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| 1 | Glycated hemoglobin and antidiabetic strategies as risk factors for hepatocellular carcinoma显示文摘AIM: To evaluate the relationship between glycemic control [assessed by glycated hemoglobin (HbA1c)], antidiabetic therapies and the risk of hepatocellular carcinoma (HCC).METHODS: We recruited 465 patients with HCC, 618 cases with liver cirrhosis and 490 controls with no liver disease. Among subjects with type 2 diabetes mellitus (DM2), the associations between the antidiabetic strategies and HbA1c level with HCC were determined through 2 series of multivariate logistic regression models using cirrhotic patients and controls as comparison groups. RESULTS: DM2 prevalence was 31.2% in patients with HCC, 23.2% in cirrhotic patients and 12.6% in controls (P < 0.0001). In 86% of study subjects, DM2 had been diagnosed for more than 1 year before the HCC diagnosis. HCC patients with DM2 had a 1.52.5fold increased risk of liver cancer. The HbA1c mean levels were signif icantly higher in DM2 patients with HCC than in cirrhoticand control DM2 patients. Antidiabetic treatment with metformin was more common among cirrhotic and control DM2 subjects than among cases with HCC. In both series of multivariate analyses, treatment with metformin signif icantly reduced the risk of HCC by more than 80% compared with sulphonylureas and insulin therapy. No signif icant differences were seen between sulphonylureas and insulin treatment. Elevated HbA1c levels were positively related to the risk for HCC in diabetic patients, with a 26%50% increase in risk for each 1% increase in HbA1c values.CONCLUSION: In patients with preexisting DM2, the risk of HCC is positively associated with poor chronic glycemic control and significantly decreased by metformin therapy. | Valter Donadon Massimiliano Balbi Francesca Valent Angelo Avogaro | 2010 | World Journal of Gastroenterology2010，16，24： | 15 |
| 2 | Diabetes Induces p66shc Gene Expression in Human Peripheral Blood Mononuclear Cells: Relationship to Oxidative Stress显示文摘 | Elisa Pagnin Gianpaolo Fadini Renzo de Toni Antonio Tiengo Lorenzo Calò Angelo Avogaro | 2005 | The Journal of Clinical Endocrinology & Metabolism2005，，2： | 1 |
| 3 | Piragliatin (RO4389620), a Novel Glucokinase Activator, Lowers Plasma Glucose Both in the Postabsorptive State and after a Glucose Challenge in Patients with Type 2 Diabetes Mellitus: A Mechanistic Study显示文摘 | Riccardo C. Bonadonna Tim Heise Christophe Arbet-Engels Christoph Kapitza Angelo Avogaro Joe Grimsby Jay Zhi Joseph F. Grippo Raffaella Balena | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，11： | 1 |
| 4 | Impact of Diabetes on Epidemiology, Treatment, and Outcomes of Patients With Heart Failure显示文摘 | Alessandra Dei Cas Sadiya S. Khan Javed Butler Robert J. Mentz Robert O. Bonow Angelo Avogaro Diethelm Tschoepe Wolfram Doehner Stephen J. Greene Michele Senni Mihai Gheorghiade Gregg C. Fonarow | 2014 | JACC: Heart Failure2014，，： | 1 |
| 5 | Detection of Coronary Artery Disease in Asymptomatic Patients With Type 2 Diabetes Mellitus显示文摘 | Roldano Scognamiglio Christian Negut Angelo Ramondo Antonio Tiengo Angelo Avogaro | 2006 | Journal of the American College of Cardiology2006，，1： | 1 |
| 6 | Effects of treatment with sulfonlurea drugs or insulin on ischemia induced myocardial dysfunctionin type 2diabetes 显示文摘 | Scognamiglio Roldano Avogaro Angelo Vigili-de-Kreutzenberg Saula | 2002 | Diabetes2002，51，： | 1 |
| 7 | Endothelial dysfunction in type 2 diabetes mellitus显示文摘 | Angelo Avogaro Gian Paolo Fadini Alessandra Gallo Elisa Pagnin Saula de Kreutzenberg | 2005 | Nutrition Metabolism and Cardiovascular Diseases2005，，： | 1 |
| 8 | Pro-inflammatory monocyte-macrophage polarization imbalance in human hypercholesterolemia and atherosclerosis显示文摘 | Gian Paolo Fadini Francesco Simoni Roberta Cappellari Nicola Vitturi Silvia Galasso Saula Vigili de Kreutzenberg Lorenzo Previato Angelo Avogaro | 2014 | Atherosclerosis2014，，2： | 1 |
| 9 | Independent glucose and weight-reducing effects of Liraglutide in a real-world population of type 2 diabetic outpatients显示文摘 | Gian Paolo Fadini Natalino Simioni Vera Frison Michela Dal Pos Michela Bettio Paola Rocchini Angelo Avogaro | 2013 | Acta Diabetologica2013，，6： | 1 |
| 10 | Insulin signaling and life span 显示文摘 | Angelo Avogaro Saula Vigili de Kreutzenberg Gian Paolo Fadini | 2010 | Pflugers Arch Eur J Physiol2010，459，： | 1 |
| 11 | Incidence and risk factors for stroke in type 2 diabetoc patients:The dal study显示文摘 | Angelo Avogaro Marina Maggini | | Stroke0，38，4： | 1 |
| 12 | Monocyte NADPH oxidase subunit P22phox and inducible hemeoxygenase-1 gene expression are increased in typeⅡdiabetic patients: Relationship with oxidative stress显示文摘 | Angelo Avogaro Elisa Pagnin Lorenzo Calo | 2003 | Clin Endocrinol Metab2003，88，4： | 1 |
| 13 | Detection of Coronary Artery Disease in Asymptomatic Patients With Type 2 Diabetes Mellitus显示文摘 | Roldano Scognamiglio Christian Negut Angelo Ramondo Antonio Tiengo Angelo Avogaro | 2006 | Journal of the American College of Cardiology2006，，1： | 1 |
| 14 | Achieving glycemic control in patients with type 2 diabetes and renal impairment显示文摘 | Angelo Avogaro Guntram Schernthaner | 2013 | Acta Diabetologica2013，，3： | 1 |
| 15 | Endothelial dysfunction: Causes and con- sequences in patients with diabetes mellitus Original Research Article显示文摘 | ANGELO AVOGARO SAULA VIGILI DE KREUTZENBERG G1ANPAOLO FADINI | 2008 | Diabetes Research and Clinical Practice2008，82，2： | 1 |
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