | Markus W Dirk H Angela S | 2008 | Foot and Ankle Surgery2008，，14： | 1 |
| 10 | N-terminal pro-brain natriuretic peptide:an independent risk predictor of cardiovascular congestion,mortality,and adverse cardiovascular outcomes in chronic peritoneal dialysis patients显示文摘 | Angela Yee-Moon W Christopher Wai-Kei L Cheuk-Man Y | 2007 | Am Soc Nephrol2007，18，： | 1 |
| 11 | Heart failure with preserved or reduced ejection fractionin patients treated with peritoneal dialysis显示文摘 | Angela Y M W Mei Wang Christopher W K L | 2013 | Am J of Kid Dis2013，616，7： | 1 |
| 12 | Epidemiological evidence on health effects of ultrafine particles显示文摘 | Angela I M H-Erich W Wolfgang K | 2002 | Journal of Aerosol Medicine2002，15，2： | 1 |
| 13 | Flexibility in algal endosymbioses shapes growth in reef corals显示文摘 | ANGELA F L MADELEINE J H Bette L W | 2004 | Science2004，304，： | 1 |
| 14 | Sexual risk behavior, marriage and ART: a study of HIV-positive people in Papua New Guinea显示文摘 | Wing YNM Angela K Heather W | 2013 | AIDS Research and Therapy2013，10，1： | 1 |
| 15 | Short Form 36 ( SF - 36 ) Health Survey Questionnaire:no rmative data for adult of working age 显示文摘 | Crisp in J Angela C Lorlter W | 1993 | BMJ1993，306，： | 1 |
| 16 | The abnormal cytotoxicities 2,5-diaziridinyl-1,4-benzoquinone-3-phenyl esters 显示文摘 | Angela M D F Robert H J H Timothy W W | 2000 | Anti-Cancer Drug Design2000，15，5： | 1 |
| 17 | Short Form 36 ( SF-36 ) Health Survey Questionnaire:normative data for adult of working age 显示文摘 | crispin J Angela C Lorlter W | 1993 | BMJ1993，306，： | 1 |
| 18 | The mid-region of parathyroid hormone (1-34) serves as a functional docking domain in receptor activation显示文摘 | Angela W Martina C Beena E | 2006 | Biochem2006，45，7： | 1 |
| 19 | Bacteria ingestion by Daphnia galeata in a biomanipulated reservoir:a mechanism stabilizing bioma- nipulation? 显示文摘 | Norbert K Angela B Clemens W | 1999 | Hydrobiologia1999，403，： | 1 |
| 20 | A comparison of eating behaviors between children with and without autism显示文摘 | Kimberly AS Keith W Angela FS | 2004 | Journal of Autism and Developmental Disorders2004，34，4： | 1 |
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