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| 1 | Dismicrobism in inflammatory bowel disease and colorectal cancer: Changes in response of colocytes显示文摘Patients with inflammatory bowel disease(IBD)have an increased risk of 10%-15%developing colorectal cancer(CRC)that is a common disease of high economic costs in developed countries.The CRC has been increasing in recent years and its mortality rates are very high.Multiple biological and biochemical factors are responsible for the onset and progression of this pathology.Moreover,it appears absolutely necessary to investigate the environmental factors favoring the onset of CRC and the promotion of colonic health.The gut microflora,or microbiota,has an extensive diversity both quantitatively and qualitatively.In utero,the intestine of the mammalian fetus is sterile.At birth,the intestinal microbiota is acquired by ingesting maternal anal or vaginal organisms,ultimately developing into a stable community,with marked variations in microbial composition between individuals.The development of IBD is often associated with qualitative and quantitative disorders of the intestinal microbial flora(dysbiosis).The healthy human gut harbours about10 different bacterial species distributed in colony forming units which colonize the gastrointestinal tract.The intestinal microbiota plays a fundamental role in health and in the progression of diseases such as IBD and CRC.In healthy subjects,the main control of intestinal bacterial colonization occurs through gastric acidity but other factors such as endoluminal temperature,competition between different bacterial strains,peristalsis and drugs can influence the intestinal microenvironment.The microbiota exerts diverse physiological functions to include:growth inhibition of pathogenic microorganisms,synthesis of compounds useful for the trophism of colonic mucosa,regulation of intestinal lymphoid tissue and synthesis of amino acids.Furthermore,mucus seems to play an important role in protecting the intestinal mucosa and maintaining its integrity.Changes in the microbiota composition are mainly influenced by diet and age,as well as genetic factors.Increasing evidence indicates that dysbiosis favors the production of genotoxins and metabolites associated with carcinogenesis and induces dysregulation of the immune response whichpromotes and sustains inflammation in IBD leading to carcinogenesis.A disequilibrium in gut microflora composition leads to the specific activation of gut associated lymphoid tissue.The associated chronic inflammatory process associated increases the risk of developing CRC.Ulcerative colitis and Crohn’s disease are the two major IBDs characterized by an early onset and extraintestinal manifestations,such as rheumatoid arthritis.The pathogenesis of both diseases is complex and not yet fully known.However,it is widely accepted that an inappropriate immune response to microbial flora can play a pivotal role in IBD pathogenesis. | Giovanni Tomasello Pietro Tralongo Provvidenza Damiani Emanuele Sinagra Benedetto Di Trapani Marie Noelle Zeenny Inaya Hajj Hussein Abdo Jurjus Angelo Leone | 2014 | World Journal of Gastroenterology2014，20，48： | 10 |
| 2 | Mir-23b and miR- 130b expression is downregulated in pituitary adenomas显示文摘 | Leone V Langella C Angelo DD | 2014 | Mol Cell Endocrinol2014，390，12： | 1 |
| 3 | Mir-23b and miR-130b expression is downregulated in pituitary adenomas 显示文摘 | Leone V Langella C D'Angelo D | 2014 | Mol Cell Endocrinol2014，390，1： | 1 |
| 4 | The High Mobility Group A proteins contribute to thyroid cell transformation by regulating miR-603 and miR- 10b expression显示文摘 | Mussnich P D'angelo D Leone V | 2013 | Molecular Qncology2013，7，3： | 1 |
| 5 | MiR-1is a tumor suppressor in thyroid carcinogenesis targeting CCND2,CXCR4,and SDF-1alpha显示文摘 | Leone V D’Angelo D Rubio I | 2011 | J Clin Endocrinol Metab2011，96，9： | 1 |
| 6 | Characterization of pathogenic Vibrio parahaemolyticus isolates from clinical sources in spain and comparison with asian and north american pandemic isolates 显示文摘 | Jaime Martinez - Urtaza Antonio Lozano - Leon Angelo DePaola | 2004 | J Clin Microbiol2004，42，10： | 1 |
| 7 | Paradoxical Contributions of Non-Compacted and Compacted Segments to Global Left Ventricular Dysfunction in Isolated Left Ventricular Noncompaction显示文摘 | Carla Lofiego Elena Biagini Marinella Ferlito Ferdinando Pasquale Guido Rocchi Enrica Perugini Ornella Leone Giovanni Bracchetti Kadir Caliskan Angelo Branzi Folkert J. ten Cate Claudio Rapezzi | 2006 | The American Journal of Cardiology2006，，5： | 1 |
| 8 | MicroRNA-133 Controls Vascular Smooth Muscle Cell Phenotypic Switch In Vitro and Vascular Remodeling In Vivo显示文摘 | Daniele Torella Claudio Iaconetti Daniele Catalucci Georgina M. Ellison Angelo Leone Cheryl D. Waring Angela Bochicchio Carla Vicinanza Iolanda Aquila Antonio Curcio Gianluigi Condorelli Ciro Indolfi | 2011 | Circulation Research2011，，8： | 1 |
| 9 | MicroRNA-133 Controls Vascular Smooth Muscle Cell Phenotypic Switch In Vitro and Vascular Remodeling In Vivo显示文摘 | Daniele Torella Claudio Iaconetti Daniele Catalucci Georgina M. Ellison Angelo Leone Cheryl D. Waring Angela Bochicchio Carla Vicinanza Iolanda Aquila Antonio Curcio Gianluigi Condorelli Ciro Indolfi | 2011 | Circulation Research2011，，8： | 1 |
| 10 | Characterization of pathogenic Vibrio parahaemolyticus isolates from clinical sources in spain and comparison with asian and north american pandemic isolates 显示文摘 | Jaime Martinez - Urtaza Antonio Lozano - Leon Angelo DePaola | 2004 | J Clin Microbiol2004，42，10： | 1 |
| 11 | Characterization of pathogenic Vibrio parahaemolyticus isolates from clinical sources in spain and comparison with Asian and North American pandemic isolates显示文摘 | Jaime Martinez - Urtaza Antonio Lozano -Leon Angelo DePaola | 2004 | J Clin Microbio2004，42，10： | 1 |
| 12 | Characterization of pathogenic V ibrio parahaem olyticus isolates from clinical sources in spain and comparison with asian and north American pandemic isolates 显示文摘 | Jaime Martinez - Urtaza Antonio Lozano - Leon Angelo DePaola | 2004 | Clin Microbiol2004，42，10： | 1 |
| 13 | Characterization of pathogenic Vibrio parahaemolyticus isolates from clinical sources in spain and comparison with Asian and North American pandemic isolates显示文摘 | Jaime Martinez - Urtaza Antonio Lozano- Leon Angelo DePaola | 2004 | Journal of Clinical Microbiology2004，，： | 1 |
| 14 | The High Mobility Group A proteins contribute to thyroid cell transformation by regulating miR-603 and miR-10b expression显示文摘 | Mussnich P D'Angelo D Leone V | 2013 | Mol Oneol2013，7，3： | 1 |
| 15 | miR-23b and miR-130b expression is downregulated in pituitary adenomas显示文摘 | Vincenza Leone Concetta Langella Daniela D’Angelo Paula Mussnich Anne Wierinckx Luigi Terracciano Gerald Raverot Joel Lachuer Sandra Rotondi Marie-Lise Jaffrain-Rea Jacqueline Trouillas Alfredo Fusco | 2014 | Molecular and Cellular Endocrinology (-)2014，，1： | 1 |
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