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| 1 | Hepatic steatosis,low-grade chronic inflammation and hormone/growth factor/adipokine imbalance显示文摘Non-alcoholic fatty liver disease (NAFLD), a further expression of metabolic syndrome, strictly linked to obesity and diabetes mellitus, is characterized by insulin resistance (IR), elevated serum levels of free fatty acids and fatty infi ltration of the liver, which is known as hepatic steatosis. Hepatocyte apoptosis is a key feature of this disease and correlates with its severity. Free-fatty-acidinduced toxicity represents one of mechanisms for the pathogenesis of NAFLD and hormones, growth factors and adipokines influence also play a key role. This review highlights the various pathways that contribute to the development of hepatic steatosis. Circulating concentrations of inflammatory cytokines are reckoned to be the most important factor in causing and maintaining IR. Low-grade chronic inflammation is fundamental in the progression of NAFLD toward higher risk cirrhotic states. | Giovanni Tarantino Silvia Savastano Annamaria Colao | 2010 | World Journal of Gastroenterology2010，16，38： | 22 |
| 2 | Serum Bcl-2 concentrations in overweight-obese subjects with nonalcoholic fatty liver disease显示文摘AIM: To shed some light on the relationship between anti-apoptotic serum Bcl-2 concentrations and metabolic status, anthropometric parameters, inflammation indices, and non-alcoholic fatty liver disease severity were investigated in 43 young individuals with fatty liver (FL)and 41 with nonalcoholic steatohepatitis (NASH).METHODS: Circulating levels of Bcl-2 were detected in 84 patients with ultrasono graphic findings of 'bright liver' and/or hyper-transaminasemia of unknown origin and/or increase in γ-glutamyl-transpeptidase (γ-GT)strictly in the absence of other acute or chronic liver disease, whose age was not advanced, who gave consent to liver biopsy and were then divided on the basis of the histological results into two groups (43 with FL and 41 with NASH). Twenty lean subjects, apparently healthy and young, were chosen as controls.RESULTS: Serum Bcl-2 concentrations were significantly higher in the FL group than in the NASH group. Insulin resistance and γ-GT activity were significantly higher in NASH subjects. Apoptotic hepatocytes were significantly more numerous in NASH patients. NASH patients presented with larger spleens and augmented C-reactive protein (CRP) concentrations than healthy subjects. Steatosis grade at histology was similar in both NASH and FL populations. The number of apoptotic cells was significantly related to anti-apoptotic Bcl-2 protein values in FL patients. Bcl-2 serum levels positively correlated to body mass index (BMI) values (P ≤ 0.0001) but not to age of the population. Triglycerides/HDL ratio correlated well to waist circumference in males (P = 0.0008).γ-GT activity was associated with homeostatic metabolic assessment (HOMA) (P = 0.0003) and with serum ferritin (P = 0.02). Bcl-2 concentrations were not related to either spleen size or CRP values. NASH patients presented a weak negative correlation between lobular inflammation and Bcl-2 levels. A prediction by low values of serum Bcl-2 towards a greater presence of metaboli-cally unhealthy overweight/obese patients (MUOs) was evidenced. HOMA, BMI and uric acid, in that sequence,best predicted serum Bcl-2 concentrations.CONCLUSION: MUOs could be detected by Bcl-2 levels.By favoring the life span of hepatocytes, and enhancing triglyceride formation, the anti-apoptotic process inhibits free fatty acids toxicity in FL. | Giovanni Tarantino Francesco Scopacasa Annamaria Colao Domenico Capone Marianna Tarantino Ernesto Grimaldi Silvia Savastano | 2011 | World Journal of Gastroenterology2011，17，48： | 10 |
| 3 | Hepatic steatosis in overweight/obese females: New screening method for those at risk显示文摘AIM: To identify which parameters could help to distinguish the 'metabolically benign obesity', which is not accompanied by insulin resistance (IR) and early atherosclerosis.METHODS: Eighty two of 124 overweight/obese females formed the study population, which was divided into two groups (52 and 30 subjects, respectively) with and without IR according to a HO meostatic Metabolic Assessment (HOMA) cut-off of 2, and were studied in a cross-sectional manner. The main outcome measures were waist circumference, serum uric acid, high-density lipoprotein-cholesterol and triglycerides, alanine amino-transferase, blood pressure and the two imaging para-meters, hepatic steatosis and longitudinal diameter of the spleen, which were measured in relation to the presence/absence of IR. RESULTS: A variable grade of visceral obesity was observed in all subjects with the exception of three.Obesity of a severe grade was represented more in the group of IR individuals (P = 0.01). Hepatic steatosis, revealed at ultrasound, was more pronounced in IR than in non-IR subjects (P = 0.005). The two groups also demonstrated a clear difference in longitudinal spleen diameter and blood pressure, with raised and signif icant values in the IR group. Metabolic syndrome was frequent in the IR group, and was not modified when adjusted for menopause (P = 0.001). At linear regression, the β values of waist circumference and body mass index predicting HOMA were 0.295, P = 0.007 and 0.41, P = 0.0001, respectively. Measures of spleen longitudinal diameter were well predicted by body mass index (BMI) values, β = 0.35, P = 0.01, and by HOMA, β = 0.41, P = 0.0001. Blood pressure was predicted by HOMA values, β = 0.39, P = 0.0001). HOMA and hepatic steatosis were highly associated (rho = 0.34, P = 0.002). Interestingly, IR patients were almost twice as likely to have hepatic steatosis as non-IR patients. Among the MS criteria, blood pressure was very accurate in identifying the presence of IR (AUROC for systolic blood pressure 0.66, cut-off 125 mm of Hg, sensibility 64%, specif icity 75%; AUROC for diastolic blood pressure 0.70, cut-off 85 mm of Hg, sensibility 54.5%, specif icity 75%). CONCLUSION: As health care costs are skyrocketing, reliable and mainly inexpensive tools are advisable to better defi ne subjects who really need to lose weight. | Giovanni Tarantino Genoveffa Pizza Annamaria Colao Fabrizio Pasanisi Paolo Conca Patrizia Colicchio Carmine Finelli Franco Contaldo Carolina Di Somma Silvia Savastano | 2009 | World Journal of Gastroenterology2009，15，45： | 4 |
| 4 | Spleen:A new role ffoorr an old player?显示文摘The spleen could be considered a neglected organ.To date,it has been deemed an ancillary organ in portal hypertension or an organ localization in lymphoproliferative diseases,even though it has had significant attention in infectious diseases for some time.Now,it is thought to be central in regulating the immune system,a metabolic asset and involved in endocrine function with regard to nonalcoholic fatty liver disease.The main mechanisms involved in this complex network will be critically discussed in this article. | Giovanni Tarantino Silvia Savastano Domenico Capone Annamaria Colao | 2011 | World Journal of Gastroenterology2011，17，33： | 2 |
| 5 | US-Guided Percutaneous Radiofrequency Thermal Ablation for the Treatment of Solid Benign Hyperfunctioning or Compressive Thyroid Nodules显示文摘 | Maurilio Deandrea Paolo Limone Edoardo Basso Alberto Mormile Federico Ragazzoni Elena Gamarra Stefano Spiezia Antongiulio Faggiano Annamaria Colao Filippo Molinari Roberto Garberoglio | 2008 | Ultrasound in Medicine & Biology2008，，5： | 1 |
| 6 | Bisphenol A in polycystic ovary syndrome and its association with liver–spleen axis显示文摘 | Giovanni Tarantino Rossella Valentino Carolina Di Somma Vittoria D’Esposito Federica Passaretti Genoveffa Pizza Valentina Brancato Francesco Orio Pietro Formisano Annamaria Colao Silvia Savastano | 2013 | Clin Endocrinol2013，，3： | 1 |
| 7 | Systemic Complications of Acromegaly: Epidemiology, Pathogenesis, and Management显示文摘 | Annamaria Colao Diego Ferone Paolo Marzullo Gaetano Lombardi | 2004 | Endocrine Reviews2004，，1： | 1 |
| 8 | Secondary diabetes associated with principal endocrinopathies: the impact of new treatment modalities显示文摘 | Eugenia Resmini Francesco Minuto Annamaria Colao Diego Ferone | 2009 | Acta Diabetologica2009，，2： | 1 |
| 9 | Pathophysiology of Diabetes Mellitus in Cushing’s Syndrome显示文摘 | Pivonello Rosario De Leo Monica Vitale Pasquale Cozzolino Alessia Simeoli Chiara De Martino Maria Cristina Lombardi Gaetano Colao Annamaria | 2010 | Neuroendocrinology2010，，： | 1 |
| 10 | Dopastatins:somatostatin -dopamine chimeric molecules显示文摘 | Annamaria Colao | 2010 | Tumori2010，96，： | 1 |
| 11 | Orbital scintigraphy with In- Diethylenetriamine Pentaacetic Acid- D - Phe'J- Octreotide Predicts the clinical response to corticosteroid therapy in Patients with Graves' Ophthalmopathy显示文摘 | Annamaria Colao | 1998 | Clin Endocrinol Metabol1998，83，： | 1 |
| 12 | Somatostatin Analogues: Treatment of Pituitary and Neuroendocrine Tumors显示文摘 | Annamaria Colao Antongiulio Faggiano Rosario Pivonello | 2010 | Progress in Brain Research2010，，： | 1 |
| 13 | Predictors of Tumor Shrinkage after Primary Therapy with Somatostatin Analogs in Acromegaly: A Prospective Study in 99 Patients显示文摘 | Annamaria Colao Rosario Pivonello Renata S. Auriemma Francesco Briganti Mariano Galdiero Fabio Tortora Ferdinando Caranci Sossio Cirillo Gaetano Lombardi | 2006 | The Journal of Clinical Endocrinology & Metabolism2006，，6： | 1 |
| 14 | Pancreatic neuroendocrine tumor with hypoglycemia and elevated insulin-like growth factor II:a case report显示文摘Pancreatic neuroendocrine tumors(pNETs)can be associated with different clinical syndromes.Insulinoma is the most common functioning pNET characterized by hypoglycemia and hyperinsulinemia.The authors report a case of a man presenting with hypoglycemia and biochemical features of insulinoma.A pancreatic lesion was found and growth hormone(GH)deficiency was also diagnosed associated with an empty sella present on the pituitary magnetic resonance imaging.The disappearance of hypoglycemia and normalization of GH secretion after surgical resection of the pancreatic lesion,revealed a rare pNET secreting insulin-like growth factor II. | Roberta Modica Antonella Di Sarno Annamaria Colao Antongiulio Faggiano | 2016 | Journal of Cancer Metastasis and Treatment2016，2，1： | 0 |
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