|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chemotherapy for hepatocellular carcinoma:The present and the future显示文摘Hepatocellular carcinoma(HCC) is the most common primary tumor of the liver. Its relationship to chronic liver diseases, in particular cirrhosis, develops on a background of viral hepatitis, excessive alcohol intake or metabolic steatohepatitis, leads to a high incidence and prevalence of this neoplasia worldwide. Despite the spread of HCC, its treatment it's still a hard challenge, due to high rate of late diagnosis and to lack of therapeutic options for advanced disease. In fact radical surgery and liver transplantation, the most radical therapeutic approaches, are indicated only in case of early diagnosis. Even local therapies, such as transarterial chemoembolization, find limited indications, leading to an important problem regarding treatment of advanced disease. In this situation, until terminal HCC occurs, systemic therapy is the only possible approach, with sorafenib as the only standard treatment available. Anyway, the efficacy of this drug is limited and many efforts are necessary to understand who could benefit more with this treatment. Therefore, other molecules for a targeted therapy were evaluated, but only regorafenib showed promising results. Beside molecular target therapy, also cytotoxic drugs, in particular oxaliplatinand gemcitabine-based regimens, and immune-checkpoint inhibitors were tested with interesting results. The future of the treatment of this neoplasia is linked to our ability to understand its mechanisms of resistance and to find novel therapeutic targets, with the objective to purpose individualized approaches to patients affected by advanced HCC. | Marco Le Grazie Maria Rosa Biagini Mirko Tarocchi Simone Polvani Andrea Galli | 2017 | World Journal of Hepatology2017，9，21： | 11 |
| 2 | Endoscopicultrasonographyforsurveillanceofindividualsathighriskfor pancreaticcancer显示文摘Pancreatic cancer is a highly lethal disease with a ge-netic susceptibility and familial aggregation found in 3%-16% of patients. Early diagnosis remains the only hope for curative treatment and improvement of prog-nosis. This can be reached by the implementation of an intensive screening program, actually recommended for individuals at high-risk for pancreatic cancer de-velopment. The aim of this strategy is to identify pre-malignant precursors or asymptomatic pancreatic can-cer lesions, curable by surgery. Endoscopic ultrasound (EUS) with or without fine needle aspiration(FNA) seems to be the most promising technique for early de-tection of pancreatic cancer. It has been described as a highly sensitive and accurate tool, especially for small and cystic lesions. Pancreatic intraepithelial neoplasia, a precursor lesion which is highly represented in high-risk individuals, seems to have characteristics chronic pancreatitis-like changes well detected by EUS. Many screening protocols have demonstrated high diagnostic yields for pancreatic pre-malignant lesions, allowing prophylactic pancreatectomies. However, it shows a high interobserver variety even among experienced en-dosonographers and a low sensitivity in case of chronic pancreatitis. Some new techniques such as contrast-en-hanced harmonic EUS, computer-aided diagnostic tech-niques, confocal laser endomicroscopy miniprobe andthe detection of DNA abnormalities or protein markersby FNA, promise improvement of the diagnostic yield ofEUS. As the resolution of imaging improves and as ourknowledge of precursor lesions grows, we believe thatEUS could become the most suitable method to detectcurable pancreatic neoplasms in correctly identifiedasymptomatic at-risk patients. | Lami G Biagini MR Galli A | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，7： | 8 |
| 3 | Hyperhomocysteinemia and hypercoagulability in primary biliary cirrhosis显示文摘瞄准:在有人半胱氨酸(HCY ) 和 haemostatic 系统的各种各样的部件的 PBC 和它的关系估计 hypercoagulability。方法:我们调查了 51 个 PBC 病人(43F/8M;意味着年龄:63+/-13.9 年) 并且 102 个健康题目(86 个 women/16 人;63+/-13 年) ,并且由 PFA-100 由 Sonoclot 分析和血小板功能在全血评估了 haemostatic 过程设备。我们然后测量了 HCY (禁食并且在蛋氨酸装载以后) ,织物因素(TF ) , thrombin-antithrombin 建筑群(梭织) , D 暗淡(D-D ) , thrombomodulin (TM ) , folic,维生素 B6 和 B12 血浆铺平。C677T 5,10-methylenetetrahydrofolate 还原酶(MTHFR ) 多型性被分析。结果:病人的 Sonoclot 率值是显著地(P<0.001 ) 比那些高控制。山峰价值的 Sonoclot 时间和 PFA-100 闭合时间在病人和控制是可比较的。梭织, TF 和 HCY 层次,两个在禁食并且蛋氨酸以后的装载,显著地(P<0.001 ) 在病人更高与比在控制。维生素缺乏在 45/51 病人(88.2%) 被检测。同型结合的 TT677 MTHFR 遗传型的流行比在控制(17.5%)(P<0.05 ) 在病人(31.4%) 是显著地更高的。Sonoclot 率价值与 HCY 层次和 TF 显著地相关。结论:在 PBC, hyper-HCY 与维生素缺少和基因预先安排因素有关。内皮激活的增加的 TF 和 HCY 层次和符号与 hypercoagulability 被联系并且可以在血凝固激活有一个重要角色。 | Maria Rosa Biagini Alessandro Tozzi Rossella Marcucci Rita Paniccia Sandra Fedi Stefano Milani Andrea Galli Elisabetta Ceni Marco Capanni Raffaele Manta Rosanna Abbate Calogero Surrenti | 2006 | World Journal of Gastroenterology2006，12，10： | 6 |
| 4 | Wind response of large roofs of stations and arena显示文摘 | Biagini P Borri C Facchini L | 2007 | Journal of Wind Engineering and Industrial Aerodynamics2007，95，911： | 1 |
| 5 | Comparison of a multiplexed fluorescent covalent microsphere immunoassay and an Enzyme-Linked Immunosorbent Assay for measurement of human immunoglobulin G antibodies to anthrax toxins显示文摘 | Biagini RE Sammons DL Smith JP | 2004 | Clin Diagn Lab Immunol2004，11，1： | 1 |
| 6 | Rapid, sensitive, and specific lateral-flow immunochromatographic device to measure anti-anthrax protective antigen immunoglohulin G in serum and whole blood 显示文摘 | Biagini R E Sammons D L Smith J P | 2006 | Clin Vaccine Immunol2006，13，： | 1 |
| 7 | Smiultameous measurement of specific serum IgG responses to five select agents显示文摘 | Biagini RE Sammons DL Smith JP | 2005 | Anal Bioanal Chem2005，382，4： | 1 |
| 8 | A system for surgical staging and management of spinal tumors: a clinical outcome study of giant cell tumors of the spine显示文摘 | Hart RA Boriani S Biagini R | 1997 | Spine1997，22，： | 1 |
| 9 | Determination and phylogenetic analysis of partial sequences from TT virus isolates显示文摘 | Biagini P Gallian P Attoui H | 1999 | Gen Virol1999，80，2： | 1 |
| 10 | sensitive, and specific lateral-flow immunochromatographic device to measure antianthrax protective antigen immunoglobulin g in serum and whole blood显示文摘 | Biagini RE Sammons DL Smith JP | 2006 | Clin Vaccine Immunol2006，13，5： | 1 |
| 11 | Staging and treatment of pri mary tumors of the spine 显示文摘 | Broiani S Bandiera S Biagini F | 1999 | Current Opinion in Orthopopedics1999，10，2： | 1 |
| 12 | The pilocarpine model of temporal lobe epilepsy显示文摘 | Giulia Curia Daniela Longo Giuseppe Biagini Roland S.G. Jones Massimo Avoli | 2008 | Journal of Neuroscience Methods2008，，2： | 1 |
| 13 | Reconstruction of parodontal tissue with chitosan显示文摘 | Muzzarelli R Biagini G Pugnaloni A | 1989 | Biomaterials1989，9，： | 1 |
| 14 | Primary bone tumors of the spine: terminology and surgical staging 显示文摘 | Boriani S Weinstein JN Biagini R | 1997 | Spine1997，22，9： | 1 |
| 15 | Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria 显示文摘 | BIAGINI G A VIRIYAVEJAKUL O O’NEILL P M | 2006 | Antimicrob Agents Chemother2006，50，： | 1 |
| 16 | Pacemaker stress echocardiography predicts cardiac events in patients wi permanent pacemaker显示文摘 | Biagini E Sehinkel AF Elhendy A | 2005 | Am J Med2005，118，12： | 1 |
| 17 | Combined protocol for treatment of secondary effect from facial nerve palsy 显示文摘 | Monini S Carlo AD Biagini M | 2011 | Acta Oto Ltryngologica2011，131，： | 1 |
| 18 | The combined effect of acupuncture and Tanacetum parthenium on quality of life in women with headache:randomised study显示文摘 | Ferro EC Biagini AP da SilvaE | 2012 | Acupunct Med2012，30，4： | 1 |
| 19 | Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study显示文摘 | CAPANNI M CALELLA F BIAGINI M R | 2006 | Alimentary Pharmacology and Therapeutics2006，23，8： | 1 |
| 20 | Guidelines for the diag- nosis and treatment of non-ST-segment elevation acute cor- onary syndromes: the taskforce for the diagnosis and treat- ment of non-ST-segment elevation acute coronary syndro- mes of the European Society of Cardiology显示文摘 | Rapezzi C Biagini E Branzi A | 2008 | Eur Heart J2008，29，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员