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| 1 | Hepatitis C virus lymphotropism and peculiar immunological phenotype:Effects on natural history and antiviral therapy显示文摘Hepatitis C virus(HCV) has been recognized to be both a hepato-and lymphotropic virus.HCV lymphotropism represents an essential lap in the pathogenesis of virusrelated autoimmune and lymphoproliferative disorders,ranging from clonal expansion of B-cells with organ-and non-organ-specific autoantibody production up to overt non-Hodgkin's lymphoma along a continuous step-by-step model of B-cell lymphomagenesis,where the intermediated mixed cryoglobulinemia could be considered as a stage of suppressible antigen-driven lymphoproliferation.HCV infection of lymphoid cells could set up privileged reservoirs able to interfere with the host viral clearance eff iciency and may be implicated in viral recurrence after apparently successful antiviral therapy.The HCV long-lasting extrahepatic replicative state generates an abnormal systemic immunological response,easily detectable by searching simple laboratory and clinical parameters,mainly represented by vasculitis-like skin features and hypocomplementemia.The presence or absence of this hypersensitivity pattern seems to correlate with the antiviral response and could be identif ied as a novel immunological cofactor.Further research is required to fully verify the real impact on therapeutic choice/regimen. | Paolo Conca Giovanni Tarantino | 2009 | World Journal of Gastroenterology2009，15，19： | 5 |
| 2 | Hepatic steatosis in overweight/obese females: New screening method for those at risk显示文摘AIM: To identify which parameters could help to distinguish the 'metabolically benign obesity', which is not accompanied by insulin resistance (IR) and early atherosclerosis.METHODS: Eighty two of 124 overweight/obese females formed the study population, which was divided into two groups (52 and 30 subjects, respectively) with and without IR according to a HO meostatic Metabolic Assessment (HOMA) cut-off of 2, and were studied in a cross-sectional manner. The main outcome measures were waist circumference, serum uric acid, high-density lipoprotein-cholesterol and triglycerides, alanine amino-transferase, blood pressure and the two imaging para-meters, hepatic steatosis and longitudinal diameter of the spleen, which were measured in relation to the presence/absence of IR. RESULTS: A variable grade of visceral obesity was observed in all subjects with the exception of three.Obesity of a severe grade was represented more in the group of IR individuals (P = 0.01). Hepatic steatosis, revealed at ultrasound, was more pronounced in IR than in non-IR subjects (P = 0.005). The two groups also demonstrated a clear difference in longitudinal spleen diameter and blood pressure, with raised and signif icant values in the IR group. Metabolic syndrome was frequent in the IR group, and was not modified when adjusted for menopause (P = 0.001). At linear regression, the β values of waist circumference and body mass index predicting HOMA were 0.295, P = 0.007 and 0.41, P = 0.0001, respectively. Measures of spleen longitudinal diameter were well predicted by body mass index (BMI) values, β = 0.35, P = 0.01, and by HOMA, β = 0.41, P = 0.0001. Blood pressure was predicted by HOMA values, β = 0.39, P = 0.0001). HOMA and hepatic steatosis were highly associated (rho = 0.34, P = 0.002). Interestingly, IR patients were almost twice as likely to have hepatic steatosis as non-IR patients. Among the MS criteria, blood pressure was very accurate in identifying the presence of IR (AUROC for systolic blood pressure 0.66, cut-off 125 mm of Hg, sensibility 64%, specif icity 75%; AUROC for diastolic blood pressure 0.70, cut-off 85 mm of Hg, sensibility 54.5%, specif icity 75%). CONCLUSION: As health care costs are skyrocketing, reliable and mainly inexpensive tools are advisable to better defi ne subjects who really need to lose weight. | Giovanni Tarantino Genoveffa Pizza Annamaria Colao Fabrizio Pasanisi Paolo Conca Patrizia Colicchio Carmine Finelli Franco Contaldo Carolina Di Somma Silvia Savastano | 2009 | World Journal of Gastroenterology2009，15，45： | 4 |
| 3 | Intestinal Specific LXR Activation Stimulates Reverse Cholesterol Transport and Protects from Atherosclerosis显示文摘 | Giuseppe Lo Sasso Stefania Murzilli Lorena Salvatore Ilenia D’Errico Michele Petruzzelli Paola Conca Zhao-Yan Jiang Laura Calabresi Paolo Parini Antonio Moschetta | 2010 | Cell Metabolism2010，，2： | 1 |
| 4 | Could inflammatory markers help diagnose nonalcoholic steatohepatitis?显示文摘 | Giovanni Tarantino Paolo Conca Fabrizio Pasanisi Manuela Ariello Maria Mastrolia Adriano Arena Marianna Tarantino Francesco Scopacasa Raffaela Vecchione | 2009 | European Journal of Gastroenterology & Hepatology2009，，5： | 1 |
| 5 | Flow cytometry assay of myeloid dendritic cells (mDCs)in peripheral blood during acute hepatitis C:Possible pathogenetic mechanisms显示文摘瞄准:到驴骨髓的的树枝状的房间(CD11c+) 的表示子集在在感染的自然科学的尖锐 HCV 肝炎和它的可能的参与期间。方法:我们与尖锐丙肝(AHC )( 组 A ) 注册了 11 个病人,有尖锐肝炎 A (啊哈) 的 10 个病人(同样易传染的控制 -- 组 B ) 并且在这的 10 个健康施主(组 C ) 学习。所有病人经历了选择流动血细胞计数 gating 策略估计骨髓的的树枝状的房间(mDCs ) 的外部数字在尖锐肝炎期间理解可能的角色和差别。结果:有尖锐 HCV 肝炎的 11 个病人中的八个没与健康个人相比显示出 mDCs 的任何增加,当 mDCs 的重要减少在绝对房间计数被发现时(z =-2.37;P<0.05 ) 并且百分比(z =-2.30;P<0.05 ) 同样与啊哈相比。相反,留下组 A 的三个病人有是的一个更高的 mDCs 数字和百分比发生在组 B。在六个月以后,有趣地,那些病人没证明 mDCs 子集的任何增加长期地被感染。当三在 HAV 急性感染随外部 mDCs 的增加使遭到,,时,解决了病。结论:mDCs 的增加的缺乏可能在尖锐丙肝期间是涉及感染的 chronicization 的一个重要因素。 | Alessandro Perrella Luigi Atripaldi Pasquale Bellopede Tommaso Patarino Costanza Sbreglia Giovanni Tarantino Paolo Sorrentino Paolo Conca Luca Ruggiero Oreste Perrella | 2006 | World Journal of Gastroenterology2006，12，7： | 1 |
| 6 | Could inflammatory markers help diagnose nonalcoholic steatohepatitis?显示文摘 | Giovanni Tarantino Paolo Conca Fabrizio Pasanisi Manuela Ariello Maria Mastrolia Adriano Arena Marianna Tarantino Francesco Scopacasa Raffaela Vecchione | 2009 | European Journal of Gastroenterology & Hepatology2009，，5： | 1 |
| 7 | Does protracted antiviral therapy impact on HCV-related liver cirrhosis progression?显示文摘AIM: To study the outcomes of patients with compensated hepatitis C virus-related cirrhosis. METHODS: Twenty-four grade A5 and 11 grade A6 of Child-Pugh classification cirrhotic patients with active virus replication, treated for a mean period of 31.3 ± 5.1 mo with moderate doses of interferon-alpha and ribavirin, were compared to a cohort of 36 patients with similar characteristics, without antiviral treatment. Salivary caffeine concentration, a liver test of microsomal function, was determined at the starting and thrice in course of therapy after a mean period of 11 ± 1.6 mo, meanwhile the resistive index of splenic artery at ultra sound Doppler, an indirect index of portal hypertension, was only measured at the beginning and the end of study. RESULTS: Eight out of the 24 A5- (33.3%) and 5 out of the 11 A6- (45.45%) treated-cirrhotic patients showed a significant improvement in the total overnight salivary caffeine assessment. A reduction up to 20% of the resistive index of splenic artery was obtained in 3 out of the 8 A5- (37.5%) and in 2 out of the 5 A6- (40%) cirrhotic patients with an improved liver function, which showed a clear tendency to decrease at the end of therapy. The hepatitis C virus clearance was achieved in 3 out of the 24 (12.5%) A5- and 1 out of the 11 (0.091%) A6-patients after a median period of 8.5 mo combined therapy. In the cohort of non-treated cirrhotic patients, not only the considered parameters remained unchanged, but 3 patients (8.3%) had a worsening ofthe Child-Pugh score (P = 0.001).CONCLUSION: A prolonged antiviral therapy with moderate dosages of interferon-alpha and ribavirin shows a trend to stable liver function or to ameliorate the residual liver function, the entity of portal hypertension and the compensation status at acceptable costs. | Giovanni Tarantino Antonio Gentile Domenico Capone Vincenzo Basile Marianna Tarantino Matteo Nicola Dario Di Minno Alberto Cuocolo Paolo Conca | 2007 | World Journal of Gastroenterology2007，13，36： | 0 |
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