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| 1 | Phytate:impact on environment and human nutrition.A challenge for molecular breeding显示文摘Phytic acid (PA) is the primary storage compound of phosphorus in seeds accounting for up to 80% of the total seed phosphorus and contributing as much as 1.5% to the seed dry weight. The negatively charged phosphate in PA strongly binds to metallic cations of Ca, Fe, K, Mg, Mn and Zn making them insoluble and thus unavailable as nutritional factors. Phytate mainly accumulates in protein storage vacuoles as globoids, predominantly located in the aleurone layer (wheat, barley and rice) or in the embryo (maize). During germination, phytate is hydrolysed by endogenous phytase(s) and other phosphatases to release phosphate, inositol and micronutrients to support the emerging seedling. PA and its derivatives are also implicated in RNA export, DNA repair, signalling, endocytosis and cell vesicular trafficking. Our recent studies on purification of phytate globoids, their mineral composition and dephytinization by wheat phytase will be discussed. Biochemical data for purified and characterized phytases isolated from more than 23 plant species are presented, the dephosphorylation pathways of phytic acid by different classes of phytases are compared, and the application of phytase in food and feed is discussed. | Lisbeth BOHN Anne S. MEYER Sren K. RASMUSSEN | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，3： | 30 |
| 2 | 国际糖尿病足工作组:糖尿病足溃疡预防指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分显示文摘国际糖尿病足工作组(IWGDF)1999年发布了关于预防和管理糖尿病足病的循证指南。该指南旨在预防糖尿病患者的足部溃疡,并在2015年,IWGDF对预防指南进行了更新。我们遵循GRADE(grading of recommendations assessment development and evaluation)的评分方法,采用以患者为观察对象、有干预措施、与对照组进行比较、观察结局(patient-intervention-comparison-outcome,PICO)的方法来设计临床问题和关键成果,对医学科学文献进行系统评价,并撰写推荐意见及其理由。这些推荐基于系统评价中发现的证据质量、专家意见,以及益处及危害的权重、患者偏好、可行性和适用性以及与干预相关成本的权衡。我们建议对处于极低溃疡风险的患者每年做一次筛查,了解其是否有周围神经病变和外周血管病变,对高风险人群检查的频率要更高,以筛查其他危险因素。为了预防足溃疡,要对有危险因素的患者进行健康教育,教育患者适当地对足部进行自我护理以及对溃疡前症状进行有效治疗。指导中高危患者穿着合适的治疗鞋,并对其足部皮肤温度进行监测。处方治疗鞋在行走过程中具有明显的减轻足底压力的效果,能够防止足底溃疡复发。急性足溃疡或即将发生的足溃疡保守治疗失败,应考虑手术干预。我们不建议使用神经松解减压术。对高危患者给予综合足部医疗护理,以防溃疡复发。贯彻这些推荐将有助于医疗专业人员对有足溃疡风险的糖尿病患者提供更好的护理,降低糖尿病足溃疡的发生率,使足部健康维持更长的时间即增加无足病的天数,显著减少糖尿病患者和医疗机构的负担。 | Sicco A.Bus Larry A.Lavery Matilde Monteiro-Soares Anne Rasmussen Anita Raspovic Isabel C.N.Sacco Jaap J.van Netten 无 罗颖琪 李炳辉(译) 许樟荣(审校) | 2019 | 感染.炎症.修复2019，20，3： | 14 |
| 3 | Size-asymmetric root competition in deep,nutrient-poor soil显示文摘Aims There is much evidence that plant competition below ground is size symmetric,i.e.that competing plants share contested resources in proportion to their sizes.Several researchers have hypothesized that a patchy distribution of soil nutrients could result in size-asymmetric root competition.We tested this hypothesis.Methods In a greenhouse experiment,Triticum aestivum(wheat)individ-uals of different initial sizes were grown alone or with below-ground competition from one neighbour,in 1 m tall,narrow containers in a nitrogen-poor field soil with(i)no added nitro-gen,(ii)nitrogen fertilizer mixed into the upper 50 cm,and(iii)the same amount of fertilizer mixed into a 20-30 cm deep layer.We measured total leaf length throughout the experiment,and above-ground biomass and nitrogen concentration at harvest.We also measured root depth and frequency over time in a subset of containers.Important Findings Competing plants were half the size of non-competing plants,meaning that root competition was very strong.Root competition was size-asym-metric to some degree in all soil treatments.Neighbours larger than the target plant showed a greater per-unit-size effect on target growth than neighbours smaller than the target.Size variation increased over time for competing individuals,but decreased for non-competing pairs.Contrary to expectations,the presence of a high-nutrient patch reduced the strength and size asymmetry of competition temporarily.Size asym-metry in poor,deep soils may result from directionality in resource interception as roots compete for limited nutrients by growing deeper into soil layers that have not yet been exploited.Root competition can be size asymmetric,but not to the same degree as competition for light. | Camilla Ruø Rasmussen Anne Nygaard Weisbach Kristian Thorup-Kristensen Jacob Weiner | 2019 | Journal of Plant Ecology2019，12，1： | 2 |
| 4 | Idiopathic extensive peliosis hepatis treated with liver transplantation显示文摘 | Masanobu Hyodo Anne Mellon Mogensen Peter N?rgaard Larsen Andre Wettergren Allan Rasmussen Preben Kirkegaard Yoshikazu Yasuda Hideo Nagai | 2004 | Journal of Hepato - Biliary - Pancreatic Surgery2004，，5： | 1 |
| 5 | Prevalence of patients at nutritional risk in Danish hospitals显示文摘 | Henrik H?jgaard Rasmussen Jens Kondrup Michael Staun Karin Ladefoged Hanne Kristensen Anne Wengler | 2004 | Clinical Nutrition2004，，5： | 1 |
| 6 | Idiopathic extensive peliosis hepatis treated with liver transplantation显示文摘 | Masanobu Hyodo Anne Mellon Mogensen Peter N?rgaard Larsen Andre Wettergren Allan Rasmussen Preben Kirkegaard Yoshikazu Yasuda Hideo Nagai | 2004 | Journal of Hepato - Biliary - Pancreatic Surgery2004，，5： | 1 |
| 7 | 土壤和水酸化对于健康的危害:瑞典的研究项目显示文摘环境的酸化是一个全球性的问题。对于酸的沉降量大而水体和土壤的缓冲性能低的地区而言,酸化问题尤其严重。考虑到在土壤和水体中的酸的沉降物的相当大的影响,重要的是确定其对于人类健康可能有哪些危害及危害的程度。瑞典的环境保护机构从1991年开始进行一项五年研究计划,以研究酸的沉降对于人类健康的危害。这个研究项目的研究内容集中于酸沉降的间接效应。这些间接效应主要是由于微量元素的迁移性改变的结果,导致在大多数情况下使微量元素的含量增加,而在少数情况下微量元素则减少。通过食物链,人体所摄入的有毒元素及必需元素的量可能发生改变。此项研究项目的目标是查明:①酸化作用在多大程度上改变人类所接触的各种元素,包括总的数量级或者其化学状态;②这些改变对于人类的健康有什么作用。此项研究的目的则是尽早发现其对于健康的作用,以求能够防止其对于人类健康的恶劣影响。尽管有一些迹象表明,有毒元素的暴露,如钙、甲基汞和铅等,以及有益元素如硒等的吸收都有可能受到酸的沉降的影响,但目前尚无确凿的证据说明其对于人类的健康有所危害。然而,现有的资料清楚表明,安全度是很小的,应当尽量努力将暴露于一切有毒元素的来源保持在尽可能低的水平上。 | Agneta Oskarsson Gunnar Nordberg Mats Block Finn Rasmussen Rolf Petterson Staffan Skerfving Marie Vahter Anders Wicklund Glynn Toxicology Ingrid Oborn Marie-Louise Heikensten and Ann Thuvander Section for Research on Environmental Pollution Research and 齐文同 | 1996 | 人类环境杂志1996，25，8： | 1 |
| 8 | Prevalence of patients at nutritional risk in Danish hospitals显示文摘 | Henrik H?jgaard Rasmussen Jens Kondrup Michael Staun Karin Ladefoged Hanne Kristensen Anne Wengler | 2004 | Clinical Nutrition2004，，5： | 1 |
| 9 | Adaptation of the bacterial community to mercury contamination显示文摘 | Anne Kirstine Muller Lase Dam Rasmussen Soren Johannes Sorensen | 2001 | FEMS Microbiology Letter2001，204，1： | 1 |
| 10 | Occupational risk of exposure to methicillin-resistant Staphylococcus aureus(MRSA)and the quality of infection hygiene in nursing homes显示文摘Methicillin-resistant Staphylococcus aureus(MRSA)is an increasing health concern across the globe and is often prevalent at long-term care facilities,such as nursing homes.However,we know little of whether nursing home staff is exposed to MRSA via air and surfaces.We investigated whether staff members at nursing homes are colonised with and exposed to culturable MRSA,and assessed staff members'self-reported knowledge of MRSA and compliance with infection hygiene guidelines.Five nursing homes with MRSA positive residents were visited in Copenhagen,Denmark.Personal bioaerosol exposure samples and environmental samples from surfaces,sedimented dust and bioaerosols were examined for MRSA and methicillin-suscqjtible S.aureus(MSSA)to determine occupational exposure.Swabs were taken from staffs*nose,throat,and hands to determine whether they were colonised with MRSA.An online questionnaire about MRSA and infection control was distributed.No staff members were colonised with MRSA,but MRSA was detected in the rooms of the colonised residents in two out of the five nursing homes.MRSA was observed in air(n=4 out of 42,ranging from 2.9-1.9 CFU/m^(3)),sedimented dust(n=1 out of 58,1.1 ×10^(3) CFU/m^(2)/d),and on surfaces(n=9 out of 113,0.04-70.8 CFU/m^(2)).The questionnaire revealed that half of the staff members worry about spreading MRSA to others.Identified aspects for improvement were improved availability and use of protective equipment,not transferring cleaning supplies(e.g.,vacuum cleaners)between residents'rooms and to reduce worry of MRSA,e.g.,through education. | Pil Uthaug Rasmussen Katrine Uhrbrand Mette Damkjaer Bartels Helle Neustrup Dorina Gabriela Karottki Ute Biiltmann Anne Mette Madsen | 2021 | Frontiers of Environmental Science & Engineering2021，15，3： | 1 |
| 11 | Update: Interim Guidelines for Health Care Providers Caring for Pregnant Women and Women of Reproductive Age with Possible Zika Virus Exposure - United States, 2016显示文摘 | Titilope Oduyebo Emily E Petersen Sonja A Rasmussen Paul S Mead Dana Meaney-Delman Christina M Renquist Sascha R Ellington Marc Fischer J Erin Staples Ann M Powers Julie Villanueva Romeo R Galang Ada Dieke Jorge L Mu?oz Margaret A Honein Denise J Jamieson | 2016 | MMWR. Morbidity and Mortality Weekly Report2016，，： | 1 |
| 12 | Risk factors for mortality and ischemic heart disease in patients with long-term type 1 diabetes显示文摘 | Jakob Grauslund Trine M.M. J?rgensen Mads Nybo Anders Green Lars M. Rasmussen Anne Katrin Sj?lie | 2010 | Journal of Diabetes and Its Complications2010，，4： | 1 |
| 13 | Beta-endorphin response to an acute pain stimulus 显示文摘 | Natalie Ann Rasmussen Lynne A Farr | 2009 | Journal of Neuroscience Methods2009，177，： | 1 |
| 14 | Beta-endorph in response to an acute pain stimulus显示文摘 | Natalie Ann Rasmussen Lynne A Farr | 2009 | Journal of Neuroscience Methods2009，177，： | 1 |
| 15 | Deactivation of vanadia-based commercial SCR catalysts by polyphosphoric acids显示文摘 | CASTELLINO F RASMUSSEN S B JENSEN A 0 JOHNS SON J E FEHRM ANN R | 2008 | Applied Catalysis B: Environmental2008，83，： | 1 |
| 16 | 肥胖患者罗库溴铵的给药剂量应按理想体重还是校正体重计算显示文摘背景对于肥胖患者,药代动力学参数显示,应按照患者的理想体重计算罗库溴铵给药剂量,但此方生却可能延长罗库溴铵起效时间或不能满足插管条件。本研究按不同的校正体重将患者分成3组,并分别按照校正体重计算罗库溴铵给药剂量,比较3组中罗库溴铵的起效时间、插管条件和药物持续时间。方法将51例择期行腹腔镜胃束带减容术和胃转流术的肥胖患者随机分成3组,平均体重指数为44(34-72)kg/m^2,分别按照理想体重(IBW组,n=17)、理想体重加超标体重的20%[校正体重(CBW)20%组,n=17]、理想阵重加起标体重的40%(CBW40%组,n=17)计算罗库溴铵给药剂量(0.6mg/kg).所有患者都采用丙泊酚-瑞芬太尼复合麻醉。一次静注丙泊酚200mg并以5mg·kg^-1·h^-1泵注维持麻醉,瑞芬太尼则以1.0μg·kg^-1·min^-1的速度维持输注,2种药物均采用CBW40%组的校正体重计算给药量。采用TOF(4个成串刺激)监测神经肌肉功能,首要观察指标为罗库溴铵持续时间,即4个成串神经刺激中第4个肌颤搐的恢复时间。结果IBW组、CBW20%组和CBW40%组罗车溴铵持续时间分别为32(18~49)分钟、38(25~66)分钟和42(24—66)分钟,IBW组和CBW40%组间差异有统计学差异(P=0.001):而在各组罗库溴铵的起效时间(分别为85、84和80秒)和注药后90秒内的插管条件差异无统计学意义。结论对于行胃束带减容术和胃转流术的肥胖患者,按照理想体重给予罗库溴铵后其持续时间短,不会明显延长药物的起效时间,也不会影响插管条件。 | Christian S. Meyhoff, MD, PhD JФrgen Lund, MD Morten T. Jenstrup, MD Casper Claudius, MD, PhD Anne M. Scrensen, MD, PhD JФrgen Viby-Mogensen, MD, DMSc Lars S. Rasmussen, MD, PhD, DMSc 肖洁(译) 王祥瑞(校) | 2011 | 麻醉与镇痛2011，7，4： | 0 |
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